#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q86XR7	uniprotkb:P14778	intact:EBI-525927|uniprotkb:B3Y698|ensembl:ENSP00000415139|uniprotkb:Q6JUT2	intact:EBI-525905|uniprotkb:Q587I7|ensembl:ENSP00000386380	psi-mi:tcam2_human(display_long)|uniprotkb:TRIF-related adapter molecule(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor domain-containing protein(gene name synonym)|uniprotkb:Toll-like receptor adaptor protein 3(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 502(gene name synonym)|uniprotkb:TICAM2(gene name)|psi-mi:TICAM2(display_short)|uniprotkb:TIRP(gene name synonym)|uniprotkb:TIRAP3(gene name synonym)|uniprotkb:TRAM(gene name synonym)	psi-mi:il1r1_human(display_long)|uniprotkb:Interleukin-1 receptor type I(gene name synonym)|uniprotkb:Interleukin-1 receptor alpha(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:CD121 antigen-like family member A(gene name synonym)|uniprotkb:IL1RT1(gene name synonym)|uniprotkb:IL1R1(gene name)|psi-mi:IL1R1(display_short)|uniprotkb:IL1R(gene name synonym)|uniprotkb:IL1RA(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Bin et al. (2003)	pubmed:12721283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-525923	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157941.1|refseq:NP_067681.1|ensembl:ENSG00000243414(gene)|ensembl:ENST00000427199(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007030"(Golgi organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035669"(TRAM-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071650"("negative regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:2000494"(positive regulation of interleukin-18-mediated signaling pathway)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR015720(TMP21 related)|interpro:IPR035897|rcsb pdb:2M1W|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-6798695|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-975163|refseq:NP_001157940.1|dip:DIP-33488N	refseq:NP_000868.1|refseq:XP_005263987.1|refseq:XP_005263991.1|refseq:NP_001275635.1|refseq:XP_011509417.1|refseq:XP_011509418.1|refseq:XP_011509419.1|refseq:XP_011509420.1|ensembl:ENSG00000115594(gene)|ensembl:ENST00000410023(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0004909"(interleukin-1, type I, activating receptor activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000661"(positive regulation of interleukin-1-mediated signaling pathway)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR004076(Interleukin-1 receptor IL1R)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|interpro:IPR041416|rcsb pdb:1G0Y|rcsb pdb:1IRA|rcsb pdb:1ITB|rcsb pdb:4DEP|rcsb pdb:4GAF|reactome:R-HSA-6783783|reactome:R-HSA-9020702|reactome:R-HSA-9679191|dip:DIP-93N|refseq:NP_001307907.1|refseq:NP_001307909.1|refseq:NP_001307910.1|refseq:NP_001307911.1|refseq:NP_001307912.1|refseq:NP_001307913.1|refseq:NP_001307914.1|refseq:XP_016859478.1	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/04/06	2014/10/16	rogid:+VKC9HGfNztWtFzjO9FB2NTuChg9606	rogid:2qxcax5pAtmXBQudsAOyK1V2/Oo9606	intact-crc:2883CE9009DD36BB|rigid:xM6l/Z5XAl//S06gykcZItP1O/U	false	ha tag:n-n	flag tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q86XR7	uniprotkb:Q9NPH3	intact:EBI-525927|uniprotkb:B3Y698|ensembl:ENSP00000415139|uniprotkb:Q6JUT2	intact:EBI-525939|uniprotkb:O14915|uniprotkb:Q86WJ7|uniprotkb:B1NLD0|uniprotkb:D3DNW0|ensembl:ENSP00000072516|ensembl:ENSP00000390541|ensembl:ENSP00000401132|ensembl:ENSP00000412053	psi-mi:tcam2_human(display_long)|uniprotkb:TRIF-related adapter molecule(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor domain-containing protein(gene name synonym)|uniprotkb:Toll-like receptor adaptor protein 3(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 502(gene name synonym)|uniprotkb:TICAM2(gene name)|psi-mi:TICAM2(display_short)|uniprotkb:TIRP(gene name synonym)|uniprotkb:TIRAP3(gene name synonym)|uniprotkb:TRAM(gene name synonym)	psi-mi:il1ap_human(display_long)|uniprotkb:IL1RAP(gene name)|psi-mi:IL1RAP(display_short)|uniprotkb:C3orf13(gene name synonym)|uniprotkb:IL1R3(gene name synonym)|uniprotkb:Interleukin-1 receptor 3(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Bin et al. (2003)	pubmed:12721283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-525972	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157941.1|refseq:NP_067681.1|ensembl:ENSG00000243414(gene)|ensembl:ENST00000427199(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007030"(Golgi organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035669"(TRAM-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071650"("negative regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:2000494"(positive regulation of interleukin-18-mediated signaling pathway)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR015720(TMP21 related)|interpro:IPR035897|rcsb pdb:2M1W|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-6798695|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-975163|refseq:NP_001157940.1|dip:DIP-33488N	refseq:NP_001161400.1|refseq:NP_001161401.1|refseq:NP_001161402.1|refseq:NP_001161403.1|refseq:NP_002173.1|refseq:NP_608273.1|dip:DIP-33487N|ensembl:ENSG00000196083(gene)|ensembl:ENST00000072516(transcript)|ensembl:ENST00000412504(transcript)|ensembl:ENST00000439062(transcript)|ensembl:ENST00000447382(transcript)|go:"GO:0002114"(interleukin-33 receptor activity)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0045087"(innate immune response)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099545"(trans-synaptic signaling by trans-synaptic complex)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0016020"(membrane)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|interpro:IPR041416|rcsb pdb:3O4O|rcsb pdb:4DEP|reactome:R-HSA-1257604|reactome:R-HSA-388844|reactome:R-HSA-6811558|reactome:R-HSA-9014826|reactome:R-HSA-9014843|reactome:R-HSA-9020702	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/04/06	2014/10/16	rogid:+VKC9HGfNztWtFzjO9FB2NTuChg9606	rogid:G3A02KnaI98Ea4SzAFjUvCCnfnM9606	intact-crc:53214384822A8B36|rigid:hT/273I9hEQQMvLAfI/1R1SY8eY	false	ha tag:n-n	flag tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P58753	uniprotkb:Q86XR7	intact:EBI-528644|uniprotkb:Q8N5E5|uniprotkb:B3KW65|uniprotkb:Q56UI0|uniprotkb:Q56UH9|ensembl:ENSP00000376446|ensembl:ENSP00000376447|ensembl:ENSP00000436967	intact:EBI-525927|uniprotkb:B3Y698|ensembl:ENSP00000415139|uniprotkb:Q6JUT2	psi-mi:tirap_human(display_long)|uniprotkb:MyD88 adapter-like protein(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:TIRAP(gene name)|psi-mi:TIRAP(display_short)|uniprotkb:MAL(gene name synonym)	psi-mi:tcam2_human(display_long)|uniprotkb:TRIF-related adapter molecule(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor domain-containing protein(gene name synonym)|uniprotkb:Toll-like receptor adaptor protein 3(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 502(gene name synonym)|uniprotkb:TICAM2(gene name)|psi-mi:TICAM2(display_short)|uniprotkb:TIRP(gene name synonym)|uniprotkb:TIRAP3(gene name synonym)|uniprotkb:TRAM(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Bin et al. (2003)	pubmed:12721283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-525987	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001305705.1|refseq:NP_001305706.1|refseq:NP_001034750.1|refseq:NP_683708.1|refseq:XP_005271456.2|refseq:XP_011540878.1|ensembl:ENSG00000150455(gene)|ensembl:ENST00000392679(transcript)|ensembl:ENST00000392680(transcript)|ensembl:ENST00000479770(transcript)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032738"(positive regulation of interleukin-15 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035665"(TIRAP-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017279(Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap)|interpro:IPR035897|mint:P58753|rcsb pdb:2NDH|rcsb pdb:2Y92|rcsb pdb:3UB2|rcsb pdb:3UB3|rcsb pdb:3UB4|rcsb pdb:4FZ5|rcsb pdb:4LQD|rcsb pdb:5T7Q|rcsb pdb:5UZB|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|refseq:XP_016872651.1|dip:DIP-33489N	refseq:NP_001157941.1|refseq:NP_067681.1|ensembl:ENSG00000243414(gene)|ensembl:ENST00000427199(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007030"(Golgi organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035669"(TRAM-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071650"("negative regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:2000494"(positive regulation of interleukin-18-mediated signaling pathway)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR015720(TMP21 related)|interpro:IPR035897|rcsb pdb:2M1W|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-6798695|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-975163|refseq:NP_001157940.1|dip:DIP-33488N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/04/06	2014/10/16	rogid:UmeekccCTOn8783GJqByIj+JIDE9606	rogid:+VKC9HGfNztWtFzjO9FB2NTuChg9606	intact-crc:09D8E49474EEBCB8|rigid:FMYObOYDhvTRBHqJDvr4h1r1PZU	false	flag tag:c-c	ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q86XR7	uniprotkb:Q8IUC6	intact:EBI-525927|uniprotkb:B3Y698|ensembl:ENSP00000415139|uniprotkb:Q6JUT2	intact:EBI-525995|uniprotkb:O75532|uniprotkb:Q86XP8|uniprotkb:Q96GA0|uniprotkb:B3Y691|ensembl:ENSP00000248244	psi-mi:tcam2_human(display_long)|uniprotkb:TRIF-related adapter molecule(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor domain-containing protein(gene name synonym)|uniprotkb:Toll-like receptor adaptor protein 3(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 502(gene name synonym)|uniprotkb:TICAM2(gene name)|psi-mi:TICAM2(display_short)|uniprotkb:TIRP(gene name synonym)|uniprotkb:TIRAP3(gene name synonym)|uniprotkb:TRAM(gene name synonym)	psi-mi:tcam1_human(display_long)|uniprotkb:PRVTIRB(gene name synonym)|uniprotkb:TRIF(gene name synonym)|uniprotkb:Proline-rich, vinculin and TIR domain-containing protein B(gene name synonym)|uniprotkb:Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 502H(gene name synonym)|uniprotkb:TICAM1(gene name)|psi-mi:TICAM1(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Bin et al. (2003)	pubmed:12721283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-526002	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157941.1|refseq:NP_067681.1|ensembl:ENSG00000243414(gene)|ensembl:ENST00000427199(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007030"(Golgi organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035669"(TRAM-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071650"("negative regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:2000494"(positive regulation of interleukin-18-mediated signaling pathway)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR015720(TMP21 related)|interpro:IPR035897|rcsb pdb:2M1W|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-6798695|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-975163|refseq:NP_001157940.1|dip:DIP-33488N	refseq:NP_891549.1|ensembl:ENSG00000127666(gene)|ensembl:ENST00000248244(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0010008"(endosome membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097342"(ripoptosome)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017278(Toll-interleukin I receptor domain-containing adaptor protein, Ticam)|interpro:IPR025735|interpro:IPR035897|interpro:IPR040886|rcsb pdb:2M1X|rcsb pdb:2M63|rcsb pdb:3RC4|rcsb pdb:4BSX|rcsb pdb:4C0M|rcsb pdb:5JEL|reactome:R-HSA-140534|reactome:R-HSA-166166|reactome:R-HSA-168164|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-5602566|reactome:R-HSA-5602571|reactome:R-HSA-9013957|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-975163|dip:DIP-33490N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/04/06	2014/10/16	rogid:+VKC9HGfNztWtFzjO9FB2NTuChg9606	rogid:QolsJvUL2R6GSyE8ZmpFyJIBoH89606	intact-crc:D54DDF2328A79E32|rigid:yzjxK1/iryRAX5l6kSk+QPFSPYc	false	ha tag:n-n	flag tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y4K3	uniprotkb:Q86XR7	intact:EBI-359276|uniprotkb:Q8NEH5|uniprotkb:A6NKI7|uniprotkb:A8KAB3|ensembl:ENSP00000337853|ensembl:ENSP00000433623|uniprotkb:D3DR16	intact:EBI-525927|uniprotkb:B3Y698|ensembl:ENSP00000415139|uniprotkb:Q6JUT2	psi-mi:traf6_human(display_long)|uniprotkb:TRAF6(gene name)|psi-mi:TRAF6(display_short)|uniprotkb:RNF85(gene name synonym)|uniprotkb:Interleukin-1 signal transducer(gene name synonym)|uniprotkb:RING finger protein 85(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)	psi-mi:tcam2_human(display_long)|uniprotkb:TRIF-related adapter molecule(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor domain-containing protein(gene name synonym)|uniprotkb:Toll-like receptor adaptor protein 3(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 502(gene name synonym)|uniprotkb:TICAM2(gene name)|psi-mi:TICAM2(display_short)|uniprotkb:TIRP(gene name synonym)|uniprotkb:TIRAP3(gene name synonym)|uniprotkb:TRAM(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Bin et al. (2003)	pubmed:12721283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-526010	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004611.1|refseq:NP_665802.1|ensembl:ENSG00000175104(gene)|ensembl:ENST00000348124(transcript)|ensembl:ENST00000526995(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002753"(cytoplasmic pattern recognition receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:Q9Y4K3|rcsb pdb:1LB4|rcsb pdb:1LB5|go:"GO:0070534"(protein K63-linked ubiquitination)|rcsb pdb:1LB6|rcsb pdb:2ECI|rcsb pdb:2JMD|rcsb pdb:3HCS|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:4Z8M|rcsb pdb:5ZUJ|rcsb pdb:6A33|go:"GO:0070555"(response to interleukin-1)|rcsb pdb:7L3L|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-193692|reactome:R-HSA-202424|reactome:R-HSA-205043|go:"GO:0071222"(cellular response to lipopolysaccharide)|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-2871837|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-6811558|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9645460|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975144|reactome:R-HSA-975155|reactome:R-HSA-975163|reactome:R-HSA-975871|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|dip:DIP-27515N	refseq:NP_001157941.1|refseq:NP_067681.1|ensembl:ENSG00000243414(gene)|ensembl:ENST00000427199(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007030"(Golgi organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035669"(TRAM-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071650"("negative regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:2000494"(positive regulation of interleukin-18-mediated signaling pathway)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR015720(TMP21 related)|interpro:IPR035897|rcsb pdb:2M1W|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-6798695|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-975163|refseq:NP_001157940.1|dip:DIP-33488N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/04/06	2014/10/16	rogid:m0TTXwlrtXnnjXWbg0MsEULlq0I9606	rogid:+VKC9HGfNztWtFzjO9FB2NTuChg9606	intact-crc:CABDCAD680D8C99E|rigid:FT4e/R+LP8eMjoGY0iMzpSnO7z0	false	flag tag:n-n|binding-associated region:76-171(IPR000157)	ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)