#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P70196	uniprotkb:Q793I8	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	intact:EBI-524817|uniprotkb:Q3TLY9|ensembl:ENSMUSP00000054036|ensembl:ENSMUSP00000126692|ensembl:ENSMUSP00000127700|ensembl:ENSMUSP00000132309	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:tifa_mouse(display_long)|uniprotkb:Tifa(gene name)|psi-mi:Tifa(display_short)|uniprotkb:T2bp(gene name synonym)|uniprotkb:TRAF2-binding protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Takatsuna et al. (2003)	pubmed:12566447|mint:MINT-5216092	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-524826	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	refseq:NP_660115.1|refseq:XP_006501299.1|refseq:XP_006501300.1|refseq:XP_006501301.1|refseq:XP_006501302.1|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR033621|rcsb pdb:6L9U|rcsb pdb:6L9V|rcsb pdb:6L9W|reactome:R-MMU-9645460|ensembl:ENSMUSG00000046688(gene)|ensembl:ENSMUST00000054483(transcript)|ensembl:ENSMUST00000163775(transcript)|ensembl:ENSMUST00000164447(transcript)|ensembl:ENSMUST00000171621(transcript)|go:"GO:0002753"(cytoplasmic pattern recognition receptor signaling pathway)|go:"GO:0005737"(cytoplasm)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/04/01	2014/10/16	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	rogid:ZEUXpymZElB35SHHXpuZqq+ab9410090	intact-crc:2358FABA9B68A255|rigid:CWv7xSNvKKlpri70jpXB6chVY0g	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q793I8	uniprotkb:Q62406	intact:EBI-524817|uniprotkb:Q3TLY9|ensembl:ENSMUSP00000054036|ensembl:ENSMUSP00000126692|ensembl:ENSMUSP00000127700|ensembl:ENSMUSP00000132309	intact:EBI-448533|uniprotkb:Q6Y3Z5|uniprotkb:Q6Y3Z6|uniprotkb:B1AUW4|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:tifa_mouse(display_long)|uniprotkb:Tifa(gene name)|psi-mi:Tifa(display_short)|uniprotkb:T2bp(gene name synonym)|uniprotkb:TRAF2-binding protein(gene name synonym)	psi-mi:irak1_mouse(display_long)|uniprotkb:Pelle-like protein kinase(gene name synonym)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)	psi-mi:"MI:0096"(pull down)	Takatsuna et al. (2003)	pubmed:12566447|mint:MINT-5216092	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-524852	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_660115.1|refseq:XP_006501299.1|refseq:XP_006501300.1|refseq:XP_006501301.1|refseq:XP_006501302.1|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR033621|rcsb pdb:6L9U|rcsb pdb:6L9V|rcsb pdb:6L9W|reactome:R-MMU-9645460|ensembl:ENSMUSG00000046688(gene)|ensembl:ENSMUST00000054483(transcript)|ensembl:ENSMUST00000163775(transcript)|ensembl:ENSMUST00000164447(transcript)|ensembl:ENSMUST00000171621(transcript)|go:"GO:0002753"(cytoplasmic pattern recognition receptor signaling pathway)|go:"GO:0005737"(cytoplasm)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)	refseq:NP_001171447.1|refseq:NP_032389.2|refseq:NP_001171445.1|dip:DIP-31491N|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)|go:"GO:0001959"(regulation of cytokine-mediated signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035533|interpro:IPR035536|mint:Q62406|reactome:R-MMU-1257604|reactome:R-MMU-168638|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-445989|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-450321|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-975144|reactome:R-MMU-450302	-	-	-	-	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/04/01	2014/10/16	rogid:ZEUXpymZElB35SHHXpuZqq+ab9410090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:148BA6A2336E595C|rigid:/0Sxj3UqgLWf+cRU5l1pHYrmmY8	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62406	uniprotkb:P70196	intact:EBI-448533|uniprotkb:Q6Y3Z5|uniprotkb:Q6Y3Z6|uniprotkb:B1AUW4|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	psi-mi:irak1_mouse(display_long)|uniprotkb:Pelle-like protein kinase(gene name synonym)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Takatsuna et al. (2003)	pubmed:12566447|mint:MINT-5216092	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-524838	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171447.1|refseq:NP_032389.2|refseq:NP_001171445.1|dip:DIP-31491N|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)|go:"GO:0001959"(regulation of cytokine-mediated signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035533|interpro:IPR035536|mint:Q62406|reactome:R-MMU-1257604|reactome:R-MMU-168638|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-445989|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-450321|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-975144|reactome:R-MMU-450302	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	-	-	-	comment:"Co-expression of the TRAF2 binding protein (TIFA) in this assay increased binding of TRAF6 to IRAK-1"	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/04/01	2014/10/16	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	intact-crc:23F142F6FAF72E29|rigid:NcTkqDpX3fuJqYwrtGBR9nF1dy0	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70196	uniprotkb:Q793I8	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	intact:EBI-524817|uniprotkb:Q3TLY9|ensembl:ENSMUSP00000054036|ensembl:ENSMUSP00000126692|ensembl:ENSMUSP00000127700|ensembl:ENSMUSP00000132309	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:tifa_mouse(display_long)|uniprotkb:Tifa(gene name)|psi-mi:Tifa(display_short)|uniprotkb:T2bp(gene name synonym)|uniprotkb:TRAF2-binding protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Takatsuna et al. (2003)	pubmed:12566447|mint:MINT-5216092	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-524882	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	refseq:NP_660115.1|refseq:XP_006501299.1|refseq:XP_006501300.1|refseq:XP_006501301.1|refseq:XP_006501302.1|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR033621|rcsb pdb:6L9U|rcsb pdb:6L9V|rcsb pdb:6L9W|reactome:R-MMU-9645460|ensembl:ENSMUSG00000046688(gene)|ensembl:ENSMUST00000054483(transcript)|ensembl:ENSMUST00000163775(transcript)|ensembl:ENSMUST00000164447(transcript)|ensembl:ENSMUST00000171621(transcript)|go:"GO:0002753"(cytoplasmic pattern recognition receptor signaling pathway)|go:"GO:0005737"(cytoplasm)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)	-	-	-	-	taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell)	-	2005/04/01	2014/10/16	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	rogid:ZEUXpymZElB35SHHXpuZqq+ab9410090	intact-crc:7208DE54F7FA829C|rigid:CWv7xSNvKKlpri70jpXB6chVY0g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q793I8	uniprotkb:Q62406	intact:EBI-524817|uniprotkb:Q3TLY9|ensembl:ENSMUSP00000054036|ensembl:ENSMUSP00000126692|ensembl:ENSMUSP00000127700|ensembl:ENSMUSP00000132309	intact:EBI-448533|uniprotkb:Q6Y3Z5|uniprotkb:Q6Y3Z6|uniprotkb:B1AUW4|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:tifa_mouse(display_long)|uniprotkb:Tifa(gene name)|psi-mi:Tifa(display_short)|uniprotkb:T2bp(gene name synonym)|uniprotkb:TRAF2-binding protein(gene name synonym)	psi-mi:irak1_mouse(display_long)|uniprotkb:Pelle-like protein kinase(gene name synonym)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Takatsuna et al. (2003)	pubmed:12566447|mint:MINT-5216092	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-524885	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_660115.1|refseq:XP_006501299.1|refseq:XP_006501300.1|refseq:XP_006501301.1|refseq:XP_006501302.1|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR033621|rcsb pdb:6L9U|rcsb pdb:6L9V|rcsb pdb:6L9W|reactome:R-MMU-9645460|ensembl:ENSMUSG00000046688(gene)|ensembl:ENSMUST00000054483(transcript)|ensembl:ENSMUST00000163775(transcript)|ensembl:ENSMUST00000164447(transcript)|ensembl:ENSMUST00000171621(transcript)|go:"GO:0002753"(cytoplasmic pattern recognition receptor signaling pathway)|go:"GO:0005737"(cytoplasm)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)	refseq:NP_001171447.1|refseq:NP_032389.2|refseq:NP_001171445.1|dip:DIP-31491N|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)|go:"GO:0001959"(regulation of cytokine-mediated signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035533|interpro:IPR035536|mint:Q62406|reactome:R-MMU-1257604|reactome:R-MMU-168638|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-445989|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-450321|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-975144|reactome:R-MMU-450302	-	-	-	stimulant:"This interaction was only detected in cells pretreated with Interleukin-1 (IL-1)"	taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell)	-	2005/04/01	2014/10/16	rogid:ZEUXpymZElB35SHHXpuZqq+ab9410090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:ADD5F9EF4BF12EA7|rigid:/0Sxj3UqgLWf+cRU5l1pHYrmmY8	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q793I8	uniprotkb:Q793I8	intact:EBI-524817|uniprotkb:Q3TLY9|ensembl:ENSMUSP00000054036|ensembl:ENSMUSP00000126692|ensembl:ENSMUSP00000127700|ensembl:ENSMUSP00000132309	intact:EBI-524817|uniprotkb:Q3TLY9|ensembl:ENSMUSP00000054036|ensembl:ENSMUSP00000126692|ensembl:ENSMUSP00000127700|ensembl:ENSMUSP00000132309	psi-mi:tifa_mouse(display_long)|uniprotkb:Tifa(gene name)|psi-mi:Tifa(display_short)|uniprotkb:T2bp(gene name synonym)|uniprotkb:TRAF2-binding protein(gene name synonym)	psi-mi:tifa_mouse(display_long)|uniprotkb:Tifa(gene name)|psi-mi:Tifa(display_short)|uniprotkb:T2bp(gene name synonym)|uniprotkb:TRAF2-binding protein(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Takatsuna et al. (2003)	pubmed:12566447|mint:MINT-5216092	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-524903	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_660115.1|refseq:XP_006501299.1|refseq:XP_006501300.1|refseq:XP_006501301.1|refseq:XP_006501302.1|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR033621|rcsb pdb:6L9U|rcsb pdb:6L9V|rcsb pdb:6L9W|reactome:R-MMU-9645460|ensembl:ENSMUSG00000046688(gene)|ensembl:ENSMUST00000054483(transcript)|ensembl:ENSMUST00000163775(transcript)|ensembl:ENSMUST00000164447(transcript)|ensembl:ENSMUST00000171621(transcript)|go:"GO:0002753"(cytoplasmic pattern recognition receptor signaling pathway)|go:"GO:0005737"(cytoplasm)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)	refseq:NP_660115.1|refseq:XP_006501299.1|refseq:XP_006501300.1|refseq:XP_006501301.1|refseq:XP_006501302.1|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR033621|rcsb pdb:6L9U|rcsb pdb:6L9V|rcsb pdb:6L9W|reactome:R-MMU-9645460|ensembl:ENSMUSG00000046688(gene)|ensembl:ENSMUST00000054483(transcript)|ensembl:ENSMUST00000163775(transcript)|ensembl:ENSMUST00000164447(transcript)|ensembl:ENSMUST00000171621(transcript)|go:"GO:0002753"(cytoplasmic pattern recognition receptor signaling pathway)|go:"GO:0005737"(cytoplasm)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/01	2014/10/16	rogid:ZEUXpymZElB35SHHXpuZqq+ab9410090	rogid:ZEUXpymZElB35SHHXpuZqq+ab9410090	intact-crc:88742EAE04C1106B|rigid:Uckvt9xV3GXasTP9MmSa3/dvkFE	false	-	-	3	0	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)