#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:X2JAU8 uniprotkb:Q9VAT0 intact:EBI-167691|uniprotkb:X2J8V0|uniprotkb:X2JC77|uniprotkb:X2JCQ1|uniprotkb:X2JGF9|uniprotkb:M9NE66|uniprotkb:M9NF56|uniprotkb:M9NFQ1|uniprotkb:Q9VSU8|ensemblmetazoa:FBpp0310643 intact:EBI-132019|ensemblmetazoa:FBpp0084721|ensemblmetazoa:FBpp0084722|ensemblmetazoa:FBpp0307744 psi-mi:nwk_drome(display_long)|uniprotkb:nwk(gene name)|psi-mi:nwk(display_short)|uniprotkb:CG43479(orf name) psi-mi:q9vat0_drome(display_long)|uniprotkb:D-WASP(gene name synonym)|uniprotkb:Dm WASP(gene name synonym)|uniprotkb:DmWASP(gene name synonym)|uniprotkb:Dmel\CG1520(gene name synonym)|uniprotkb:WASP(gene name synonym)|uniprotkb:WSP(gene name synonym)|uniprotkb:Wasp(gene name synonym)|uniprotkb:Wsp(gene name synonym)|uniprotkb:dWASP(gene name synonym)|uniprotkb:wasp(gene name synonym)|uniprotkb:wsp(gene name synonym)|uniprotkb:Dmel_CG1520(orf name)|uniprotkb:WASp(gene name)|psi-mi:WASp(display_short)|uniprotkb:CG1520(orf name) psi-mi:"MI:0096"(pull down) Coyle et al. (2004) pubmed:14980202 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-603256 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0263456|refseq:NP_001286994.1|ensemblmetazoa:FBgn0263456(gene)|ensemblmetazoa:FBtr0344239(transcript)|go:"GO:0001881"(receptor recycling)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0030424"(axon)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0055037"(recycling endosome)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR031160|interpro:IPR035460|interpro:IPR036028|refseq:NP_001246689.1|refseq:NP_001246690.1|refseq:NP_001246691.1|refseq:NP_001246692.1|refseq:NP_001286993.1|refseq:NP_001286995.1|refseq:NP_001286996.1|refseq:NP_001286997.1|refseq:NP_648290.3 refseq:NP_651637.1|refseq:NP_733257.1|flybase:FBgn0024273|refseq:NP_001263045.1|ensemblmetazoa:FBgn0024273(gene)|ensemblmetazoa:FBtr0085352(transcript)|ensemblmetazoa:FBtr0085353(transcript)|ensemblmetazoa:FBtr0336768(transcript)|go:"GO:0003383"(apical constriction)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007286"(spermatid development)|go:"GO:0007409"(axonogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007423"(sensory organ development)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0008407"(chaeta morphogenesis)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0016028"(rhabdomere)|go:"GO:0016203"(muscle attachment)|go:"GO:0016476"(regulation of embryonic cell shape)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936|go:"GO:0001578"(microtubule bundle formation) go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction) - - - taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/20 2019/02/20 rogid:4o13X34Hsz46rCSZD3pGk05pWck7227 rogid:cY9fXLlqd2jIkqxFj1mlI4s/s387227 intact-crc:4994619E8814A973|rigid:++e4GOjhOpW6TW6QGRpAgEuoOtA false glutathione s tranferase tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:X2JAU8 uniprotkb:Q9VAT0 intact:EBI-167691|uniprotkb:X2J8V0|uniprotkb:X2JC77|uniprotkb:X2JCQ1|uniprotkb:X2JGF9|uniprotkb:M9NE66|uniprotkb:M9NF56|uniprotkb:M9NFQ1|uniprotkb:Q9VSU8|ensemblmetazoa:FBpp0310643 intact:EBI-132019|ensemblmetazoa:FBpp0084721|ensemblmetazoa:FBpp0084722|ensemblmetazoa:FBpp0307744 psi-mi:nwk_drome(display_long)|uniprotkb:nwk(gene name)|psi-mi:nwk(display_short)|uniprotkb:CG43479(orf name) psi-mi:q9vat0_drome(display_long)|uniprotkb:D-WASP(gene name synonym)|uniprotkb:Dm WASP(gene name synonym)|uniprotkb:DmWASP(gene name synonym)|uniprotkb:Dmel\CG1520(gene name synonym)|uniprotkb:WASP(gene name synonym)|uniprotkb:WSP(gene name synonym)|uniprotkb:Wasp(gene name synonym)|uniprotkb:Wsp(gene name synonym)|uniprotkb:dWASP(gene name synonym)|uniprotkb:wasp(gene name synonym)|uniprotkb:wsp(gene name synonym)|uniprotkb:Dmel_CG1520(orf name)|uniprotkb:WASp(gene name)|psi-mi:WASp(display_short)|uniprotkb:CG1520(orf name) psi-mi:"MI:0096"(pull down) Coyle et al. (2004) pubmed:14980202 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-608424 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0263456|refseq:NP_001286994.1|ensemblmetazoa:FBgn0263456(gene)|ensemblmetazoa:FBtr0344239(transcript)|go:"GO:0001881"(receptor recycling)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0030424"(axon)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0055037"(recycling endosome)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR031160|interpro:IPR035460|interpro:IPR036028|refseq:NP_001246689.1|refseq:NP_001246690.1|refseq:NP_001246691.1|refseq:NP_001246692.1|refseq:NP_001286993.1|refseq:NP_001286995.1|refseq:NP_001286996.1|refseq:NP_001286997.1|refseq:NP_648290.3 refseq:NP_651637.1|refseq:NP_733257.1|flybase:FBgn0024273|refseq:NP_001263045.1|ensemblmetazoa:FBgn0024273(gene)|ensemblmetazoa:FBtr0085352(transcript)|ensemblmetazoa:FBtr0085353(transcript)|ensemblmetazoa:FBtr0336768(transcript)|go:"GO:0003383"(apical constriction)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007286"(spermatid development)|go:"GO:0007409"(axonogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007423"(sensory organ development)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0008407"(chaeta morphogenesis)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0016028"(rhabdomere)|go:"GO:0016203"(muscle attachment)|go:"GO:0016476"(regulation of embryonic cell shape)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936|go:"GO:0001578"(microtubule bundle formation) go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction) - - comment:The authors says the interaction was also shown in a yeast two hybrid experiment, using nwk as a bait. It also showed the importance of the SH3 domain. taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/20 2019/02/20 rogid:4o13X34Hsz46rCSZD3pGk05pWck7227 rogid:cY9fXLlqd2jIkqxFj1mlI4s/s387227 intact-crc:55DDFAFCB4AEA7B7|rigid:++e4GOjhOpW6TW6QGRpAgEuoOtA false glutathione s tranferase tag:?-?|binding-associated region:545..545-601..601(IPR001452) - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:X2JAU8 uniprotkb:Q9VAT0 intact:EBI-167691|uniprotkb:X2J8V0|uniprotkb:X2JC77|uniprotkb:X2JCQ1|uniprotkb:X2JGF9|uniprotkb:M9NE66|uniprotkb:M9NF56|uniprotkb:M9NFQ1|uniprotkb:Q9VSU8|ensemblmetazoa:FBpp0310643 intact:EBI-132019|ensemblmetazoa:FBpp0084721|ensemblmetazoa:FBpp0084722|ensemblmetazoa:FBpp0307744 psi-mi:nwk_drome(display_long)|uniprotkb:nwk(gene name)|psi-mi:nwk(display_short)|uniprotkb:CG43479(orf name) psi-mi:q9vat0_drome(display_long)|uniprotkb:D-WASP(gene name synonym)|uniprotkb:Dm WASP(gene name synonym)|uniprotkb:DmWASP(gene name synonym)|uniprotkb:Dmel\CG1520(gene name synonym)|uniprotkb:WASP(gene name synonym)|uniprotkb:WSP(gene name synonym)|uniprotkb:Wasp(gene name synonym)|uniprotkb:Wsp(gene name synonym)|uniprotkb:dWASP(gene name synonym)|uniprotkb:wasp(gene name synonym)|uniprotkb:wsp(gene name synonym)|uniprotkb:Dmel_CG1520(orf name)|uniprotkb:WASp(gene name)|psi-mi:WASp(display_short)|uniprotkb:CG1520(orf name) psi-mi:"MI:0428"(imaging technique) Coyle et al. (2004) pubmed:14980202 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-608415 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0263456|refseq:NP_001286994.1|ensemblmetazoa:FBgn0263456(gene)|ensemblmetazoa:FBtr0344239(transcript)|go:"GO:0001881"(receptor recycling)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0030424"(axon)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0055037"(recycling endosome)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR031160|interpro:IPR035460|interpro:IPR036028|refseq:NP_001246689.1|refseq:NP_001246690.1|refseq:NP_001246691.1|refseq:NP_001246692.1|refseq:NP_001286993.1|refseq:NP_001286995.1|refseq:NP_001286996.1|refseq:NP_001286997.1|refseq:NP_648290.3 refseq:NP_651637.1|refseq:NP_733257.1|flybase:FBgn0024273|refseq:NP_001263045.1|ensemblmetazoa:FBgn0024273(gene)|ensemblmetazoa:FBtr0085352(transcript)|ensemblmetazoa:FBtr0085353(transcript)|ensemblmetazoa:FBtr0336768(transcript)|go:"GO:0003383"(apical constriction)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007286"(spermatid development)|go:"GO:0007409"(axonogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007423"(sensory organ development)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0008407"(chaeta morphogenesis)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0016028"(rhabdomere)|go:"GO:0016203"(muscle attachment)|go:"GO:0016476"(regulation of embryonic cell shape)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936|go:"GO:0001578"(microtubule bundle formation) go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0007528"(neuromuscular junction development) - - - taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2005/06/20 2019/02/20 rogid:4o13X34Hsz46rCSZD3pGk05pWck7227 rogid:cY9fXLlqd2jIkqxFj1mlI4s/s387227 intact-crc:0201243E73066093|rigid:++e4GOjhOpW6TW6QGRpAgEuoOtA false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)