#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P22812 uniprotkb:Q7K105 intact:EBI-93181|uniprotkb:Q9VN15|uniprotkb:B7Z0I9|uniprotkb:E8NH30|ensemblmetazoa:FBpp0291542 intact:EBI-129988|ensemblmetazoa:FBpp0087679|ensemblmetazoa:FBpp0305215|ensemblmetazoa:FBpp0311274 psi-mi:tube_drome(display_long)|uniprotkb:CG10520(orf name)|uniprotkb:tub(gene name)|psi-mi:tub(display_short)|uniprotkb:tube(gene name synonym) psi-mi:q7k105_drome(display_long)|uniprotkb:Myd88(gene name)|psi-mi:Myd88(display_short)|uniprotkb:DMMYD88(gene name synonym)|uniprotkb:DmMyD88(gene name synonym)|uniprotkb:DmMyd88(gene name synonym)|uniprotkb:Dmel\CG2078(gene name synonym)|uniprotkb:"EP(2)2535"(gene name synonym)|uniprotkb:Kra(gene name synonym)|uniprotkb:LD20892(gene name synonym)|uniprotkb:MYD88(gene name synonym)|uniprotkb:MyD88(gene name synonym)|uniprotkb:Myd88F(gene name synonym)|uniprotkb:dMYd88(gene name synonym)|uniprotkb:dMyD88(gene name synonym)|uniprotkb:dMyd88(gene name synonym)|uniprotkb:kra(gene name synonym)|uniprotkb:myd88(gene name synonym)|uniprotkb:CG2078(orf name)|uniprotkb:Dmel_CG2078(orf name) psi-mi:"MI:0019"(coimmunoprecipitation) Sun et al. (2002) pubmed:12351681|mint:MINT-5215780 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-524580 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001189164.1|flybase:FBgn0003882|go:"GO:0048262"(determination of dorsal/ventral asymmetry)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR029397|rcsb pdb:1D2Z|reactome:R-DME-209442|reactome:R-DME-214842|reactome:R-DME-214844|reactome:R-DME-214862|reactome:R-DME-214863|reactome:R-DME-214869|reactome:R-DME-214874|go:"GO:0045087"(innate immune response)|ensemblmetazoa:FBgn0003882(gene)|ensemblmetazoa:FBtr0302338(transcript)|go:"GO:0002804"(positive regulation of antifungal peptide production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007526"(larval somatic muscle development)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009620"(response to fungus)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035172"(hemocyte proliferation)|dip:DIP-27623N refseq:NP_610479.1|flybase:FBgn0033402|refseq:NP_001286246.1|ensemblmetazoa:FBgn0033402(gene)|ensemblmetazoa:FBtr0088598(transcript)|ensemblmetazoa:FBtr0333000(transcript)|ensemblmetazoa:FBtr0345024(transcript)|go:"GO:0002225"(positive regulation of antimicrobial peptide production)|go:"GO:0002347"(response to tumor cell)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002804"(positive regulation of antifungal peptide production)|go:"GO:0005121"(Toll binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050832"(defense response to fungus)|go:"GO:0070976"(TIR domain binding)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR035897|reactome:R-DME-1810476|reactome:R-DME-209442|reactome:R-DME-214842|reactome:R-DME-214844|reactome:R-DME-214862|reactome:R-DME-214863|reactome:R-DME-214869|reactome:R-DME-214874|reactome:R-DME-3134963|interpro:IPR000157(Toll-Interleukin receptor)|refseq:NP_001260821.1 - - - - taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2005/03/30 2014/10/16 rogid:v00LZV72cvvYVI5cCthONXIlmrs7227 rogid:ylgI2zl+aLG3S8D2ER2DrTRUpI47227 intact-crc:0F6481A529998111|rigid:wldgN2majJxREvftSUEmhwg7UTg false v5 tag:?-?|binding-associated region:?-?(IPR000488) - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q05652 uniprotkb:P22812 intact:EBI-115059|uniprotkb:Q9VB57|ensemblmetazoa:FBpp0084549|ensemblmetazoa:FBpp0306780|uniprotkb:B8A3X2|uniprotkb:Q8T005 intact:EBI-93181|uniprotkb:Q9VN15|uniprotkb:B7Z0I9|uniprotkb:E8NH30|ensemblmetazoa:FBpp0291542 psi-mi:kpel_drome(display_long)|uniprotkb:CG5974(orf name)|uniprotkb:pll(gene name)|psi-mi:pll(display_short) psi-mi:tube_drome(display_long)|uniprotkb:CG10520(orf name)|uniprotkb:tub(gene name)|psi-mi:tub(display_short)|uniprotkb:tube(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Sun et al. (2002) pubmed:12351681|mint:MINT-5215780 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-524591 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_476971.1|flybase:FBgn0010441|ensemblmetazoa:FBgn0010441(gene)|ensemblmetazoa:FBtr0085179(transcript)|ensemblmetazoa:FBtr0334732(transcript)|go:"GO:0002804"(positive regulation of antifungal peptide production)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0005886"(plasma membrane)|go:"GO:0007526"(larval somatic muscle development)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035172"(hemocyte proliferation)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045087"(innate immune response)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048262"(determination of dorsal/ventral asymmetry)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR037924|rcsb pdb:1D2Z|rcsb pdb:1IK7|rcsb pdb:1YGO|reactome:R-DME-214842|reactome:R-DME-214844|reactome:R-DME-214862|reactome:R-DME-214869|reactome:R-DME-214874|refseq:NP_001263008.1|dip:DIP-27622N refseq:NP_001189164.1|flybase:FBgn0003882|go:"GO:0048262"(determination of dorsal/ventral asymmetry)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR029397|rcsb pdb:1D2Z|reactome:R-DME-209442|reactome:R-DME-214842|reactome:R-DME-214844|reactome:R-DME-214862|reactome:R-DME-214863|reactome:R-DME-214869|reactome:R-DME-214874|go:"GO:0045087"(innate immune response)|ensemblmetazoa:FBgn0003882(gene)|ensemblmetazoa:FBtr0302338(transcript)|go:"GO:0002804"(positive regulation of antifungal peptide production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007526"(larval somatic muscle development)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009620"(response to fungus)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035172"(hemocyte proliferation)|dip:DIP-27623N - - - - taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2005/03/30 2014/10/16 rogid:mzeAsv/CpnfUVe9V4AISjg51tqA7227 rogid:v00LZV72cvvYVI5cCthONXIlmrs7227 intact-crc:AF1F905BB688F8EC|rigid:CBP6+LAxAvEVwY1/uwqyn2iFqUM false v5 tag:?-?|binding-associated region:1-206(IPR000488) binding-associated region:?-?(IPR000488)|myc tag:?-?|mutation decreasing interaction:50-50 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)