#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P60763 uniprotkb:Q9UHY1 intact:EBI-767084|uniprotkb:O14658|uniprotkb:Q5U0M8|ensembl:ENSP00000304283 intact:EBI-749731|uniprotkb:Q53FZ5|uniprotkb:Q96SU3|uniprotkb:B3KV40|uniprotkb:D6W558|ensembl:ENSP00000233557|ensembl:ENSP00000369181 psi-mi:rac3_human(display_long)|uniprotkb:p21-Rac3(gene name synonym)|uniprotkb:RAC3(gene name)|psi-mi:RAC3(display_short) psi-mi:nrbp_human(display_long)|uniprotkb:NRBP1(gene name)|psi-mi:NRBP1(display_short)|uniprotkb:BCON3(gene name synonym)|uniprotkb:NRBP(gene name synonym) psi-mi:"MI:0018"(two hybrid) De et al. (2002) pubmed:11956649 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-767080 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005043.1|dip:DIP-33881N|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:2C2H|rcsb pdb:2G0N|rcsb pdb:2IC5|rcsb pdb:2OV2|rcsb pdb:2QME|rcsb pdb:6TM1|reactome:R-HSA-4086400|reactome:R-HSA-9013423|ensembl:ENSG00000169750(gene)|ensembl:ENST00000306897(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0012505"(endomembrane system)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030426"(growth cone)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031941"(filamentous actin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045202"(synapse)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071944"(cell periphery)|go:"GO:0030027"(lamellipodium) refseq:NP_037524.1|refseq:NP_001308286.1|refseq:NP_001308287.1|refseq:NP_001308288.1|refseq:NP_001308290.1|refseq:NP_001308291.1|refseq:NP_001308292.1|ensembl:ENSG00000115216(gene)|ensembl:ENST00000233557(transcript)|ensembl:ENST00000379852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|reactome:R-HSA-383280 - - - - taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2005/12/13 2014/10/16 rogid:YWu9Tmqxzxu49RSwmyfhawoOUis9606 rogid:goSncKy0TZmmVuw5UPUDsCiAzkk9606 intact-crc:1EADBD94C3EE43FC|rigid:fLyZnF4AChFhr9O+MHdVtElK7nc false - binding-associated region:1-426 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9UHY1 uniprotkb:P60763 intact:EBI-749731|uniprotkb:Q53FZ5|uniprotkb:Q96SU3|uniprotkb:B3KV40|uniprotkb:D6W558|ensembl:ENSP00000233557|ensembl:ENSP00000369181 intact:EBI-767084|uniprotkb:O14658|uniprotkb:Q5U0M8|ensembl:ENSP00000304283 psi-mi:nrbp_human(display_long)|uniprotkb:NRBP1(gene name)|psi-mi:NRBP1(display_short)|uniprotkb:BCON3(gene name synonym)|uniprotkb:NRBP(gene name synonym) psi-mi:rac3_human(display_long)|uniprotkb:p21-Rac3(gene name synonym)|uniprotkb:RAC3(gene name)|psi-mi:RAC3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) De et al. (2002) pubmed:11956649 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-767101 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037524.1|refseq:NP_001308286.1|refseq:NP_001308287.1|refseq:NP_001308288.1|refseq:NP_001308290.1|refseq:NP_001308291.1|refseq:NP_001308292.1|ensembl:ENSG00000115216(gene)|ensembl:ENST00000233557(transcript)|ensembl:ENST00000379852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|reactome:R-HSA-383280 refseq:NP_005043.1|dip:DIP-33881N|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:2C2H|rcsb pdb:2G0N|rcsb pdb:2IC5|rcsb pdb:2OV2|rcsb pdb:2QME|rcsb pdb:6TM1|reactome:R-HSA-4086400|reactome:R-HSA-9013423|ensembl:ENSG00000169750(gene)|ensembl:ENST00000306897(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0012505"(endomembrane system)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030426"(growth cone)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031941"(filamentous actin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045202"(synapse)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071944"(cell periphery)|go:"GO:0030027"(lamellipodium) - - - comment:JNK and p38 protein kinases also pulled down in this complex but could not be further identified due to non-specificity of antibodies. taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2005/12/13 2014/10/16 rogid:goSncKy0TZmmVuw5UPUDsCiAzkk9606 rogid:YWu9Tmqxzxu49RSwmyfhawoOUis9606 intact-crc:83CA1465B4685B39|rigid:fLyZnF4AChFhr9O+MHdVtElK7nc false binding-associated region:1-426|ha tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P60763 uniprotkb:Q9UHY1 intact:EBI-767084|uniprotkb:O14658|uniprotkb:Q5U0M8|ensembl:ENSP00000304283 intact:EBI-749731|uniprotkb:Q53FZ5|uniprotkb:Q96SU3|uniprotkb:B3KV40|uniprotkb:D6W558|ensembl:ENSP00000233557|ensembl:ENSP00000369181 psi-mi:rac3_human(display_long)|uniprotkb:p21-Rac3(gene name synonym)|uniprotkb:RAC3(gene name)|psi-mi:RAC3(display_short) psi-mi:nrbp_human(display_long)|uniprotkb:NRBP1(gene name)|psi-mi:NRBP1(display_short)|uniprotkb:BCON3(gene name synonym)|uniprotkb:NRBP(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) De et al. (2002) pubmed:11956649 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-767115 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005043.1|dip:DIP-33881N|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:2C2H|rcsb pdb:2G0N|rcsb pdb:2IC5|rcsb pdb:2OV2|rcsb pdb:2QME|rcsb pdb:6TM1|reactome:R-HSA-4086400|reactome:R-HSA-9013423|ensembl:ENSG00000169750(gene)|ensembl:ENST00000306897(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0012505"(endomembrane system)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030426"(growth cone)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031941"(filamentous actin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045202"(synapse)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071944"(cell periphery)|go:"GO:0030027"(lamellipodium) refseq:NP_037524.1|refseq:NP_001308286.1|refseq:NP_001308287.1|refseq:NP_001308288.1|refseq:NP_001308290.1|refseq:NP_001308291.1|refseq:NP_001308292.1|ensembl:ENSG00000115216(gene)|ensembl:ENST00000233557(transcript)|ensembl:ENST00000379852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|reactome:R-HSA-383280 go:"GO:0001726"(ruffle)|go:"GO:0048471"(perinuclear region of cytoplasm) - - comment:JNK and p38 protein kinases also pulled down in this complex but could not be further identified due to non-specificity of antibodies. taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2005/12/13 2014/10/16 rogid:YWu9Tmqxzxu49RSwmyfhawoOUis9606 rogid:goSncKy0TZmmVuw5UPUDsCiAzkk9606 intact-crc:3F5DB744CE8CE48D|rigid:fLyZnF4AChFhr9O+MHdVtElK7nc false tag:?-? binding-associated region:1-426|ha tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)