#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q924N4-1 uniprotkb:Q9Z1W9 intact:EBI-620992|ensembl:ENSMUSP00000028549 intact:EBI-444764|uniprotkb:Q80W13|ensembl:ENSMUSP00000099776 psi-mi:q924n4-1(display_long)|uniprotkb:KCC3a(isoform synonym)|uniprotkb:Slc12a6(gene name)|psi-mi:Slc12a6(display_short)|uniprotkb:Kcc3(gene name synonym)|uniprotkb:Electroneutral potassium-chloride cotransporter 3(gene name synonym)|uniprotkb:K-Cl cotransporter 3(gene name synonym) psi-mi:stk39_mouse(display_long)|uniprotkb:Serine/threonine-protein kinase 39(gene name synonym)|uniprotkb:Stk39(gene name)|psi-mi:Stk39(display_short)|uniprotkb:Spak(gene name synonym) psi-mi:"MI:0018"(two hybrid) Piechotta et al. (2002) pubmed:12386165 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-621002 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000027130(gene)|ensembl:ENSMUST00000028549(transcript)|intact:EBI-620972(s12a6_mouse) refseq:NP_058562.1|ensembl:ENSMUSG00000027030(gene)|ensembl:ENSMUST00000102715(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036438"(maintenance of lens transparency)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050801"(ion homeostasis)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1905408"(negative regulation of creatine transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|mint:Q9Z1W9|rcsb pdb:5D9H|rcsb pdb:5DBX|dip:DIP-31911N - - - - taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2005/07/20 2014/10/16 rogid:DsFyn24ksop7mIzunj96LE6yheY10090 rogid:iZk2DNNQxkBwjRvl0DNNt2YZcSc10090 intact-crc:C079AE00B4664F03|rigid:U7yQTrcBi7bMhW5h3+7V6SD/MLs false binding-associated region:?-? binding-associated region:350..350-556 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q924N4-1 uniprotkb:Q9Z1W9 intact:EBI-620992|ensembl:ENSMUSP00000028549 intact:EBI-444764|uniprotkb:Q80W13|ensembl:ENSMUSP00000099776 psi-mi:q924n4-1(display_long)|uniprotkb:KCC3a(isoform synonym)|uniprotkb:Slc12a6(gene name)|psi-mi:Slc12a6(display_short)|uniprotkb:Kcc3(gene name synonym)|uniprotkb:Electroneutral potassium-chloride cotransporter 3(gene name synonym)|uniprotkb:K-Cl cotransporter 3(gene name synonym) psi-mi:stk39_mouse(display_long)|uniprotkb:Serine/threonine-protein kinase 39(gene name synonym)|uniprotkb:Stk39(gene name)|psi-mi:Stk39(display_short)|uniprotkb:Spak(gene name synonym) psi-mi:"MI:0018"(two hybrid) Piechotta et al. (2002) pubmed:12386165 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-621022 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000027130(gene)|ensembl:ENSMUST00000028549(transcript)|intact:EBI-620972(s12a6_mouse) refseq:NP_058562.1|ensembl:ENSMUSG00000027030(gene)|ensembl:ENSMUST00000102715(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036438"(maintenance of lens transparency)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050801"(ion homeostasis)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1905408"(negative regulation of creatine transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|mint:Q9Z1W9|rcsb pdb:5D9H|rcsb pdb:5DBX|dip:DIP-31911N - - - - taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2005/07/20 2014/10/16 rogid:DsFyn24ksop7mIzunj96LE6yheY10090 rogid:iZk2DNNQxkBwjRvl0DNNt2YZcSc10090 intact-crc:BA7EFAB878FE4C3D|rigid:U7yQTrcBi7bMhW5h3+7V6SD/MLs false binding-associated region:?-? binding-associated region:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6P9R2 uniprotkb:Q924N4-1 intact:EBI-621035|ensembl:ENSMUSP00000042155|uniprotkb:Q8BVZ9|uniprotkb:Q8C0B9 intact:EBI-620992|ensembl:ENSMUSP00000028549 psi-mi:oxsr1_mouse(display_long)|uniprotkb:Oxidative stress-responsive 1 protein(gene name synonym)|uniprotkb:Oxsr1(gene name)|psi-mi:Oxsr1(display_short)|uniprotkb:Osr1(gene name synonym) psi-mi:q924n4-1(display_long)|uniprotkb:KCC3a(isoform synonym)|uniprotkb:Slc12a6(gene name)|psi-mi:Slc12a6(display_short)|uniprotkb:Kcc3(gene name synonym)|uniprotkb:Electroneutral potassium-chloride cotransporter 3(gene name synonym)|uniprotkb:K-Cl cotransporter 3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Piechotta et al. (2002) pubmed:12386165 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-621047 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000036737(gene)|ensembl:ENSMUST00000040853(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1990869"(cellular response to chemokine)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|interpro:IPR028749|refseq:XP_006511982.1|refseq:NP_598746.2 ensembl:ENSMUSG00000027130(gene)|ensembl:ENSMUST00000028549(transcript)|intact:EBI-620972(s12a6_mouse) - - - - taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2005/07/20 2014/10/16 rogid:ibtVTZ1P0rNeo2PHW6Mf7EKsLG010090 rogid:DsFyn24ksop7mIzunj96LE6yheY10090 intact-crc:FFCDB850B97DF2DA|rigid:TlWh8NAYTEpgtLoIOuE58+LMiEI false - binding-associated region:10-27 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q924N4-2 uniprotkb:Q9Z1W9 intact:EBI-620997|ensembl:ENSMUSP00000051490 intact:EBI-444764|uniprotkb:Q80W13|ensembl:ENSMUSP00000099776 psi-mi:q924n4-2(display_long)|uniprotkb:KCC3b(isoform synonym)|uniprotkb:Slc12a6(gene name)|psi-mi:Slc12a6(display_short)|uniprotkb:Kcc3(gene name synonym)|uniprotkb:Electroneutral potassium-chloride cotransporter 3(gene name synonym)|uniprotkb:K-Cl cotransporter 3(gene name synonym) psi-mi:stk39_mouse(display_long)|uniprotkb:Serine/threonine-protein kinase 39(gene name synonym)|uniprotkb:Stk39(gene name)|psi-mi:Stk39(display_short)|uniprotkb:Spak(gene name synonym) psi-mi:"MI:0018"(two hybrid) Piechotta et al. (2002) pubmed:12386165 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-621057 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUST00000053666(transcript)|ensembl:ENSMUSG00000027130(gene)|intact:EBI-620972(s12a6_mouse) refseq:NP_058562.1|ensembl:ENSMUSG00000027030(gene)|ensembl:ENSMUST00000102715(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036438"(maintenance of lens transparency)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050801"(ion homeostasis)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1905408"(negative regulation of creatine transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|mint:Q9Z1W9|rcsb pdb:5D9H|rcsb pdb:5DBX|dip:DIP-31911N - isoform-comment:Produced by alternative promoter usage. - - taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2005/07/20 2014/10/16 rogid:OaIdFkxBtvO7gEmlf69f84eh/to10090 rogid:iZk2DNNQxkBwjRvl0DNNt2YZcSc10090 intact-crc:0C8AF2771102E6E8|rigid:HP61a3QTJm4Xi4PRttOxLfJyXwI false binding-associated region:1-15 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P55012 uniprotkb:Q9Z1W9 intact:EBI-621078|uniprotkb:E9PYU3 intact:EBI-444764|uniprotkb:Q80W13|ensembl:ENSMUSP00000099776 psi-mi:s12a2_mouse(display_long)|uniprotkb:Basolateral Na-K-Cl symporter(gene name synonym)|uniprotkb:Slc12a2(gene name)|psi-mi:Slc12a2(display_short)|uniprotkb:Nkcc1(gene name synonym)|uniprotkb:"Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2"(gene name synonym) psi-mi:stk39_mouse(display_long)|uniprotkb:Serine/threonine-protein kinase 39(gene name synonym)|uniprotkb:Stk39(gene name)|psi-mi:Stk39(display_short)|uniprotkb:Spak(gene name synonym) psi-mi:"MI:0018"(two hybrid) Piechotta et al. (2002) pubmed:12386165 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-621071 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0008511"("sodium:potassium:chloride symporter activity")|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015377"("cation:chloride symporter activity")|go:"GO:0015379"("potassium:chloride symporter activity")|go:"GO:0015696"|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030321"(transepithelial chloride transport)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045795"(positive regulation of cell volume)|go:"GO:0046873"(metal ion transmembrane transporter activity)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0055064"(chloride ion homeostasis)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:1904450"(positive regulation of aspartate secretion)|go:"GO:1904464"(regulation of matrix metallopeptidase secretion)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:0070634"(transepithelial ammonium transport)|go:"GO:0071944"(cell periphery)|go:"GO:0098658"(inorganic anion import across plasma membrane)|go:"GO:0098659"(inorganic cation import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|refseq:NP_033220.2|interpro:IPR004841(Amino acid permease-associated region)|interpro:IPR013612(Amino acid permease N-terminal)|interpro:IPR002443(Na-K-Cl co-transporter)|interpro:IPR002444(Na-K-Cl co-transporter 1)|interpro:IPR004842(Na-K-Cl cotransporter superfamily)|interpro:IPR018491|reactome:R-MMU-426117 refseq:NP_058562.1|ensembl:ENSMUSG00000027030(gene)|ensembl:ENSMUST00000102715(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036438"(maintenance of lens transparency)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050801"(ion homeostasis)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1905408"(negative regulation of creatine transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|mint:Q9Z1W9|rcsb pdb:5D9H|rcsb pdb:5DBX|dip:DIP-31911N - - - - taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2005/07/20 2014/10/16 rogid:FJk+AWb4h4TK+0tm17AYasf03HM10090 rogid:iZk2DNNQxkBwjRvl0DNNt2YZcSc10090 intact-crc:E82AFF7C998ECCBA|rigid:TZUDUGUSWweNGUmyw2/djaIImdk false binding-associated region:73-90 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13621 uniprotkb:Q9Z1W9 intact:EBI-621099|intact:EBI-28983044|ensembl:ENSP00000370381|ensembl:ENSP00000495332|uniprotkb:A8JYA2|uniprotkb:E9PDW4 intact:EBI-444764|uniprotkb:Q80W13|ensembl:ENSMUSP00000099776 psi-mi:s12a1_human(display_long)|uniprotkb:"Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2"(gene name synonym)|uniprotkb:Kidney-specific Na-K-Cl symporter(gene name synonym)|uniprotkb:SLC12A1(gene name)|psi-mi:SLC12A1(display_short)|uniprotkb:NKCC2(gene name synonym) psi-mi:stk39_mouse(display_long)|uniprotkb:Serine/threonine-protein kinase 39(gene name synonym)|uniprotkb:Stk39(gene name)|psi-mi:Stk39(display_short)|uniprotkb:Spak(gene name synonym) psi-mi:"MI:0018"(two hybrid) Piechotta et al. (2002) pubmed:12386165 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-621094 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000074803(gene)|ensembl:ENST00000380993(transcript)|ensembl:ENST00000647546(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0008511"("sodium:potassium:chloride symporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0055064"(chloride ion homeostasis)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0015379"("potassium:chloride symporter activity")|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR002445(Na-K-Cl co-transporter 2)|interpro:IPR004841(Amino acid permease-associated region)|interpro:IPR004842(Na-K-Cl cotransporter superfamily)|interpro:IPR002443(Na-K-Cl co-transporter)|interpro:IPR013612(Amino acid permease N-terminal)|interpro:IPR018491|reactome:R-HSA-426117|reactome:R-HSA-5619104|ensembl:ENSP00000370381|ensembl:ENST00000396577|ensembl:ENSP00000379822|ensembl:ENST00000647232|ensembl:ENSP00000493875|ensembl:ENSP00000495332|refseq:NP_000329.2|refseq:NP_001171761.1 refseq:NP_058562.1|ensembl:ENSMUSG00000027030(gene)|ensembl:ENSMUST00000102715(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036438"(maintenance of lens transparency)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050801"(ion homeostasis)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1905408"(negative regulation of creatine transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|mint:Q9Z1W9|rcsb pdb:5D9H|rcsb pdb:5DBX|dip:DIP-31911N - - - caution:Sequence of S12a1 given in paper conflicts with that in entry at positions 19 and 24. taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2005/07/20 2014/10/16 rogid:NIZZRj4URjsXzSFCbvDVGwNPmjU9606 rogid:iZk2DNNQxkBwjRvl0DNNt2YZcSc10090 intact-crc:B1FEC6053C7B5A11|rigid:XB13Z6Uso208JK3Unp8GnhUWpBg false mutation decreasing interaction:20-20|mutation decreasing interaction:21-21|mutation decreasing interaction:23-23|mutation decreasing interaction:24-24|mutation decreasing interaction:25-25|mutation decreasing interaction:27-27|mutation decreasing interaction:28-28|binding-associated region:19-28 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6P9R2 uniprotkb:Q924N4-1 intact:EBI-621035|ensembl:ENSMUSP00000042155|uniprotkb:Q8BVZ9|uniprotkb:Q8C0B9 intact:EBI-620992|ensembl:ENSMUSP00000028549 psi-mi:oxsr1_mouse(display_long)|uniprotkb:Oxidative stress-responsive 1 protein(gene name synonym)|uniprotkb:Oxsr1(gene name)|psi-mi:Oxsr1(display_short)|uniprotkb:Osr1(gene name synonym) psi-mi:q924n4-1(display_long)|uniprotkb:KCC3a(isoform synonym)|uniprotkb:Slc12a6(gene name)|psi-mi:Slc12a6(display_short)|uniprotkb:Kcc3(gene name synonym)|uniprotkb:Electroneutral potassium-chloride cotransporter 3(gene name synonym)|uniprotkb:K-Cl cotransporter 3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Piechotta et al. (2002) pubmed:12386165 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-621133 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000036737(gene)|ensembl:ENSMUST00000040853(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1990869"(cellular response to chemokine)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|interpro:IPR028749|refseq:XP_006511982.1|refseq:NP_598746.2 ensembl:ENSMUSG00000027130(gene)|ensembl:ENSMUST00000028549(transcript)|intact:EBI-620972(s12a6_mouse) - - - - taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2005/07/20 2014/10/16 rogid:ibtVTZ1P0rNeo2PHW6Mf7EKsLG010090 rogid:DsFyn24ksop7mIzunj96LE6yheY10090 intact-crc:8322A818833150B0|rigid:TlWh8NAYTEpgtLoIOuE58+LMiEI false - mutation decreasing interaction:14-14|mutation decreasing interaction:15-15|mutation decreasing interaction:17-17|mutation decreasing interaction:19-19|mutation decreasing interaction:21-21|mutation decreasing interaction:22-22|binding-associated region:10-27 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6P9R2 uniprotkb:P55012 intact:EBI-621035|ensembl:ENSMUSP00000042155|uniprotkb:Q8BVZ9|uniprotkb:Q8C0B9 intact:EBI-621078|uniprotkb:E9PYU3 psi-mi:oxsr1_mouse(display_long)|uniprotkb:Oxidative stress-responsive 1 protein(gene name synonym)|uniprotkb:Oxsr1(gene name)|psi-mi:Oxsr1(display_short)|uniprotkb:Osr1(gene name synonym) psi-mi:s12a2_mouse(display_long)|uniprotkb:Basolateral Na-K-Cl symporter(gene name synonym)|uniprotkb:Slc12a2(gene name)|psi-mi:Slc12a2(display_short)|uniprotkb:Nkcc1(gene name synonym)|uniprotkb:"Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2"(gene name synonym) psi-mi:"MI:0018"(two hybrid) Piechotta et al. (2002) pubmed:12386165 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-621139 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000036737(gene)|ensembl:ENSMUST00000040853(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1990869"(cellular response to chemokine)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|interpro:IPR028749|refseq:XP_006511982.1|refseq:NP_598746.2 go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0008511"("sodium:potassium:chloride symporter activity")|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015377"("cation:chloride symporter activity")|go:"GO:0015379"("potassium:chloride symporter activity")|go:"GO:0015696"|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030321"(transepithelial chloride transport)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045795"(positive regulation of cell volume)|go:"GO:0046873"(metal ion transmembrane transporter activity)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0055064"(chloride ion homeostasis)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:1904450"(positive regulation of aspartate secretion)|go:"GO:1904464"(regulation of matrix metallopeptidase secretion)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:0070634"(transepithelial ammonium transport)|go:"GO:0071944"(cell periphery)|go:"GO:0098658"(inorganic anion import across plasma membrane)|go:"GO:0098659"(inorganic cation import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|refseq:NP_033220.2|interpro:IPR004841(Amino acid permease-associated region)|interpro:IPR013612(Amino acid permease N-terminal)|interpro:IPR002443(Na-K-Cl co-transporter)|interpro:IPR002444(Na-K-Cl co-transporter 1)|interpro:IPR004842(Na-K-Cl cotransporter superfamily)|interpro:IPR018491|reactome:R-MMU-426117 - - - - taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2005/07/20 2014/10/16 rogid:ibtVTZ1P0rNeo2PHW6Mf7EKsLG010090 rogid:FJk+AWb4h4TK+0tm17AYasf03HM10090 intact-crc:6DAFAC563C2FB93E|rigid:3asNFdF/Tkb/XHQ/ps8eFbdcRGU false - binding-associated region:73-90 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6P9R2 uniprotkb:Q924N4-2 intact:EBI-621035|ensembl:ENSMUSP00000042155|uniprotkb:Q8BVZ9|uniprotkb:Q8C0B9 intact:EBI-620997|ensembl:ENSMUSP00000051490 psi-mi:oxsr1_mouse(display_long)|uniprotkb:Oxidative stress-responsive 1 protein(gene name synonym)|uniprotkb:Oxsr1(gene name)|psi-mi:Oxsr1(display_short)|uniprotkb:Osr1(gene name synonym) psi-mi:q924n4-2(display_long)|uniprotkb:KCC3b(isoform synonym)|uniprotkb:Slc12a6(gene name)|psi-mi:Slc12a6(display_short)|uniprotkb:Kcc3(gene name synonym)|uniprotkb:Electroneutral potassium-chloride cotransporter 3(gene name synonym)|uniprotkb:K-Cl cotransporter 3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Piechotta et al. (2002) pubmed:12386165 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-621145 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000036737(gene)|ensembl:ENSMUST00000040853(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1990869"(cellular response to chemokine)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|interpro:IPR028749|refseq:XP_006511982.1|refseq:NP_598746.2 ensembl:ENSMUST00000053666(transcript)|ensembl:ENSMUSG00000027130(gene)|intact:EBI-620972(s12a6_mouse) - - isoform-comment:Produced by alternative promoter usage. - taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2005/07/20 2014/10/16 rogid:ibtVTZ1P0rNeo2PHW6Mf7EKsLG010090 rogid:OaIdFkxBtvO7gEmlf69f84eh/to10090 intact-crc:55EC2AA30A09522A|rigid:E4Ex/miejmQUk4p8sWi9qJ/yO7U false - binding-associated region:1-15 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6P9R2 uniprotkb:Q13621 intact:EBI-621035|ensembl:ENSMUSP00000042155|uniprotkb:Q8BVZ9|uniprotkb:Q8C0B9 intact:EBI-621099|intact:EBI-28983044|ensembl:ENSP00000370381|ensembl:ENSP00000495332|uniprotkb:A8JYA2|uniprotkb:E9PDW4 psi-mi:oxsr1_mouse(display_long)|uniprotkb:Oxidative stress-responsive 1 protein(gene name synonym)|uniprotkb:Oxsr1(gene name)|psi-mi:Oxsr1(display_short)|uniprotkb:Osr1(gene name synonym) psi-mi:s12a1_human(display_long)|uniprotkb:"Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2"(gene name synonym)|uniprotkb:Kidney-specific Na-K-Cl symporter(gene name synonym)|uniprotkb:SLC12A1(gene name)|psi-mi:SLC12A1(display_short)|uniprotkb:NKCC2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Piechotta et al. (2002) pubmed:12386165 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-621158 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000036737(gene)|ensembl:ENSMUST00000040853(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1990869"(cellular response to chemokine)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|interpro:IPR028749|refseq:XP_006511982.1|refseq:NP_598746.2 ensembl:ENSG00000074803(gene)|ensembl:ENST00000380993(transcript)|ensembl:ENST00000647546(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0008511"("sodium:potassium:chloride symporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0055064"(chloride ion homeostasis)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0015379"("potassium:chloride symporter activity")|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR002445(Na-K-Cl co-transporter 2)|interpro:IPR004841(Amino acid permease-associated region)|interpro:IPR004842(Na-K-Cl cotransporter superfamily)|interpro:IPR002443(Na-K-Cl co-transporter)|interpro:IPR013612(Amino acid permease N-terminal)|interpro:IPR018491|reactome:R-HSA-426117|reactome:R-HSA-5619104|ensembl:ENSP00000370381|ensembl:ENST00000396577|ensembl:ENSP00000379822|ensembl:ENST00000647232|ensembl:ENSP00000493875|ensembl:ENSP00000495332|refseq:NP_000329.2|refseq:NP_001171761.1 - - - caution:Sequence of S12a1 given in paper conflicts with that in entry at positions 19 and 24. taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2005/07/20 2014/10/16 rogid:ibtVTZ1P0rNeo2PHW6Mf7EKsLG010090 rogid:NIZZRj4URjsXzSFCbvDVGwNPmjU9606 intact-crc:1C2F83CB68A1522F|rigid:FnRS78+fTYAHZCyb0j7dR2a+oZo false - binding-associated region:19-28|mutation decreasing interaction:20-20|mutation decreasing interaction:21-21|mutation decreasing interaction:23-23|mutation decreasing interaction:24-24|mutation decreasing interaction:25-25|mutation decreasing interaction:27-27|mutation decreasing interaction:28-28 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Z1W9 uniprotkb:Q924N4-1 intact:EBI-444764|uniprotkb:Q80W13|ensembl:ENSMUSP00000099776 intact:EBI-620992|ensembl:ENSMUSP00000028549 psi-mi:stk39_mouse(display_long)|uniprotkb:Serine/threonine-protein kinase 39(gene name synonym)|uniprotkb:Stk39(gene name)|psi-mi:Stk39(display_short)|uniprotkb:Spak(gene name synonym) psi-mi:q924n4-1(display_long)|uniprotkb:KCC3a(isoform synonym)|uniprotkb:Slc12a6(gene name)|psi-mi:Slc12a6(display_short)|uniprotkb:Kcc3(gene name synonym)|uniprotkb:Electroneutral potassium-chloride cotransporter 3(gene name synonym)|uniprotkb:K-Cl cotransporter 3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Piechotta et al. (2002) pubmed:12386165 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-621178 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_058562.1|ensembl:ENSMUSG00000027030(gene)|ensembl:ENSMUST00000102715(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036438"(maintenance of lens transparency)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050801"(ion homeostasis)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1905408"(negative regulation of creatine transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|mint:Q9Z1W9|rcsb pdb:5D9H|rcsb pdb:5DBX|dip:DIP-31911N ensembl:ENSMUSG00000027130(gene)|ensembl:ENSMUST00000028549(transcript)|intact:EBI-620972(s12a6_mouse) - - - - taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2005/07/20 2014/10/16 rogid:iZk2DNNQxkBwjRvl0DNNt2YZcSc10090 rogid:DsFyn24ksop7mIzunj96LE6yheY10090 intact-crc:F3D172858E2244C5|rigid:U7yQTrcBi7bMhW5h3+7V6SD/MLs false - binding-associated region:14-22|mutation decreasing interaction:14-14|mutation decreasing interaction:15-15|mutation decreasing interaction:17-17|mutation decreasing interaction:19-19|mutation decreasing interaction:21-21|mutation decreasing interaction:22-22 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Z1W9 uniprotkb:Q924N4-1 intact:EBI-444764|uniprotkb:Q80W13|ensembl:ENSMUSP00000099776 intact:EBI-620992|ensembl:ENSMUSP00000028549 psi-mi:stk39_mouse(display_long)|uniprotkb:Serine/threonine-protein kinase 39(gene name synonym)|uniprotkb:Stk39(gene name)|psi-mi:Stk39(display_short)|uniprotkb:Spak(gene name synonym) psi-mi:q924n4-1(display_long)|uniprotkb:KCC3a(isoform synonym)|uniprotkb:Slc12a6(gene name)|psi-mi:Slc12a6(display_short)|uniprotkb:Kcc3(gene name synonym)|uniprotkb:Electroneutral potassium-chloride cotransporter 3(gene name synonym)|uniprotkb:K-Cl cotransporter 3(gene name synonym) psi-mi:"MI:0096"(pull down) Piechotta et al. (2002) pubmed:12386165 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-621309 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_058562.1|ensembl:ENSMUSG00000027030(gene)|ensembl:ENSMUST00000102715(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036438"(maintenance of lens transparency)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050801"(ion homeostasis)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1905408"(negative regulation of creatine transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|mint:Q9Z1W9|rcsb pdb:5D9H|rcsb pdb:5DBX|dip:DIP-31911N ensembl:ENSMUSG00000027130(gene)|ensembl:ENSMUST00000028549(transcript)|intact:EBI-620972(s12a6_mouse) - - - - taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/07/20 2014/10/16 rogid:iZk2DNNQxkBwjRvl0DNNt2YZcSc10090 rogid:DsFyn24ksop7mIzunj96LE6yheY10090 intact-crc:E73AE51ED764C06B|rigid:U7yQTrcBi7bMhW5h3+7V6SD/MLs false binding-associated region:350..350-556|ha tag:?-? binding-associated region:10-23|glutathione s tranferase tag:?-?|mutation decreasing interaction:15-15 - - psi-mi:"MI:0072"(monoclonal antibody western blot) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:Q9Z1W9 uniprotkb:P55012 intact:EBI-444764|uniprotkb:Q80W13|ensembl:ENSMUSP00000099776 intact:EBI-621078|uniprotkb:E9PYU3 psi-mi:stk39_mouse(display_long)|uniprotkb:Serine/threonine-protein kinase 39(gene name synonym)|uniprotkb:Stk39(gene name)|psi-mi:Stk39(display_short)|uniprotkb:Spak(gene name synonym) psi-mi:s12a2_mouse(display_long)|uniprotkb:Basolateral Na-K-Cl symporter(gene name synonym)|uniprotkb:Slc12a2(gene name)|psi-mi:Slc12a2(display_short)|uniprotkb:Nkcc1(gene name synonym)|uniprotkb:"Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2"(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Piechotta et al. (2002) pubmed:12386165 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-621329 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_058562.1|ensembl:ENSMUSG00000027030(gene)|ensembl:ENSMUST00000102715(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036438"(maintenance of lens transparency)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050801"(ion homeostasis)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1905408"(negative regulation of creatine transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|mint:Q9Z1W9|rcsb pdb:5D9H|rcsb pdb:5DBX|dip:DIP-31911N go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0008511"("sodium:potassium:chloride symporter activity")|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015377"("cation:chloride symporter activity")|go:"GO:0015379"("potassium:chloride symporter activity")|go:"GO:0015696"|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030321"(transepithelial chloride transport)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045795"(positive regulation of cell volume)|go:"GO:0046873"(metal ion transmembrane transporter activity)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0055064"(chloride ion homeostasis)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:1904450"(positive regulation of aspartate secretion)|go:"GO:1904464"(regulation of matrix metallopeptidase secretion)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:0070634"(transepithelial ammonium transport)|go:"GO:0071944"(cell periphery)|go:"GO:0098658"(inorganic anion import across plasma membrane)|go:"GO:0098659"(inorganic cation import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|refseq:NP_033220.2|interpro:IPR004841(Amino acid permease-associated region)|interpro:IPR013612(Amino acid permease N-terminal)|interpro:IPR002443(Na-K-Cl co-transporter)|interpro:IPR002444(Na-K-Cl co-transporter 1)|interpro:IPR004842(Na-K-Cl cotransporter superfamily)|interpro:IPR018491|reactome:R-MMU-426117 - - - - taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2005/07/20 2014/10/16 rogid:iZk2DNNQxkBwjRvl0DNNt2YZcSc10090 rogid:FJk+AWb4h4TK+0tm17AYasf03HM10090 intact-crc:5CCC1B0C69ABB902|rigid:TZUDUGUSWweNGUmyw2/djaIImdk false - - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot)