#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O95049 uniprotkb:Q8NI35 intact:EBI-1171427|uniprotkb:A6NFP3|uniprotkb:Q32N01|uniprotkb:B3KR73|uniprotkb:B4E2W6|uniprotkb:F5H2X0|uniprotkb:F5H4S9|uniprotkb:B3KXZ0|uniprotkb:K7EK22|intact:EBI-10970160|ensembl:ENSP00000439278 intact:EBI-724390|uniprotkb:O15249|uniprotkb:O43742|uniprotkb:O60833|uniprotkb:Q5VUA5|uniprotkb:Q5VUA6|uniprotkb:Q5VUA7|uniprotkb:Q5VUA8|uniprotkb:Q5VUA9|uniprotkb:Q5VUB0|uniprotkb:Q8WU78|uniprotkb:Q9H3N9|ensembl:ENSP00000360200 psi-mi:zo3_human(display_long)|uniprotkb:Zonula occludens protein 3(gene name synonym)|uniprotkb:Zona occludens protein 3(gene name synonym)|uniprotkb:Tight junction protein 3(gene name synonym)|uniprotkb:TJP3(gene name)|psi-mi:TJP3(display_short)|uniprotkb:ZO3(gene name synonym) psi-mi:inadl_human(display_long)|uniprotkb:CIPP(gene name synonym)|uniprotkb:Channel-interacting PDZ domain-containing protein(gene name synonym)|uniprotkb:PATJ(gene name)|psi-mi:PATJ(display_short)|uniprotkb:INADL(gene name synonym)|uniprotkb:Pals1-associated tight junction protein(gene name synonym)|uniprotkb:Protein associated to tight junctions(gene name synonym) psi-mi:"MI:0428"(imaging technique) Roh et al. (2002) pubmed:12021270|mint:MINT-5215403 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8417397|mint:MINT-58722 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254489.1|refseq:NP_001254490.1|ensembl:ENSG00000105289(gene)|ensembl:ENST00000541714(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005420(Zona occludens protein ZO-3)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|rcsb pdb:3KFV|go:"GO:0005923"(bicellular tight junction)|mint:MINT-715347(identity) ensembl:ENSP00000360200|ensembl:ENST00000484937|ensembl:ENSP00000433669|ensembl:ENSG00000132849(gene)|ensembl:ENST00000371158(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120192"(tight junction assembly)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR015132(L27-2)|interpro:IPR036034|interpro:IPR036892|mint:Q8NI35|rcsb pdb:1VF6|rcsb pdb:2D92|rcsb pdb:2DAZ|rcsb pdb:2DB5|rcsb pdb:2DLU|rcsb pdb:2DM8|rcsb pdb:2DMZ|rcsb pdb:2EHR|rcsb pdb:4Q2N|rcsb pdb:6IRD|reactome:R-HSA-420029|mint:MINT-715342(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F7B|comment:homomint|comment:mint taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells") - 2005/06/20 2014/10/16 rogid:bJciuPizUo/lOq89solMYusjm009606 rogid:brzBKZb3r39w13Ds5X/1jB6YMyM9606 intact-crc:8FF1D6D26875F27C|rigid:ONHyFkvH/Gptbl/LVRBf9dS8qpQ false - - - - psi-mi:"MI:0661"(experimental participant identification) psi-mi:"MI:0661"(experimental participant identification) uniprotkb:O95832 uniprotkb:Q8NI35 intact:EBI-723889|ensembl:ENSP00000295522 intact:EBI-724390|uniprotkb:O15249|uniprotkb:O43742|uniprotkb:O60833|uniprotkb:Q5VUA5|uniprotkb:Q5VUA6|uniprotkb:Q5VUA7|uniprotkb:Q5VUA8|uniprotkb:Q5VUA9|uniprotkb:Q5VUB0|uniprotkb:Q8WU78|uniprotkb:Q9H3N9|ensembl:ENSP00000360200 psi-mi:cld1_human(display_long)|uniprotkb:Senescence-associated epithelial membrane protein(gene name synonym)|uniprotkb:CLDN1(gene name)|psi-mi:CLDN1(display_short)|uniprotkb:CLD1(gene name synonym)|uniprotkb:SEMP1(gene name synonym)|uniprotkb:UNQ481/PRO944(orf name) psi-mi:inadl_human(display_long)|uniprotkb:CIPP(gene name synonym)|uniprotkb:Channel-interacting PDZ domain-containing protein(gene name synonym)|uniprotkb:PATJ(gene name)|psi-mi:PATJ(display_short)|uniprotkb:INADL(gene name synonym)|uniprotkb:Pals1-associated tight junction protein(gene name synonym)|uniprotkb:Protein associated to tight junctions(gene name synonym) psi-mi:"MI:0096"(pull down) Roh et al. (2002) pubmed:12021270|mint:MINT-5215403 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8417417|mint:MINT-58719 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_066924.1|ensembl:ENSG00000163347(gene)|ensembl:ENST00000295522(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007568"(aging)|go:"GO:0008065"(establishment of blood-nerve barrier)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016338"(calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034331"(cell junction maintenance)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042802"(identical protein binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045471"(response to ethanol)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0060054"(positive regulation of epithelial cell proliferation involved in wound healing)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0061772"(xenobiotic transport across blood-nerve barrier)|go:"GO:0070160"(tight junction)|go:"GO:0070673"(response to interleukin-18)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071284"(cellular response to lead ion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0097421"(liver regeneration)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|go:"GO:1903545"(cellular response to butyrate)|interpro:IPR003548(Claudin-1)|interpro:IPR004031(PMP-22/EMP/MP20/Claudin)|interpro:IPR006187(Claudin)|interpro:IPR017974|reactome:R-HSA-420029|mint:MINT-715391(identity) ensembl:ENSP00000360200|ensembl:ENST00000484937|ensembl:ENSP00000433669|ensembl:ENSG00000132849(gene)|ensembl:ENST00000371158(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120192"(tight junction assembly)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR015132(L27-2)|interpro:IPR036034|interpro:IPR036892|mint:Q8NI35|rcsb pdb:1VF6|rcsb pdb:2D92|rcsb pdb:2DAZ|rcsb pdb:2DB5|rcsb pdb:2DLU|rcsb pdb:2DM8|rcsb pdb:2DMZ|rcsb pdb:2EHR|rcsb pdb:4Q2N|rcsb pdb:6IRD|reactome:R-HSA-420029|mint:MINT-715381(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F5|comment:homomint|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/20 2014/10/16 rogid:38MxEaRUYqwdpkJgOUMtw0/gJsY9606 rogid:brzBKZb3r39w13Ds5X/1jB6YMyM9606 intact-crc:C68628A9E7AC6EB6|rigid:EbbmOhy6F34tQuz5iaI3TH6Ann8 false tag:?-?(MINT-715395)|binding-associated region:191-211(MINT-715392) tag:?-?(MINT-715386)|binding-associated region:1435-1517(MINT-715382) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8NI35 uniprotkb:O95049 intact:EBI-724390|uniprotkb:O15249|uniprotkb:O43742|uniprotkb:O60833|uniprotkb:Q5VUA5|uniprotkb:Q5VUA6|uniprotkb:Q5VUA7|uniprotkb:Q5VUA8|uniprotkb:Q5VUA9|uniprotkb:Q5VUB0|uniprotkb:Q8WU78|uniprotkb:Q9H3N9|ensembl:ENSP00000360200 intact:EBI-1171427|uniprotkb:A6NFP3|uniprotkb:Q32N01|uniprotkb:B3KR73|uniprotkb:B4E2W6|uniprotkb:F5H2X0|uniprotkb:F5H4S9|uniprotkb:B3KXZ0|uniprotkb:K7EK22|intact:EBI-10970160|ensembl:ENSP00000439278 psi-mi:inadl_human(display_long)|uniprotkb:CIPP(gene name synonym)|uniprotkb:Channel-interacting PDZ domain-containing protein(gene name synonym)|uniprotkb:PATJ(gene name)|psi-mi:PATJ(display_short)|uniprotkb:INADL(gene name synonym)|uniprotkb:Pals1-associated tight junction protein(gene name synonym)|uniprotkb:Protein associated to tight junctions(gene name synonym) psi-mi:zo3_human(display_long)|uniprotkb:Zonula occludens protein 3(gene name synonym)|uniprotkb:Zona occludens protein 3(gene name synonym)|uniprotkb:Tight junction protein 3(gene name synonym)|uniprotkb:TJP3(gene name)|psi-mi:TJP3(display_short)|uniprotkb:ZO3(gene name synonym) psi-mi:"MI:0096"(pull down) Roh et al. (2002) pubmed:12021270|mint:MINT-5215403 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8417445|mint:MINT-58720 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000360200|ensembl:ENST00000484937|ensembl:ENSP00000433669|ensembl:ENSG00000132849(gene)|ensembl:ENST00000371158(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120192"(tight junction assembly)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR015132(L27-2)|interpro:IPR036034|interpro:IPR036892|mint:Q8NI35|rcsb pdb:1VF6|rcsb pdb:2D92|rcsb pdb:2DAZ|rcsb pdb:2DB5|rcsb pdb:2DLU|rcsb pdb:2DM8|rcsb pdb:2DMZ|rcsb pdb:2EHR|rcsb pdb:4Q2N|rcsb pdb:6IRD|reactome:R-HSA-420029|mint:MINT-715358(identity) refseq:NP_001254489.1|refseq:NP_001254490.1|ensembl:ENSG00000105289(gene)|ensembl:ENST00000541714(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005420(Zona occludens protein ZO-3)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|rcsb pdb:3KFV|go:"GO:0005923"(bicellular tight junction)|mint:MINT-715368(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F5|comment:homomint|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/20 2014/10/16 rogid:brzBKZb3r39w13Ds5X/1jB6YMyM9606 rogid:bJciuPizUo/lOq89solMYusjm009606 intact-crc:2DDDBA36F83B312F|rigid:ONHyFkvH/Gptbl/LVRBf9dS8qpQ false tag:?-?(MINT-715363)|binding-associated region:1068-1157(MINT-715359) tag:?-?(MINT-715372)|binding-associated region:899-919(MINT-715369) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8NI35 uniprotkb:O95049 intact:EBI-724390|uniprotkb:O15249|uniprotkb:O43742|uniprotkb:O60833|uniprotkb:Q5VUA5|uniprotkb:Q5VUA6|uniprotkb:Q5VUA7|uniprotkb:Q5VUA8|uniprotkb:Q5VUA9|uniprotkb:Q5VUB0|uniprotkb:Q8WU78|uniprotkb:Q9H3N9|ensembl:ENSP00000360200 intact:EBI-1171427|uniprotkb:A6NFP3|uniprotkb:Q32N01|uniprotkb:B3KR73|uniprotkb:B4E2W6|uniprotkb:F5H2X0|uniprotkb:F5H4S9|uniprotkb:B3KXZ0|uniprotkb:K7EK22|intact:EBI-10970160|ensembl:ENSP00000439278 psi-mi:inadl_human(display_long)|uniprotkb:CIPP(gene name synonym)|uniprotkb:Channel-interacting PDZ domain-containing protein(gene name synonym)|uniprotkb:PATJ(gene name)|psi-mi:PATJ(display_short)|uniprotkb:INADL(gene name synonym)|uniprotkb:Pals1-associated tight junction protein(gene name synonym)|uniprotkb:Protein associated to tight junctions(gene name synonym) psi-mi:zo3_human(display_long)|uniprotkb:Zonula occludens protein 3(gene name synonym)|uniprotkb:Zona occludens protein 3(gene name synonym)|uniprotkb:Tight junction protein 3(gene name synonym)|uniprotkb:TJP3(gene name)|psi-mi:TJP3(display_short)|uniprotkb:ZO3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Roh et al. (2002) pubmed:12021270|mint:MINT-5215403 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8417481|mint:MINT-58721 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000360200|ensembl:ENST00000484937|ensembl:ENSP00000433669|ensembl:ENSG00000132849(gene)|ensembl:ENST00000371158(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120192"(tight junction assembly)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR015132(L27-2)|interpro:IPR036034|interpro:IPR036892|mint:Q8NI35|rcsb pdb:1VF6|rcsb pdb:2D92|rcsb pdb:2DAZ|rcsb pdb:2DB5|rcsb pdb:2DLU|rcsb pdb:2DM8|rcsb pdb:2DMZ|rcsb pdb:2EHR|rcsb pdb:4Q2N|rcsb pdb:6IRD|reactome:R-HSA-420029|mint:MINT-715406(identity) refseq:NP_001254489.1|refseq:NP_001254490.1|ensembl:ENSG00000105289(gene)|ensembl:ENST00000541714(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005420(Zona occludens protein ZO-3)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|rcsb pdb:3KFV|go:"GO:0005923"(bicellular tight junction)|mint:MINT-715415(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F7A|comment:homomint|comment:mint taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells") - 2005/06/20 2014/10/16 rogid:brzBKZb3r39w13Ds5X/1jB6YMyM9606 rogid:bJciuPizUo/lOq89solMYusjm009606 intact-crc:799A5A55165E7404|rigid:ONHyFkvH/Gptbl/LVRBf9dS8qpQ false binding-associated region:?-?(MINT-715407)|tag:?-?(MINT-715410) tag:?-?(MINT-715416) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0072"(monoclonal antibody western blot)