#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q16539	uniprotkb:Q16512	intact:EBI-73946|uniprotkb:A8K6P4|uniprotkb:B0LPH0|uniprotkb:A6ZJ92|uniprotkb:O60776|uniprotkb:Q13083|uniprotkb:Q14084|uniprotkb:Q8TDX0|uniprotkb:B5TY32|ensembl:ENSP00000229794	intact:EBI-602382|intact:EBI-1384186|intact:EBI-748186|uniprotkb:A8K7W5|uniprotkb:B2R9R4|uniprotkb:B3KVN3|uniprotkb:Q504U4|uniprotkb:Q8IUV5|uniprotkb:Q9UD44|uniprotkb:Q15143|ensembl:ENSP00000242783	psi-mi:mk14_human(display_long)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:Cytokine suppressive anti-inflammatory drug-binding protein(gene name synonym)|uniprotkb:MAX-interacting protein 2(gene name synonym)|uniprotkb:MAP kinase MXI2(gene name synonym)|uniprotkb:SAPK2A(gene name synonym)|uniprotkb:MAPK14(gene name)|psi-mi:MAPK14(display_short)|uniprotkb:CSBP(gene name synonym)|uniprotkb:CSBP1(gene name synonym)|uniprotkb:CSBP2(gene name synonym)|uniprotkb:CSPB1(gene name synonym)|uniprotkb:MXI2(gene name synonym)|uniprotkb:Stress-activated protein kinase 2a(gene name synonym)	psi-mi:pkn1_human(display_long)|uniprotkb:PKN1(gene name)|psi-mi:PKN1(display_short)|uniprotkb:PKN(gene name synonym)|uniprotkb:PRK1(gene name synonym)|uniprotkb:PRKCL1(gene name synonym)|uniprotkb:PAK1(gene name synonym)|uniprotkb:Protease-activated kinase 1(gene name synonym)|uniprotkb:Protein kinase C-like 1(gene name synonym)|uniprotkb:Protein kinase C-like PKN(gene name synonym)|uniprotkb:Protein kinase PKN-alpha(gene name synonym)|uniprotkb:Protein-kinase C-related kinase 1(gene name synonym)|uniprotkb:Serine-threonine protein kinase N(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Takahashi et al. (2003)	pubmed:12761180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-602400	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306.1|refseq:NP_620581.1|refseq:NP_620582.1|refseq:NP_620583.1|dip:DIP-30987N|ensembl:ENSG00000112062(gene)|ensembl:ENST00000229794(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:Q16539|rcsb pdb:1A9U|rcsb pdb:1BL6|rcsb pdb:1BL7|rcsb pdb:1BMK|rcsb pdb:1DI9|rcsb pdb:1IAN|rcsb pdb:1KV1|rcsb pdb:1KV2|rcsb pdb:1M7Q|rcsb pdb:1OUK|rcsb pdb:1OUY|rcsb pdb:1OVE|rcsb pdb:1OZ1|rcsb pdb:1R39|rcsb pdb:1R3C|rcsb pdb:1W7H|rcsb pdb:1W82|rcsb pdb:1W83|rcsb pdb:1W84|rcsb pdb:1WBN|rcsb pdb:1WBO|rcsb pdb:1WBS|rcsb pdb:1WBT|rcsb pdb:1WBV|rcsb pdb:1WBW|rcsb pdb:1WFC|rcsb pdb:1YQJ|rcsb pdb:1ZYJ|rcsb pdb:1ZZ2|rcsb pdb:1ZZL|rcsb pdb:2BAJ|rcsb pdb:2BAK|rcsb pdb:2BAL|rcsb pdb:2BAQ|rcsb pdb:2FSL|rcsb pdb:2FSM|rcsb pdb:2FSO|rcsb pdb:2FST|rcsb pdb:2GFS|rcsb pdb:2I0H|rcsb pdb:2LGC|rcsb pdb:2NPQ|rcsb pdb:2OKR|rcsb pdb:2ONL|rcsb pdb:2QD9|rcsb pdb:2RG5|rcsb pdb:2RG6|rcsb pdb:2Y8O|rcsb pdb:2YIS|rcsb pdb:2YIW|rcsb pdb:2YIX|rcsb pdb:2ZAZ|rcsb pdb:2ZB0|rcsb pdb:2ZB1|rcsb pdb:3BV2|rcsb pdb:3BV3|rcsb pdb:3BX5|rcsb pdb:3C5U|rcsb pdb:3CTQ|rcsb pdb:3D7Z|rcsb pdb:3D83|rcsb pdb:3DS6|rcsb pdb:3DT1|rcsb pdb:3E92|rcsb pdb:3E93|rcsb pdb:3FC1|rcsb pdb:3FI4|rcsb pdb:3FKL|rcsb pdb:3FKN|rcsb pdb:3FKO|rcsb pdb:3FL4|rcsb pdb:3FLN|rcsb pdb:3FLQ|rcsb pdb:3FLS|rcsb pdb:3FLW|rcsb pdb:3FLY|rcsb pdb:3FLZ|rcsb pdb:3FMH|rcsb pdb:3FMJ|rcsb pdb:3FMK|rcsb pdb:3FML|rcsb pdb:3FMM|rcsb pdb:3FMN|rcsb pdb:3FSF|rcsb pdb:3FSK|rcsb pdb:3GC7|rcsb pdb:3GCP|rcsb pdb:3GCQ|rcsb pdb:3GCS|rcsb pdb:3GCU|rcsb pdb:3GCV|rcsb pdb:3GFE|rcsb pdb:3GI3|rcsb pdb:3HA8|rcsb pdb:3HEC|rcsb pdb:3HEG|rcsb pdb:3HL7|rcsb pdb:3HLL|rcsb pdb:3HP2|rcsb pdb:3HP5|rcsb pdb:3HRB|rcsb pdb:3HUB|rcsb pdb:3HUC|rcsb pdb:3HV3|rcsb pdb:3HV4|rcsb pdb:3HV5|rcsb pdb:3HV6|rcsb pdb:3HV7|rcsb pdb:3HVC|rcsb pdb:3IPH|rcsb pdb:3ITZ|rcsb pdb:3IW5|rcsb pdb:3IW6|rcsb pdb:3IW7|rcsb pdb:3IW8|rcsb pdb:3K3I|rcsb pdb:3K3J|rcsb pdb:3KF7|rcsb pdb:3KQ7|rcsb pdb:3L8S|rcsb pdb:3L8X|rcsb pdb:3LFA|rcsb pdb:3LFB|rcsb pdb:3LFC|rcsb pdb:3LFD|rcsb pdb:3LFE|rcsb pdb:3LFF|rcsb pdb:3LHJ|rcsb pdb:3MGY|rcsb pdb:3MH0|rcsb pdb:3MH1|rcsb pdb:3MH2|rcsb pdb:3MH3|rcsb pdb:3MPA|rcsb pdb:3MPT|rcsb pdb:3MVL|rcsb pdb:3MVM|rcsb pdb:3MW1|rcsb pdb:3NEW|rcsb pdb:3NNU|rcsb pdb:3NNV|rcsb pdb:3NNW|rcsb pdb:3NNX|rcsb pdb:3NWW|rcsb pdb:3O8P|rcsb pdb:3O8T|rcsb pdb:3O8U|rcsb pdb:3OBG|rcsb pdb:3OBJ|rcsb pdb:3OC1|rcsb pdb:3OCG|rcsb pdb:3OD6|rcsb pdb:3ODY|rcsb pdb:3ODZ|rcsb pdb:3OEF|rcsb pdb:3PG3|rcsb pdb:3QUD|rcsb pdb:3QUE|rcsb pdb:3RIN|rcsb pdb:3ROC|rcsb pdb:3S3I|rcsb pdb:3S4Q|rcsb pdb:3U8W|rcsb pdb:3UVP|rcsb pdb:3UVQ|rcsb pdb:3UVR|rcsb pdb:3ZS5|rcsb pdb:3ZSG|rcsb pdb:3ZSH|rcsb pdb:3ZSI|rcsb pdb:3ZYA|rcsb pdb:4A9Y|rcsb pdb:4AA0|rcsb pdb:4AA4|rcsb pdb:4AA5|rcsb pdb:4AAC|rcsb pdb:4DLI|rcsb pdb:4DLJ|rcsb pdb:4E5A|rcsb pdb:4E5B|rcsb pdb:4E6A|rcsb pdb:4E6C|rcsb pdb:4E8A|rcsb pdb:4EH2|rcsb pdb:4EH3|rcsb pdb:4EH4|rcsb pdb:4EH5|rcsb pdb:4EH6|rcsb pdb:4EH7|rcsb pdb:4EH8|rcsb pdb:4EH9|rcsb pdb:4EHV|rcsb pdb:4EWQ|rcsb pdb:4F9W|rcsb pdb:4F9Y|rcsb pdb:4FA2|rcsb pdb:4GEO|rcsb pdb:4KIN|rcsb pdb:4KIP|rcsb pdb:4KIQ|rcsb pdb:4L8M|rcsb pdb:4R3C|rcsb pdb:4ZTH|rcsb pdb:5ETA|rcsb pdb:5ETC|rcsb pdb:5ETF|rcsb pdb:5ETI|rcsb pdb:5ML5|rcsb pdb:5MTX|rcsb pdb:5MTY|rcsb pdb:5MZ3|rcsb pdb:5N63|rcsb pdb:5N64|rcsb pdb:5N65|rcsb pdb:5N66|rcsb pdb:5N67|rcsb pdb:5N68|rcsb pdb:5O8U|rcsb pdb:5O8V|rcsb pdb:5OMG|rcsb pdb:5OMH|rcsb pdb:5TBE|rcsb pdb:5TCO|rcsb pdb:5WJJ|rcsb pdb:5XYX|rcsb pdb:5XYY|rcsb pdb:6ANL|rcsb pdb:6HWT|rcsb pdb:6HWU|rcsb pdb:6HWV|rcsb pdb:6M95|rcsb pdb:6M9L|rcsb pdb:6OHD|rcsb pdb:6QDZ|rcsb pdb:6QE1|rcsb pdb:6QYX|rcsb pdb:6RFO|rcsb pdb:6SFI|rcsb pdb:6SFJ|rcsb pdb:6SFK|rcsb pdb:6SFO|rcsb pdb:6TCA|rcsb pdb:6ZQS|rcsb pdb:6ZWP|reactome:R-HSA-168638|reactome:R-HSA-171007|reactome:R-HSA-198753|reactome:R-HSA-2151209|reactome:R-HSA-2559580|reactome:R-HSA-376172|reactome:R-HSA-418592|reactome:R-HSA-432142|reactome:R-HSA-4420097|reactome:R-HSA-450302|reactome:R-HSA-450341|reactome:R-HSA-450604|reactome:R-HSA-525793|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-6804756|reactome:R-HSA-9662834	refseq:NP_002732.3|refseq:NP_998725.1|dip:DIP-34240N|ensembl:ENSG00000123143(gene)|ensembl:ENST00000242783(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0010631"(epithelial cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030496"(midbody)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035402"("histone kinase activity (H3-T11 specific)")|go:"GO:0035407"(histone H3-T11 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048536"(spleen development)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR035892|interpro:IPR036274|interpro:IPR037313|interpro:IPR037317|interpro:IPR037784|rcsb pdb:1CXZ|rcsb pdb:1URF|rcsb pdb:2RMK|rcsb pdb:4NKG|rcsb pdb:4OTD|rcsb pdb:4OTG|rcsb pdb:4OTH|rcsb pdb:4OTI|reactome:R-HSA-5625740|reactome:R-HSA-5625886|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013149|go:"GO:0003014"(renal system process)	-	-	-	comment:Weak interaction|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2005/06/15	2014/10/16	rogid:oI6EOrCDVMQ6FDVBHSiYYoKZHns9606	rogid:4g0klnFDUlztO05MH9R4sECDTtU9606	intact-crc:E547497CEF2258B1|rigid:NBBrq+rowguyuSy8DzV2BRycK1M	false	-	flag tag:?-?	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P53778	uniprotkb:Q16512	intact:EBI-602406|uniprotkb:Q6IC53|uniprotkb:Q14260|uniprotkb:Q99588|uniprotkb:Q99672|ensembl:ENSP00000215659	intact:EBI-602382|intact:EBI-1384186|intact:EBI-748186|uniprotkb:A8K7W5|uniprotkb:B2R9R4|uniprotkb:B3KVN3|uniprotkb:Q504U4|uniprotkb:Q8IUV5|uniprotkb:Q9UD44|uniprotkb:Q15143|ensembl:ENSP00000242783	psi-mi:mk12_human(display_long)|uniprotkb:Extracellular signal-regulated kinase 6(gene name synonym)|uniprotkb:Stress-activated protein kinase 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 gamma(gene name synonym)|uniprotkb:MAPK12(gene name)|psi-mi:MAPK12(display_short)|uniprotkb:ERK6(gene name synonym)|uniprotkb:SAPK3(gene name synonym)	psi-mi:pkn1_human(display_long)|uniprotkb:PKN1(gene name)|psi-mi:PKN1(display_short)|uniprotkb:PKN(gene name synonym)|uniprotkb:PRK1(gene name synonym)|uniprotkb:PRKCL1(gene name synonym)|uniprotkb:PAK1(gene name synonym)|uniprotkb:Protease-activated kinase 1(gene name synonym)|uniprotkb:Protein kinase C-like 1(gene name synonym)|uniprotkb:Protein kinase C-like PKN(gene name synonym)|uniprotkb:Protein kinase PKN-alpha(gene name synonym)|uniprotkb:Protein-kinase C-related kinase 1(gene name synonym)|uniprotkb:Serine-threonine protein kinase N(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Takahashi et al. (2003)	pubmed:12761180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-602432	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001290181.1|refseq:NP_002960.2|dip:DIP-34241N|ensembl:ENSG00000188130(gene)|ensembl:ENST00000215659(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038786|mint:P53778|rcsb pdb:1CM8|rcsb pdb:4QUM|rcsb pdb:6UNA|rcsb pdb:7CGA|reactome:R-HSA-168638|reactome:R-HSA-171007|reactome:R-HSA-2151209|reactome:R-HSA-376172|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5675221	refseq:NP_002732.3|refseq:NP_998725.1|dip:DIP-34240N|ensembl:ENSG00000123143(gene)|ensembl:ENST00000242783(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0010631"(epithelial cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030496"(midbody)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035402"("histone kinase activity (H3-T11 specific)")|go:"GO:0035407"(histone H3-T11 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048536"(spleen development)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR035892|interpro:IPR036274|interpro:IPR037313|interpro:IPR037317|interpro:IPR037784|rcsb pdb:1CXZ|rcsb pdb:1URF|rcsb pdb:2RMK|rcsb pdb:4NKG|rcsb pdb:4OTD|rcsb pdb:4OTG|rcsb pdb:4OTH|rcsb pdb:4OTI|reactome:R-HSA-5625740|reactome:R-HSA-5625886|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013149|go:"GO:0003014"(renal system process)	go:"GO:0000165"(MAPK cascade)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2005/06/15	2014/10/16	rogid:S+3tRoF9CGZSsMEsejxLUOpMN5g9606	rogid:4g0klnFDUlztO05MH9R4sECDTtU9606	intact-crc:84E7DDA77AB063E6|rigid:yKCrBOfL53eN1qPh7t+IRRMcgVA	false	-	flag tag:?-?	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q16512	uniprotkb:P53778	intact:EBI-602382|intact:EBI-1384186|intact:EBI-748186|uniprotkb:A8K7W5|uniprotkb:B2R9R4|uniprotkb:B3KVN3|uniprotkb:Q504U4|uniprotkb:Q8IUV5|uniprotkb:Q9UD44|uniprotkb:Q15143|ensembl:ENSP00000242783	intact:EBI-602406|uniprotkb:Q6IC53|uniprotkb:Q14260|uniprotkb:Q99588|uniprotkb:Q99672|ensembl:ENSP00000215659	psi-mi:pkn1_human(display_long)|uniprotkb:PKN1(gene name)|psi-mi:PKN1(display_short)|uniprotkb:PKN(gene name synonym)|uniprotkb:PRK1(gene name synonym)|uniprotkb:PRKCL1(gene name synonym)|uniprotkb:PAK1(gene name synonym)|uniprotkb:Protease-activated kinase 1(gene name synonym)|uniprotkb:Protein kinase C-like 1(gene name synonym)|uniprotkb:Protein kinase C-like PKN(gene name synonym)|uniprotkb:Protein kinase PKN-alpha(gene name synonym)|uniprotkb:Protein-kinase C-related kinase 1(gene name synonym)|uniprotkb:Serine-threonine protein kinase N(gene name synonym)	psi-mi:mk12_human(display_long)|uniprotkb:Extracellular signal-regulated kinase 6(gene name synonym)|uniprotkb:Stress-activated protein kinase 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 gamma(gene name synonym)|uniprotkb:MAPK12(gene name)|psi-mi:MAPK12(display_short)|uniprotkb:ERK6(gene name synonym)|uniprotkb:SAPK3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Takahashi et al. (2003)	pubmed:12761180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-602438	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002732.3|refseq:NP_998725.1|dip:DIP-34240N|ensembl:ENSG00000123143(gene)|ensembl:ENST00000242783(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0010631"(epithelial cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030496"(midbody)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035402"("histone kinase activity (H3-T11 specific)")|go:"GO:0035407"(histone H3-T11 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048536"(spleen development)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR035892|interpro:IPR036274|interpro:IPR037313|interpro:IPR037317|interpro:IPR037784|rcsb pdb:1CXZ|rcsb pdb:1URF|rcsb pdb:2RMK|rcsb pdb:4NKG|rcsb pdb:4OTD|rcsb pdb:4OTG|rcsb pdb:4OTH|rcsb pdb:4OTI|reactome:R-HSA-5625740|reactome:R-HSA-5625886|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013149|go:"GO:0003014"(renal system process)	refseq:NP_001290181.1|refseq:NP_002960.2|dip:DIP-34241N|ensembl:ENSG00000188130(gene)|ensembl:ENST00000215659(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038786|mint:P53778|rcsb pdb:1CM8|rcsb pdb:4QUM|rcsb pdb:6UNA|rcsb pdb:7CGA|reactome:R-HSA-168638|reactome:R-HSA-171007|reactome:R-HSA-2151209|reactome:R-HSA-376172|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5675221	go:"GO:0000165"(MAPK cascade)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2005/06/15	2014/10/16	rogid:4g0klnFDUlztO05MH9R4sECDTtU9606	rogid:S+3tRoF9CGZSsMEsejxLUOpMN5g9606	intact-crc:47FF9D4EF1AC8AED|rigid:yKCrBOfL53eN1qPh7t+IRRMcgVA	false	ha tag:?-?|binding-associated region:?-942	flag tag:?-?	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q16512	uniprotkb:P46734	intact:EBI-602382|intact:EBI-1384186|intact:EBI-748186|uniprotkb:A8K7W5|uniprotkb:B2R9R4|uniprotkb:B3KVN3|uniprotkb:Q504U4|uniprotkb:Q8IUV5|uniprotkb:Q9UD44|uniprotkb:Q15143|ensembl:ENSP00000242783	intact:EBI-602462|uniprotkb:Q99441|uniprotkb:Q9UE71|uniprotkb:Q9UE72|uniprotkb:B3KSK7|ensembl:ENSP00000345083	psi-mi:pkn1_human(display_long)|uniprotkb:PKN1(gene name)|psi-mi:PKN1(display_short)|uniprotkb:PKN(gene name synonym)|uniprotkb:PRK1(gene name synonym)|uniprotkb:PRKCL1(gene name synonym)|uniprotkb:PAK1(gene name synonym)|uniprotkb:Protease-activated kinase 1(gene name synonym)|uniprotkb:Protein kinase C-like 1(gene name synonym)|uniprotkb:Protein kinase C-like PKN(gene name synonym)|uniprotkb:Protein kinase PKN-alpha(gene name synonym)|uniprotkb:Protein-kinase C-related kinase 1(gene name synonym)|uniprotkb:Serine-threonine protein kinase N(gene name synonym)	psi-mi:mp2k3_human(display_long)|uniprotkb:MAPK/ERK kinase 3(gene name synonym)|uniprotkb:MAP2K3(gene name)|psi-mi:MAP2K3(display_short)|uniprotkb:MEK3(gene name synonym)|uniprotkb:MKK3(gene name synonym)|uniprotkb:PRKMK3(gene name synonym)|uniprotkb:SKK2(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Takahashi et al. (2003)	pubmed:12761180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-602493	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002732.3|refseq:NP_998725.1|dip:DIP-34240N|ensembl:ENSG00000123143(gene)|ensembl:ENST00000242783(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0010631"(epithelial cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030496"(midbody)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035402"("histone kinase activity (H3-T11 specific)")|go:"GO:0035407"(histone H3-T11 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048536"(spleen development)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR035892|interpro:IPR036274|interpro:IPR037313|interpro:IPR037317|interpro:IPR037784|rcsb pdb:1CXZ|rcsb pdb:1URF|rcsb pdb:2RMK|rcsb pdb:4NKG|rcsb pdb:4OTD|rcsb pdb:4OTG|rcsb pdb:4OTH|rcsb pdb:4OTI|reactome:R-HSA-5625740|reactome:R-HSA-5625886|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013149|go:"GO:0003014"(renal system process)	refseq:NP_002747.2|refseq:NP_659731.1|refseq:XP_011522261.1|refseq:XP_016880347.1|refseq:XP_016880348.1|refseq:NP_001303261.1|refseq:XP_005256780.1|dip:DIP-34242N|ensembl:ENSG00000034152(gene)|ensembl:ENST00000342679(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P46734|reactome:R-HSA-2559580|reactome:R-HSA-450302|reactome:R-HSA-5210891	go:"GO:0000165"(MAPK cascade)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2005/06/15	2014/10/16	rogid:4g0klnFDUlztO05MH9R4sECDTtU9606	rogid:OcAgoYfpPPQycfZ6tr52FCRzcOU9606	intact-crc:60520C57C5592C92|rigid:uD5JU7HHpMbcB15mwB3Koi0LV3M	false	binding-associated region:?-942|flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P52564	uniprotkb:Q16512	intact:EBI-448135|ensembl:ENSP00000468348	intact:EBI-602382|intact:EBI-1384186|intact:EBI-748186|uniprotkb:A8K7W5|uniprotkb:B2R9R4|uniprotkb:B3KVN3|uniprotkb:Q504U4|uniprotkb:Q8IUV5|uniprotkb:Q9UD44|uniprotkb:Q15143|ensembl:ENSP00000242783	psi-mi:mp2k6_human(display_long)|uniprotkb:MAPK/ERK kinase 6(gene name synonym)|uniprotkb:PRKMK6(gene name synonym)|uniprotkb:MAP2K6(gene name)|psi-mi:MAP2K6(display_short)|uniprotkb:MEK6(gene name synonym)|uniprotkb:MKK6(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 3(gene name synonym)|uniprotkb:SKK3(gene name synonym)	psi-mi:pkn1_human(display_long)|uniprotkb:PKN1(gene name)|psi-mi:PKN1(display_short)|uniprotkb:PKN(gene name synonym)|uniprotkb:PRK1(gene name synonym)|uniprotkb:PRKCL1(gene name synonym)|uniprotkb:PAK1(gene name synonym)|uniprotkb:Protease-activated kinase 1(gene name synonym)|uniprotkb:Protein kinase C-like 1(gene name synonym)|uniprotkb:Protein kinase C-like PKN(gene name synonym)|uniprotkb:Protein kinase PKN-alpha(gene name synonym)|uniprotkb:Protein-kinase C-related kinase 1(gene name synonym)|uniprotkb:Serine-threonine protein kinase N(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Takahashi et al. (2003)	pubmed:12761180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-602525	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002749.2|dip:DIP-31346N|reactome:R-HSA-525793|reactome:R-HSA-6811555|reactome:R-HSA-9020702|ensembl:ENSG00000108984(gene)|ensembl:ENST00000590474(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022602"(ovulation cycle process)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060348"(bone development)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0072709"(cellular response to sorbitol)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P52564|rcsb pdb:2Y8O|rcsb pdb:3ENM|rcsb pdb:3FME|go:"GO:0002931"(response to ischemia)|rcsb pdb:3VN9|rcsb pdb:5ETF|reactome:R-HSA-168638|reactome:R-HSA-2559580|reactome:R-HSA-450302|reactome:R-HSA-5210891	refseq:NP_002732.3|refseq:NP_998725.1|dip:DIP-34240N|ensembl:ENSG00000123143(gene)|ensembl:ENST00000242783(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0010631"(epithelial cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030496"(midbody)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035402"("histone kinase activity (H3-T11 specific)")|go:"GO:0035407"(histone H3-T11 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048536"(spleen development)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR035892|interpro:IPR036274|interpro:IPR037313|interpro:IPR037317|interpro:IPR037784|rcsb pdb:1CXZ|rcsb pdb:1URF|rcsb pdb:2RMK|rcsb pdb:4NKG|rcsb pdb:4OTD|rcsb pdb:4OTG|rcsb pdb:4OTH|rcsb pdb:4OTI|reactome:R-HSA-5625740|reactome:R-HSA-5625886|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013149|go:"GO:0003014"(renal system process)	go:"GO:0000165"(MAPK cascade)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2005/06/15	2014/10/16	rogid:7RQ/LBAms1wKpD6Rv+ijvMIzDXA9606	rogid:4g0klnFDUlztO05MH9R4sECDTtU9606	intact-crc:7901E7C65D66B8B1|rigid:0c0oenjHtoPWIA7Uc2jzTADCprE	false	ha tag:?-?	binding-associated region:?-942|flag tag:?-?	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q16512	uniprotkb:Q9NYL2-1	intact:EBI-602382|intact:EBI-1384186|intact:EBI-748186|uniprotkb:A8K7W5|uniprotkb:B2R9R4|uniprotkb:B3KVN3|uniprotkb:Q504U4|uniprotkb:Q8IUV5|uniprotkb:Q9UD44|uniprotkb:Q15143|ensembl:ENSP00000242783	intact:EBI-687346|ensembl:ENSP00000364361|ensembl:ENSP00000387259	psi-mi:pkn1_human(display_long)|uniprotkb:PKN1(gene name)|psi-mi:PKN1(display_short)|uniprotkb:PKN(gene name synonym)|uniprotkb:PRK1(gene name synonym)|uniprotkb:PRKCL1(gene name synonym)|uniprotkb:PAK1(gene name synonym)|uniprotkb:Protease-activated kinase 1(gene name synonym)|uniprotkb:Protein kinase C-like 1(gene name synonym)|uniprotkb:Protein kinase C-like PKN(gene name synonym)|uniprotkb:Protein kinase PKN-alpha(gene name synonym)|uniprotkb:Protein-kinase C-related kinase 1(gene name synonym)|uniprotkb:Serine-threonine protein kinase N(gene name synonym)	psi-mi:q9nyl2-1(display_long)|uniprotkb:MAP3K20(gene name)|psi-mi:MAP3K20(display_short)|uniprotkb:Human cervical cancer suppressor gene 4 protein(gene name synonym)|uniprotkb:Leucine zipper- and sterile alpha motif-containing kinase(gene name synonym)|uniprotkb:MLK-like mitogen-activated protein triple kinase(gene name synonym)|uniprotkb:MLTK(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase kinase MLT(gene name synonym)|uniprotkb:Mixed lineage kinase-related kinase(gene name synonym)|uniprotkb:Sterile alpha motif- and leucine zipper-containing kinase AZK(gene name synonym)|uniprotkb:ZAK(gene name synonym)|uniprotkb:HCCS4(orf name)|uniprotkb:Alpha(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Takahashi et al. (2003)	pubmed:12761180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-602554	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002732.3|refseq:NP_998725.1|dip:DIP-34240N|ensembl:ENSG00000123143(gene)|ensembl:ENST00000242783(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0010631"(epithelial cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030496"(midbody)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035402"("histone kinase activity (H3-T11 specific)")|go:"GO:0035407"(histone H3-T11 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048536"(spleen development)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR035892|interpro:IPR036274|interpro:IPR037313|interpro:IPR037317|interpro:IPR037784|rcsb pdb:1CXZ|rcsb pdb:1URF|rcsb pdb:2RMK|rcsb pdb:4NKG|rcsb pdb:4OTD|rcsb pdb:4OTG|rcsb pdb:4OTH|rcsb pdb:4OTI|reactome:R-HSA-5625740|reactome:R-HSA-5625886|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013149|go:"GO:0003014"(renal system process)	intact:EBI-602273(isoform-parent)|ensembl:ENSG00000091436(gene)|ensembl:ENST00000375213(transcript)|ensembl:ENST00000409176(transcript)	go:"GO:0000165"(MAPK cascade)	-	-	comment:Experiments conducted with MLTKalpha isoform|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2005/06/15	2014/10/16	rogid:4g0klnFDUlztO05MH9R4sECDTtU9606	rogid:r8AGxedcm7rLHlwHGc0wKwzHXbM9606	intact-crc:D3E6F97D7DD5F48E|rigid:Vyg5IuON7rYNAGI+Ep2PAO+CGJI	false	flag tag:?-?	-	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q9NYL2-1	uniprotkb:Q16512	intact:EBI-687346|ensembl:ENSP00000364361|ensembl:ENSP00000387259	intact:EBI-602382|intact:EBI-1384186|intact:EBI-748186|uniprotkb:A8K7W5|uniprotkb:B2R9R4|uniprotkb:B3KVN3|uniprotkb:Q504U4|uniprotkb:Q8IUV5|uniprotkb:Q9UD44|uniprotkb:Q15143|ensembl:ENSP00000242783	psi-mi:q9nyl2-1(display_long)|uniprotkb:MAP3K20(gene name)|psi-mi:MAP3K20(display_short)|uniprotkb:Human cervical cancer suppressor gene 4 protein(gene name synonym)|uniprotkb:Leucine zipper- and sterile alpha motif-containing kinase(gene name synonym)|uniprotkb:MLK-like mitogen-activated protein triple kinase(gene name synonym)|uniprotkb:MLTK(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase kinase MLT(gene name synonym)|uniprotkb:Mixed lineage kinase-related kinase(gene name synonym)|uniprotkb:Sterile alpha motif- and leucine zipper-containing kinase AZK(gene name synonym)|uniprotkb:ZAK(gene name synonym)|uniprotkb:HCCS4(orf name)|uniprotkb:Alpha(isoform synonym)	psi-mi:pkn1_human(display_long)|uniprotkb:PKN1(gene name)|psi-mi:PKN1(display_short)|uniprotkb:PKN(gene name synonym)|uniprotkb:PRK1(gene name synonym)|uniprotkb:PRKCL1(gene name synonym)|uniprotkb:PAK1(gene name synonym)|uniprotkb:Protease-activated kinase 1(gene name synonym)|uniprotkb:Protein kinase C-like 1(gene name synonym)|uniprotkb:Protein kinase C-like PKN(gene name synonym)|uniprotkb:Protein kinase PKN-alpha(gene name synonym)|uniprotkb:Protein-kinase C-related kinase 1(gene name synonym)|uniprotkb:Serine-threonine protein kinase N(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Takahashi et al. (2003)	pubmed:12761180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-602565	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-602273(isoform-parent)|ensembl:ENSG00000091436(gene)|ensembl:ENST00000375213(transcript)|ensembl:ENST00000409176(transcript)	refseq:NP_002732.3|refseq:NP_998725.1|dip:DIP-34240N|ensembl:ENSG00000123143(gene)|ensembl:ENST00000242783(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0010631"(epithelial cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030496"(midbody)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035402"("histone kinase activity (H3-T11 specific)")|go:"GO:0035407"(histone H3-T11 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048536"(spleen development)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR035892|interpro:IPR036274|interpro:IPR037313|interpro:IPR037317|interpro:IPR037784|rcsb pdb:1CXZ|rcsb pdb:1URF|rcsb pdb:2RMK|rcsb pdb:4NKG|rcsb pdb:4OTD|rcsb pdb:4OTG|rcsb pdb:4OTH|rcsb pdb:4OTI|reactome:R-HSA-5625740|reactome:R-HSA-5625886|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013149|go:"GO:0003014"(renal system process)	go:"GO:0000165"(MAPK cascade)	-	-	comment:Experiments conducted with MLTKalpha isoform|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2005/06/15	2014/10/16	rogid:r8AGxedcm7rLHlwHGc0wKwzHXbM9606	rogid:4g0klnFDUlztO05MH9R4sECDTtU9606	intact-crc:9FB632577190A865|rigid:Vyg5IuON7rYNAGI+Ep2PAO+CGJI	false	ha tag:?-?|sufficient binding region:284-800	flag tag:?-?	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)