#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O89100 uniprotkb:Q13094 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 intact:EBI-346946|uniprotkb:Q53XV4|uniprotkb:A8KA25|ensembl:ENSP00000046794 psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:lcp2_human(display_long)|uniprotkb:LCP2(gene name)|psi-mi:LCP2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Harkiolaki et al. (2003) mint:MINT-5216408|pubmed:12773374 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8652888|mint:MINT-60135 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-1724363(identity) refseq:NP_005556.1|dip:DIP-31812N|ensembl:ENSG00000043462(gene)|ensembl:ENST00000046794(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|mint:Q13094|rcsb pdb:1H3H|rcsb pdb:1YWO|rcsb pdb:2EAP|rcsb pdb:2ROR|rcsb pdb:6ZCJ|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|mint:MINT-1724373(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:T1|kd:0.181 micromolar|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/07/08 2014/10/16 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 rogid:lZa+nAuqvGDrNe3Jhxn/JQaU5ug9606 intact-crc:65F34B836E965546|rigid:CdNz7rvyX5qVEBfcRryNtgolXkY false tag:?-?(MINT-1724367)|binding-associated region:256-322(MINT-1724364) binding-associated region:231-243(MINT-1724374)|mutation decreasing interaction:233-233,236-236,237-237,240-240,241-241(MINT-1724376) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:Q8WWW8 uniprotkb:O89100 intact:EBI-7964503|uniprotkb:E9PB44|intact:MINT-1594309|uniprotkb:A6NHF8|ensembl:ENSP00000358588 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 psi-mi:gab3_human(display_long)|uniprotkb:GAB3(gene name)|psi-mi:GAB3(display_short)|uniprotkb:Growth factor receptor bound protein 2-associated protein 3(gene name synonym)|uniprotkb:GRB2-associated binder 3(gene name synonym) psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Harkiolaki et al. (2003) mint:MINT-5216408|pubmed:12773374 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8652965|mint:MINT-60137 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_542179.1|refseq:NP_001075042.1|refseq:NP_001269212.1|refseq:XP_005274705.1|refseq:XP_006724867.1|ensembl:ENST00000369575(transcript)|go:"GO:0030225"(macrophage differentiation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|ensembl:ENSG00000160219(gene)|mint:MINT-1594327(identity) refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-1594317(identity) - comment:mint|function:Unknown function|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:T1|kd:0.387 micromolar|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/07/08 2014/10/16 rogid:BF15TdUa4cutDIMJ9aTjySEYW5E9606 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 intact-crc:E007F12C2FC7F77E|rigid:nIlrbBfowv80C41AjXQZc6oIHus false binding-associated region:434-446(MINT-1594328) tag:?-?(MINT-1594321)|binding-associated region:256-322(MINT-1594318) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O89100 uniprotkb:Q13480 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 intact:EBI-517684|uniprotkb:Q4W5G2|uniprotkb:Q6P1W2|uniprotkb:A8K152|ensembl:ENSP00000262994 psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:gab1_human(display_long)|uniprotkb:Growth factor receptor bound protein 2-associated protein 1(gene name synonym)|uniprotkb:GRB2-associated binder 1(gene name synonym)|uniprotkb:GAB1(gene name)|psi-mi:GAB1(display_short) psi-mi:"MI:0065"(isothermal titration calorimetry) Harkiolaki et al. (2003) mint:MINT-5216408|pubmed:12773374 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8652924|mint:MINT-60136 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-1745636(identity) ensembl:ENSP00000262994|ensembl:ENST00000262995|ensembl:ENSP00000262995|refseq:NP_002030.2|refseq:NP_997006.1|ensembl:ENSG00000109458(gene)|ensembl:ENST00000262994(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0090668"(endothelial cell chemotaxis to vascular endothelial growth factor)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|mint:Q13480|rcsb pdb:4QSY|reactome:R-HSA-109704|reactome:R-HSA-1236382|reactome:R-HSA-1257604|reactome:R-HSA-180292|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8865999|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027276|reactome:R-HSA-9028335|reactome:R-HSA-9664565|reactome:R-HSA-9665348|mint:MINT-1745646(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:T1|kd:0.603 micromolar|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/07/08 2014/10/16 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 rogid:AIK39gZJknpy3vQK/GraIpBbgzU9606 intact-crc:6C19EDED22C8354B|rigid:14t2KJxrJI71Qa8eMxoN49CjUAU false tag:?-?(MINT-1745640)|binding-associated region:256-322(MINT-1745637) binding-associated region:515-527(MINT-1745647) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:O89100 uniprotkb:O95630 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 intact:EBI-396676|uniprotkb:Q3MJE7|uniprotkb:D6W5H7|uniprotkb:B5M0B6|ensembl:ENSP00000344742|ensembl:ENSP00000377633|ensembl:ENSP00000377636|ensembl:ENSP00000386548|ensembl:ENSP00000506833|ensembl:ENSP00000506845|ensembl:ENSP00000506865|ensembl:ENSP00000506958|ensembl:ENSP00000507014|ensembl:ENSP00000507054|ensembl:ENSP00000507081|ensembl:ENSP00000507092|ensembl:ENSP00000507639|ensembl:ENSP00000507658|ensembl:ENSP00000507864 psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:stabp_human(display_long)|uniprotkb:AMSH(gene name synonym)|uniprotkb:STAMBP(gene name)|psi-mi:STAMBP(display_short)|uniprotkb:Associated molecule with the SH3 domain of STAM(gene name synonym)|uniprotkb:Endosome-associated ubiquitin isopeptidase(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Harkiolaki et al. (2003) mint:MINT-5216408|pubmed:12773374 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8653013|mint:MINT-60139 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-1758154(identity) refseq:NP_006454.1|refseq:NP_964010.1|refseq:NP_998787.1|refseq:XP_005264145.1|refseq:XP_011530785.1|refseq:XP_016858664.1|go:"GO:0016020"(membrane)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR037518|interpro:IPR044098|mint:O95630|rcsb pdb:2XZE|rcsb pdb:3RZU|rcsb pdb:3RZV|rcsb pdb:5IXF|reactome:R-HSA-5689901|ensembl:ENSG00000124356(gene)|ensembl:ENST00000339566(transcript)|ensembl:ENST00000394070(transcript)|ensembl:ENST00000394073(transcript)|ensembl:ENST00000409707(transcript)|ensembl:ENST00000682351(transcript)|ensembl:ENST00000682379(transcript)|ensembl:ENST00000682558(transcript)|ensembl:ENST00000682847(transcript)|ensembl:ENST00000683036(transcript)|ensembl:ENST00000683317(transcript)|ensembl:ENST00000683518(transcript)|ensembl:ENST00000683818(transcript)|ensembl:ENST00000684095(transcript)|ensembl:ENST00000684312(transcript)|ensembl:ENST00000684585(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|dip:DIP-33062N|mint:MINT-1758164(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:T1|kd:0.473 micromolar|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/07/08 2014/10/16 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 rogid:JUvszgPz9rog/OEpmABJ295BaLw9606 intact-crc:5169CE242E5861AC|rigid:6MOAJEnUpp/qjN27FmJFPJAsgUc false binding-associated region:256-322(MINT-1758155)|tag:?-?(MINT-1758158) binding-associated region:229-241(MINT-1758165) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:P40818 uniprotkb:O89100 intact:EBI-1050865|uniprotkb:Q2TB31|uniprotkb:Q7Z3U2|uniprotkb:Q86VA0|uniprotkb:Q8IWI7|ensembl:ENSP00000302239|ensembl:ENSP00000379721|uniprotkb:B4DKA8 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 psi-mi:ubp8_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 8(gene name synonym)|uniprotkb:Deubiquitinating enzyme 8(gene name synonym)|uniprotkb:USP8(gene name)|psi-mi:USP8(display_short)|uniprotkb:KIAA0055(gene name synonym)|uniprotkb:UBPY(gene name synonym)|uniprotkb:Ubiquitin isopeptidase Y(gene name synonym)|uniprotkb:Ubiquitin thioesterase 8(gene name synonym) psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Harkiolaki et al. (2003) mint:MINT-5216408|pubmed:12773374 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8652989|mint:MINT-60138 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001122082.1|refseq:NP_005145.3|refseq:NP_001269978.1|refseq:XP_011520495.1|ensembl:ENSG00000138592(gene)|ensembl:ENST00000307179(transcript)|ensembl:ENST00000396444(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043197"(dendritic spine)|go:"GO:0045296"(cadherin binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001763(Rhodanese-like)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036873|interpro:IPR038765|mint:P40818|rcsb pdb:1WHB|rcsb pdb:2A9U|rcsb pdb:2GFO|rcsb pdb:2GWF|rcsb pdb:3N3K|rcsb pdb:6F09|reactome:R-HSA-1358803|reactome:R-HSA-4641263|reactome:R-HSA-5689880|reactome:R-HSA-6807004|refseq:XP_006720824.1|dip:DIP-40365N|mint:MINT-1705427(identity) refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-1705417(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:T1|kd:0.94 micromolar|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/07/08 2014/10/16 rogid:hpBBzyA4lc9is80ZFJBr1fyEyOM9606 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 intact-crc:CE360B991B8B73F1|rigid:SWWQclYmNjhuivkZ1vJBMWZ58O4 false binding-associated region:403-415(MINT-1705428) tag:?-?(MINT-1705421)|binding-associated region:256-322(MINT-1705418) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q13094 uniprotkb:O89100 intact:EBI-346946|uniprotkb:Q53XV4|uniprotkb:A8KA25|ensembl:ENSP00000046794 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 psi-mi:lcp2_human(display_long)|uniprotkb:LCP2(gene name)|psi-mi:LCP2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Harkiolaki et al. (2003) mint:MINT-5216408|pubmed:12773374 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8653062|mint:MINT-60141 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005556.1|dip:DIP-31812N|ensembl:ENSG00000043462(gene)|ensembl:ENST00000046794(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|mint:Q13094|rcsb pdb:1H3H|rcsb pdb:1YWO|rcsb pdb:2EAP|rcsb pdb:2ROR|rcsb pdb:6ZCJ|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|mint:MINT-1729812(identity) refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-1729804(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:T1 F2|kd:0.118 micromolar|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/07/08 2014/10/16 rogid:lZa+nAuqvGDrNe3Jhxn/JQaU5ug9606 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 intact-crc:417222EC10CBA737|rigid:CdNz7rvyX5qVEBfcRryNtgolXkY false binding-associated region:231-243(MINT-1729813) binding-associated region:256-322(MINT-1729805) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O89100 uniprotkb:Q8WV28 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49 psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short) psi-mi:"MI:0065"(isothermal titration calorimetry) Harkiolaki et al. (2003) mint:MINT-5216408|pubmed:12773374 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8653037|mint:MINT-60140 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-1619888(identity) refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1|mint:MINT-1619898(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:T1|kd:0.921 micromolar|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/07/08 2014/10/16 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 rogid:befGiho6PlVSSMPyb84d31TT/So9606 intact-crc:8499FB8E1BEC0F70|rigid:BudD2kmRAnko2/cWuLXGRq6WSIg false tag:?-?(MINT-1619892)|binding-associated region:256-322(MINT-1619889) binding-associated region:202-214(MINT-1619899) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:O89100 uniprotkb:Q13094 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 intact:EBI-346946|uniprotkb:Q53XV4|uniprotkb:A8KA25|ensembl:ENSP00000046794 psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:lcp2_human(display_long)|uniprotkb:LCP2(gene name)|psi-mi:LCP2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:"MI:0069"(mass spectrometry studies of complexes) Harkiolaki et al. (2003) mint:MINT-5216408|pubmed:12773374 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8653091|mint:MINT-60142 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-1629509(identity) refseq:NP_005556.1|dip:DIP-31812N|ensembl:ENSG00000043462(gene)|ensembl:ENST00000046794(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|mint:Q13094|rcsb pdb:1H3H|rcsb pdb:1YWO|rcsb pdb:2EAP|rcsb pdb:2ROR|rcsb pdb:6ZCJ|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|mint:MINT-1629517(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:T2 F4|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/07/08 2014/10/16 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 rogid:lZa+nAuqvGDrNe3Jhxn/JQaU5ug9606 intact-crc:8F50F654C822ABE5|rigid:CdNz7rvyX5qVEBfcRryNtgolXkY false binding-associated region:256-322(MINT-1629510) binding-associated region:231-243(MINT-1629518) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)