#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P52734	uniprotkb:Q60598	intact:EBI-6992536|ensembl:ENSMUSP00000026296|uniprotkb:Q921L2|intact:MINT-272222	intact:EBI-397955|intact:EBI-4281621|uniprotkb:Q3UGC2|ensembl:ENSMUSP00000099368	psi-mi:fgd1_mouse(display_long)|uniprotkb:Fgd1(gene name)|psi-mi:Fgd1(display_short)|uniprotkb:Faciogenital dysplasia 1 protein homolog(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 3(gene name synonym)|uniprotkb:Rho/Rac guanine nucleotide exchange factor FGD1(gene name synonym)	psi-mi:src8_mouse(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)|uniprotkb:Ems1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hou et al. (2003)	pubmed:12913069|mint:MINT-5216617	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992580|mint:MINT-56701	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025265(gene)|ensembl:ENSMUST00000026296(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0046872"(metal ion binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR035899|interpro:IPR035939|interpro:IPR035941|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-9013148|refseq:NP_032027.2|mint:MINT-738500(identity)	refseq:NP_031829.2|ensembl:ENSMUSG00000031078(gene)|ensembl:ENSMUST00000103079(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|interpro:IPR036028|mint:Q60598|rcsb pdb:2F9X|rcsb pdb:3ULR|rcsb pdb:5NV1|rcsb pdb:5NVJ|rcsb pdb:5NXJ|reactome:R-MMU-8856828|dip:DIP-31562N|mint:MINT-738506(identity)	-	comment:mint|function:Activates CDC42, a member of the Ras-like family of Rho-and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/03/22	2014/10/16	rogid:+moi9C3+tDgW7Y10QH4sGNqpr8w10090	rogid:4hLyMrquWdlJnIX2pHuXqYtQgkE10090	intact-crc:4C1D29B83E380830|rigid:5z7caAYZ1t5YtH+6WqM//jyCy+4	false	tag:?-?(MINT-738501)	tag:?-?(MINT-738510)|binding-associated region:434-546(MINT-738507)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q62418-2	uniprotkb:P52734	intact:EBI-6992635|intact:MINT-100795|ensembl:ENSMUSP00000099992	intact:EBI-6992536|ensembl:ENSMUSP00000026296|uniprotkb:Q921L2|intact:MINT-272222	psi-mi:q62418-2(display_long)|uniprotkb:Abp1(gene name synonym)|uniprotkb:Actin-binding protein 1(gene name synonym)|uniprotkb:SH3 domain-containing protein 7(gene name synonym)|uniprotkb:Sh3p7(gene name synonym)|uniprotkb:Dbnl(gene name)|psi-mi:Dbnl(display_short)	psi-mi:fgd1_mouse(display_long)|uniprotkb:Fgd1(gene name)|psi-mi:Fgd1(display_short)|uniprotkb:Faciogenital dysplasia 1 protein homolog(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 3(gene name synonym)|uniprotkb:Rho/Rac guanine nucleotide exchange factor FGD1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hou et al. (2003)	pubmed:12913069|mint:MINT-5216617	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992652|mint:MINT-56702	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1550322(isoform-parent)|ensembl:ENSMUSG00000020476(gene)|ensembl:ENSMUST00000102928(transcript)|mint:MINT-738369(identity)	ensembl:ENSMUSG00000025265(gene)|ensembl:ENSMUST00000026296(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0046872"(metal ion binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR035899|interpro:IPR035939|interpro:IPR035941|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-9013148|refseq:NP_032027.2|mint:MINT-738363(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|function:Activates CDC42, a member of the Ras-like family of Rho-and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape|comment:"Stoichiometry: 1.0"	figure legend:F1|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/03/22	2014/10/16	rogid:MlYYeyvJZOgx4q+dCUB6eMOe0io10090	rogid:+moi9C3+tDgW7Y10QH4sGNqpr8w10090	intact-crc:136B8984AF030C0C|rigid:dz/AsAcOFirHZD/qXP9sHefOpzk	false	binding-associated region:344-433(MINT-738370)|tag:?-?(MINT-738373)	tag:?-?(MINT-738364)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P52734	uniprotkb:Q62418	intact:EBI-6992536|ensembl:ENSMUSP00000026296|uniprotkb:Q921L2|intact:MINT-272222	intact:EBI-1550322|uniprotkb:Q80WP1|uniprotkb:Q8BH56|uniprotkb:Q3TG34|uniprotkb:Q3U5X3|uniprotkb:Q3U8I5|uniprotkb:Q3UZ33|uniprotkb:Q5NCI5|uniprotkb:Q5NCI6|uniprotkb:Q5NCI7|ensembl:ENSMUSP00000020769	psi-mi:fgd1_mouse(display_long)|uniprotkb:Fgd1(gene name)|psi-mi:Fgd1(display_short)|uniprotkb:Faciogenital dysplasia 1 protein homolog(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 3(gene name synonym)|uniprotkb:Rho/Rac guanine nucleotide exchange factor FGD1(gene name synonym)	psi-mi:dbnl_mouse(display_long)|uniprotkb:Dbnl(gene name)|psi-mi:Dbnl(display_short)|uniprotkb:Abp1(gene name synonym)|uniprotkb:Sh3p7(gene name synonym)|uniprotkb:SH3 domain-containing protein 7(gene name synonym)|uniprotkb:Actin-binding protein 1(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Hou et al. (2003)	pubmed:12913069|mint:MINT-5216617	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992723|mint:MINT-56703	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025265(gene)|ensembl:ENSMUST00000026296(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0046872"(metal ion binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR035899|interpro:IPR035939|interpro:IPR035941|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-9013148|refseq:NP_032027.2|mint:MINT-738576(identity)	refseq:NP_001139780.1|refseq:NP_001139781.1|refseq:NP_038838.1|dip:DIP-39835N|ensembl:ENSMUSG00000020476(gene)|ensembl:ENSMUST00000020769(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007416"(synapse assembly)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0043204"(perikaryon)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0071800"(podosome assembly)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|interpro:IPR035717|interpro:IPR036028|mint:Q62418|reactome:R-MMU-264870|reactome:R-MMU-6794361|reactome:R-MMU-6798695|interpro:IPR001452(Src homology-3)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR029006|interpro:IPR029923|mint:MINT-738583(identity)	-	comment:mint|function:Activates CDC42, a member of the Ras-like family of Rho-and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4|comment:homomint|comment:mint	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2005/03/22	2014/10/16	rogid:+moi9C3+tDgW7Y10QH4sGNqpr8w10090	rogid:uRFrfUfKF7cfhsrbleRauR33+g810090	intact-crc:41AD397BD663F5A6|rigid:Ah8k6+q6FcbcyDHf450Qtp+lTjM	false	tag:?-?(MINT-738577)	-	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)
uniprotkb:P52734	uniprotkb:Q60598	intact:EBI-6992536|ensembl:ENSMUSP00000026296|uniprotkb:Q921L2|intact:MINT-272222	intact:EBI-397955|intact:EBI-4281621|uniprotkb:Q3UGC2|ensembl:ENSMUSP00000099368	psi-mi:fgd1_mouse(display_long)|uniprotkb:Fgd1(gene name)|psi-mi:Fgd1(display_short)|uniprotkb:Faciogenital dysplasia 1 protein homolog(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 3(gene name synonym)|uniprotkb:Rho/Rac guanine nucleotide exchange factor FGD1(gene name synonym)	psi-mi:src8_mouse(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)|uniprotkb:Ems1(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Hou et al. (2003)	pubmed:12913069|mint:MINT-5216617	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992739|mint:MINT-56704	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025265(gene)|ensembl:ENSMUST00000026296(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0046872"(metal ion binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR035899|interpro:IPR035939|interpro:IPR035941|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-9013148|refseq:NP_032027.2|mint:MINT-738403(identity)	refseq:NP_031829.2|ensembl:ENSMUSG00000031078(gene)|ensembl:ENSMUST00000103079(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|interpro:IPR036028|mint:Q60598|rcsb pdb:2F9X|rcsb pdb:3ULR|rcsb pdb:5NV1|rcsb pdb:5NVJ|rcsb pdb:5NXJ|reactome:R-MMU-8856828|dip:DIP-31562N|mint:MINT-738410(identity)	-	comment:mint|function:Activates CDC42, a member of the Ras-like family of Rho-and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4|comment:homomint|comment:mint	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2005/03/22	2014/10/16	rogid:+moi9C3+tDgW7Y10QH4sGNqpr8w10090	rogid:4hLyMrquWdlJnIX2pHuXqYtQgkE10090	intact-crc:33FE90078C9857F0|rigid:5z7caAYZ1t5YtH+6WqM//jyCy+4	false	tag:?-?(MINT-738404)	-	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)
uniprotkb:P52734	uniprotkb:Q60598	intact:EBI-6992536|ensembl:ENSMUSP00000026296|uniprotkb:Q921L2|intact:MINT-272222	intact:EBI-397955|intact:EBI-4281621|uniprotkb:Q3UGC2|ensembl:ENSMUSP00000099368	psi-mi:fgd1_mouse(display_long)|uniprotkb:Fgd1(gene name)|psi-mi:Fgd1(display_short)|uniprotkb:Faciogenital dysplasia 1 protein homolog(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 3(gene name synonym)|uniprotkb:Rho/Rac guanine nucleotide exchange factor FGD1(gene name synonym)	psi-mi:src8_mouse(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)|uniprotkb:Ems1(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Hou et al. (2003)	pubmed:12913069|mint:MINT-5216617	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992782|mint:MINT-56709	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025265(gene)|ensembl:ENSMUST00000026296(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0046872"(metal ion binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR035899|interpro:IPR035939|interpro:IPR035941|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-9013148|refseq:NP_032027.2|mint:MINT-738383(identity)	refseq:NP_031829.2|ensembl:ENSMUSG00000031078(gene)|ensembl:ENSMUST00000103079(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|interpro:IPR036028|mint:Q60598|rcsb pdb:2F9X|rcsb pdb:3ULR|rcsb pdb:5NV1|rcsb pdb:5NVJ|rcsb pdb:5NXJ|reactome:R-MMU-8856828|dip:DIP-31562N|mint:MINT-738390(identity)	-	comment:mint|function:Activates CDC42, a member of the Ras-like family of Rho-and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F6|comment:homomint|comment:mint	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2005/03/22	2014/10/16	rogid:+moi9C3+tDgW7Y10QH4sGNqpr8w10090	rogid:4hLyMrquWdlJnIX2pHuXqYtQgkE10090	intact-crc:22CC9F5C931EE18C|rigid:5z7caAYZ1t5YtH+6WqM//jyCy+4	false	tag:?-?(MINT-738384)	binding-associated region:491-546(MINT-738391)|tag:?-?(MINT-738394)	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)
uniprotkb:P52734	uniprotkb:Q60598	intact:EBI-6992536|ensembl:ENSMUSP00000026296|uniprotkb:Q921L2|intact:MINT-272222	intact:EBI-397955|intact:EBI-4281621|uniprotkb:Q3UGC2|ensembl:ENSMUSP00000099368	psi-mi:fgd1_mouse(display_long)|uniprotkb:Fgd1(gene name)|psi-mi:Fgd1(display_short)|uniprotkb:Faciogenital dysplasia 1 protein homolog(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 3(gene name synonym)|uniprotkb:Rho/Rac guanine nucleotide exchange factor FGD1(gene name synonym)	psi-mi:src8_mouse(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)|uniprotkb:Ems1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hou et al. (2003)	pubmed:12913069|mint:MINT-5216617	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992813|mint:MINT-56705	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025265(gene)|ensembl:ENSMUST00000026296(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0046872"(metal ion binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR035899|interpro:IPR035939|interpro:IPR035941|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-9013148|refseq:NP_032027.2|mint:MINT-738420(identity)	refseq:NP_031829.2|ensembl:ENSMUSG00000031078(gene)|ensembl:ENSMUST00000103079(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|interpro:IPR036028|mint:Q60598|rcsb pdb:2F9X|rcsb pdb:3ULR|rcsb pdb:5NV1|rcsb pdb:5NVJ|rcsb pdb:5NXJ|reactome:R-MMU-8856828|dip:DIP-31562N|mint:MINT-738429(identity)	-	comment:mint|function:Activates CDC42, a member of the Ras-like family of Rho-and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5|comment:homomint|comment:mint	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2005/03/22	2014/10/16	rogid:+moi9C3+tDgW7Y10QH4sGNqpr8w10090	rogid:4hLyMrquWdlJnIX2pHuXqYtQgkE10090	intact-crc:653328089C83D71F|rigid:5z7caAYZ1t5YtH+6WqM//jyCy+4	false	tag:?-?(MINT-738424)|mutation decreasing interaction:151-151,162-162(MINT-738421)	tag:?-?(MINT-738430)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P52734	uniprotkb:Q62418	intact:EBI-6992536|ensembl:ENSMUSP00000026296|uniprotkb:Q921L2|intact:MINT-272222	intact:EBI-1550322|uniprotkb:Q80WP1|uniprotkb:Q8BH56|uniprotkb:Q3TG34|uniprotkb:Q3U5X3|uniprotkb:Q3U8I5|uniprotkb:Q3UZ33|uniprotkb:Q5NCI5|uniprotkb:Q5NCI6|uniprotkb:Q5NCI7|ensembl:ENSMUSP00000020769	psi-mi:fgd1_mouse(display_long)|uniprotkb:Fgd1(gene name)|psi-mi:Fgd1(display_short)|uniprotkb:Faciogenital dysplasia 1 protein homolog(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 3(gene name synonym)|uniprotkb:Rho/Rac guanine nucleotide exchange factor FGD1(gene name synonym)	psi-mi:dbnl_mouse(display_long)|uniprotkb:Dbnl(gene name)|psi-mi:Dbnl(display_short)|uniprotkb:Abp1(gene name synonym)|uniprotkb:Sh3p7(gene name synonym)|uniprotkb:SH3 domain-containing protein 7(gene name synonym)|uniprotkb:Actin-binding protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hou et al. (2003)	pubmed:12913069|mint:MINT-5216617	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992851|mint:MINT-56707	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025265(gene)|ensembl:ENSMUST00000026296(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0046872"(metal ion binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR035899|interpro:IPR035939|interpro:IPR035941|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-9013148|refseq:NP_032027.2|mint:MINT-738558(identity)	refseq:NP_001139780.1|refseq:NP_001139781.1|refseq:NP_038838.1|dip:DIP-39835N|ensembl:ENSMUSG00000020476(gene)|ensembl:ENSMUST00000020769(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007416"(synapse assembly)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0043204"(perikaryon)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0071800"(podosome assembly)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|interpro:IPR035717|interpro:IPR036028|mint:Q62418|reactome:R-MMU-264870|reactome:R-MMU-6794361|reactome:R-MMU-6798695|interpro:IPR001452(Src homology-3)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR029006|interpro:IPR029923|mint:MINT-738567(identity)	-	comment:mint|function:Activates CDC42, a member of the Ras-like family of Rho-and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5|comment:homomint|comment:mint	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2005/03/22	2014/10/16	rogid:+moi9C3+tDgW7Y10QH4sGNqpr8w10090	rogid:uRFrfUfKF7cfhsrbleRauR33+g810090	intact-crc:9543954596D93718|rigid:Ah8k6+q6FcbcyDHf450Qtp+lTjM	false	tag:?-?(MINT-738562)|mutation decreasing interaction:151-151,162-162(MINT-738559)	tag:?-?(MINT-738568)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P52734	uniprotkb:Q60598	intact:EBI-6992536|ensembl:ENSMUSP00000026296|uniprotkb:Q921L2|intact:MINT-272222	intact:EBI-397955|intact:EBI-4281621|uniprotkb:Q3UGC2|ensembl:ENSMUSP00000099368	psi-mi:fgd1_mouse(display_long)|uniprotkb:Fgd1(gene name)|psi-mi:Fgd1(display_short)|uniprotkb:Faciogenital dysplasia 1 protein homolog(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 3(gene name synonym)|uniprotkb:Rho/Rac guanine nucleotide exchange factor FGD1(gene name synonym)	psi-mi:src8_mouse(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)|uniprotkb:Ems1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Hou et al. (2003)	pubmed:12913069|mint:MINT-5216617	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992929|mint:MINT-56712	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025265(gene)|ensembl:ENSMUST00000026296(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0046872"(metal ion binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR035899|interpro:IPR035939|interpro:IPR035941|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-9013148|refseq:NP_032027.2|mint:MINT-738538(identity)	refseq:NP_031829.2|ensembl:ENSMUSG00000031078(gene)|ensembl:ENSMUST00000103079(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|interpro:IPR036028|mint:Q60598|rcsb pdb:2F9X|rcsb pdb:3ULR|rcsb pdb:5NV1|rcsb pdb:5NVJ|rcsb pdb:5NXJ|reactome:R-MMU-8856828|dip:DIP-31562N|mint:MINT-738546(identity)	-	comment:mint|function:Activates CDC42, a member of the Ras-like family of Rho-and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3A|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/03/22	2014/10/16	rogid:+moi9C3+tDgW7Y10QH4sGNqpr8w10090	rogid:4hLyMrquWdlJnIX2pHuXqYtQgkE10090	intact-crc:3449EF1BA9DFCED8|rigid:5z7caAYZ1t5YtH+6WqM//jyCy+4	false	tag:?-?(MINT-738541)|binding-associated region:147-169(MINT-738539)	binding-associated region:490-546(MINT-738547)|tag:?-?(MINT-738550)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P52734	uniprotkb:Q60598	intact:EBI-6992536|ensembl:ENSMUSP00000026296|uniprotkb:Q921L2|intact:MINT-272222	intact:EBI-397955|intact:EBI-4281621|uniprotkb:Q3UGC2|ensembl:ENSMUSP00000099368	psi-mi:fgd1_mouse(display_long)|uniprotkb:Fgd1(gene name)|psi-mi:Fgd1(display_short)|uniprotkb:Faciogenital dysplasia 1 protein homolog(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 3(gene name synonym)|uniprotkb:Rho/Rac guanine nucleotide exchange factor FGD1(gene name synonym)	psi-mi:src8_mouse(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)|uniprotkb:Ems1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Hou et al. (2003)	pubmed:12913069|mint:MINT-5216617	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992882|mint:MINT-56711	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025265(gene)|ensembl:ENSMUST00000026296(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0046872"(metal ion binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR035899|interpro:IPR035939|interpro:IPR035941|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-9013148|refseq:NP_032027.2|mint:MINT-738480(identity)	refseq:NP_031829.2|ensembl:ENSMUSG00000031078(gene)|ensembl:ENSMUST00000103079(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|interpro:IPR036028|mint:Q60598|rcsb pdb:2F9X|rcsb pdb:3ULR|rcsb pdb:5NV1|rcsb pdb:5NVJ|rcsb pdb:5NXJ|reactome:R-MMU-8856828|dip:DIP-31562N|mint:MINT-738488(identity)	-	comment:mint|function:Activates CDC42, a member of the Ras-like family of Rho-and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/03/22	2014/10/16	rogid:+moi9C3+tDgW7Y10QH4sGNqpr8w10090	rogid:4hLyMrquWdlJnIX2pHuXqYtQgkE10090	intact-crc:B93E0870C147A72B|rigid:5z7caAYZ1t5YtH+6WqM//jyCy+4	false	tag:?-?(MINT-738483)|binding-associated region:131-195(MINT-738481)	binding-associated region:490-546(MINT-738489)|tag:?-?(MINT-738492)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P52734	uniprotkb:Q62418	intact:EBI-6992536|ensembl:ENSMUSP00000026296|uniprotkb:Q921L2|intact:MINT-272222	intact:EBI-1550322|uniprotkb:Q80WP1|uniprotkb:Q8BH56|uniprotkb:Q3TG34|uniprotkb:Q3U5X3|uniprotkb:Q3U8I5|uniprotkb:Q3UZ33|uniprotkb:Q5NCI5|uniprotkb:Q5NCI6|uniprotkb:Q5NCI7|ensembl:ENSMUSP00000020769	psi-mi:fgd1_mouse(display_long)|uniprotkb:Fgd1(gene name)|psi-mi:Fgd1(display_short)|uniprotkb:Faciogenital dysplasia 1 protein homolog(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 3(gene name synonym)|uniprotkb:Rho/Rac guanine nucleotide exchange factor FGD1(gene name synonym)	psi-mi:dbnl_mouse(display_long)|uniprotkb:Dbnl(gene name)|psi-mi:Dbnl(display_short)|uniprotkb:Abp1(gene name synonym)|uniprotkb:Sh3p7(gene name synonym)|uniprotkb:SH3 domain-containing protein 7(gene name synonym)|uniprotkb:Actin-binding protein 1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Hou et al. (2003)	pubmed:12913069|mint:MINT-5216617	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992955|mint:MINT-56713	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025265(gene)|ensembl:ENSMUST00000026296(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0046872"(metal ion binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR035899|interpro:IPR035939|interpro:IPR035941|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-9013148|refseq:NP_032027.2|mint:MINT-738518(identity)	refseq:NP_001139780.1|refseq:NP_001139781.1|refseq:NP_038838.1|dip:DIP-39835N|ensembl:ENSMUSG00000020476(gene)|ensembl:ENSMUST00000020769(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007416"(synapse assembly)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0043204"(perikaryon)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0071800"(podosome assembly)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|interpro:IPR035717|interpro:IPR036028|mint:Q62418|reactome:R-MMU-264870|reactome:R-MMU-6794361|reactome:R-MMU-6798695|interpro:IPR001452(Src homology-3)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR029006|interpro:IPR029923|mint:MINT-738526(identity)	-	comment:mint|function:Activates CDC42, a member of the Ras-like family of Rho-and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/03/22	2014/10/16	rogid:+moi9C3+tDgW7Y10QH4sGNqpr8w10090	rogid:uRFrfUfKF7cfhsrbleRauR33+g810090	intact-crc:F5FE22893CC29EEA|rigid:Ah8k6+q6FcbcyDHf450Qtp+lTjM	false	binding-associated region:147-169(MINT-738519)|tag:?-?(MINT-738521)	binding-associated region:318-433(MINT-738527)|tag:?-?(MINT-738530)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P52734	uniprotkb:Q62418	intact:EBI-6992536|ensembl:ENSMUSP00000026296|uniprotkb:Q921L2|intact:MINT-272222	intact:EBI-1550322|uniprotkb:Q80WP1|uniprotkb:Q8BH56|uniprotkb:Q3TG34|uniprotkb:Q3U5X3|uniprotkb:Q3U8I5|uniprotkb:Q3UZ33|uniprotkb:Q5NCI5|uniprotkb:Q5NCI6|uniprotkb:Q5NCI7|ensembl:ENSMUSP00000020769	psi-mi:fgd1_mouse(display_long)|uniprotkb:Fgd1(gene name)|psi-mi:Fgd1(display_short)|uniprotkb:Faciogenital dysplasia 1 protein homolog(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 3(gene name synonym)|uniprotkb:Rho/Rac guanine nucleotide exchange factor FGD1(gene name synonym)	psi-mi:dbnl_mouse(display_long)|uniprotkb:Dbnl(gene name)|psi-mi:Dbnl(display_short)|uniprotkb:Abp1(gene name synonym)|uniprotkb:Sh3p7(gene name synonym)|uniprotkb:SH3 domain-containing protein 7(gene name synonym)|uniprotkb:Actin-binding protein 1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Hou et al. (2003)	pubmed:12913069|mint:MINT-5216617	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992981|mint:MINT-56714	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025265(gene)|ensembl:ENSMUST00000026296(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0046872"(metal ion binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR035899|interpro:IPR035939|interpro:IPR035941|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-9013148|refseq:NP_032027.2|mint:MINT-738460(identity)	refseq:NP_001139780.1|refseq:NP_001139781.1|refseq:NP_038838.1|dip:DIP-39835N|ensembl:ENSMUSG00000020476(gene)|ensembl:ENSMUST00000020769(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007416"(synapse assembly)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0043204"(perikaryon)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0071800"(podosome assembly)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|interpro:IPR035717|interpro:IPR036028|mint:Q62418|reactome:R-MMU-264870|reactome:R-MMU-6794361|reactome:R-MMU-6798695|interpro:IPR001452(Src homology-3)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR029006|interpro:IPR029923|mint:MINT-738468(identity)	-	comment:mint|function:Activates CDC42, a member of the Ras-like family of Rho-and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3A|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/03/22	2014/10/16	rogid:+moi9C3+tDgW7Y10QH4sGNqpr8w10090	rogid:uRFrfUfKF7cfhsrbleRauR33+g810090	intact-crc:5DEA2E0FC257F8FB|rigid:Ah8k6+q6FcbcyDHf450Qtp+lTjM	false	binding-associated region:131-195(MINT-738461)|tag:?-?(MINT-738463)	binding-associated region:318-433(MINT-738469)|tag:?-?(MINT-738472)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)