#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9H0N5	uniprotkb:Q9Y463	intact:EBI-634289|uniprotkb:Q8TD40|ensembl:ENSP00000254908|ensembl:ENSP00000421544	intact:EBI-634187|uniprotkb:O75258|uniprotkb:O75788|uniprotkb:O75789|ensembl:ENSP00000312789|ensembl:ENSP00000469863|ensembl:ENSP00000485915|ensembl:ENSP00000486377	psi-mi:phs2_human(display_long)|uniprotkb:4-alpha-hydroxy-tetrahydropterin dehydratase 2(gene name synonym)|uniprotkb:DcoH-like protein DCoHm(gene name synonym)|uniprotkb:Dimerization cofactor of hepatocyte nuclear factor 1 from muscle(gene name synonym)|uniprotkb:HNF-1-alpha dimerization cofactor(gene name synonym)|uniprotkb:PCBD2(gene name)|psi-mi:PCBD2(display_short)|uniprotkb:DCOH2(gene name synonym)|uniprotkb:DCOHM(gene name synonym)	psi-mi:dyr1b_human(display_long)|uniprotkb:Mirk protein kinase(gene name synonym)|uniprotkb:Minibrain-related kinase(gene name synonym)|uniprotkb:DYRK1B(gene name)|psi-mi:DYRK1B(display_short)|uniprotkb:MIRK(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Lim et al. (2002)	pubmed:11980910	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-634299	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115527.3|ensembl:ENSG00000132570(gene)|ensembl:ENST00000254908(transcript)|ensembl:ENST00000512783(transcript)|go:"GO:0004505"(phenylalanine 4-monooxygenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0008124"(4-alpha-hydroxytetrahydrobiopterin dehydratase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR001533(Transcriptional coactivator/pterin dehydratase)|interpro:IPR036428|rcsb pdb:4C45	refseq:NP_004705.1|refseq:NP_006474.1|refseq:NP_006475.1|refseq:XP_005259455.1|ensembl:ENSG00000105204(gene)|ensembl:ENSG00000281320(gene)|ensembl:ENST00000323039(transcript)|ensembl:ENST00000593685(transcript)|ensembl:ENST00000625757(transcript)|ensembl:ENST00000631090(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007520"(myoblast fusion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q9Y463|go:"GO:0106310"(protein serine kinase activity)	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/08/17	2014/10/16	rogid:pFuv42zNbVBtFSZ8duBoohlDJGY9606	rogid:MaG/ZUw0KMo5JxQdeIhMu0DebXI9606	intact-crc:6490E012EC3A6948|rigid:rAByTohgzj8Bh7U8QzSPIrsNWgo	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9H0N5	uniprotkb:Q9Y463	intact:EBI-634289|uniprotkb:Q8TD40|ensembl:ENSP00000254908|ensembl:ENSP00000421544	intact:EBI-634187|uniprotkb:O75258|uniprotkb:O75788|uniprotkb:O75789|ensembl:ENSP00000312789|ensembl:ENSP00000469863|ensembl:ENSP00000485915|ensembl:ENSP00000486377	psi-mi:phs2_human(display_long)|uniprotkb:4-alpha-hydroxy-tetrahydropterin dehydratase 2(gene name synonym)|uniprotkb:DcoH-like protein DCoHm(gene name synonym)|uniprotkb:Dimerization cofactor of hepatocyte nuclear factor 1 from muscle(gene name synonym)|uniprotkb:HNF-1-alpha dimerization cofactor(gene name synonym)|uniprotkb:PCBD2(gene name)|psi-mi:PCBD2(display_short)|uniprotkb:DCOH2(gene name synonym)|uniprotkb:DCOHM(gene name synonym)	psi-mi:dyr1b_human(display_long)|uniprotkb:Mirk protein kinase(gene name synonym)|uniprotkb:Minibrain-related kinase(gene name synonym)|uniprotkb:DYRK1B(gene name)|psi-mi:DYRK1B(display_short)|uniprotkb:MIRK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lim et al. (2002)	pubmed:11980910	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-634844	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115527.3|ensembl:ENSG00000132570(gene)|ensembl:ENST00000254908(transcript)|ensembl:ENST00000512783(transcript)|go:"GO:0004505"(phenylalanine 4-monooxygenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0008124"(4-alpha-hydroxytetrahydrobiopterin dehydratase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR001533(Transcriptional coactivator/pterin dehydratase)|interpro:IPR036428|rcsb pdb:4C45	refseq:NP_004705.1|refseq:NP_006474.1|refseq:NP_006475.1|refseq:XP_005259455.1|ensembl:ENSG00000105204(gene)|ensembl:ENSG00000281320(gene)|ensembl:ENST00000323039(transcript)|ensembl:ENST00000593685(transcript)|ensembl:ENST00000625757(transcript)|ensembl:ENST00000631090(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007520"(myoblast fusion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q9Y463|go:"GO:0106310"(protein serine kinase activity)	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/08/17	2014/10/16	rogid:pFuv42zNbVBtFSZ8duBoohlDJGY9606	rogid:MaG/ZUw0KMo5JxQdeIhMu0DebXI9606	intact-crc:0BC0ABDB1B4302B6|rigid:rAByTohgzj8Bh7U8QzSPIrsNWgo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46734	uniprotkb:Q9Y463	intact:EBI-602462|uniprotkb:Q99441|uniprotkb:Q9UE71|uniprotkb:Q9UE72|uniprotkb:B3KSK7|ensembl:ENSP00000345083	intact:EBI-634187|uniprotkb:O75258|uniprotkb:O75788|uniprotkb:O75789|ensembl:ENSP00000312789|ensembl:ENSP00000469863|ensembl:ENSP00000485915|ensembl:ENSP00000486377	psi-mi:mp2k3_human(display_long)|uniprotkb:MAPK/ERK kinase 3(gene name synonym)|uniprotkb:MAP2K3(gene name)|psi-mi:MAP2K3(display_short)|uniprotkb:MEK3(gene name synonym)|uniprotkb:MKK3(gene name synonym)|uniprotkb:PRKMK3(gene name synonym)|uniprotkb:SKK2(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 2(gene name synonym)	psi-mi:dyr1b_human(display_long)|uniprotkb:Mirk protein kinase(gene name synonym)|uniprotkb:Minibrain-related kinase(gene name synonym)|uniprotkb:DYRK1B(gene name)|psi-mi:DYRK1B(display_short)|uniprotkb:MIRK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lim et al. (2002)	pubmed:11980910	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-636006	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002747.2|refseq:NP_659731.1|refseq:XP_011522261.1|refseq:XP_016880347.1|refseq:XP_016880348.1|refseq:NP_001303261.1|refseq:XP_005256780.1|dip:DIP-34242N|ensembl:ENSG00000034152(gene)|ensembl:ENST00000342679(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P46734|reactome:R-HSA-2559580|reactome:R-HSA-450302|reactome:R-HSA-5210891	refseq:NP_004705.1|refseq:NP_006474.1|refseq:NP_006475.1|refseq:XP_005259455.1|ensembl:ENSG00000105204(gene)|ensembl:ENSG00000281320(gene)|ensembl:ENST00000323039(transcript)|ensembl:ENST00000593685(transcript)|ensembl:ENST00000625757(transcript)|ensembl:ENST00000631090(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007520"(myoblast fusion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q9Y463|go:"GO:0106310"(protein serine kinase activity)	-	-	-	isoform-comment:Residue numbering in paper suggests that isoform 1 of MAP2K3 is used in the experiment, but since this is not clear entry has been annotated to the parent protein	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/08/17	2014/10/16	rogid:OcAgoYfpPPQycfZ6tr52FCRzcOU9606	rogid:MaG/ZUw0KMo5JxQdeIhMu0DebXI9606	intact-crc:64D5CA8C28044B20|rigid:2CoRFbiqQj/9dIbYnSBZib6vIJ8	false	mutation increasing interaction:222-222|mutation increasing interaction:218-218	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y463	uniprotkb:P46734	intact:EBI-634187|uniprotkb:O75258|uniprotkb:O75788|uniprotkb:O75789|ensembl:ENSP00000312789|ensembl:ENSP00000469863|ensembl:ENSP00000485915|ensembl:ENSP00000486377	intact:EBI-602462|uniprotkb:Q99441|uniprotkb:Q9UE71|uniprotkb:Q9UE72|uniprotkb:B3KSK7|ensembl:ENSP00000345083	psi-mi:dyr1b_human(display_long)|uniprotkb:Mirk protein kinase(gene name synonym)|uniprotkb:Minibrain-related kinase(gene name synonym)|uniprotkb:DYRK1B(gene name)|psi-mi:DYRK1B(display_short)|uniprotkb:MIRK(gene name synonym)	psi-mi:mp2k3_human(display_long)|uniprotkb:MAPK/ERK kinase 3(gene name synonym)|uniprotkb:MAP2K3(gene name)|psi-mi:MAP2K3(display_short)|uniprotkb:MEK3(gene name synonym)|uniprotkb:MKK3(gene name synonym)|uniprotkb:PRKMK3(gene name synonym)|uniprotkb:SKK2(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 2(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Lim et al. (2002)	pubmed:11980910	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-636016	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004705.1|refseq:NP_006474.1|refseq:NP_006475.1|refseq:XP_005259455.1|ensembl:ENSG00000105204(gene)|ensembl:ENSG00000281320(gene)|ensembl:ENST00000323039(transcript)|ensembl:ENST00000593685(transcript)|ensembl:ENST00000625757(transcript)|ensembl:ENST00000631090(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007520"(myoblast fusion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q9Y463|go:"GO:0106310"(protein serine kinase activity)	refseq:NP_002747.2|refseq:NP_659731.1|refseq:XP_011522261.1|refseq:XP_016880347.1|refseq:XP_016880348.1|refseq:NP_001303261.1|refseq:XP_005256780.1|dip:DIP-34242N|ensembl:ENSG00000034152(gene)|ensembl:ENST00000342679(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P46734|reactome:R-HSA-2559580|reactome:R-HSA-450302|reactome:R-HSA-5210891	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	isoform-comment:Residue numbering in paper suggests that isoform 1 of MAP2K3 is used in the experiment, but since this is not clear entry has been annotated to the parent protein	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/08/17	2014/10/16	rogid:MaG/ZUw0KMo5JxQdeIhMu0DebXI9606	rogid:OcAgoYfpPPQycfZ6tr52FCRzcOU9606	intact-crc:A1C88444C3439F3F|rigid:2CoRFbiqQj/9dIbYnSBZib6vIJ8	false	-	mutation increasing interaction:222-222|mutation increasing interaction:218-218	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20823	uniprotkb:Q9Y463	intact:EBI-636034|uniprotkb:Q2M3H2|uniprotkb:Q99861|uniprotkb:E0YMJ5|uniprotkb:A5Z2R8|uniprotkb:E0YMK0|uniprotkb:E0YMK1|uniprotkb:E2I9R4|uniprotkb:E2I9R5|uniprotkb:F5H5U3	intact:EBI-634187|uniprotkb:O75258|uniprotkb:O75788|uniprotkb:O75789|ensembl:ENSP00000312789|ensembl:ENSP00000469863|ensembl:ENSP00000485915|ensembl:ENSP00000486377	psi-mi:hnf1a_human(display_long)|uniprotkb:Liver-specific transcription factor LF-B1(gene name synonym)|uniprotkb:HNF1A(gene name)|psi-mi:HNF1A(display_short)|uniprotkb:TCF1(gene name synonym)|uniprotkb:Transcription factor 1(gene name synonym)	psi-mi:dyr1b_human(display_long)|uniprotkb:Mirk protein kinase(gene name synonym)|uniprotkb:Minibrain-related kinase(gene name synonym)|uniprotkb:DYRK1B(gene name)|psi-mi:DYRK1B(display_short)|uniprotkb:MIRK(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Lim et al. (2002)	pubmed:11980910	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-636072	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000536.5|refseq:NP_001293108.1|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030073"(insulin secretion)|go:"GO:0031016"(pancreas development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035623"(renal glucose absorption)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046323"(glucose import)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|interpro:IPR001356(Homeobox)|interpro:IPR006897(Hepatocyte nuclear factor 1, beta isoform, C-terminal)|interpro:IPR006898(Hepatocyte nuclear factor 1, alpha isoform C-terminal)|interpro:IPR006899(Hepatocyte nuclear factor 1, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR023219|interpro:IPR039066|rcsb pdb:1IC8|rcsb pdb:2GYP|reactome:R-HSA-210745|dip:DIP-33544N|mint:P20823	refseq:NP_004705.1|refseq:NP_006474.1|refseq:NP_006475.1|refseq:XP_005259455.1|ensembl:ENSG00000105204(gene)|ensembl:ENSG00000281320(gene)|ensembl:ENST00000323039(transcript)|ensembl:ENST00000593685(transcript)|ensembl:ENST00000625757(transcript)|ensembl:ENST00000631090(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007520"(myoblast fusion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q9Y463|go:"GO:0106310"(protein serine kinase activity)	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	resulting-ptm:Phosphorylation on Ser-249	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/08/17	2014/10/16	rogid:T/hHqwjDiZ9hytsn6n8a9oQt+EQ9606	rogid:MaG/ZUw0KMo5JxQdeIhMu0DebXI9606	intact-crc:DD63D1A82DEAA84E|rigid:6ikpiIH0oMiPIU0N5YJ4EWBjSes	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20823	uniprotkb:Q9Y463	intact:EBI-636034|uniprotkb:Q2M3H2|uniprotkb:Q99861|uniprotkb:E0YMJ5|uniprotkb:A5Z2R8|uniprotkb:E0YMK0|uniprotkb:E0YMK1|uniprotkb:E2I9R4|uniprotkb:E2I9R5|uniprotkb:F5H5U3	intact:EBI-634187|uniprotkb:O75258|uniprotkb:O75788|uniprotkb:O75789|ensembl:ENSP00000312789|ensembl:ENSP00000469863|ensembl:ENSP00000485915|ensembl:ENSP00000486377	psi-mi:hnf1a_human(display_long)|uniprotkb:Liver-specific transcription factor LF-B1(gene name synonym)|uniprotkb:HNF1A(gene name)|psi-mi:HNF1A(display_short)|uniprotkb:TCF1(gene name synonym)|uniprotkb:Transcription factor 1(gene name synonym)	psi-mi:dyr1b_human(display_long)|uniprotkb:Mirk protein kinase(gene name synonym)|uniprotkb:Minibrain-related kinase(gene name synonym)|uniprotkb:DYRK1B(gene name)|psi-mi:DYRK1B(display_short)|uniprotkb:MIRK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lim et al. (2002)	pubmed:11980910	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-636031	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000536.5|refseq:NP_001293108.1|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030073"(insulin secretion)|go:"GO:0031016"(pancreas development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035623"(renal glucose absorption)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046323"(glucose import)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|interpro:IPR001356(Homeobox)|interpro:IPR006897(Hepatocyte nuclear factor 1, beta isoform, C-terminal)|interpro:IPR006898(Hepatocyte nuclear factor 1, alpha isoform C-terminal)|interpro:IPR006899(Hepatocyte nuclear factor 1, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR023219|interpro:IPR039066|rcsb pdb:1IC8|rcsb pdb:2GYP|reactome:R-HSA-210745|dip:DIP-33544N|mint:P20823	refseq:NP_004705.1|refseq:NP_006474.1|refseq:NP_006475.1|refseq:XP_005259455.1|ensembl:ENSG00000105204(gene)|ensembl:ENSG00000281320(gene)|ensembl:ENST00000323039(transcript)|ensembl:ENST00000593685(transcript)|ensembl:ENST00000625757(transcript)|ensembl:ENST00000631090(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007520"(myoblast fusion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q9Y463|go:"GO:0106310"(protein serine kinase activity)	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/08/17	2014/10/16	rogid:T/hHqwjDiZ9hytsn6n8a9oQt+EQ9606	rogid:MaG/ZUw0KMo5JxQdeIhMu0DebXI9606	intact-crc:D767D76E6D491185|rigid:HaUu2kYAu8b2wPSzC0ks+o7wjLQ	false	glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20823	uniprotkb:Q9H0N5	intact:EBI-636034|uniprotkb:Q2M3H2|uniprotkb:Q99861|uniprotkb:E0YMJ5|uniprotkb:A5Z2R8|uniprotkb:E0YMK0|uniprotkb:E0YMK1|uniprotkb:E2I9R4|uniprotkb:E2I9R5|uniprotkb:F5H5U3	intact:EBI-634289|uniprotkb:Q8TD40|ensembl:ENSP00000254908|ensembl:ENSP00000421544	psi-mi:hnf1a_human(display_long)|uniprotkb:Liver-specific transcription factor LF-B1(gene name synonym)|uniprotkb:HNF1A(gene name)|psi-mi:HNF1A(display_short)|uniprotkb:TCF1(gene name synonym)|uniprotkb:Transcription factor 1(gene name synonym)	psi-mi:phs2_human(display_long)|uniprotkb:4-alpha-hydroxy-tetrahydropterin dehydratase 2(gene name synonym)|uniprotkb:DcoH-like protein DCoHm(gene name synonym)|uniprotkb:Dimerization cofactor of hepatocyte nuclear factor 1 from muscle(gene name synonym)|uniprotkb:HNF-1-alpha dimerization cofactor(gene name synonym)|uniprotkb:PCBD2(gene name)|psi-mi:PCBD2(display_short)|uniprotkb:DCOH2(gene name synonym)|uniprotkb:DCOHM(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lim et al. (2002)	pubmed:11980910	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-636031	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000536.5|refseq:NP_001293108.1|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030073"(insulin secretion)|go:"GO:0031016"(pancreas development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035623"(renal glucose absorption)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046323"(glucose import)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|interpro:IPR001356(Homeobox)|interpro:IPR006897(Hepatocyte nuclear factor 1, beta isoform, C-terminal)|interpro:IPR006898(Hepatocyte nuclear factor 1, alpha isoform C-terminal)|interpro:IPR006899(Hepatocyte nuclear factor 1, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR023219|interpro:IPR039066|rcsb pdb:1IC8|rcsb pdb:2GYP|reactome:R-HSA-210745|dip:DIP-33544N|mint:P20823	refseq:NP_115527.3|ensembl:ENSG00000132570(gene)|ensembl:ENST00000254908(transcript)|ensembl:ENST00000512783(transcript)|go:"GO:0004505"(phenylalanine 4-monooxygenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0008124"(4-alpha-hydroxytetrahydrobiopterin dehydratase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR001533(Transcriptional coactivator/pterin dehydratase)|interpro:IPR036428|rcsb pdb:4C45	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/08/17	2014/10/16	rogid:T/hHqwjDiZ9hytsn6n8a9oQt+EQ9606	rogid:pFuv42zNbVBtFSZ8duBoohlDJGY9606	intact-crc:D767D76E6D491185|rigid:HaUu2kYAu8b2wPSzC0ks+o7wjLQ	false	glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20823	uniprotkb:Q9Y463	intact:EBI-636034|uniprotkb:Q2M3H2|uniprotkb:Q99861|uniprotkb:E0YMJ5|uniprotkb:A5Z2R8|uniprotkb:E0YMK0|uniprotkb:E0YMK1|uniprotkb:E2I9R4|uniprotkb:E2I9R5|uniprotkb:F5H5U3	intact:EBI-634187|uniprotkb:O75258|uniprotkb:O75788|uniprotkb:O75789|ensembl:ENSP00000312789|ensembl:ENSP00000469863|ensembl:ENSP00000485915|ensembl:ENSP00000486377	psi-mi:hnf1a_human(display_long)|uniprotkb:Liver-specific transcription factor LF-B1(gene name synonym)|uniprotkb:HNF1A(gene name)|psi-mi:HNF1A(display_short)|uniprotkb:TCF1(gene name synonym)|uniprotkb:Transcription factor 1(gene name synonym)	psi-mi:dyr1b_human(display_long)|uniprotkb:Mirk protein kinase(gene name synonym)|uniprotkb:Minibrain-related kinase(gene name synonym)|uniprotkb:DYRK1B(gene name)|psi-mi:DYRK1B(display_short)|uniprotkb:MIRK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lim et al. (2002)	pubmed:11980910	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-636062	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000536.5|refseq:NP_001293108.1|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030073"(insulin secretion)|go:"GO:0031016"(pancreas development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035623"(renal glucose absorption)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046323"(glucose import)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|interpro:IPR001356(Homeobox)|interpro:IPR006897(Hepatocyte nuclear factor 1, beta isoform, C-terminal)|interpro:IPR006898(Hepatocyte nuclear factor 1, alpha isoform C-terminal)|interpro:IPR006899(Hepatocyte nuclear factor 1, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR023219|interpro:IPR039066|rcsb pdb:1IC8|rcsb pdb:2GYP|reactome:R-HSA-210745|dip:DIP-33544N|mint:P20823	refseq:NP_004705.1|refseq:NP_006474.1|refseq:NP_006475.1|refseq:XP_005259455.1|ensembl:ENSG00000105204(gene)|ensembl:ENSG00000281320(gene)|ensembl:ENST00000323039(transcript)|ensembl:ENST00000593685(transcript)|ensembl:ENST00000625757(transcript)|ensembl:ENST00000631090(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007520"(myoblast fusion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q9Y463|go:"GO:0106310"(protein serine kinase activity)	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/08/17	2014/10/16	rogid:T/hHqwjDiZ9hytsn6n8a9oQt+EQ9606	rogid:MaG/ZUw0KMo5JxQdeIhMu0DebXI9606	intact-crc:98EEAA5D680B2220|rigid:6ikpiIH0oMiPIU0N5YJ4EWBjSes	false	glutathione s tranferase tag:?-?|necessary binding region:112-203	35s radiolabel:?-?|necessary binding region:111-233	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)