#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q4LDD4	uniprotkb:P25095	intact:EBI-764994|uniprotkb:B2RUJ3|uniprotkb:Q3UDD2|uniprotkb:Q3US99|uniprotkb:Q58ET6|uniprotkb:Q6PEQ9|uniprotkb:Q6ZQ48|ensembl:ENSMUSP00000081958	intact:EBI-764979|uniprotkb:Q9QVS5|ensembl:ENSRNOP00000034687	psi-mi:arap1_mouse(display_long)|uniprotkb:Arap1(gene name)|psi-mi:Arap1(display_short)|uniprotkb:Centd2(gene name synonym)|uniprotkb:Kiaa0782(gene name synonym)|uniprotkb:Centaurin-delta-2(gene name synonym)	psi-mi:agtra_rat(display_long)|uniprotkb:Angiotensin II type-1A receptor(gene name synonym)|uniprotkb:Agtr1(gene name)|psi-mi:Agtr1(display_short)|uniprotkb:Agtr1a(gene name synonym)|uniprotkb:At1a(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Guo et al. (2003)	pubmed:14559250	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-764999	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035200.1|refseq:NP_001035201.1|refseq:NP_081456.2|refseq:NP_932764.1|refseq:XP_011240199.1|refseq:XP_006508249.1|refseq:XP_006508250.1|refseq:XP_006508251.1|ensembl:ENSMUSG00000032812(gene)|ensembl:ENSMUST00000084896(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0051270"(regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070412"(R-SMAD binding)|interpro:IPR000159(Ras-association)|interpro:IPR000198(RhoGAP)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR037278|interpro:IPR037858|interpro:IPR038508|rcsb pdb:5XHZ|reactome:R-MMU-8849469|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149	rgd:2070|refseq:NP_112247.2|refseq:XP_008769816.1|refseq:XP_006253944.1|ensembl:ENSRNOG00000018346(gene)|ensembl:ENSRNOT00000038532(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001822"(kidney development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001991"(regulation of systemic arterial blood pressure by circulatory renin-angiotensin)|go:"GO:0002001"(renin secretion into blood stream)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002035"(brain renin-angiotensin system)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006885"(regulation of pH)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009651"(response to salt stress)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0012505"(endomembrane system)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031968"(organelle outer membrane)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P25095|rcsb pdb:2AC6|rcsb pdb:2AH3|reactome:R-RNO-375276|reactome:R-RNO-416476|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042756"(drinking behavior)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0042310"(vasoconstriction)	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/12/08	2014/10/16	rogid:aNOHsfDMoFvnctFt0xwYwO7R/SE10090	rogid:IBt+94S4gpjhzcKvbWNtv+8Xuqs10116	intact-crc:1EA404B2D728EE16|rigid:d5W+XsVgedxtSv+JE94vfdQNj78	false	-	binding-associated region:?-?	-	-	psi-mi:"MI:0056"(full identification by DNA sequencing)	psi-mi:"MI:0056"(full identification by DNA sequencing)
uniprotkb:Q4LDD4	uniprotkb:P25095	intact:EBI-764994|uniprotkb:B2RUJ3|uniprotkb:Q3UDD2|uniprotkb:Q3US99|uniprotkb:Q58ET6|uniprotkb:Q6PEQ9|uniprotkb:Q6ZQ48|ensembl:ENSMUSP00000081958	intact:EBI-764979|uniprotkb:Q9QVS5|ensembl:ENSRNOP00000034687	psi-mi:arap1_mouse(display_long)|uniprotkb:Arap1(gene name)|psi-mi:Arap1(display_short)|uniprotkb:Centd2(gene name synonym)|uniprotkb:Kiaa0782(gene name synonym)|uniprotkb:Centaurin-delta-2(gene name synonym)	psi-mi:agtra_rat(display_long)|uniprotkb:Angiotensin II type-1A receptor(gene name synonym)|uniprotkb:Agtr1(gene name)|psi-mi:Agtr1(display_short)|uniprotkb:Agtr1a(gene name synonym)|uniprotkb:At1a(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Guo et al. (2003)	pubmed:14559250	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-765017	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035200.1|refseq:NP_001035201.1|refseq:NP_081456.2|refseq:NP_932764.1|refseq:XP_011240199.1|refseq:XP_006508249.1|refseq:XP_006508250.1|refseq:XP_006508251.1|ensembl:ENSMUSG00000032812(gene)|ensembl:ENSMUST00000084896(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0051270"(regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070412"(R-SMAD binding)|interpro:IPR000159(Ras-association)|interpro:IPR000198(RhoGAP)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR037278|interpro:IPR037858|interpro:IPR038508|rcsb pdb:5XHZ|reactome:R-MMU-8849469|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149	rgd:2070|refseq:NP_112247.2|refseq:XP_008769816.1|refseq:XP_006253944.1|ensembl:ENSRNOG00000018346(gene)|ensembl:ENSRNOT00000038532(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001822"(kidney development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001991"(regulation of systemic arterial blood pressure by circulatory renin-angiotensin)|go:"GO:0002001"(renin secretion into blood stream)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002035"(brain renin-angiotensin system)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006885"(regulation of pH)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009651"(response to salt stress)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0012505"(endomembrane system)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031968"(organelle outer membrane)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P25095|rcsb pdb:2AC6|rcsb pdb:2AH3|reactome:R-RNO-375276|reactome:R-RNO-416476|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042756"(drinking behavior)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0042310"(vasoconstriction)	-	-	-	comment:"The truncated fragment of AT-1A (P25095) of 295-318AA did not interact with ARAP1 (Q4LDD4)(shown in Figure 1C)."	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/12/08	2014/10/16	rogid:aNOHsfDMoFvnctFt0xwYwO7R/SE10090	rogid:IBt+94S4gpjhzcKvbWNtv+8Xuqs10116	intact-crc:6D74D246D61354BE|rigid:d5W+XsVgedxtSv+JE94vfdQNj78	false	-	binding-associated region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25095	uniprotkb:Q5I0H0	intact:EBI-764979|uniprotkb:Q9QVS5|ensembl:ENSRNOP00000034687	intact:EBI-765046	psi-mi:agtra_rat(display_long)|uniprotkb:Angiotensin II type-1A receptor(gene name synonym)|uniprotkb:Agtr1(gene name)|psi-mi:Agtr1(display_short)|uniprotkb:Agtr1a(gene name synonym)|uniprotkb:At1a(gene name synonym)	psi-mi:q5i0h0_rat(display_long)|uniprotkb:Centd2(gene name)|psi-mi:Centd2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Guo et al. (2003)	pubmed:14559250	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-765059	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2070|refseq:NP_112247.2|refseq:XP_008769816.1|refseq:XP_006253944.1|ensembl:ENSRNOG00000018346(gene)|ensembl:ENSRNOT00000038532(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001822"(kidney development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001991"(regulation of systemic arterial blood pressure by circulatory renin-angiotensin)|go:"GO:0002001"(renin secretion into blood stream)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002035"(brain renin-angiotensin system)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006885"(regulation of pH)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009651"(response to salt stress)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0012505"(endomembrane system)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031968"(organelle outer membrane)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P25095|rcsb pdb:2AC6|rcsb pdb:2AH3|reactome:R-RNO-375276|reactome:R-RNO-416476|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042756"(drinking behavior)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0042310"(vasoconstriction)	interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000159(Ras-association)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR000198(RhoGAP)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0007165"(signal transduction)	-	-	-	comment:"A truncated mutant of AT-1A (P25095) containing 1-318AA did not interact with ARAP1, indicating that the carboxyl terminal region between residues 319-359 of the receptor is important for the interaction."|agonist:"The presence of Angiotensin II promoted the association beween the AT-1A receptor and rat ARAP1 (Q510H0), with maximum effect after 30-45 mins of exposure to Ang II."	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/12/08	2014/10/16	rogid:IBt+94S4gpjhzcKvbWNtv+8Xuqs10116	rogid:bFp6CI0WcCOyWUtHNRGYP6aHQL010116	intact-crc:08FF3AC7834167A2|rigid:Q9QN/GHjZu0KdWWQj7lXotWmYG8	false	flag tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P25095	uniprotkb:Q5I0H0	intact:EBI-764979|uniprotkb:Q9QVS5|ensembl:ENSRNOP00000034687	intact:EBI-765046	psi-mi:agtra_rat(display_long)|uniprotkb:Angiotensin II type-1A receptor(gene name synonym)|uniprotkb:Agtr1(gene name)|psi-mi:Agtr1(display_short)|uniprotkb:Agtr1a(gene name synonym)|uniprotkb:At1a(gene name synonym)	psi-mi:q5i0h0_rat(display_long)|uniprotkb:Centd2(gene name)|psi-mi:Centd2(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Guo et al. (2003)	pubmed:14559250	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-765145	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2070|refseq:NP_112247.2|refseq:XP_008769816.1|refseq:XP_006253944.1|ensembl:ENSRNOG00000018346(gene)|ensembl:ENSRNOT00000038532(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001822"(kidney development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001991"(regulation of systemic arterial blood pressure by circulatory renin-angiotensin)|go:"GO:0002001"(renin secretion into blood stream)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002035"(brain renin-angiotensin system)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006885"(regulation of pH)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009651"(response to salt stress)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0012505"(endomembrane system)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031968"(organelle outer membrane)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P25095|rcsb pdb:2AC6|rcsb pdb:2AH3|reactome:R-RNO-375276|reactome:R-RNO-416476|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042756"(drinking behavior)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0042310"(vasoconstriction)	interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000159(Ras-association)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR000198(RhoGAP)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0007165"(signal transduction)	go:"GO:0005886"(plasma membrane)	-	-	-	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/12/08	2014/10/16	rogid:IBt+94S4gpjhzcKvbWNtv+8Xuqs10116	rogid:bFp6CI0WcCOyWUtHNRGYP6aHQL010116	intact-crc:7AB6F3FDADA2975F|rigid:Q9QN/GHjZu0KdWWQj7lXotWmYG8	false	flag tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)