#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P23142-1 uniprotkb:P06931 intact:EBI-8516738|intact:MINT-245737|ensembl:ENSP00000331544 intact:EBI-7281937|intact:MINT-245691 psi-mi:p23142-1(display_long)|uniprotkb:FBLN1(gene name)|psi-mi:FBLN1(display_short)|uniprotkb:PP213(orf name) psi-mi:ve6_bpv1(display_long)|uniprotkb:E6(gene name)|psi-mi:E6(display_short) psi-mi:"MI:0096"(pull down) Du et al. (2002) mint:MINT-5215688|pubmed:12200142 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8516747|mint:MINT-73212 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-726652(isoform-parent)|ensembl:ENSG00000077942(gene)|ensembl:ENST00000327858(transcript)|mint:MINT-719865(identity) mint:P06931|refseq:NP_056737.1|go:"GO:0003677"(DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0042025"(host cell nucleus)|interpro:IPR001334(E6 early regulatory protein)|interpro:IPR038575|rcsb pdb:3PY7|dip:DIP-41442N|mint:MINT-719860(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:mint|function:Transcriptional transactivator. Binds double stranded DNA|comment:"Stoichiometry: 1.0" figure legend:F2A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/12/07 2014/10/16 rogid:a47ZJLXWeghGIY9xJTQI7VujuMk9606 rogid:t7zpnnYzcptAb/QY0/BzzSW5zTI337052 intact-crc:5336FBA61BED0C45|rigid:xDTITWfG0wcaVbxC3unJ8bahRQI false binding-associated region:262-578(MINT-719866)|glutathione s tranferase tag:?-?(MINT-719868) - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P23142-1 uniprotkb:P06463 intact:EBI-8516738|intact:MINT-245737|ensembl:ENSP00000331544 intact:EBI-1186926 psi-mi:p23142-1(display_long)|uniprotkb:FBLN1(gene name)|psi-mi:FBLN1(display_short)|uniprotkb:PP213(orf name) psi-mi:ve6_hpv18(display_long)|uniprotkb:E6(gene name)|psi-mi:E6(display_short) psi-mi:"MI:0096"(pull down) Du et al. (2002) mint:MINT-5215688|pubmed:12200142 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8516787|mint:MINT-73214 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-726652(isoform-parent)|ensembl:ENSG00000077942(gene)|ensembl:ENST00000327858(transcript)|mint:MINT-719883(identity) refseq:NP_040310.1|go:"GO:0003677"(DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001334(E6 early regulatory protein)|interpro:IPR038575|rcsb pdb:2I04|rcsb pdb:2I0I|rcsb pdb:2I0L|rcsb pdb:4JOR|rcsb pdb:5IC3|rcsb pdb:5K4F|rcsb pdb:6SJV|rcsb pdb:6ZFD|rcsb pdb:6ZFG|mint:P06463|dip:DIP-44730N|mint:MINT-719878(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/12/07 2014/10/16 rogid:a47ZJLXWeghGIY9xJTQI7VujuMk9606 rogid:X7TgcVayyyOKnVPXRlcbN6FVtYQ333761 intact-crc:A4507B9BAFDBF11B|rigid:fT1brsYgMllgsPhxlUh1tzgTHk4 false binding-associated region:262-578(MINT-719884)|glutathione s tranferase tag:?-?(MINT-719886) - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P23142-1 uniprotkb:P03126 intact:EBI-8516738|intact:MINT-245737|ensembl:ENSP00000331544 intact:EBI-1177242|uniprotkb:Q71BI7 psi-mi:p23142-1(display_long)|uniprotkb:FBLN1(gene name)|psi-mi:FBLN1(display_short)|uniprotkb:PP213(orf name) psi-mi:ve6_hpv16(display_long)|uniprotkb:E6(gene name)|psi-mi:E6(display_short) psi-mi:"MI:0096"(pull down) Du et al. (2002) mint:MINT-5215688|pubmed:12200142 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8516767|mint:MINT-73213 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-726652(isoform-parent)|ensembl:ENSG00000077942(gene)|ensembl:ENST00000327858(transcript)|mint:MINT-720011(identity) refseq:NP_041325.1|go:"GO:0003677"(DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR001334(E6 early regulatory protein)|interpro:IPR038575|rcsb pdb:1VZN|rcsb pdb:2FK4|rcsb pdb:2KPL|rcsb pdb:2LJX|rcsb pdb:2LJY|rcsb pdb:2LJZ|rcsb pdb:4GIZ|rcsb pdb:4JOP|rcsb pdb:4XR8|rcsb pdb:6HKS|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|mint:P03126|dip:DIP-44706N|mint:MINT-720006(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/12/07 2014/10/16 rogid:a47ZJLXWeghGIY9xJTQI7VujuMk9606 rogid:m9USUwG2VskhrMAdtZ9gSULmGBY333760 intact-crc:BEACE530A182E0D8|rigid:AVWlVol/ndCo6tmfNS5L6Xz0yw4 false binding-associated region:262-578(MINT-720012)|glutathione s tranferase tag:?-?(MINT-720014) - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P06931 uniprotkb:P23142-1 intact:EBI-7281937|intact:MINT-245691 intact:EBI-8516738|intact:MINT-245737|ensembl:ENSP00000331544 psi-mi:ve6_bpv1(display_long)|uniprotkb:E6(gene name)|psi-mi:E6(display_short) psi-mi:p23142-1(display_long)|uniprotkb:FBLN1(gene name)|psi-mi:FBLN1(display_short)|uniprotkb:PP213(orf name) psi-mi:"MI:0096"(pull down) Du et al. (2002) mint:MINT-5215688|pubmed:12200142 taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8516845|mint:MINT-73216 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P06931|refseq:NP_056737.1|go:"GO:0003677"(DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0042025"(host cell nucleus)|interpro:IPR001334(E6 early regulatory protein)|interpro:IPR038575|rcsb pdb:3PY7|dip:DIP-41442N|mint:MINT-719914(identity) intact:EBI-726652(isoform-parent)|ensembl:ENSG00000077942(gene)|ensembl:ENST00000327858(transcript)|mint:MINT-719921(identity) - comment:mint|function:Transcriptional transactivator. Binds double stranded DNA|comment:"Stoichiometry: 1.0" comment:mint|comment:"Stoichiometry: 1.0" figure legend:NFA|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/12/07 2014/10/16 rogid:t7zpnnYzcptAb/QY0/BzzSW5zTI337052 rogid:a47ZJLXWeghGIY9xJTQI7VujuMk9606 intact-crc:A5B41E319B7FCDDE|rigid:xDTITWfG0wcaVbxC3unJ8bahRQI false glutathione s tranferase tag:?-?(MINT-719915) binding-associated region:343-483(MINT-719922) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P23142-1 uniprotkb:P17386 intact:EBI-8516738|intact:MINT-245737|ensembl:ENSP00000331544 intact:EBI-8516807|intact:MINT-245922 psi-mi:p23142-1(display_long)|uniprotkb:FBLN1(gene name)|psi-mi:FBLN1(display_short)|uniprotkb:PP213(orf name) psi-mi:ve6_hpv31(display_long)|uniprotkb:E6(gene name)|psi-mi:E6(display_short) psi-mi:"MI:0096"(pull down) Du et al. (2002) mint:MINT-5215688|pubmed:12200142 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10585(hpv31)|taxid:10585(Human papillomavirus type 31) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8516825|mint:MINT-73215 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-726652(isoform-parent)|ensembl:ENSG00000077942(gene)|ensembl:ENST00000327858(transcript)|mint:MINT-719937(identity) rcsb pdb:6SLM|interpro:IPR038575|go:"GO:0003677"(DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001334(E6 early regulatory protein)|mint:MINT-719932(identity) - comment:mint|comment:"Stoichiometry: 1.0" function:"Transcriptional transactivator. Binds double stranded DNA. Has transforming activity. Inactivates, with E6-AP ubiquitin-protein ligase, the human TP53/p53 tumor suppressor protein by targeting it to degradation. Binds and targets human MUPP1/MPDZ protein to degradation. Those two functions presumably contribute to transforming activity (By similarity). Interaction with human FBLN1 protein also seems to be linked to cell transformation"|comment:mint|comment:"Stoichiometry: 1.0" figure legend:F2B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/12/07 2014/10/16 rogid:a47ZJLXWeghGIY9xJTQI7VujuMk9606 rogid:sO3qrbtAGW4kCgFp7rhj0Bd3Eq410585 intact-crc:2037F1AF06D1B83B|rigid:SlTUdb8zAxp7dcuiBReIFL83t1k false glutathione s tranferase tag:?-?(MINT-719940)|binding-associated region:262-578(MINT-719938) - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P23142-1 uniprotkb:P03126 intact:EBI-8516738|intact:MINT-245737|ensembl:ENSP00000331544 intact:EBI-1177242|uniprotkb:Q71BI7 psi-mi:p23142-1(display_long)|uniprotkb:FBLN1(gene name)|psi-mi:FBLN1(display_short)|uniprotkb:PP213(orf name) psi-mi:ve6_hpv16(display_long)|uniprotkb:E6(gene name)|psi-mi:E6(display_short) psi-mi:"MI:0096"(pull down) Du et al. (2002) mint:MINT-5215688|pubmed:12200142 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8516865|mint:MINT-73217 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-726652(isoform-parent)|ensembl:ENSG00000077942(gene)|ensembl:ENST00000327858(transcript)|mint:MINT-719903(identity) refseq:NP_041325.1|go:"GO:0003677"(DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR001334(E6 early regulatory protein)|interpro:IPR038575|rcsb pdb:1VZN|rcsb pdb:2FK4|rcsb pdb:2KPL|rcsb pdb:2LJX|rcsb pdb:2LJY|rcsb pdb:2LJZ|rcsb pdb:4GIZ|rcsb pdb:4JOP|rcsb pdb:4XR8|rcsb pdb:6HKS|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|mint:P03126|dip:DIP-44706N|mint:MINT-719896(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:NFA|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/12/07 2014/10/16 rogid:a47ZJLXWeghGIY9xJTQI7VujuMk9606 rogid:m9USUwG2VskhrMAdtZ9gSULmGBY333760 intact-crc:43863BBCD9D99049|rigid:AVWlVol/ndCo6tmfNS5L6Xz0yw4 false binding-associated region:343-483(MINT-719904) glutathione s tranferase tag:?-?(MINT-719897) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q08879 uniprotkb:P06931 intact:EBI-8394126|uniprotkb:Q91ZC9|uniprotkb:Q08878|intact:MINT-245863|uniprotkb:Q8C3B1|uniprotkb:Q922K8|ensembl:ENSMUSP00000054583 intact:EBI-7281937|intact:MINT-245691 psi-mi:fbln1_mouse(display_long)|uniprotkb:Fbln1(gene name)|psi-mi:Fbln1(display_short)|uniprotkb:Basement-membrane protein 90(gene name synonym) psi-mi:ve6_bpv1(display_long)|uniprotkb:E6(gene name)|psi-mi:E6(display_short) psi-mi:"MI:0018"(two hybrid) Du et al. (2002) mint:MINT-5215688|pubmed:12200142 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8516893|mint:MINT-73211 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034310.2|refseq:NP_001334017.1|ensembl:ENSMUSG00000006369(gene)|ensembl:ENSMUST00000057410(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007566"(embryo implantation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0071953"(elastic fiber)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1904188"(negative regulation of transformation of host cell by virus)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000647"(negative regulation of stem cell proliferation)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017048(Fibulin-1)|interpro:IPR018097|interpro:IPR026823|mint:Q08879|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|mint:MINT-719959(identity) mint:P06931|refseq:NP_056737.1|go:"GO:0003677"(DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0042025"(host cell nucleus)|interpro:IPR001334(E6 early regulatory protein)|interpro:IPR038575|rcsb pdb:3PY7|dip:DIP-41442N|mint:MINT-719952(identity) - comment:mint|function:"Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes"|comment:"Stoichiometry: 1.0" comment:mint|function:Transcriptional transactivator. Binds double stranded DNA|comment:"Stoichiometry: 1.0" figure legend:NFA|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2005/12/07 2014/10/16 rogid:wsHVgwYdck7EFaz0SUX1lQgrgOU10090 rogid:t7zpnnYzcptAb/QY0/BzzSW5zTI337052 intact-crc:7D75A06502AD69E2|rigid:Lp9/OliyKl8qYv3KTloLaH4bwT0 false tag:?-?(MINT-719962)|binding-associated region:343-483(MINT-719960) tag:?-?(MINT-719953) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P06931 uniprotkb:P23142-1 intact:EBI-7281937|intact:MINT-245691 intact:EBI-8516738|intact:MINT-245737|ensembl:ENSP00000331544 psi-mi:ve6_bpv1(display_long)|uniprotkb:E6(gene name)|psi-mi:E6(display_short) psi-mi:p23142-1(display_long)|uniprotkb:FBLN1(gene name)|psi-mi:FBLN1(display_short)|uniprotkb:PP213(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Du et al. (2002) mint:MINT-5215688|pubmed:12200142 taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8516924|mint:MINT-73218 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P06931|refseq:NP_056737.1|go:"GO:0003677"(DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0042025"(host cell nucleus)|interpro:IPR001334(E6 early regulatory protein)|interpro:IPR038575|rcsb pdb:3PY7|dip:DIP-41442N|mint:MINT-719974(identity) intact:EBI-726652(isoform-parent)|ensembl:ENSG00000077942(gene)|ensembl:ENST00000327858(transcript)|mint:MINT-719981(identity) - comment:mint|function:Transcriptional transactivator. Binds double stranded DNA|comment:"Stoichiometry: 1.0" comment:mint|comment:"Stoichiometry: 1.0" figure legend:F3|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2005/12/07 2014/10/16 rogid:t7zpnnYzcptAb/QY0/BzzSW5zTI337052 rogid:a47ZJLXWeghGIY9xJTQI7VujuMk9606 intact-crc:6549C3384F8FA059|rigid:xDTITWfG0wcaVbxC3unJ8bahRQI false flag tag:?-?(MINT-719975) - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:P23142-1 uniprotkb:P03126 intact:EBI-8516738|intact:MINT-245737|ensembl:ENSP00000331544 intact:EBI-1177242|uniprotkb:Q71BI7 psi-mi:p23142-1(display_long)|uniprotkb:FBLN1(gene name)|psi-mi:FBLN1(display_short)|uniprotkb:PP213(orf name) psi-mi:ve6_hpv16(display_long)|uniprotkb:E6(gene name)|psi-mi:E6(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Du et al. (2002) mint:MINT-5215688|pubmed:12200142 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8516947|mint:MINT-73219 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-726652(isoform-parent)|ensembl:ENSG00000077942(gene)|ensembl:ENST00000327858(transcript)|mint:MINT-719998(identity) refseq:NP_041325.1|go:"GO:0003677"(DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR001334(E6 early regulatory protein)|interpro:IPR038575|rcsb pdb:1VZN|rcsb pdb:2FK4|rcsb pdb:2KPL|rcsb pdb:2LJX|rcsb pdb:2LJY|rcsb pdb:2LJZ|rcsb pdb:4GIZ|rcsb pdb:4JOP|rcsb pdb:4XR8|rcsb pdb:6HKS|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|mint:P03126|dip:DIP-44706N|mint:MINT-719991(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F3|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2005/12/07 2014/10/16 rogid:a47ZJLXWeghGIY9xJTQI7VujuMk9606 rogid:m9USUwG2VskhrMAdtZ9gSULmGBY333760 intact-crc:F09069995DD61B72|rigid:AVWlVol/ndCo6tmfNS5L6Xz0yw4 false - flag tag:?-?(MINT-719992) - - psi-mi:"MI:0072"(monoclonal antibody western blot) psi-mi:"MI:0078"(nucleotide sequence identification)