#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q62640	uniprotkb:O88382	intact:EBI-6988856|uniprotkb:Q63225|intact:MINT-257777	intact:EBI-696179|uniprotkb:Q9R271	psi-mi:grid1_rat(display_long)|uniprotkb:Grid1(gene name)|psi-mi:Grid1(display_short)	psi-mi:magi2_rat(display_long)|uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)|uniprotkb:Synaptic-scaffolding molecule(gene name synonym)|uniprotkb:Sscam(gene name synonym)|uniprotkb:Magi2(gene name)|psi-mi:Magi2(display_short)|uniprotkb:Acvrinp1(gene name synonym)|uniprotkb:Aip1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Yap et al. (2003)	mint:MINT-5216135|pubmed:12589829	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8603866|mint:MINT-58344	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0035176"(social behavior)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|rgd:68366|interpro:IPR019594|refseq:NP_077354.1|interpro:IPR028082|rcsb pdb:6KSP|rcsb pdb:6KSS|mint:MINT-728236(identity)	rgd:621855|refseq:NP_446073.1|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR030036|interpro:IPR027417|mint:O88382|interpro:IPR036020|interpro:IPR036034|go:"GO:0043113"(receptor clustering)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070697"(activin receptor binding)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003094"(glomerular filtration)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0038180"(nerve growth factor signaling pathway)|mint:MINT-728232(identity)	-	function:Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2A|comment:mint	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2005/05/11	2014/10/16	rogid:Avhdy9xXioD+uqXoL83gw1dp9gk10116	rogid:aZhWv5f2U8vKQoE9oFMfsQ8rgvQ10116	intact-crc:3B50157F28712E1D|rigid:CyBWd8LVOj0Ha7QVEUk3jXUCgz4	false	mutation decreasing interaction:1004-1007(MINT-728237)	-	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q62640	uniprotkb:O88382	intact:EBI-6988856|uniprotkb:Q63225|intact:MINT-257777	intact:EBI-696179|uniprotkb:Q9R271	psi-mi:grid1_rat(display_long)|uniprotkb:Grid1(gene name)|psi-mi:Grid1(display_short)	psi-mi:magi2_rat(display_long)|uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)|uniprotkb:Synaptic-scaffolding molecule(gene name synonym)|uniprotkb:Sscam(gene name synonym)|uniprotkb:Magi2(gene name)|psi-mi:Magi2(display_short)|uniprotkb:Acvrinp1(gene name synonym)|uniprotkb:Aip1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Yap et al. (2003)	mint:MINT-5216135|pubmed:12589829	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8603882|mint:MINT-58345	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0035176"(social behavior)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|rgd:68366|interpro:IPR019594|refseq:NP_077354.1|interpro:IPR028082|rcsb pdb:6KSP|rcsb pdb:6KSS|mint:MINT-728222(identity)	rgd:621855|refseq:NP_446073.1|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR030036|interpro:IPR027417|mint:O88382|interpro:IPR036020|interpro:IPR036034|go:"GO:0043113"(receptor clustering)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070697"(activin receptor binding)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003094"(glomerular filtration)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0038180"(nerve growth factor signaling pathway)|mint:MINT-728218(identity)	-	function:Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2A|comment:mint	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2005/05/11	2014/10/16	rogid:Avhdy9xXioD+uqXoL83gw1dp9gk10116	rogid:aZhWv5f2U8vKQoE9oFMfsQ8rgvQ10116	intact-crc:F562A9F4300655CE|rigid:CyBWd8LVOj0Ha7QVEUk3jXUCgz4	false	mutation decreasing interaction:1004-1007(MINT-728223)	-	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q62640	uniprotkb:O88382	intact:EBI-6988856|uniprotkb:Q63225|intact:MINT-257777	intact:EBI-696179|uniprotkb:Q9R271	psi-mi:grid1_rat(display_long)|uniprotkb:Grid1(gene name)|psi-mi:Grid1(display_short)	psi-mi:magi2_rat(display_long)|uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)|uniprotkb:Synaptic-scaffolding molecule(gene name synonym)|uniprotkb:Sscam(gene name synonym)|uniprotkb:Magi2(gene name)|psi-mi:Magi2(display_short)|uniprotkb:Acvrinp1(gene name synonym)|uniprotkb:Aip1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Yap et al. (2003)	mint:MINT-5216135|pubmed:12589829	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8603906|mint:MINT-58346	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0035176"(social behavior)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|rgd:68366|interpro:IPR019594|refseq:NP_077354.1|interpro:IPR028082|rcsb pdb:6KSP|rcsb pdb:6KSS|mint:MINT-728255(identity)	rgd:621855|refseq:NP_446073.1|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR030036|interpro:IPR027417|mint:O88382|interpro:IPR036020|interpro:IPR036034|go:"GO:0043113"(receptor clustering)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070697"(activin receptor binding)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003094"(glomerular filtration)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0038180"(nerve growth factor signaling pathway)|mint:MINT-728248(identity)	-	function:Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3B|comment:mint	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2005/05/11	2014/10/16	rogid:Avhdy9xXioD+uqXoL83gw1dp9gk10116	rogid:aZhWv5f2U8vKQoE9oFMfsQ8rgvQ10116	intact-crc:01C4521BCCCC40EE|rigid:CyBWd8LVOj0Ha7QVEUk3jXUCgz4	false	-	tag:?-?(MINT-728249)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O43424	uniprotkb:O88382	intact:EBI-8604158|ensembl:ENSP00000282020|uniprotkb:Q4KKV0|uniprotkb:Q4KKU9|intact:MINT-257823|uniprotkb:Q59FZ1|uniprotkb:E9PH24|uniprotkb:Q4KKU8	intact:EBI-696179|uniprotkb:Q9R271	psi-mi:grid2_human(display_long)|uniprotkb:GRID2(gene name)|psi-mi:GRID2(display_short)|uniprotkb:GLURD2(gene name synonym)	psi-mi:magi2_rat(display_long)|uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)|uniprotkb:Synaptic-scaffolding molecule(gene name synonym)|uniprotkb:Sscam(gene name synonym)|uniprotkb:Magi2(gene name)|psi-mi:Magi2(display_short)|uniprotkb:Acvrinp1(gene name synonym)|uniprotkb:Aip1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yap et al. (2003)	mint:MINT-5216135|pubmed:12589829	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8604196|mint:MINT-58343	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0015276"(ligand-gated ion channel activity)|ensembl:ENSG00000152208(gene)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043197"(dendritic spine)|ensembl:ENST00000282020(transcript)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1904861"(excitatory synapse assembly)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|rcsb pdb:5KC8|rcsb pdb:5KCA|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|refseq:NP_001501.2|refseq:NP_001273767.1|mint:MINT-728276(identity)	rgd:621855|refseq:NP_446073.1|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR030036|interpro:IPR027417|mint:O88382|interpro:IPR036020|interpro:IPR036034|go:"GO:0043113"(receptor clustering)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070697"(activin receptor binding)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003094"(glomerular filtration)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0038180"(nerve growth factor signaling pathway)|mint:MINT-728266(identity)	-	function:Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2B F2C|comment:"1)Amino acid substitutions,  to Pro ( d2 (T1005P)) or  to Ala ( d2 (I1007A)), at the C-terminus of d2 receptor also diminished the interaction with S-SCAM/MAGI-2<br><br><br><br>2)The PKC activation increased binding activity between the proteins, while no enhancement on the protein interaction by phosphorylation was observed in the absence of RE element or amino-acid substitution at the phosphorylation site (  to Ala).<br><br><br><br><br><br>"|comment:homomint|comment:mint	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/05/11	2014/10/16	rogid:LB8SBrf4/5cGTz+nk8g87q1s5BQ9606	rogid:aZhWv5f2U8vKQoE9oFMfsQ8rgvQ10116	intact-crc:F5A9AB3D56B8CF3D|rigid:giHZHCDOI2ySsPrEluXERRupxiU	false	tag:?-?(MINT-728284)|binding-associated region:921-1007(MINT-728277)|O-phospho-L-serine:295-295(MINT-728280)|mutation decreasing interaction:1004-1007(MINT-728282)	binding-associated region:1149-1223(MINT-728267)|tag:?-?(MINT-728271)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O43424	uniprotkb:O88382	intact:EBI-8604158|ensembl:ENSP00000282020|uniprotkb:Q4KKV0|uniprotkb:Q4KKU9|intact:MINT-257823|uniprotkb:Q59FZ1|uniprotkb:E9PH24|uniprotkb:Q4KKU8	intact:EBI-696179|uniprotkb:Q9R271	psi-mi:grid2_human(display_long)|uniprotkb:GRID2(gene name)|psi-mi:GRID2(display_short)|uniprotkb:GLURD2(gene name synonym)	psi-mi:magi2_rat(display_long)|uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)|uniprotkb:Synaptic-scaffolding molecule(gene name synonym)|uniprotkb:Sscam(gene name synonym)|uniprotkb:Magi2(gene name)|psi-mi:Magi2(display_short)|uniprotkb:Acvrinp1(gene name synonym)|uniprotkb:Aip1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yap et al. (2003)	mint:MINT-5216135|pubmed:12589829	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8604362|mint:MINT-58342	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0015276"(ligand-gated ion channel activity)|ensembl:ENSG00000152208(gene)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043197"(dendritic spine)|ensembl:ENST00000282020(transcript)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1904861"(excitatory synapse assembly)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|rcsb pdb:5KC8|rcsb pdb:5KCA|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|refseq:NP_001501.2|refseq:NP_001273767.1|mint:MINT-728306(identity)	rgd:621855|refseq:NP_446073.1|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR030036|interpro:IPR027417|mint:O88382|interpro:IPR036020|interpro:IPR036034|go:"GO:0043113"(receptor clustering)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070697"(activin receptor binding)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003094"(glomerular filtration)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0038180"(nerve growth factor signaling pathway)|mint:MINT-728296(identity)	-	function:Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:The authors also showed the interaction between API 1074-1227 which includes a repetitive element upstream the PDZ5.|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/05/11	2014/10/16	rogid:LB8SBrf4/5cGTz+nk8g87q1s5BQ9606	rogid:aZhWv5f2U8vKQoE9oFMfsQ8rgvQ10116	intact-crc:82124CDCE379418C|rigid:giHZHCDOI2ySsPrEluXERRupxiU	false	binding-associated region:921-1007(MINT-728307)|tag:?-?(MINT-728312)|mutation decreasing interaction:1004-1007(MINT-728310)	tag:?-?(MINT-728301)|binding-associated region:1149-1223(MINT-728297)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)