#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9UBN7	uniprotkb:Q8IXJ6	intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046	intact:EBI-477232|uniprotkb:O95889|uniprotkb:Q924Y7|uniprotkb:Q9P0G8|uniprotkb:Q9UNT0|uniprotkb:Q9Y6E9|ensembl:ENSP00000249396|ensembl:ENSP00000489602|uniprotkb:A8K3V1|uniprotkb:B2RB45|uniprotkb:U5TP13	psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym)	psi-mi:sir2_human(display_long)|uniprotkb:SIR2-like protein 2(gene name synonym)|uniprotkb:SIRT2(gene name)|psi-mi:SIRT2(display_short)|uniprotkb:SIR2L(gene name synonym)|uniprotkb:SIR2L2(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	North et al. (2003)	pubmed:12620231	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-489322	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N	ensembl:ENSG00000068903(gene)|ensembl:ENSG00000283100(gene)|ensembl:ENST00000249396(transcript)|ensembl:ENST00000634533(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006342"|go:"GO:0006348"|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006914"(autophagy)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0008134"(transcription factor binding)|rcsb pdb:6L66|rcsb pdb:6L71|rcsb pdb:6L72|rcsb pdb:6NR0|rcsb pdb:6QCN|rcsb pdb:7BOS|rcsb pdb:7BOT|reactome:R-HSA-2995383|rcsb pdb:5D7O|rcsb pdb:5D7P|rcsb pdb:5D7Q|rcsb pdb:5DY4|rcsb pdb:5DY5|rcsb pdb:5FYQ|rcsb pdb:5G4C|rcsb pdb:5MAR|rcsb pdb:5MAT|rcsb pdb:5Y0Z|rcsb pdb:5Y5N|rcsb pdb:5YQL|rcsb pdb:5YQM|rcsb pdb:5YQN|rcsb pdb:5YQO|rcsb pdb:6L65|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0021762"(substantia nigra development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033010"(paranodal junction)|go:"GO:0033270"(paranode region of axon)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044242"(cellular lipid catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045836"(positive regulation of meiotic nuclear division)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046970"("NAD-dependent histone deacetylase activity (H4-K16 specific)")|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051775"(response to redox state)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061433"(cellular response to caloric restriction)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070446"(negative regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0072686"(mitotic spindle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0097386"(glial cell projection)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000777"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR017328(NAD-dependent deacetylase sirtuin-2, eukaryota)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|mint:Q8IXJ6|rcsb pdb:1J8F|rcsb pdb:3ZGO|rcsb pdb:3ZGV|rcsb pdb:4L3O|rcsb pdb:4R8M|rcsb pdb:4RMG|rcsb pdb:4RMH|rcsb pdb:4RMI|rcsb pdb:4RMJ|rcsb pdb:4X3O|rcsb pdb:4X3P|rcsb pdb:4Y6L|rcsb pdb:4Y6O|go:"GO:0051301"(cell division)|rcsb pdb:4Y6Q|refseq:NP_001180215.1|refseq:NP_036369.2|refseq:NP_085096.1|refseq:XP_011524956.1|refseq:XP_011524957.1|refseq:XP_006723174.1|dip:DIP-33350N	go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0005874"(microtubule)	-	-	-	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/01/28	2014/10/16	rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606	rogid:d4mOZOyT5RubJjE+a8wQhsWR6WI9606	intact-crc:64A4E77CAB797B78|rigid:PmdQKNQrgwCJksrsz1wnN9BIo08	false	flag tag:c-c	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IXJ6	uniprotkb:Q9UBN7	intact:EBI-477232|uniprotkb:O95889|uniprotkb:Q924Y7|uniprotkb:Q9P0G8|uniprotkb:Q9UNT0|uniprotkb:Q9Y6E9|ensembl:ENSP00000249396|ensembl:ENSP00000489602|uniprotkb:A8K3V1|uniprotkb:B2RB45|uniprotkb:U5TP13	intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046	psi-mi:sir2_human(display_long)|uniprotkb:SIR2-like protein 2(gene name synonym)|uniprotkb:SIRT2(gene name)|psi-mi:SIRT2(display_short)|uniprotkb:SIR2L(gene name synonym)|uniprotkb:SIR2L2(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 2(gene name synonym)	psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	North et al. (2003)	pubmed:12620231	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-489368	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000068903(gene)|ensembl:ENSG00000283100(gene)|ensembl:ENST00000249396(transcript)|ensembl:ENST00000634533(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006342"|go:"GO:0006348"|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006914"(autophagy)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0008134"(transcription factor binding)|rcsb pdb:6L66|rcsb pdb:6L71|rcsb pdb:6L72|rcsb pdb:6NR0|rcsb pdb:6QCN|rcsb pdb:7BOS|rcsb pdb:7BOT|reactome:R-HSA-2995383|rcsb pdb:5D7O|rcsb pdb:5D7P|rcsb pdb:5D7Q|rcsb pdb:5DY4|rcsb pdb:5DY5|rcsb pdb:5FYQ|rcsb pdb:5G4C|rcsb pdb:5MAR|rcsb pdb:5MAT|rcsb pdb:5Y0Z|rcsb pdb:5Y5N|rcsb pdb:5YQL|rcsb pdb:5YQM|rcsb pdb:5YQN|rcsb pdb:5YQO|rcsb pdb:6L65|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0021762"(substantia nigra development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033010"(paranodal junction)|go:"GO:0033270"(paranode region of axon)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044242"(cellular lipid catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045836"(positive regulation of meiotic nuclear division)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046970"("NAD-dependent histone deacetylase activity (H4-K16 specific)")|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051775"(response to redox state)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061433"(cellular response to caloric restriction)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070446"(negative regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0072686"(mitotic spindle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0097386"(glial cell projection)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000777"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR017328(NAD-dependent deacetylase sirtuin-2, eukaryota)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|mint:Q8IXJ6|rcsb pdb:1J8F|rcsb pdb:3ZGO|rcsb pdb:3ZGV|rcsb pdb:4L3O|rcsb pdb:4R8M|rcsb pdb:4RMG|rcsb pdb:4RMH|rcsb pdb:4RMI|rcsb pdb:4RMJ|rcsb pdb:4X3O|rcsb pdb:4X3P|rcsb pdb:4Y6L|rcsb pdb:4Y6O|go:"GO:0051301"(cell division)|rcsb pdb:4Y6Q|refseq:NP_001180215.1|refseq:NP_036369.2|refseq:NP_085096.1|refseq:XP_011524956.1|refseq:XP_011524957.1|refseq:XP_006723174.1|dip:DIP-33350N	go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N	go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0005874"(microtubule)	-	-	-	taxid:9606(human-cls)|taxid:9606("Homo sapiens fibroblast cell line (GM03318)")	-	2005/01/28	2014/10/16	rogid:d4mOZOyT5RubJjE+a8wQhsWR6WI9606	rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606	intact-crc:7C7AA4679055AAF7|rigid:PmdQKNQrgwCJksrsz1wnN9BIo08	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)