#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99MR1	uniprotkb:Q60760	intact:EBI-8392648|uniprotkb:Q6Y7W9|intact:MINT-266563|uniprotkb:Q571A0|ensembl:ENSMUSP00000031727	intact:EBI-861810|uniprotkb:O35352|uniprotkb:Q7TSA4|uniprotkb:Q8BSH4|uniprotkb:Q8BSS5|uniprotkb:Q91WC5|uniprotkb:Q3TQ71	psi-mi:ggyf1_mouse(display_long)|uniprotkb:PERQ amino acid-rich with GYF domain-containing protein 1(gene name synonym)|uniprotkb:Kiaa4110(gene name synonym)|uniprotkb:Gigyf1(gene name)|psi-mi:Gigyf1(display_short)|uniprotkb:Perq1(gene name synonym)	psi-mi:grb10_mouse(display_long)|uniprotkb:GRB10 adapter protein(gene name synonym)|uniprotkb:Grb10(gene name)|psi-mi:Grb10(display_short)|uniprotkb:Meg1(gene name synonym)|uniprotkb:Maternally expressed gene 1 protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Giovannone et al. (2003)	mint:MINT-5216402|pubmed:12771153	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8652150|mint:MINT-51133	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011239256.1|refseq:NP_113596.2|ensembl:ENSMUSG00000029714(gene)|ensembl:ENSMUST00000031727(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|interpro:IPR003169(GYF)|interpro:IPR035445|mint:Q99MR1|mint:MINT-734640(identity)	refseq:NP_001171100.1|refseq:NP_034475.2|refseq:XP_006514592.1|refseq:XP_011241966.1|dip:DIP-446N|mint:Q60760|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010467"(gene expression)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904738"(vascular associated smooth muscle cell migration)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035036|interpro:IPR035037|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|rcsb pdb:3M7F|reactome:R-MMU-1433557|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8853659|reactome:R-MMU-9607240|mint:MINT-734632(identity)	-	comment:mint|function:May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:NFA|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/01/18	2014/10/16	rogid:Ld7UGLuGdLLxvGsM18HPzd1p3jE10090	rogid:C9XuqNdwDCBTKfbCLR6mIdyd9bw10090	intact-crc:237160BD123DDC11|rigid:RniNIUPJQ7ks7/GyDavJ6du5vy0	false	tag:?-?(MINT-734641)	binding-associated region:1-172(MINT-734633)|tag:?-?(MINT-734635)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6Y7W8	uniprotkb:Q60760	intact:EBI-8652170|uniprotkb:Q8K0R0|uniprotkb:Q3UNS2|intact:MINT-266607|uniprotkb:Q8R0A3|uniprotkb:Q0VGQ7|uniprotkb:Q63ZU9|uniprotkb:Q80TV1|ensembl:ENSMUSP00000027475|ensembl:ENSMUSP00000133327	intact:EBI-861810|uniprotkb:O35352|uniprotkb:Q7TSA4|uniprotkb:Q8BSH4|uniprotkb:Q8BSS5|uniprotkb:Q91WC5|uniprotkb:Q3TQ71	psi-mi:ggyf2_mouse(display_long)|uniprotkb:Kiaa0642(gene name synonym)|uniprotkb:Perq2(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 15 protein(gene name synonym)|uniprotkb:Gigyf2(gene name)|psi-mi:Gigyf2(display_short)|uniprotkb:Tnrc15(gene name synonym)|uniprotkb:PERQ amino acid-rich with GYF domain-containing protein 2(gene name synonym)	psi-mi:grb10_mouse(display_long)|uniprotkb:GRB10 adapter protein(gene name synonym)|uniprotkb:Grb10(gene name)|psi-mi:Grb10(display_short)|uniprotkb:Meg1(gene name synonym)|uniprotkb:Maternally expressed gene 1 protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Giovannone et al. (2003)	mint:MINT-5216402|pubmed:12771153	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8652223|mint:MINT-51134	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103682.1|refseq:NP_666224.3|refseq:XP_006529527.1|refseq:XP_006529528.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007631"(feeding behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043204"(perikaryon)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050881"(musculoskeletal movement)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070064"(proline-rich region binding)|go:"GO:1990635"(proximal dendrite)|interpro:IPR003169(GYF)|interpro:IPR035445|ensembl:ENSMUSG00000048000(gene)|ensembl:ENSMUST00000027475(transcript)|ensembl:ENSMUST00000174501(transcript)|mint:MINT-734682(identity)	refseq:NP_001171100.1|refseq:NP_034475.2|refseq:XP_006514592.1|refseq:XP_011241966.1|dip:DIP-446N|mint:Q60760|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010467"(gene expression)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904738"(vascular associated smooth muscle cell migration)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035036|interpro:IPR035037|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|rcsb pdb:3M7F|reactome:R-MMU-1433557|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8853659|reactome:R-MMU-9607240|mint:MINT-734674(identity)	-	comment:mint|function:May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:NFA|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/01/18	2014/10/16	rogid:XjYRWxaHyi+oSBy+5fX2jnJKU7I10090	rogid:C9XuqNdwDCBTKfbCLR6mIdyd9bw10090	intact-crc:BCC57488AA2AF63E|rigid:e4CgLwGALzFv4c4NlGki3xkQoTc	false	tag:?-?(MINT-734683)	binding-associated region:1-172(MINT-734675)|tag:?-?(MINT-734677)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6Y7W8	uniprotkb:Q60760	intact:EBI-8652170|uniprotkb:Q8K0R0|uniprotkb:Q3UNS2|intact:MINT-266607|uniprotkb:Q8R0A3|uniprotkb:Q0VGQ7|uniprotkb:Q63ZU9|uniprotkb:Q80TV1|ensembl:ENSMUSP00000027475|ensembl:ENSMUSP00000133327	intact:EBI-861810|uniprotkb:O35352|uniprotkb:Q7TSA4|uniprotkb:Q8BSH4|uniprotkb:Q8BSS5|uniprotkb:Q91WC5|uniprotkb:Q3TQ71	psi-mi:ggyf2_mouse(display_long)|uniprotkb:Kiaa0642(gene name synonym)|uniprotkb:Perq2(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 15 protein(gene name synonym)|uniprotkb:Gigyf2(gene name)|psi-mi:Gigyf2(display_short)|uniprotkb:Tnrc15(gene name synonym)|uniprotkb:PERQ amino acid-rich with GYF domain-containing protein 2(gene name synonym)	psi-mi:grb10_mouse(display_long)|uniprotkb:GRB10 adapter protein(gene name synonym)|uniprotkb:Grb10(gene name)|psi-mi:Grb10(display_short)|uniprotkb:Meg1(gene name synonym)|uniprotkb:Maternally expressed gene 1 protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Giovannone et al. (2003)	mint:MINT-5216402|pubmed:12771153	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8652242|mint:MINT-51135	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103682.1|refseq:NP_666224.3|refseq:XP_006529527.1|refseq:XP_006529528.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007631"(feeding behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043204"(perikaryon)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050881"(musculoskeletal movement)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070064"(proline-rich region binding)|go:"GO:1990635"(proximal dendrite)|interpro:IPR003169(GYF)|interpro:IPR035445|ensembl:ENSMUSG00000048000(gene)|ensembl:ENSMUST00000027475(transcript)|ensembl:ENSMUST00000174501(transcript)|mint:MINT-734700(identity)	refseq:NP_001171100.1|refseq:NP_034475.2|refseq:XP_006514592.1|refseq:XP_011241966.1|dip:DIP-446N|mint:Q60760|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010467"(gene expression)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904738"(vascular associated smooth muscle cell migration)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035036|interpro:IPR035037|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|rcsb pdb:3M7F|reactome:R-MMU-1433557|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8853659|reactome:R-MMU-9607240|mint:MINT-734691(identity)	-	comment:mint|function:May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3B|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/01/18	2014/10/16	rogid:XjYRWxaHyi+oSBy+5fX2jnJKU7I10090	rogid:C9XuqNdwDCBTKfbCLR6mIdyd9bw10090	intact-crc:7D18E520C404CFFF|rigid:e4CgLwGALzFv4c4NlGki3xkQoTc	false	tag:?-?(MINT-734709)|binding-associated region:547-563(MINT-734701)|mutation decreasing interaction:561-561,562-562,563-563,557-557(MINT-734704)	tag:?-?(MINT-734695)|binding-associated region:1-172(MINT-734692)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99MR1	uniprotkb:Q60760	intact:EBI-8392648|uniprotkb:Q6Y7W9|intact:MINT-266563|uniprotkb:Q571A0|ensembl:ENSMUSP00000031727	intact:EBI-861810|uniprotkb:O35352|uniprotkb:Q7TSA4|uniprotkb:Q8BSH4|uniprotkb:Q8BSS5|uniprotkb:Q91WC5|uniprotkb:Q3TQ71	psi-mi:ggyf1_mouse(display_long)|uniprotkb:PERQ amino acid-rich with GYF domain-containing protein 1(gene name synonym)|uniprotkb:Kiaa4110(gene name synonym)|uniprotkb:Gigyf1(gene name)|psi-mi:Gigyf1(display_short)|uniprotkb:Perq1(gene name synonym)	psi-mi:grb10_mouse(display_long)|uniprotkb:GRB10 adapter protein(gene name synonym)|uniprotkb:Grb10(gene name)|psi-mi:Grb10(display_short)|uniprotkb:Meg1(gene name synonym)|uniprotkb:Maternally expressed gene 1 protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Giovannone et al. (2003)	mint:MINT-5216402|pubmed:12771153	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8652272|mint:MINT-51136	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011239256.1|refseq:NP_113596.2|ensembl:ENSMUSG00000029714(gene)|ensembl:ENSMUST00000031727(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|interpro:IPR003169(GYF)|interpro:IPR035445|mint:Q99MR1|mint:MINT-734657(identity)	refseq:NP_001171100.1|refseq:NP_034475.2|refseq:XP_006514592.1|refseq:XP_011241966.1|dip:DIP-446N|mint:Q60760|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010467"(gene expression)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904738"(vascular associated smooth muscle cell migration)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035036|interpro:IPR035037|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|rcsb pdb:3M7F|reactome:R-MMU-1433557|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8853659|reactome:R-MMU-9607240|mint:MINT-734649(identity)	-	comment:mint|function:May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/01/18	2014/10/16	rogid:Ld7UGLuGdLLxvGsM18HPzd1p3jE10090	rogid:C9XuqNdwDCBTKfbCLR6mIdyd9bw10090	intact-crc:85D93F0AEC3B2C37|rigid:RniNIUPJQ7ks7/GyDavJ6du5vy0	false	binding-associated region:489-505(MINT-734658)|tag:?-?(MINT-734666)|mutation decreasing interaction:503-503,504-504,505-505,499-499(MINT-734661)	binding-associated region:1-172(MINT-734650)|tag:?-?(MINT-734652)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99MR1	uniprotkb:Q60760	intact:EBI-8392648|uniprotkb:Q6Y7W9|intact:MINT-266563|uniprotkb:Q571A0|ensembl:ENSMUSP00000031727	intact:EBI-861810|uniprotkb:O35352|uniprotkb:Q7TSA4|uniprotkb:Q8BSH4|uniprotkb:Q8BSS5|uniprotkb:Q91WC5|uniprotkb:Q3TQ71	psi-mi:ggyf1_mouse(display_long)|uniprotkb:PERQ amino acid-rich with GYF domain-containing protein 1(gene name synonym)|uniprotkb:Kiaa4110(gene name synonym)|uniprotkb:Gigyf1(gene name)|psi-mi:Gigyf1(display_short)|uniprotkb:Perq1(gene name synonym)	psi-mi:grb10_mouse(display_long)|uniprotkb:GRB10 adapter protein(gene name synonym)|uniprotkb:Grb10(gene name)|psi-mi:Grb10(display_short)|uniprotkb:Meg1(gene name synonym)|uniprotkb:Maternally expressed gene 1 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Giovannone et al. (2003)	mint:MINT-5216402|pubmed:12771153	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8652310|mint:MINT-51137	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011239256.1|refseq:NP_113596.2|ensembl:ENSMUSG00000029714(gene)|ensembl:ENSMUST00000031727(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|interpro:IPR003169(GYF)|interpro:IPR035445|mint:Q99MR1|mint:MINT-734739(identity)	refseq:NP_001171100.1|refseq:NP_034475.2|refseq:XP_006514592.1|refseq:XP_011241966.1|dip:DIP-446N|mint:Q60760|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010467"(gene expression)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904738"(vascular associated smooth muscle cell migration)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035036|interpro:IPR035037|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|rcsb pdb:3M7F|reactome:R-MMU-1433557|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8853659|reactome:R-MMU-9607240|mint:MINT-734735(identity)	-	comment:mint|function:May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5A|comment:homomint|comment:mint	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2005/01/18	2014/10/16	rogid:Ld7UGLuGdLLxvGsM18HPzd1p3jE10090	rogid:C9XuqNdwDCBTKfbCLR6mIdyd9bw10090	intact-crc:907B9A099E5612B3|rigid:RniNIUPJQ7ks7/GyDavJ6du5vy0	false	binding-associated region:489-505(MINT-734740)|tag:?-?(MINT-734743)	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99MR1	uniprotkb:P05017	intact:EBI-8392648|uniprotkb:Q6Y7W9|intact:MINT-266563|uniprotkb:Q571A0|ensembl:ENSMUSP00000031727	intact:EBI-8652350|uniprotkb:Q6LDP4|uniprotkb:P05018|intact:MINT-266530|uniprotkb:Q8C4U6|ensembl:ENSMUSP00000093005|ensembl:ENSMUSP00000113905	psi-mi:ggyf1_mouse(display_long)|uniprotkb:PERQ amino acid-rich with GYF domain-containing protein 1(gene name synonym)|uniprotkb:Kiaa4110(gene name synonym)|uniprotkb:Gigyf1(gene name)|psi-mi:Gigyf1(display_short)|uniprotkb:Perq1(gene name synonym)	psi-mi:igf1_mouse(display_long)|uniprotkb:Igf1(gene name)|psi-mi:Igf1(display_short)|uniprotkb:Igf-1(gene name synonym)|uniprotkb:Somatomedin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Giovannone et al. (2003)	mint:MINT-5216402|pubmed:12771153	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8652345|mint:MINT-51138	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011239256.1|refseq:NP_113596.2|ensembl:ENSMUSG00000029714(gene)|ensembl:ENSMUST00000031727(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|interpro:IPR003169(GYF)|interpro:IPR035445|mint:Q99MR1|mint:MINT-734723(identity)	refseq:NP_001300939.1|refseq:NP_034642.2|refseq:NP_001104745.1|go:"GO:0007608"(sensory perception of smell)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048468"(cell development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048839"(inner ear development)|go:"GO:0050650"(chondroitin sulfate proteoglycan biosynthetic process)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050974"(detection of mechanical stimulus involved in sensory perception)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060283"(negative regulation of oocyte development)|go:"GO:0060426"(lung vasculature development)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0060510"(type II pneumocyte differentiation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060741"(prostate gland stromal morphogenesis)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090031"(positive regulation of steroid hormone biosynthetic process)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1900142"(negative regulation of oligodendrocyte apoptotic process)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1904075"(positive regulation of trophectodermal cell proliferation)|go:"GO:1904193"(negative regulation of cholangiocyte apoptotic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:2000288"(positive regulation of myoblast proliferation)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR016179(Insulin-like)|interpro:IPR022341|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|reactome:R-MMU-114608|reactome:R-MMU-2404192|reactome:R-MMU-2428928|reactome:R-MMU-2428933|reactome:R-MMU-381426|reactome:R-MMU-422085|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014896"(muscle hypertrophy)|go:"GO:0014904"(myotube cell development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030104"(water homeostasis)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|ensembl:ENSMUSG00000020053(gene)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0042060"(wound healing)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042567"(insulin-like growth factor ternary complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|ensembl:ENSMUST00000095360(transcript)|ensembl:ENSMUST00000122386(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001775"(cell activation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002683"(negative regulation of immune system process)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005614"(interstitial matrix)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006417"(regulation of translation)|go:"GO:0007399"(nervous system development)|mint:MINT-734719(identity)	-	comment:mint|function:May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1|comment:"Stoichiometry: 1.0"	comment:mint|function:The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity|comment:"Stoichiometry: 1.0"	figure legend:F5|comment:homomint|comment:mint	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2005/01/18	2014/10/16	rogid:Ld7UGLuGdLLxvGsM18HPzd1p3jE10090	rogid:gJk16js+tt2my6saHDl7XbC5up010090	intact-crc:DD782C7A7E069A33|rigid:/O7vj51m1Tj5BH7491YO/PI4TZw	false	binding-associated region:489-505(MINT-734724)|tag:?-?(MINT-734727)	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)