#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P78536-1	uniprotkb:P26045	intact:EBI-8519206|ensembl:ENSP00000309968|intact:MINT-108313	intact:EBI-1047946|uniprotkb:A0AUW9|uniprotkb:E7EN99|uniprotkb:E9PGU7|ensembl:ENSP00000363667	psi-mi:p78536-1(display_long)|uniprotkb:ADAM17(gene name)|psi-mi:ADAM17(display_short)|uniprotkb:CSVP(gene name synonym)|uniprotkb:Snake venom-like protease(gene name synonym)|uniprotkb:TACE(gene name synonym)|uniprotkb:TNF-alpha convertase(gene name synonym)|uniprotkb:TNF-alpha-converting enzyme(gene name synonym)	psi-mi:ptn3_human(display_long)|uniprotkb:Protein-tyrosine phosphatase H1(gene name synonym)|uniprotkb:PTPN3(gene name)|psi-mi:PTPN3(display_short)|uniprotkb:PTPH1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zheng et al. (2002)	mint:MINT-5215697|pubmed:12207026	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8519219|mint:MINT-58317	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000151694(gene)|ensembl:ENST00000310823(transcript)|intact:EBI-78188(isoform-parent)|mint:MINT-720073(identity)	refseq:NP_001138840.1|refseq:NP_001138843.1|refseq:NP_002820.3|refseq:NP_001138841.1|refseq:NP_001138842.1|refseq:XP_011517191.1|refseq:XP_016870444.1|refseq:XP_016870446.1|ensembl:ENSG00000070159(gene)|ensembl:ENST00000374541(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051117"(ATPase binding)|go:"GO:0097421"(liver regeneration)|go:"GO:0098902"(regulation of membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:P26045|rcsb pdb:2B49|rcsb pdb:4QUM|rcsb pdb:4QUN|rcsb pdb:4RH5|rcsb pdb:4RH9|rcsb pdb:4RHG|rcsb pdb:4RI4|rcsb pdb:4RI5|rcsb pdb:4S0G|rcsb pdb:6HKS|rcsb pdb:6T36|reactome:R-HSA-182971|reactome:R-HSA-5675221|refseq:XP_006717262.1|refseq:XP_006717267.1|dip:DIP-38839N|mint:MINT-720064(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2|comment:P26045 MPB tagged<br><br>P78536 GST tagged|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/05/06	2014/10/16	rogid:9ZXiwccqzkHXJUHY1KNhH/ZGG+89606	rogid:7LM4ANS9aclQf1SZfn/Jmxj2fUA9606	intact-crc:FB93AFE1D3AF4E0D|rigid:wwtl3l1xO2RAA+PLCz0l6pIDVaE	false	binding-associated region:820-824(MINT-720074)|tag:?-?(MINT-720077)	tag:?-?(MINT-720068)|binding-associated region:402-605(MINT-720065)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78536	uniprotkb:P26045	intact:EBI-78188|intact:EBI-28987181|ensembl:ENSP00000309968|uniprotkb:O60226	intact:EBI-1047946|uniprotkb:A0AUW9|uniprotkb:E7EN99|uniprotkb:E9PGU7|ensembl:ENSP00000363667	psi-mi:ada17_human(display_long)|uniprotkb:ADAM17(gene name)|psi-mi:ADAM17(display_short)|uniprotkb:CSVP(gene name synonym)|uniprotkb:TACE(gene name synonym)|uniprotkb:TNF-alpha-converting enzyme(gene name synonym)|uniprotkb:TNF-alpha convertase(gene name synonym)|uniprotkb:Snake venom-like protease(gene name synonym)	psi-mi:ptn3_human(display_long)|uniprotkb:Protein-tyrosine phosphatase H1(gene name synonym)|uniprotkb:PTPN3(gene name)|psi-mi:PTPN3(display_short)|uniprotkb:PTPH1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zheng et al. (2002)	mint:MINT-5215697|pubmed:12207026	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8519259|mint:MINT-58311	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0042493"|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0033025"(regulation of mast cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0045121"(membrane raft)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0046872"(metal ion binding)|go:"GO:0048536"(spleen development)|go:"GO:0048870"(cell motility)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0071403"(cellular response to high density lipoprotein particle stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0035624"(receptor transactivation)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR024079|interpro:IPR032029|interpro:IPR034025|interpro:IPR036436|mint:P78536|rcsb pdb:1BKC|rcsb pdb:1ZXC|rcsb pdb:2A8H|rcsb pdb:2DDF|rcsb pdb:2FV5|rcsb pdb:2FV9|rcsb pdb:2I47|rcsb pdb:2M2F|rcsb pdb:2OI0|rcsb pdb:3B92|rcsb pdb:3CKI|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|rcsb pdb:3E8R|rcsb pdb:3EDZ|rcsb pdb:3EWJ|rcsb pdb:3G42|rcsb pdb:3KMC|rcsb pdb:3KME|rcsb pdb:3L0T|rcsb pdb:3L0V|rcsb pdb:3LE9|rcsb pdb:3LEA|rcsb pdb:3LGP|rcsb pdb:3O64|reactome:R-HSA-1251985|reactome:R-HSA-1442490|reactome:R-HSA-177929|reactome:R-HSA-193692|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-5362798|ensembl:ENSG00000151694(gene)|ensembl:ENST00000310823(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002467"(germinal center formation)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0008233"(peptidase activity)|reactome:R-HSA-9662834|reactome:R-HSA-982772|reactome:R-HSA-75893|refseq:NP_003174.3|ensembl:ENSP00000309968|dip:DIP-31044N|mint:MINT-720144(identity)	refseq:NP_001138840.1|refseq:NP_001138843.1|refseq:NP_002820.3|refseq:NP_001138841.1|refseq:NP_001138842.1|refseq:XP_011517191.1|refseq:XP_016870444.1|refseq:XP_016870446.1|ensembl:ENSG00000070159(gene)|ensembl:ENST00000374541(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051117"(ATPase binding)|go:"GO:0097421"(liver regeneration)|go:"GO:0098902"(regulation of membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:P26045|rcsb pdb:2B49|rcsb pdb:4QUM|rcsb pdb:4QUN|rcsb pdb:4RH5|rcsb pdb:4RH9|rcsb pdb:4RHG|rcsb pdb:4RI4|rcsb pdb:4RI5|rcsb pdb:4S0G|rcsb pdb:6HKS|rcsb pdb:6T36|reactome:R-HSA-182971|reactome:R-HSA-5675221|refseq:XP_006717262.1|refseq:XP_006717267.1|dip:DIP-38839N|mint:MINT-720135(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1|comment:"PTPH1 was not able to interact with the cytoplasmic domains of five other ADAMs tested, ADAM9 (MDC9; meltrin ), ADAM10 (MADM; Kuz), ADAM12 (meltrin ), ADAM15 (MDC15; metargidin), and ADAM19 (meltrin ) reported as se�arate entrues in MINT. Thus, PTPH1 does not appear to be a common binding partner of ADAMs, but binds specifically to the cytoplasmic domain of TACE. <br><br>"|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|partial coverage:partial coverage	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/05/06	2014/10/16	rogid:9ZXiwccqzkHXJUHY1KNhH/ZGG+89606	rogid:7LM4ANS9aclQf1SZfn/Jmxj2fUA9606	intact-crc:41BBD8029BCE142B|rigid:wwtl3l1xO2RAA+PLCz0l6pIDVaE	false	mutation decreasing interaction:824-824,822-822(MINT-720148)|binding-associated region:820-824(MINT-720145)|tag:?-?(MINT-720151)	binding-associated region:402-605(MINT-720136)|tag:?-?(MINT-720139)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z0F8	uniprotkb:P26045	intact:EBI-7848498|ensembl:ENSMUSP00000067953|uniprotkb:Q9R1U4|uniprotkb:Q9Z0K3|uniprotkb:O88726|uniprotkb:Q505A7|intact:MINT-246289	intact:EBI-1047946|uniprotkb:A0AUW9|uniprotkb:E7EN99|uniprotkb:E9PGU7|ensembl:ENSP00000363667	psi-mi:ada17_mouse(display_long)|uniprotkb:Adam17(gene name)|psi-mi:Adam17(display_short)|uniprotkb:Tace(gene name synonym)|uniprotkb:TNF-alpha-converting enzyme(gene name synonym)|uniprotkb:TNF-alpha convertase(gene name synonym)	psi-mi:ptn3_human(display_long)|uniprotkb:Protein-tyrosine phosphatase H1(gene name synonym)|uniprotkb:PTPN3(gene name)|psi-mi:PTPN3(display_short)|uniprotkb:PTPH1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zheng et al. (2002)	mint:MINT-5215697|pubmed:12207026	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8519305|mint:MINT-58318	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000052593(gene)|ensembl:ENSMUST00000064536(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002467"(germinal center formation)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0033025"(regulation of mast cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042493"|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048536"(spleen development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071403"(cellular response to high density lipoprotein particle stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR024079|interpro:IPR032029|interpro:IPR034025|interpro:IPR036436|reactome:R-MMU-193692|reactome:R-MMU-75893|refseq:NP_033745.4|refseq:NP_001264195.1|refseq:NP_001278800.1|dip:DIP-41747N|mint:MINT-720172(identity)	refseq:NP_001138840.1|refseq:NP_001138843.1|refseq:NP_002820.3|refseq:NP_001138841.1|refseq:NP_001138842.1|refseq:XP_011517191.1|refseq:XP_016870444.1|refseq:XP_016870446.1|ensembl:ENSG00000070159(gene)|ensembl:ENST00000374541(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051117"(ATPase binding)|go:"GO:0097421"(liver regeneration)|go:"GO:0098902"(regulation of membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:P26045|rcsb pdb:2B49|rcsb pdb:4QUM|rcsb pdb:4QUN|rcsb pdb:4RH5|rcsb pdb:4RH9|rcsb pdb:4RHG|rcsb pdb:4RI4|rcsb pdb:4RI5|rcsb pdb:4S0G|rcsb pdb:6HKS|rcsb pdb:6T36|reactome:R-HSA-182971|reactome:R-HSA-5675221|refseq:XP_006717262.1|refseq:XP_006717267.1|dip:DIP-38839N|mint:MINT-720163(identity)	-	function:Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway|comment:mint|comment:homomint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3|comment:"The Cys to Ala mutation in the PDZ binding domain of TACE decreased the co-immunoprecipitation of all forms of PTPH1, but did not completely abolish binding.These data are consistent with the results of the yeast two-hybrid system (in MINT as a separate entry) and of the in vitro binding assay (in MINT as a separate entry), confirming that the carboxyl-terminal sequence of TACE is necessary for PTPH1 binding. Note that in this experiments the authors used MOUSE TACE although they referred in the text to Human TACE (used for the other ecperiments) and therefore refering to the alaning scanning of the Human TACE, so that the critical AA are a Thr at 822 and a Cys at 824 (of the Human TACE)<br><br>"|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|partial coverage:partial coverage	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2005/05/06	2014/10/16	rogid:W3i2jBO2/JqainCbVRsCBU9wAmc10090	rogid:7LM4ANS9aclQf1SZfn/Jmxj2fUA9606	intact-crc:6345C6C054630B7C|rigid:KisY3ABNyyipFEgxEpag7cx+81g	false	mutation decreasing interaction:827-827,825-825(MINT-720176)|tag:?-?(MINT-720179)|binding-associated region:823-827(MINT-720173)	binding-associated region:402-605(MINT-720164)|tag:?-?(MINT-720167)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)