#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q80U87 uniprotkb:O89100 intact:EBI-1765959|uniprotkb:Q80YP2|uniprotkb:Q8R0D3|uniprotkb:Q9EQU1|uniprotkb:Q9WVP5|uniprotkb:A2AI53|ensembl:ENSMUSP00000028841 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 psi-mi:ubp8_mouse(display_long)|uniprotkb:Usp8(gene name)|psi-mi:Usp8(display_short)|uniprotkb:Kiaa0055(gene name synonym)|uniprotkb:Ubpy(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 8(gene name synonym)|uniprotkb:Deubiquitinating enzyme 8(gene name synonym)|uniprotkb:Ubiquitin isopeptidase Y(gene name synonym)|uniprotkb:Ubiquitin thioesterase 8(gene name synonym) psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:"MI:0066"(lambda phage display) Berry et al. (2002) pubmed:12176364|mint:MINT-5215643 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8507310|mint:MINT-60766 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_062703.2|ensembl:ENSMUST00000028841(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001763(Rhodanese-like)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036873|interpro:IPR038765|mint:Q80U87|rcsb pdb:1UJ0|reactome:R-MMU-1358803|reactome:R-MMU-4641263|reactome:R-MMU-5689880|reactome:R-MMU-6807004|ensembl:ENSMUSG00000027363(gene)|mint:MINT-719045(identity) refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-719036(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/30 2014/10/16 rogid:PhHue+cov/Z/PGJqR8RtRQF6qco10090 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 intact-crc:AD82086D9A5F5E77|rigid:WYc6JDHtAGLyC7GnY5yAWD5kaDw false tag:?-?(MINT-719048)|binding-associated region:405-413(MINT-719046) tag:?-?(MINT-719040)|binding-associated region:1-54(MINT-719037) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q80U87 uniprotkb:O89100 intact:EBI-1765959|uniprotkb:Q80YP2|uniprotkb:Q8R0D3|uniprotkb:Q9EQU1|uniprotkb:Q9WVP5|uniprotkb:A2AI53|ensembl:ENSMUSP00000028841 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 psi-mi:ubp8_mouse(display_long)|uniprotkb:Usp8(gene name)|psi-mi:Usp8(display_short)|uniprotkb:Kiaa0055(gene name synonym)|uniprotkb:Ubpy(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 8(gene name synonym)|uniprotkb:Deubiquitinating enzyme 8(gene name synonym)|uniprotkb:Ubiquitin isopeptidase Y(gene name synonym)|uniprotkb:Ubiquitin thioesterase 8(gene name synonym) psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:"MI:0066"(lambda phage display) Berry et al. (2002) pubmed:12176364|mint:MINT-5215643 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8507342|mint:MINT-62415 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_062703.2|ensembl:ENSMUST00000028841(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001763(Rhodanese-like)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036873|interpro:IPR038765|mint:Q80U87|rcsb pdb:1UJ0|reactome:R-MMU-1358803|reactome:R-MMU-4641263|reactome:R-MMU-5689880|reactome:R-MMU-6807004|ensembl:ENSMUSG00000027363(gene)|mint:MINT-718970(identity) refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-718961(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/30 2014/10/16 rogid:PhHue+cov/Z/PGJqR8RtRQF6qco10090 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 intact-crc:07E97989FFEE73C4|rigid:WYc6JDHtAGLyC7GnY5yAWD5kaDw false binding-associated region:699-708(MINT-718971) binding-associated region:1-54(MINT-718962)|tag:?-?(MINT-718965) - - psi-mi:"MI:0056"(full identification by DNA sequencing) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9Z1S8 uniprotkb:O89100 intact:EBI-641738|uniprotkb:Q9R1X3 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 psi-mi:gab2_mouse(display_long)|uniprotkb:Growth factor receptor bound protein 2-associated protein 2(gene name synonym)|uniprotkb:GRB2-associated binder 2(gene name synonym)|uniprotkb:PH domain-containing adaptor molecule p97(gene name synonym)|uniprotkb:Gab2(gene name)|psi-mi:Gab2(display_short) psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:"MI:0066"(lambda phage display) Berry et al. (2002) pubmed:12176364|mint:MINT-5215643 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8507408|mint:MINT-62420 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-MMU-109704|reactome:R-MMU-1433557|reactome:R-MMU-2730905|reactome:R-MMU-8853659|reactome:R-MMU-912526|dip:DIP-41351N|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|reactome:R-MMU-9674555|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-9607240|mint:MINT-718878(identity) refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-718869(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1B|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/30 2014/10/16 rogid:DV50jtkpOksZpaqjllQRhmpYkvk10090 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 intact-crc:96E367B4E09C7308|rigid:Oi239ebpwe6ngMcnCEH2zCrngOA false binding-associated region:511-519(MINT-718879) tag:?-?(MINT-718873)|binding-associated region:1-54(MINT-718870) - - psi-mi:"MI:0056"(full identification by DNA sequencing) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9QUN3 uniprotkb:O89100 intact:EBI-642145|uniprotkb:O88504|ensembl:ENSMUSP00000057844 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 psi-mi:blnk_mouse(display_long)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:Lymphocyte antigen 57(gene name synonym)|uniprotkb:Blnk(gene name)|psi-mi:Blnk(display_short)|uniprotkb:Bash(gene name synonym)|uniprotkb:Ly57(gene name synonym)|uniprotkb:Slp65(gene name synonym) psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:"MI:0066"(lambda phage display) Berry et al. (2002) pubmed:12176364|mint:MINT-5215643 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8507385|mint:MINT-62416 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032554.2|ensembl:ENSMUSG00000061132(gene)|ensembl:ENSMUST00000054769(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|rcsb pdb:2EO6|reactome:R-MMU-983695|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|mint:MINT-718934(identity) refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-718925(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/30 2014/10/16 rogid:usS1n4qdW7RcYvhLK2O11z9O4uw10090 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 intact-crc:12A3D1520075D8DB|rigid:2rJtSPvBgytIVQCq7OltBUzO5m8 false binding-associated region:204-212(MINT-718935) tag:?-?(MINT-718929)|binding-associated region:1-54(MINT-718926) - - psi-mi:"MI:0056"(full identification by DNA sequencing) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O89100 uniprotkb:P40818 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 intact:EBI-1050865|uniprotkb:Q2TB31|uniprotkb:Q7Z3U2|uniprotkb:Q86VA0|uniprotkb:Q8IWI7|ensembl:ENSP00000302239|ensembl:ENSP00000379721|uniprotkb:B4DKA8 psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:ubp8_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 8(gene name synonym)|uniprotkb:Deubiquitinating enzyme 8(gene name synonym)|uniprotkb:USP8(gene name)|psi-mi:USP8(display_short)|uniprotkb:KIAA0055(gene name synonym)|uniprotkb:UBPY(gene name synonym)|uniprotkb:Ubiquitin isopeptidase Y(gene name synonym)|uniprotkb:Ubiquitin thioesterase 8(gene name synonym) psi-mi:"MI:0049"(filter binding) Berry et al. (2002) pubmed:12176364|mint:MINT-5215643 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8507461|mint:MINT-62434 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-718889(identity) refseq:NP_001122082.1|refseq:NP_005145.3|refseq:NP_001269978.1|refseq:XP_011520495.1|ensembl:ENSG00000138592(gene)|ensembl:ENST00000307179(transcript)|ensembl:ENST00000396444(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043197"(dendritic spine)|go:"GO:0045296"(cadherin binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001763(Rhodanese-like)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036873|interpro:IPR038765|mint:P40818|rcsb pdb:1WHB|rcsb pdb:2A9U|rcsb pdb:2GFO|rcsb pdb:2GWF|rcsb pdb:3N3K|rcsb pdb:6F09|reactome:R-HSA-1358803|reactome:R-HSA-4641263|reactome:R-HSA-5689880|reactome:R-HSA-6807004|refseq:XP_006720824.1|dip:DIP-40365N|mint:MINT-718898(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1D|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/30 2014/10/16 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 rogid:hpBBzyA4lc9is80ZFJBr1fyEyOM9606 intact-crc:18247279B364D361|rigid:SWWQclYmNjhuivkZ1vJBMWZ58O4 false tag:?-?(MINT-718893)|binding-associated region:1-54(MINT-718890) - - - psi-mi:"MI:0056"(full identification by DNA sequencing) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9QYY0 uniprotkb:O89100 intact:EBI-644784|uniprotkb:Q91VW7|ensembl:ENSMUSP00000034150 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 psi-mi:gab1_mouse(display_long)|uniprotkb:Growth factor receptor bound protein 2-associated protein 1(gene name synonym)|uniprotkb:GRB2-associated binder 1(gene name synonym)|uniprotkb:Gab1(gene name)|psi-mi:Gab1(display_short) psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:"MI:0049"(filter binding) Berry et al. (2002) pubmed:12176364|mint:MINT-5215643 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8507438|mint:MINT-62425 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067331.2|ensembl:ENSMUSG00000031714(gene)|ensembl:ENSMUST00000034150(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008544"(epidermis development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0090668"(endothelial cell chemotaxis to vascular endothelial growth factor)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|mint:Q9QYY0|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-180292|reactome:R-MMU-1963642|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-9027276|dip:DIP-39377N|mint:MINT-719137(identity) refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-719128(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1D|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/30 2014/10/16 rogid:SVtcnzm9XpYftTZ3qAV/IQgJaJE10090 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 intact-crc:13B32C9B32B39596|rigid:mUlT9XsGB66ZCcMBZmpd3pAIUEA false binding-associated region:517-525(MINT-719138) tag:?-?(MINT-719132)|binding-associated region:1-54(MINT-719129) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O89100 uniprotkb:Q80U87 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 intact:EBI-1765959|uniprotkb:Q80YP2|uniprotkb:Q8R0D3|uniprotkb:Q9EQU1|uniprotkb:Q9WVP5|uniprotkb:A2AI53|ensembl:ENSMUSP00000028841 psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:ubp8_mouse(display_long)|uniprotkb:Usp8(gene name)|psi-mi:Usp8(display_short)|uniprotkb:Kiaa0055(gene name synonym)|uniprotkb:Ubpy(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 8(gene name synonym)|uniprotkb:Deubiquitinating enzyme 8(gene name synonym)|uniprotkb:Ubiquitin isopeptidase Y(gene name synonym)|uniprotkb:Ubiquitin thioesterase 8(gene name synonym) psi-mi:"MI:0049"(filter binding) Berry et al. (2002) pubmed:12176364|mint:MINT-5215643 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8507503|mint:MINT-62436 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-719110(identity) refseq:NP_062703.2|ensembl:ENSMUST00000028841(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001763(Rhodanese-like)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036873|interpro:IPR038765|mint:Q80U87|rcsb pdb:1UJ0|reactome:R-MMU-1358803|reactome:R-MMU-4641263|reactome:R-MMU-5689880|reactome:R-MMU-6807004|ensembl:ENSMUSG00000027363(gene)|mint:MINT-719119(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1D|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/30 2014/10/16 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 rogid:PhHue+cov/Z/PGJqR8RtRQF6qco10090 intact-crc:99EE1F68017BC5E1|rigid:WYc6JDHtAGLyC7GnY5yAWD5kaDw false tag:?-?(MINT-719114)|binding-associated region:1-54(MINT-719111) binding-associated region:699-708(MINT-719120) - - psi-mi:"MI:0056"(full identification by DNA sequencing) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O89100 uniprotkb:Q9QUN3 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 intact:EBI-642145|uniprotkb:O88504|ensembl:ENSMUSP00000057844 psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:blnk_mouse(display_long)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:Lymphocyte antigen 57(gene name synonym)|uniprotkb:Blnk(gene name)|psi-mi:Blnk(display_short)|uniprotkb:Bash(gene name synonym)|uniprotkb:Ly57(gene name synonym)|uniprotkb:Slp65(gene name synonym) psi-mi:"MI:0049"(filter binding) Berry et al. (2002) pubmed:12176364|mint:MINT-5215643 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8507526|mint:MINT-62437 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-719146(identity) refseq:NP_032554.2|ensembl:ENSMUSG00000061132(gene)|ensembl:ENSMUST00000054769(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|rcsb pdb:2EO6|reactome:R-MMU-983695|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|mint:MINT-719155(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1D|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/30 2014/10/16 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 rogid:usS1n4qdW7RcYvhLK2O11z9O4uw10090 intact-crc:8CA4B7B3FEE06EFE|rigid:2rJtSPvBgytIVQCq7OltBUzO5m8 false binding-associated region:1-54(MINT-719147)|tag:?-?(MINT-719150) binding-associated region:204-212(MINT-719156) - - psi-mi:"MI:0056"(full identification by DNA sequencing) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q80U87 uniprotkb:O89100 intact:EBI-1765959|uniprotkb:Q80YP2|uniprotkb:Q8R0D3|uniprotkb:Q9EQU1|uniprotkb:Q9WVP5|uniprotkb:A2AI53|ensembl:ENSMUSP00000028841 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 psi-mi:ubp8_mouse(display_long)|uniprotkb:Usp8(gene name)|psi-mi:Usp8(display_short)|uniprotkb:Kiaa0055(gene name synonym)|uniprotkb:Ubpy(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 8(gene name synonym)|uniprotkb:Deubiquitinating enzyme 8(gene name synonym)|uniprotkb:Ubiquitin isopeptidase Y(gene name synonym)|uniprotkb:Ubiquitin thioesterase 8(gene name synonym) psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:"MI:0049"(filter binding) Berry et al. (2002) pubmed:12176364|mint:MINT-5215643 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8507480|mint:MINT-62435 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_062703.2|ensembl:ENSMUST00000028841(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001763(Rhodanese-like)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036873|interpro:IPR038765|mint:Q80U87|rcsb pdb:1UJ0|reactome:R-MMU-1358803|reactome:R-MMU-4641263|reactome:R-MMU-5689880|reactome:R-MMU-6807004|ensembl:ENSMUSG00000027363(gene)|mint:MINT-718952(identity) refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-718943(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1D|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/30 2014/10/16 rogid:PhHue+cov/Z/PGJqR8RtRQF6qco10090 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 intact-crc:58FF16FBA3F81289|rigid:WYc6JDHtAGLyC7GnY5yAWD5kaDw false binding-associated region:405-413(MINT-718953) tag:?-?(MINT-718947)|binding-associated region:1-54(MINT-718944) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0056"(full identification by DNA sequencing) uniprotkb:P40818 uniprotkb:O89100 intact:EBI-1050865|uniprotkb:Q2TB31|uniprotkb:Q7Z3U2|uniprotkb:Q86VA0|uniprotkb:Q8IWI7|ensembl:ENSP00000302239|ensembl:ENSP00000379721|uniprotkb:B4DKA8 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 psi-mi:ubp8_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 8(gene name synonym)|uniprotkb:Deubiquitinating enzyme 8(gene name synonym)|uniprotkb:USP8(gene name)|psi-mi:USP8(display_short)|uniprotkb:KIAA0055(gene name synonym)|uniprotkb:UBPY(gene name synonym)|uniprotkb:Ubiquitin isopeptidase Y(gene name synonym)|uniprotkb:Ubiquitin thioesterase 8(gene name synonym) psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:"MI:0096"(pull down) Berry et al. (2002) pubmed:12176364|mint:MINT-5215643 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8507580|mint:MINT-62421 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001122082.1|refseq:NP_005145.3|refseq:NP_001269978.1|refseq:XP_011520495.1|ensembl:ENSG00000138592(gene)|ensembl:ENST00000307179(transcript)|ensembl:ENST00000396444(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043197"(dendritic spine)|go:"GO:0045296"(cadherin binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001763(Rhodanese-like)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036873|interpro:IPR038765|mint:P40818|rcsb pdb:1WHB|rcsb pdb:2A9U|rcsb pdb:2GFO|rcsb pdb:2GWF|rcsb pdb:3N3K|rcsb pdb:6F09|reactome:R-HSA-1358803|reactome:R-HSA-4641263|reactome:R-HSA-5689880|reactome:R-HSA-6807004|refseq:XP_006720824.1|dip:DIP-40365N|mint:MINT-719103(identity) refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-719094(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/30 2014/10/16 rogid:hpBBzyA4lc9is80ZFJBr1fyEyOM9606 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 intact-crc:8EC0900300D51F77|rigid:SWWQclYmNjhuivkZ1vJBMWZ58O4 false - binding-associated region:1-54(MINT-719095)|tag:?-?(MINT-719098) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O35601 uniprotkb:O89100 intact:EBI-7353747|uniprotkb:Q9Z2H3|intact:MINT-244320|ensembl:ENSMUSP00000087947 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 psi-mi:fyb1_mouse(display_long)|uniprotkb:Fyb1(gene name)|psi-mi:Fyb1(display_short)|uniprotkb:Adhesion and degranulation promoting adaptor protein(gene name synonym)|uniprotkb:FYB-120/130(gene name synonym)|uniprotkb:FYN-T-binding protein(gene name synonym)|uniprotkb:Fyb(gene name synonym)|uniprotkb:SLAP-130(gene name synonym)|uniprotkb:SLP-76-associated phosphoprotein(gene name synonym) psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:"MI:0096"(pull down) Berry et al. (2002) pubmed:12176364|mint:MINT-5215643 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8507557|mint:MINT-59493 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035945.1|refseq:NP_001265198.1|ensembl:ENSMUSG00000022148(gene)|ensembl:ENSMUST00000090461(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008289"(lipid binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030054"(cell junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR029294|interpro:IPR030635|interpro:IPR035540|interpro:IPR036028|interpro:IPR043443|reactome:R-MMU-202433|reactome:R-MMU-391160|dip:DIP-41350N|mint:MINT-718916(identity) refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-718907(identity) - comment:mint|function:"Acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/30 2014/10/16 rogid:6rfpz9eZT3M5F0khbMoHGg+/vEU10090 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 intact-crc:9E2A0EA380583EB8|rigid:5D5yiGgimPICjfjpGC59MBBUA68 false binding-associated region:229-247(MINT-718917) tag:?-?(MINT-718911)|binding-associated region:1-54(MINT-718908) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9UQC2 uniprotkb:O89100 intact:EBI-975200|ensembl:ENSP00000354952|uniprotkb:O60317|uniprotkb:A6NEW9|uniprotkb:A2RRM2|uniprotkb:A7MD36 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 psi-mi:gab2_human(display_long)|uniprotkb:Growth factor receptor bound protein 2-associated protein 2(gene name synonym)|uniprotkb:GRB2-associated binder 2(gene name synonym)|uniprotkb:pp100(gene name synonym)|uniprotkb:GAB2(gene name)|psi-mi:GAB2(display_short)|uniprotkb:KIAA0571(gene name synonym) psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:"MI:0096"(pull down) Berry et al. (2002) pubmed:12176364|mint:MINT-5215643 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8507685|mint:MINT-62424 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036428.1|refseq:NP_536739.1|reactome:R-HSA-2219530|reactome:R-HSA-2730905|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-912526|reactome:R-HSA-9607240|reactome:R-HSA-9645135|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|interpro:IPR011993(Pleckstrin homology-type)|mint:Q9UQC2|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:5EWZ|rcsb pdb:5EXA|rcsb pdb:6Y3R|rcsb pdb:6Y3S|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1839117|ensembl:ENSG00000033327(gene)|ensembl:ENST00000361507(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|interpro:IPR001849(Pleckstrin-like)|refseq:XP_006718816.1|dip:DIP-36653N|mint:MINT-719087(identity) refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-719078(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/30 2014/10/16 rogid:lH+C57KhlQQS68F59Lx8c9/nc2w9606 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 intact-crc:CF53F843506ED996|rigid:pM2aalCEIkpatZnqZe3pzkH09Dg false - binding-associated region:1-54(MINT-719079)|tag:?-?(MINT-719082) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O89100 uniprotkb:Q8WV28 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49 psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short) psi-mi:"MI:0096"(pull down) Berry et al. (2002) pubmed:12176364|mint:MINT-5215643 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8507665|mint:MINT-62423 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-719020(identity) refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1|mint:MINT-719029(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/30 2014/10/16 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 rogid:befGiho6PlVSSMPyb84d31TT/So9606 intact-crc:4BFA91340A852A03|rigid:BudD2kmRAnko2/cWuLXGRq6WSIg false tag:?-?(MINT-719024)|binding-associated region:1-54(MINT-719021) - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0113"(western blot) uniprotkb:O35601 uniprotkb:O89100 intact:EBI-7353747|uniprotkb:Q9Z2H3|intact:MINT-244320|ensembl:ENSMUSP00000087947 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 psi-mi:fyb1_mouse(display_long)|uniprotkb:Fyb1(gene name)|psi-mi:Fyb1(display_short)|uniprotkb:Adhesion and degranulation promoting adaptor protein(gene name synonym)|uniprotkb:FYB-120/130(gene name synonym)|uniprotkb:FYN-T-binding protein(gene name synonym)|uniprotkb:Fyb(gene name synonym)|uniprotkb:SLAP-130(gene name synonym)|uniprotkb:SLP-76-associated phosphoprotein(gene name synonym) psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Berry et al. (2002) pubmed:12176364|mint:MINT-5215643 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8507778|mint:MINT-62433 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035945.1|refseq:NP_001265198.1|ensembl:ENSMUSG00000022148(gene)|ensembl:ENSMUST00000090461(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008289"(lipid binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030054"(cell junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR029294|interpro:IPR030635|interpro:IPR035540|interpro:IPR036028|interpro:IPR043443|reactome:R-MMU-202433|reactome:R-MMU-391160|dip:DIP-41350N|mint:MINT-719006(identity) refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-718997(identity) - comment:mint|function:"Acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2005/06/30 2014/10/16 rogid:6rfpz9eZT3M5F0khbMoHGg+/vEU10090 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 intact-crc:927ABE6CEA2638AB|rigid:5D5yiGgimPICjfjpGC59MBBUA68 false binding-associated region:233-241(MINT-719007)|mutation decreasing interaction:237-237,240-240,241-241,233-233(MINT-719009) tag:?-?(MINT-719001)|binding-associated region:1-54(MINT-718998) - - psi-mi:"MI:0072"(monoclonal antibody western blot) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O35601 uniprotkb:O89100 intact:EBI-7353747|uniprotkb:Q9Z2H3|intact:MINT-244320|ensembl:ENSMUSP00000087947 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 psi-mi:fyb1_mouse(display_long)|uniprotkb:Fyb1(gene name)|psi-mi:Fyb1(display_short)|uniprotkb:Adhesion and degranulation promoting adaptor protein(gene name synonym)|uniprotkb:FYB-120/130(gene name synonym)|uniprotkb:FYN-T-binding protein(gene name synonym)|uniprotkb:Fyb(gene name synonym)|uniprotkb:SLAP-130(gene name synonym)|uniprotkb:SLP-76-associated phosphoprotein(gene name synonym) psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:"MI:0081"(peptide array) Berry et al. (2002) pubmed:12176364|mint:MINT-5215643 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8507856|mint:MINT-62449 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035945.1|refseq:NP_001265198.1|ensembl:ENSMUSG00000022148(gene)|ensembl:ENSMUST00000090461(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008289"(lipid binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030054"(cell junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR029294|interpro:IPR030635|interpro:IPR035540|interpro:IPR036028|interpro:IPR043443|reactome:R-MMU-202433|reactome:R-MMU-391160|dip:DIP-41350N|mint:MINT-719058(identity) refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N|mint:MINT-719066(identity) - comment:mint|function:"Acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/30 2014/10/16 rogid:6rfpz9eZT3M5F0khbMoHGg+/vEU10090 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 intact-crc:E7C3268C96AA19DF|rigid:5D5yiGgimPICjfjpGC59MBBUA68 false binding-associated region:233-241(MINT-719059)|mutation decreasing interaction:232-242(MINT-719061) binding-associated region:1-54(MINT-719067)|tag:?-?(MINT-719070) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)