#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13415	uniprotkb:P20248	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	intact:EBI-457097|ensembl:ENSP00000274026|uniprotkb:Q2M3U6|uniprotkb:Q4W5P4|uniprotkb:Q6LER8|uniprotkb:A8K7B6	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:ccna2_human(display_long)|uniprotkb:Cyclin A(gene name synonym)|uniprotkb:CCNA2(gene name)|psi-mi:CCNA2(display_short)|uniprotkb:CCN1(gene name synonym)|uniprotkb:CCNA(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Mendez et al. (2002)	pubmed:11931757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-492332	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	ensembl:ENSG00000145386(gene)|ensembl:ENST00000274026(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033762"(response to glucagon)|refseq:NP_001228.1|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044843"(cell cycle G1/S phase transition)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051301"(cell division)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0071373"(cellular response to luteinizing hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090102"(cochlea development)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR032447|interpro:IPR036915|interpro:IPR039361|mint:P20248|rcsb pdb:1E9H|rcsb pdb:1FIN|rcsb pdb:1H1P|rcsb pdb:1FVV|rcsb pdb:1GY3|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P5E|rcsb pdb:1PKD|rcsb pdb:1QMZ|rcsb pdb:1URC|rcsb pdb:1VYW|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2C4G|rcsb pdb:6SG4|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7LUO|reactome:R-HSA-1362300|reactome:R-HSA-1538133|reactome:R-HSA-170145|reactome:R-HSA-171319|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5689880|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:2CJM|rcsb pdb:2WIH|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2UUE|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3F5X|rcsb pdb:4BCK|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2V22|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCP|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:6Q6H|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4FX3|rcsb pdb:5CYI|rcsb pdb:5IF1|rcsb pdb:5LMK|rcsb pdb:5NEV|rcsb pdb:6ATH|rcsb pdb:6RIJ|rcsb pdb:6GVA|rcsb pdb:6P3W|rcsb pdb:6Q6G|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|dip:DIP-638N	go:"GO:0000808"(origin recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0005634"(nucleus)	-	-	-	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/02/09	2014/10/16	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	rogid:eAkF93loT7w//7jrIC/Nlpy5iVc9606	intact-crc:018E1661100EF645|rigid:QfNZ0rgXwBofx5KIGJUJhjtifMk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13415	uniprotkb:P78396	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	intact:EBI-375065|uniprotkb:Q5T3V0|uniprotkb:Q5U0G2|uniprotkb:Q8IY91|uniprotkb:B7Z7E3|ensembl:ENSP00000255465	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:ccna1_human(display_long)|uniprotkb:CCNA1(gene name)|psi-mi:CCNA1(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Mendez et al. (2002)	pubmed:11931757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-492332	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	refseq:XP_011533596.1|refseq:XP_011533597.1|refseq:XP_011533598.1|refseq:NP_001104515.1|refseq:NP_001104516.1|refseq:NP_001104517.1|refseq:NP_003905.1|mint:P78396|reactome:R-HSA-1538133|reactome:R-HSA-170145|reactome:R-HSA-171319|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5689880|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69205|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|interpro:IPR039361|ensembl:ENSG00000133101(gene)|ensembl:ENST00000255465(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915	go:"GO:0000808"(origin recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0005634"(nucleus)	-	-	-	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/02/09	2014/10/16	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	rogid:8AeQa5s3zeE3pH78zaNvaz1ftks9606	intact-crc:018E1661100EF645|rigid:QfNZ0rgXwBofx5KIGJUJhjtifMk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13415	uniprotkb:P24941	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Mendez et al. (2002)	pubmed:11931757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-492332	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	go:"GO:0000808"(origin recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0005634"(nucleus)	-	-	-	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/02/09	2014/10/16	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	intact-crc:018E1661100EF645|rigid:QfNZ0rgXwBofx5KIGJUJhjtifMk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13415	uniprotkb:Q13416	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Mendez et al. (2002)	pubmed:11931757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-492332	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	go:"GO:0000808"(origin recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0005634"(nucleus)	-	-	-	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/02/09	2014/10/16	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	intact-crc:018E1661100EF645|rigid:QfNZ0rgXwBofx5KIGJUJhjtifMk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13416	uniprotkb:P20248	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	intact:EBI-457097|ensembl:ENSP00000274026|uniprotkb:Q2M3U6|uniprotkb:Q4W5P4|uniprotkb:Q6LER8|uniprotkb:A8K7B6	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:ccna2_human(display_long)|uniprotkb:Cyclin A(gene name synonym)|uniprotkb:CCNA2(gene name)|psi-mi:CCNA2(display_short)|uniprotkb:CCN1(gene name synonym)|uniprotkb:CCNA(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Mendez et al. (2002)	pubmed:11931757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-492344	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	ensembl:ENSG00000145386(gene)|ensembl:ENST00000274026(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033762"(response to glucagon)|refseq:NP_001228.1|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044843"(cell cycle G1/S phase transition)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051301"(cell division)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0071373"(cellular response to luteinizing hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090102"(cochlea development)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR032447|interpro:IPR036915|interpro:IPR039361|mint:P20248|rcsb pdb:1E9H|rcsb pdb:1FIN|rcsb pdb:1H1P|rcsb pdb:1FVV|rcsb pdb:1GY3|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P5E|rcsb pdb:1PKD|rcsb pdb:1QMZ|rcsb pdb:1URC|rcsb pdb:1VYW|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2C4G|rcsb pdb:6SG4|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7LUO|reactome:R-HSA-1362300|reactome:R-HSA-1538133|reactome:R-HSA-170145|reactome:R-HSA-171319|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5689880|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:2CJM|rcsb pdb:2WIH|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2UUE|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3F5X|rcsb pdb:4BCK|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2V22|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCP|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:6Q6H|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4FX3|rcsb pdb:5CYI|rcsb pdb:5IF1|rcsb pdb:5LMK|rcsb pdb:5NEV|rcsb pdb:6ATH|rcsb pdb:6RIJ|rcsb pdb:6GVA|rcsb pdb:6P3W|rcsb pdb:6Q6G|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|dip:DIP-638N	go:"GO:0000808"(origin recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0005634"(nucleus)	-	-	-	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/02/09	2014/10/16	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	rogid:eAkF93loT7w//7jrIC/Nlpy5iVc9606	intact-crc:78DD646283159D2D|rigid:tfoUwtp5pOl4OZ+jwsrp5qki0BI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13416	uniprotkb:P78396	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	intact:EBI-375065|uniprotkb:Q5T3V0|uniprotkb:Q5U0G2|uniprotkb:Q8IY91|uniprotkb:B7Z7E3|ensembl:ENSP00000255465	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:ccna1_human(display_long)|uniprotkb:CCNA1(gene name)|psi-mi:CCNA1(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Mendez et al. (2002)	pubmed:11931757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-492344	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	refseq:XP_011533596.1|refseq:XP_011533597.1|refseq:XP_011533598.1|refseq:NP_001104515.1|refseq:NP_001104516.1|refseq:NP_001104517.1|refseq:NP_003905.1|mint:P78396|reactome:R-HSA-1538133|reactome:R-HSA-170145|reactome:R-HSA-171319|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5689880|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69205|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|interpro:IPR039361|ensembl:ENSG00000133101(gene)|ensembl:ENST00000255465(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915	go:"GO:0000808"(origin recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0005634"(nucleus)	-	-	-	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/02/09	2014/10/16	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	rogid:8AeQa5s3zeE3pH78zaNvaz1ftks9606	intact-crc:78DD646283159D2D|rigid:tfoUwtp5pOl4OZ+jwsrp5qki0BI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13416	uniprotkb:Q13415	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Mendez et al. (2002)	pubmed:11931757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-492344	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	go:"GO:0000808"(origin recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0005634"(nucleus)	-	-	-	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/02/09	2014/10/16	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	intact-crc:78DD646283159D2D|rigid:tfoUwtp5pOl4OZ+jwsrp5qki0BI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0CG47	uniprotkb:Q13415	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Mendez et al. (2002)	pubmed:11931757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-492377	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	go:"GO:0000785"(chromatin)|go:"GO:0042787"	-	-	-	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2005/02/09	2014/10/16	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	intact-crc:B3B990EF240FFFAF|rigid:/dbDyS1lep9IAtgAlHoARUIijcg	false	t7 tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13309	uniprotkb:Q13415	intact:EBI-456291|uniprotkb:Q8TDZ0|uniprotkb:Q8TDZ1|uniprotkb:Q9BV69|ensembl:ENSP00000274255|uniprotkb:A8K5E0|uniprotkb:B4DJT4	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	psi-mi:skp2_human(display_long)|uniprotkb:F-box protein Skp2(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p45(gene name synonym)|uniprotkb:p45skp2(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 1(gene name synonym)|uniprotkb:SKP2(gene name)|psi-mi:SKP2(display_short)|uniprotkb:FBXL1(gene name synonym)	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Mendez et al. (2002)	pubmed:11931757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-492406	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145604(gene)|ensembl:ENST00000274255(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|rcsb pdb:2ASS|rcsb pdb:2AST|interpro:IPR032675|rcsb pdb:7B5L|interpro:IPR036047|mint:Q13309|rcsb pdb:1FQV|rcsb pdb:7B5M|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|refseq:NP_005974.2|refseq:NP_116026.1|refseq:NP_001230049.1|dip:DIP-17011N|rcsb pdb:7B5R|reactome:R-HSA-174178|reactome:R-HSA-187577|reactome:R-HSA-5689880|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9687136|reactome:R-HSA-9708530|reactome:R-HSA-983168	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	go:"GO:0000808"(origin recognition complex)|go:"GO:0006260"(DNA replication)	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/02/09	2014/10/16	rogid:VABxcX3qu0Yr6eRNYINqvAPhPMc9606	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	intact-crc:701B9D5A8D8A04B8|rigid:42gGlJnFUreZ3K5mU5+Q9MzqVKo	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13415	uniprotkb:Q13309	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	intact:EBI-456291|uniprotkb:Q8TDZ0|uniprotkb:Q8TDZ1|uniprotkb:Q9BV69|ensembl:ENSP00000274255|uniprotkb:A8K5E0|uniprotkb:B4DJT4	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:skp2_human(display_long)|uniprotkb:F-box protein Skp2(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p45(gene name synonym)|uniprotkb:p45skp2(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 1(gene name synonym)|uniprotkb:SKP2(gene name)|psi-mi:SKP2(display_short)|uniprotkb:FBXL1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Mendez et al. (2002)	pubmed:11931757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-492430	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	ensembl:ENSG00000145604(gene)|ensembl:ENST00000274255(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|rcsb pdb:2ASS|rcsb pdb:2AST|interpro:IPR032675|rcsb pdb:7B5L|interpro:IPR036047|mint:Q13309|rcsb pdb:1FQV|rcsb pdb:7B5M|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|refseq:NP_005974.2|refseq:NP_116026.1|refseq:NP_001230049.1|dip:DIP-17011N|rcsb pdb:7B5R|reactome:R-HSA-174178|reactome:R-HSA-187577|reactome:R-HSA-5689880|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9687136|reactome:R-HSA-9708530|reactome:R-HSA-983168	go:"GO:0000808"(origin recognition complex)|go:"GO:0006260"(DNA replication)	-	-	-	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2005/02/09	2014/10/16	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	rogid:VABxcX3qu0Yr6eRNYINqvAPhPMc9606	intact-crc:D757C9B20D867D9B|rigid:42gGlJnFUreZ3K5mU5+Q9MzqVKo	false	t7 tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)