#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8BR65	uniprotkb:Q60520	intact:EBI-591431|uniprotkb:Q3UC92|uniprotkb:Q6P6K1|uniprotkb:Q7TNT0|uniprotkb:Q8BRR7|uniprotkb:Q8K5B4|ensembl:ENSMUSP00000083662	intact:EBI-349034|uniprotkb:Q60820|uniprotkb:Q62139|uniprotkb:Q62140|uniprotkb:Q7TPU8|uniprotkb:Q7TSZ2|ensembl:ENSMUSP00000045044|ensembl:ENSMUSP00000126601|ensembl:ENSMUSP00000130641|uniprotkb:Q570Z7	psi-mi:sds3_mouse(display_long)|uniprotkb:Suppressor of defective silencing 3 protein homolog(gene name synonym)|uniprotkb:Suds3(gene name)|psi-mi:Suds3(display_short)|uniprotkb:Sds3(gene name synonym)	psi-mi:sin3a_mouse(display_long)|uniprotkb:Sin3a(gene name)|psi-mi:Sin3a(display_short)|uniprotkb:Kiaa4126(gene name synonym)|uniprotkb:Transcriptional corepressor Sin3a(gene name synonym)|uniprotkb:Histone deacetylase complex subunit Sin3a(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Alland et al. (2002)	pubmed:11909966	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-591441	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116138.1|refseq:NP_848737.3|ensembl:ENSMUSG00000066900(gene)|ensembl:ENSMUST00000086471(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070822"(Sin3-type complex)|interpro:IPR013907(Sds3-like)|mint:Q8BR65|rcsb pdb:2N2H|rcsb pdb:4ZQA|reactome:R-MMU-3214815|reactome:R-MMU-5689880	refseq:NP_001103820.1|refseq:NP_001103821.1|refseq:NP_035508.2|ensembl:ENSMUSG00000042557(gene)|ensembl:ENSMUST00000049169(transcript)|ensembl:ENSMUST00000167715(transcript)|ensembl:ENSMUST00000168678(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|rcsb pdb:2RMS|reactome:R-MMU-3899300|reactome:R-MMU-400206|reactome:R-MMU-8936459|reactome:R-MMU-9022692|reactome:R-MMU-9707564|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006260"(DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006476"(protein deacetylation)|go:"GO:0007568"(aging)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010817"(regulation of hormone levels)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031937"(obsolete positive regulation of chromatin silencing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0051595"(response to methylglyoxal)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1901675"(negative regulation of histone H3-K27 acetylation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR003822(Paired amphipathic helix)|interpro:IPR013194(Histone deacetylase interacting)|interpro:IPR031693|interpro:IPR036600|interpro:IPR037969|interpro:IPR039774|mint:Q60520|rcsb pdb:1G1E|rcsb pdb:1S5Q|rcsb pdb:1S5R|rcsb pdb:2L9S|rcsb pdb:2LD7|rcsb pdb:2N2H|rcsb pdb:2RMR|refseq:XP_011240985.1|refseq:XP_011240986.1|refseq:XP_011240987.1|refseq:XP_011240988.1|refseq:XP_017168720.1|refseq:XP_006510953.1|refseq:XP_006510954.1|refseq:XP_006510955.1|refseq:XP_006510956.1|dip:DIP-469N	-	-	-	dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/05/26	2014/10/16	rogid:/OlXuvM/x3P3HVKCiDNOiNBl1rI10090	rogid:xd+Wh6NZxejENeiSl5WRDOrVDtc10090	intact-crc:C3B9DFA4F082D73C|rigid:r6UJRxTzWJIW8oyfqWuZDZZWQVA	false	tag:?-?	binding-associated region:534-890	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8BR65	uniprotkb:Q62141	intact:EBI-591431|uniprotkb:Q3UC92|uniprotkb:Q6P6K1|uniprotkb:Q7TNT0|uniprotkb:Q8BRR7|uniprotkb:Q8K5B4|ensembl:ENSMUSP00000083662	intact:EBI-591450|uniprotkb:O54976|uniprotkb:Q6A013|uniprotkb:Q8VCB8|uniprotkb:Q8VDZ5|ensembl:ENSMUSP00000004494	psi-mi:sds3_mouse(display_long)|uniprotkb:Suppressor of defective silencing 3 protein homolog(gene name synonym)|uniprotkb:Suds3(gene name)|psi-mi:Suds3(display_short)|uniprotkb:Sds3(gene name synonym)	psi-mi:sin3b_mouse(display_long)|uniprotkb:Transcriptional corepressor Sin3b(gene name synonym)|uniprotkb:Histone deacetylase complex subunit Sin3b(gene name synonym)|uniprotkb:Sin3b(gene name)|psi-mi:Sin3b(display_short)|uniprotkb:Kiaa0700(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Alland et al. (2002)	pubmed:11909966	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-591477	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116138.1|refseq:NP_848737.3|ensembl:ENSMUSG00000066900(gene)|ensembl:ENSMUST00000086471(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070822"(Sin3-type complex)|interpro:IPR013907(Sds3-like)|mint:Q8BR65|rcsb pdb:2N2H|rcsb pdb:4ZQA|reactome:R-MMU-3214815|reactome:R-MMU-5689880	refseq:NP_001106719.1|refseq:NP_033214.2|dip:DIP-470N|ensembl:ENSMUSG00000031622(gene)|ensembl:ENSMUST00000004494(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000805"(X chromosome)|go:"GO:0000806"(Y chromosome)|go:"GO:0001741"(XY body)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0016580"(Sin3 complex)|go:"GO:0030849"(autosome)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048738"(cardiac muscle tissue development)|interpro:IPR003822(Paired amphipathic helix)|interpro:IPR013194(Histone deacetylase interacting)|interpro:IPR031693|interpro:IPR036600|interpro:IPR039774|mint:Q62141|rcsb pdb:1E91|rcsb pdb:1PD7|rcsb pdb:2CR7|rcsb pdb:2CZY|rcsb pdb:2F05|rcsb pdb:5Y95|reactome:R-MMU-400206|reactome:R-MMU-8936459|reactome:R-MMU-9707564|go:"GO:0016575"(histone deacetylation)	-	-	-	comment:"The full-length Sds3 protein was able to interact with a short region of Sin3b (AA 383-550)."|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/05/26	2014/10/16	rogid:/OlXuvM/x3P3HVKCiDNOiNBl1rI10090	rogid:RILCV7LIlLhVsSBz43m63WcJ0B810090	intact-crc:5E599B8E80CC6076|rigid:aTC6w5QHFn1/1uAoZq56ja2kVeU	false	tag:?-?	binding-associated region:383-550	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8BR65	uniprotkb:Q62141	intact:EBI-591431|uniprotkb:Q3UC92|uniprotkb:Q6P6K1|uniprotkb:Q7TNT0|uniprotkb:Q8BRR7|uniprotkb:Q8K5B4|ensembl:ENSMUSP00000083662	intact:EBI-591450|uniprotkb:O54976|uniprotkb:Q6A013|uniprotkb:Q8VCB8|uniprotkb:Q8VDZ5|ensembl:ENSMUSP00000004494	psi-mi:sds3_mouse(display_long)|uniprotkb:Suppressor of defective silencing 3 protein homolog(gene name synonym)|uniprotkb:Suds3(gene name)|psi-mi:Suds3(display_short)|uniprotkb:Sds3(gene name synonym)	psi-mi:sin3b_mouse(display_long)|uniprotkb:Transcriptional corepressor Sin3b(gene name synonym)|uniprotkb:Histone deacetylase complex subunit Sin3b(gene name synonym)|uniprotkb:Sin3b(gene name)|psi-mi:Sin3b(display_short)|uniprotkb:Kiaa0700(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Alland et al. (2002)	pubmed:11909966	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-591490	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116138.1|refseq:NP_848737.3|ensembl:ENSMUSG00000066900(gene)|ensembl:ENSMUST00000086471(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070822"(Sin3-type complex)|interpro:IPR013907(Sds3-like)|mint:Q8BR65|rcsb pdb:2N2H|rcsb pdb:4ZQA|reactome:R-MMU-3214815|reactome:R-MMU-5689880	refseq:NP_001106719.1|refseq:NP_033214.2|dip:DIP-470N|ensembl:ENSMUSG00000031622(gene)|ensembl:ENSMUST00000004494(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000805"(X chromosome)|go:"GO:0000806"(Y chromosome)|go:"GO:0001741"(XY body)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0016580"(Sin3 complex)|go:"GO:0030849"(autosome)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048738"(cardiac muscle tissue development)|interpro:IPR003822(Paired amphipathic helix)|interpro:IPR013194(Histone deacetylase interacting)|interpro:IPR031693|interpro:IPR036600|interpro:IPR039774|mint:Q62141|rcsb pdb:1E91|rcsb pdb:1PD7|rcsb pdb:2CR7|rcsb pdb:2CZY|rcsb pdb:2F05|rcsb pdb:5Y95|reactome:R-MMU-400206|reactome:R-MMU-8936459|reactome:R-MMU-9707564|go:"GO:0016575"(histone deacetylation)	-	-	-	comment:"The full-length Sin3b protein was able to interact with a short region of Sds3 (AA 43-229). By deletion analysis it was found that a region AA 188-226 in Sds3 played an essential role in associating with the full-length Sin3b but was not sufficient for interaction."|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/05/26	2014/10/16	rogid:/OlXuvM/x3P3HVKCiDNOiNBl1rI10090	rogid:RILCV7LIlLhVsSBz43m63WcJ0B810090	intact-crc:7ED7A9D90974A0FD|rigid:aTC6w5QHFn1/1uAoZq56ja2kVeU	false	necessary binding region:188-226|sufficient binding region:43-229|tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8BR65	uniprotkb:Q60520	intact:EBI-591431|uniprotkb:Q3UC92|uniprotkb:Q6P6K1|uniprotkb:Q7TNT0|uniprotkb:Q8BRR7|uniprotkb:Q8K5B4|ensembl:ENSMUSP00000083662	intact:EBI-349034|uniprotkb:Q60820|uniprotkb:Q62139|uniprotkb:Q62140|uniprotkb:Q7TPU8|uniprotkb:Q7TSZ2|ensembl:ENSMUSP00000045044|ensembl:ENSMUSP00000126601|ensembl:ENSMUSP00000130641|uniprotkb:Q570Z7	psi-mi:sds3_mouse(display_long)|uniprotkb:Suppressor of defective silencing 3 protein homolog(gene name synonym)|uniprotkb:Suds3(gene name)|psi-mi:Suds3(display_short)|uniprotkb:Sds3(gene name synonym)	psi-mi:sin3a_mouse(display_long)|uniprotkb:Sin3a(gene name)|psi-mi:Sin3a(display_short)|uniprotkb:Kiaa4126(gene name synonym)|uniprotkb:Transcriptional corepressor Sin3a(gene name synonym)|uniprotkb:Histone deacetylase complex subunit Sin3a(gene name synonym)	psi-mi:"MI:0096"(pull down)	Alland et al. (2002)	pubmed:11909966	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-591512	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116138.1|refseq:NP_848737.3|ensembl:ENSMUSG00000066900(gene)|ensembl:ENSMUST00000086471(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070822"(Sin3-type complex)|interpro:IPR013907(Sds3-like)|mint:Q8BR65|rcsb pdb:2N2H|rcsb pdb:4ZQA|reactome:R-MMU-3214815|reactome:R-MMU-5689880	refseq:NP_001103820.1|refseq:NP_001103821.1|refseq:NP_035508.2|ensembl:ENSMUSG00000042557(gene)|ensembl:ENSMUST00000049169(transcript)|ensembl:ENSMUST00000167715(transcript)|ensembl:ENSMUST00000168678(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|rcsb pdb:2RMS|reactome:R-MMU-3899300|reactome:R-MMU-400206|reactome:R-MMU-8936459|reactome:R-MMU-9022692|reactome:R-MMU-9707564|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006260"(DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006476"(protein deacetylation)|go:"GO:0007568"(aging)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010817"(regulation of hormone levels)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031937"(obsolete positive regulation of chromatin silencing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0051595"(response to methylglyoxal)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1901675"(negative regulation of histone H3-K27 acetylation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR003822(Paired amphipathic helix)|interpro:IPR013194(Histone deacetylase interacting)|interpro:IPR031693|interpro:IPR036600|interpro:IPR037969|interpro:IPR039774|mint:Q60520|rcsb pdb:1G1E|rcsb pdb:1S5Q|rcsb pdb:1S5R|rcsb pdb:2L9S|rcsb pdb:2LD7|rcsb pdb:2N2H|rcsb pdb:2RMR|refseq:XP_011240985.1|refseq:XP_011240986.1|refseq:XP_011240987.1|refseq:XP_011240988.1|refseq:XP_017168720.1|refseq:XP_006510953.1|refseq:XP_006510954.1|refseq:XP_006510955.1|refseq:XP_006510956.1|dip:DIP-469N	-	-	-	dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/05/26	2014/10/16	rogid:/OlXuvM/x3P3HVKCiDNOiNBl1rI10090	rogid:xd+Wh6NZxejENeiSl5WRDOrVDtc10090	intact-crc:BF8ABFDCBB4CD8D0|rigid:r6UJRxTzWJIW8oyfqWuZDZZWQVA	false	glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62141	uniprotkb:Q8BR65	intact:EBI-591450|uniprotkb:O54976|uniprotkb:Q6A013|uniprotkb:Q8VCB8|uniprotkb:Q8VDZ5|ensembl:ENSMUSP00000004494	intact:EBI-591431|uniprotkb:Q3UC92|uniprotkb:Q6P6K1|uniprotkb:Q7TNT0|uniprotkb:Q8BRR7|uniprotkb:Q8K5B4|ensembl:ENSMUSP00000083662	psi-mi:sin3b_mouse(display_long)|uniprotkb:Transcriptional corepressor Sin3b(gene name synonym)|uniprotkb:Histone deacetylase complex subunit Sin3b(gene name synonym)|uniprotkb:Sin3b(gene name)|psi-mi:Sin3b(display_short)|uniprotkb:Kiaa0700(gene name synonym)	psi-mi:sds3_mouse(display_long)|uniprotkb:Suppressor of defective silencing 3 protein homolog(gene name synonym)|uniprotkb:Suds3(gene name)|psi-mi:Suds3(display_short)|uniprotkb:Sds3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Alland et al. (2002)	pubmed:11909966	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-591570	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001106719.1|refseq:NP_033214.2|dip:DIP-470N|ensembl:ENSMUSG00000031622(gene)|ensembl:ENSMUST00000004494(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000805"(X chromosome)|go:"GO:0000806"(Y chromosome)|go:"GO:0001741"(XY body)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0016580"(Sin3 complex)|go:"GO:0030849"(autosome)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048738"(cardiac muscle tissue development)|interpro:IPR003822(Paired amphipathic helix)|interpro:IPR013194(Histone deacetylase interacting)|interpro:IPR031693|interpro:IPR036600|interpro:IPR039774|mint:Q62141|rcsb pdb:1E91|rcsb pdb:1PD7|rcsb pdb:2CR7|rcsb pdb:2CZY|rcsb pdb:2F05|rcsb pdb:5Y95|reactome:R-MMU-400206|reactome:R-MMU-8936459|reactome:R-MMU-9707564|go:"GO:0016575"(histone deacetylation)	refseq:NP_001116138.1|refseq:NP_848737.3|ensembl:ENSMUSG00000066900(gene)|ensembl:ENSMUST00000086471(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070822"(Sin3-type complex)|interpro:IPR013907(Sds3-like)|mint:Q8BR65|rcsb pdb:2N2H|rcsb pdb:4ZQA|reactome:R-MMU-3214815|reactome:R-MMU-5689880	-	-	-	dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/05/26	2014/10/16	rogid:RILCV7LIlLhVsSBz43m63WcJ0B810090	rogid:/OlXuvM/x3P3HVKCiDNOiNBl1rI10090	intact-crc:0079C771BFFC1DE3|rigid:aTC6w5QHFn1/1uAoZq56ja2kVeU	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8BR65	uniprotkb:Q62141	intact:EBI-591431|uniprotkb:Q3UC92|uniprotkb:Q6P6K1|uniprotkb:Q7TNT0|uniprotkb:Q8BRR7|uniprotkb:Q8K5B4|ensembl:ENSMUSP00000083662	intact:EBI-591450|uniprotkb:O54976|uniprotkb:Q6A013|uniprotkb:Q8VCB8|uniprotkb:Q8VDZ5|ensembl:ENSMUSP00000004494	psi-mi:sds3_mouse(display_long)|uniprotkb:Suppressor of defective silencing 3 protein homolog(gene name synonym)|uniprotkb:Suds3(gene name)|psi-mi:Suds3(display_short)|uniprotkb:Sds3(gene name synonym)	psi-mi:sin3b_mouse(display_long)|uniprotkb:Transcriptional corepressor Sin3b(gene name synonym)|uniprotkb:Histone deacetylase complex subunit Sin3b(gene name synonym)|uniprotkb:Sin3b(gene name)|psi-mi:Sin3b(display_short)|uniprotkb:Kiaa0700(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Alland et al. (2002)	pubmed:11909966	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-591771	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116138.1|refseq:NP_848737.3|ensembl:ENSMUSG00000066900(gene)|ensembl:ENSMUST00000086471(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070822"(Sin3-type complex)|interpro:IPR013907(Sds3-like)|mint:Q8BR65|rcsb pdb:2N2H|rcsb pdb:4ZQA|reactome:R-MMU-3214815|reactome:R-MMU-5689880	refseq:NP_001106719.1|refseq:NP_033214.2|dip:DIP-470N|ensembl:ENSMUSG00000031622(gene)|ensembl:ENSMUST00000004494(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000805"(X chromosome)|go:"GO:0000806"(Y chromosome)|go:"GO:0001741"(XY body)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0016580"(Sin3 complex)|go:"GO:0030849"(autosome)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048738"(cardiac muscle tissue development)|interpro:IPR003822(Paired amphipathic helix)|interpro:IPR013194(Histone deacetylase interacting)|interpro:IPR031693|interpro:IPR036600|interpro:IPR039774|mint:Q62141|rcsb pdb:1E91|rcsb pdb:1PD7|rcsb pdb:2CR7|rcsb pdb:2CZY|rcsb pdb:2F05|rcsb pdb:5Y95|reactome:R-MMU-400206|reactome:R-MMU-8936459|reactome:R-MMU-9707564|go:"GO:0016575"(histone deacetylation)	-	-	-	comment:Displays that interaction between Sds3 and Sin3b occurs in-vivo as well as in-vitro. Deletion of AA 383-550 in Sin3b abolished interaction with Sds3 and other components of the Sin3-complex. Also deletion of AA 188-226 in Sds3 had a similar affect.|comment:Both Sds3 ans Sin3b are overexpressed.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/05/26	2014/10/16	rogid:/OlXuvM/x3P3HVKCiDNOiNBl1rI10090	rogid:RILCV7LIlLhVsSBz43m63WcJ0B810090	intact-crc:F29D9F6C7607387D|rigid:aTC6w5QHFn1/1uAoZq56ja2kVeU	false	35s radiolabel:?-?|necessary binding region:188-226|flag tag:?-?	35s radiolabel:?-?|necessary binding region:383-550	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8BR65	uniprotkb:Q8BR65	intact:EBI-591431|uniprotkb:Q3UC92|uniprotkb:Q6P6K1|uniprotkb:Q7TNT0|uniprotkb:Q8BRR7|uniprotkb:Q8K5B4|ensembl:ENSMUSP00000083662	intact:EBI-591431|uniprotkb:Q3UC92|uniprotkb:Q6P6K1|uniprotkb:Q7TNT0|uniprotkb:Q8BRR7|uniprotkb:Q8K5B4|ensembl:ENSMUSP00000083662	psi-mi:sds3_mouse(display_long)|uniprotkb:Suppressor of defective silencing 3 protein homolog(gene name synonym)|uniprotkb:Suds3(gene name)|psi-mi:Suds3(display_short)|uniprotkb:Sds3(gene name synonym)	psi-mi:sds3_mouse(display_long)|uniprotkb:Suppressor of defective silencing 3 protein homolog(gene name synonym)|uniprotkb:Suds3(gene name)|psi-mi:Suds3(display_short)|uniprotkb:Sds3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Alland et al. (2002)	pubmed:11909966	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-591863	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116138.1|refseq:NP_848737.3|ensembl:ENSMUSG00000066900(gene)|ensembl:ENSMUST00000086471(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070822"(Sin3-type complex)|interpro:IPR013907(Sds3-like)|mint:Q8BR65|rcsb pdb:2N2H|rcsb pdb:4ZQA|reactome:R-MMU-3214815|reactome:R-MMU-5689880	refseq:NP_001116138.1|refseq:NP_848737.3|ensembl:ENSMUSG00000066900(gene)|ensembl:ENSMUST00000086471(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070822"(Sin3-type complex)|interpro:IPR013907(Sds3-like)|mint:Q8BR65|rcsb pdb:2N2H|rcsb pdb:4ZQA|reactome:R-MMU-3214815|reactome:R-MMU-5689880	-	-	-	comment:"The full-length Sds3 protein was able to interact with a short region of Sds3 (AA 72-108) for homodimerization."|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/05/26	2014/10/16	rogid:/OlXuvM/x3P3HVKCiDNOiNBl1rI10090	rogid:/OlXuvM/x3P3HVKCiDNOiNBl1rI10090	intact-crc:48065A9B6C3B5260|rigid:76y66xtG8t22+9IctFXk1vSB4iE	false	tag:?-?	necessary binding region:72-108|sufficient binding region:1-187	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8BR65	uniprotkb:Q8BR65	intact:EBI-591431|uniprotkb:Q3UC92|uniprotkb:Q6P6K1|uniprotkb:Q7TNT0|uniprotkb:Q8BRR7|uniprotkb:Q8K5B4|ensembl:ENSMUSP00000083662	intact:EBI-591431|uniprotkb:Q3UC92|uniprotkb:Q6P6K1|uniprotkb:Q7TNT0|uniprotkb:Q8BRR7|uniprotkb:Q8K5B4|ensembl:ENSMUSP00000083662	psi-mi:sds3_mouse(display_long)|uniprotkb:Suppressor of defective silencing 3 protein homolog(gene name synonym)|uniprotkb:Suds3(gene name)|psi-mi:Suds3(display_short)|uniprotkb:Sds3(gene name synonym)	psi-mi:sds3_mouse(display_long)|uniprotkb:Suppressor of defective silencing 3 protein homolog(gene name synonym)|uniprotkb:Suds3(gene name)|psi-mi:Suds3(display_short)|uniprotkb:Sds3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Alland et al. (2002)	pubmed:11909966	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-591877	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116138.1|refseq:NP_848737.3|ensembl:ENSMUSG00000066900(gene)|ensembl:ENSMUST00000086471(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070822"(Sin3-type complex)|interpro:IPR013907(Sds3-like)|mint:Q8BR65|rcsb pdb:2N2H|rcsb pdb:4ZQA|reactome:R-MMU-3214815|reactome:R-MMU-5689880	refseq:NP_001116138.1|refseq:NP_848737.3|ensembl:ENSMUSG00000066900(gene)|ensembl:ENSMUST00000086471(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070822"(Sin3-type complex)|interpro:IPR013907(Sds3-like)|mint:Q8BR65|rcsb pdb:2N2H|rcsb pdb:4ZQA|reactome:R-MMU-3214815|reactome:R-MMU-5689880	-	-	-	comment:"The full-length Sds3 protein was able to interact with a short region of Sds3 (AA 1-187) for homodimerization in-vivo."|comment:Both the full-length and the n-terminus Sds3 are overexpressed.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/05/26	2014/10/16	rogid:/OlXuvM/x3P3HVKCiDNOiNBl1rI10090	rogid:/OlXuvM/x3P3HVKCiDNOiNBl1rI10090	intact-crc:6D15C6B9AAC6B0DE|rigid:76y66xtG8t22+9IctFXk1vSB4iE	false	binding-associated region:1-187	flag tag:?-?	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q8BR65	uniprotkb:Q8BR65	intact:EBI-591431|uniprotkb:Q3UC92|uniprotkb:Q6P6K1|uniprotkb:Q7TNT0|uniprotkb:Q8BRR7|uniprotkb:Q8K5B4|ensembl:ENSMUSP00000083662	intact:EBI-591431|uniprotkb:Q3UC92|uniprotkb:Q6P6K1|uniprotkb:Q7TNT0|uniprotkb:Q8BRR7|uniprotkb:Q8K5B4|ensembl:ENSMUSP00000083662	psi-mi:sds3_mouse(display_long)|uniprotkb:Suppressor of defective silencing 3 protein homolog(gene name synonym)|uniprotkb:Suds3(gene name)|psi-mi:Suds3(display_short)|uniprotkb:Sds3(gene name synonym)	psi-mi:sds3_mouse(display_long)|uniprotkb:Suppressor of defective silencing 3 protein homolog(gene name synonym)|uniprotkb:Suds3(gene name)|psi-mi:Suds3(display_short)|uniprotkb:Sds3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Alland et al. (2002)	pubmed:11909966	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-591892	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116138.1|refseq:NP_848737.3|ensembl:ENSMUSG00000066900(gene)|ensembl:ENSMUST00000086471(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070822"(Sin3-type complex)|interpro:IPR013907(Sds3-like)|mint:Q8BR65|rcsb pdb:2N2H|rcsb pdb:4ZQA|reactome:R-MMU-3214815|reactome:R-MMU-5689880	refseq:NP_001116138.1|refseq:NP_848737.3|ensembl:ENSMUSG00000066900(gene)|ensembl:ENSMUST00000086471(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070822"(Sin3-type complex)|interpro:IPR013907(Sds3-like)|mint:Q8BR65|rcsb pdb:2N2H|rcsb pdb:4ZQA|reactome:R-MMU-3214815|reactome:R-MMU-5689880	-	-	-	comment:The full-length GST-tagged-Sds3 protein was able to interact with in-vitro translated full-length Sds3 indicating that homodimerization seems to occurs via direct protein-protein interaction.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/05/26	2014/10/16	rogid:/OlXuvM/x3P3HVKCiDNOiNBl1rI10090	rogid:/OlXuvM/x3P3HVKCiDNOiNBl1rI10090	intact-crc:315970DB7CDD1F3E|rigid:76y66xtG8t22+9IctFXk1vSB4iE	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8BR65	uniprotkb:Q60520	intact:EBI-591431|uniprotkb:Q3UC92|uniprotkb:Q6P6K1|uniprotkb:Q7TNT0|uniprotkb:Q8BRR7|uniprotkb:Q8K5B4|ensembl:ENSMUSP00000083662	intact:EBI-349034|uniprotkb:Q60820|uniprotkb:Q62139|uniprotkb:Q62140|uniprotkb:Q7TPU8|uniprotkb:Q7TSZ2|ensembl:ENSMUSP00000045044|ensembl:ENSMUSP00000126601|ensembl:ENSMUSP00000130641|uniprotkb:Q570Z7	psi-mi:sds3_mouse(display_long)|uniprotkb:Suppressor of defective silencing 3 protein homolog(gene name synonym)|uniprotkb:Suds3(gene name)|psi-mi:Suds3(display_short)|uniprotkb:Sds3(gene name synonym)	psi-mi:sin3a_mouse(display_long)|uniprotkb:Sin3a(gene name)|psi-mi:Sin3a(display_short)|uniprotkb:Kiaa4126(gene name synonym)|uniprotkb:Transcriptional corepressor Sin3a(gene name synonym)|uniprotkb:Histone deacetylase complex subunit Sin3a(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Alland et al. (2002)	pubmed:11909966	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-630355	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116138.1|refseq:NP_848737.3|ensembl:ENSMUSG00000066900(gene)|ensembl:ENSMUST00000086471(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070822"(Sin3-type complex)|interpro:IPR013907(Sds3-like)|mint:Q8BR65|rcsb pdb:2N2H|rcsb pdb:4ZQA|reactome:R-MMU-3214815|reactome:R-MMU-5689880	refseq:NP_001103820.1|refseq:NP_001103821.1|refseq:NP_035508.2|ensembl:ENSMUSG00000042557(gene)|ensembl:ENSMUST00000049169(transcript)|ensembl:ENSMUST00000167715(transcript)|ensembl:ENSMUST00000168678(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|rcsb pdb:2RMS|reactome:R-MMU-3899300|reactome:R-MMU-400206|reactome:R-MMU-8936459|reactome:R-MMU-9022692|reactome:R-MMU-9707564|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006260"(DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006476"(protein deacetylation)|go:"GO:0007568"(aging)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010817"(regulation of hormone levels)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031937"(obsolete positive regulation of chromatin silencing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0051595"(response to methylglyoxal)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1901675"(negative regulation of histone H3-K27 acetylation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR003822(Paired amphipathic helix)|interpro:IPR013194(Histone deacetylase interacting)|interpro:IPR031693|interpro:IPR036600|interpro:IPR037969|interpro:IPR039774|mint:Q60520|rcsb pdb:1G1E|rcsb pdb:1S5Q|rcsb pdb:1S5R|rcsb pdb:2L9S|rcsb pdb:2LD7|rcsb pdb:2N2H|rcsb pdb:2RMR|refseq:XP_011240985.1|refseq:XP_011240986.1|refseq:XP_011240987.1|refseq:XP_011240988.1|refseq:XP_017168720.1|refseq:XP_006510953.1|refseq:XP_006510954.1|refseq:XP_006510955.1|refseq:XP_006510956.1|dip:DIP-469N	-	-	-	comment:"The full-length Sds3 protein was isolated using a c-terminus region of Sin3A (AA 534-1274)."|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/05/26	2014/10/16	rogid:/OlXuvM/x3P3HVKCiDNOiNBl1rI10090	rogid:xd+Wh6NZxejENeiSl5WRDOrVDtc10090	intact-crc:DCE11B29B824978D|rigid:r6UJRxTzWJIW8oyfqWuZDZZWQVA	false	-	binding-associated region:534-1274	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60520	uniprotkb:Q8BR65	intact:EBI-349034|uniprotkb:Q60820|uniprotkb:Q62139|uniprotkb:Q62140|uniprotkb:Q7TPU8|uniprotkb:Q7TSZ2|ensembl:ENSMUSP00000045044|ensembl:ENSMUSP00000126601|ensembl:ENSMUSP00000130641|uniprotkb:Q570Z7	intact:EBI-591431|uniprotkb:Q3UC92|uniprotkb:Q6P6K1|uniprotkb:Q7TNT0|uniprotkb:Q8BRR7|uniprotkb:Q8K5B4|ensembl:ENSMUSP00000083662	psi-mi:sin3a_mouse(display_long)|uniprotkb:Sin3a(gene name)|psi-mi:Sin3a(display_short)|uniprotkb:Kiaa4126(gene name synonym)|uniprotkb:Transcriptional corepressor Sin3a(gene name synonym)|uniprotkb:Histone deacetylase complex subunit Sin3a(gene name synonym)	psi-mi:sds3_mouse(display_long)|uniprotkb:Suppressor of defective silencing 3 protein homolog(gene name synonym)|uniprotkb:Suds3(gene name)|psi-mi:Suds3(display_short)|uniprotkb:Sds3(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Alland et al. (2002)	pubmed:11909966	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-630545	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103820.1|refseq:NP_001103821.1|refseq:NP_035508.2|ensembl:ENSMUSG00000042557(gene)|ensembl:ENSMUST00000049169(transcript)|ensembl:ENSMUST00000167715(transcript)|ensembl:ENSMUST00000168678(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|rcsb pdb:2RMS|reactome:R-MMU-3899300|reactome:R-MMU-400206|reactome:R-MMU-8936459|reactome:R-MMU-9022692|reactome:R-MMU-9707564|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006260"(DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006476"(protein deacetylation)|go:"GO:0007568"(aging)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010817"(regulation of hormone levels)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031937"(obsolete positive regulation of chromatin silencing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0051595"(response to methylglyoxal)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1901675"(negative regulation of histone H3-K27 acetylation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR003822(Paired amphipathic helix)|interpro:IPR013194(Histone deacetylase interacting)|interpro:IPR031693|interpro:IPR036600|interpro:IPR037969|interpro:IPR039774|mint:Q60520|rcsb pdb:1G1E|rcsb pdb:1S5Q|rcsb pdb:1S5R|rcsb pdb:2L9S|rcsb pdb:2LD7|rcsb pdb:2N2H|rcsb pdb:2RMR|refseq:XP_011240985.1|refseq:XP_011240986.1|refseq:XP_011240987.1|refseq:XP_011240988.1|refseq:XP_017168720.1|refseq:XP_006510953.1|refseq:XP_006510954.1|refseq:XP_006510955.1|refseq:XP_006510956.1|dip:DIP-469N	refseq:NP_001116138.1|refseq:NP_848737.3|ensembl:ENSMUSG00000066900(gene)|ensembl:ENSMUST00000086471(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070822"(Sin3-type complex)|interpro:IPR013907(Sds3-like)|mint:Q8BR65|rcsb pdb:2N2H|rcsb pdb:4ZQA|reactome:R-MMU-3214815|reactome:R-MMU-5689880	-	-	-	comment:Both proteins are endogenous.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2005/05/26	2014/10/16	rogid:xd+Wh6NZxejENeiSl5WRDOrVDtc10090	rogid:/OlXuvM/x3P3HVKCiDNOiNBl1rI10090	intact-crc:0982FE8C267E3321|rigid:r6UJRxTzWJIW8oyfqWuZDZZWQVA	false	-	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q8BR65	uniprotkb:Q62141	intact:EBI-591431|uniprotkb:Q3UC92|uniprotkb:Q6P6K1|uniprotkb:Q7TNT0|uniprotkb:Q8BRR7|uniprotkb:Q8K5B4|ensembl:ENSMUSP00000083662	intact:EBI-591450|uniprotkb:O54976|uniprotkb:Q6A013|uniprotkb:Q8VCB8|uniprotkb:Q8VDZ5|ensembl:ENSMUSP00000004494	psi-mi:sds3_mouse(display_long)|uniprotkb:Suppressor of defective silencing 3 protein homolog(gene name synonym)|uniprotkb:Suds3(gene name)|psi-mi:Suds3(display_short)|uniprotkb:Sds3(gene name synonym)	psi-mi:sin3b_mouse(display_long)|uniprotkb:Transcriptional corepressor Sin3b(gene name synonym)|uniprotkb:Histone deacetylase complex subunit Sin3b(gene name synonym)|uniprotkb:Sin3b(gene name)|psi-mi:Sin3b(display_short)|uniprotkb:Kiaa0700(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Alland et al. (2002)	pubmed:11909966	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-630556	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116138.1|refseq:NP_848737.3|ensembl:ENSMUSG00000066900(gene)|ensembl:ENSMUST00000086471(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070822"(Sin3-type complex)|interpro:IPR013907(Sds3-like)|mint:Q8BR65|rcsb pdb:2N2H|rcsb pdb:4ZQA|reactome:R-MMU-3214815|reactome:R-MMU-5689880	refseq:NP_001106719.1|refseq:NP_033214.2|dip:DIP-470N|ensembl:ENSMUSG00000031622(gene)|ensembl:ENSMUST00000004494(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000805"(X chromosome)|go:"GO:0000806"(Y chromosome)|go:"GO:0001741"(XY body)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0016580"(Sin3 complex)|go:"GO:0030849"(autosome)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048738"(cardiac muscle tissue development)|interpro:IPR003822(Paired amphipathic helix)|interpro:IPR013194(Histone deacetylase interacting)|interpro:IPR031693|interpro:IPR036600|interpro:IPR039774|mint:Q62141|rcsb pdb:1E91|rcsb pdb:1PD7|rcsb pdb:2CR7|rcsb pdb:2CZY|rcsb pdb:2F05|rcsb pdb:5Y95|reactome:R-MMU-400206|reactome:R-MMU-8936459|reactome:R-MMU-9707564|go:"GO:0016575"(histone deacetylation)	-	-	-	comment:Displays that interaction between Sds3 and Sin3b occurs in-vivo as well as in-vitro. Deletion of AA 383-550 in Sin3b abolished interaction with Sds3 and other components of the Sin3-complex. Also deletion of AA 188-226 in Sds3 had a similar affect.|comment:Both Sds3 ans Sin3b are overexpressed.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/05/26	2014/10/16	rogid:/OlXuvM/x3P3HVKCiDNOiNBl1rI10090	rogid:RILCV7LIlLhVsSBz43m63WcJ0B810090	intact-crc:8111F9551AB0A711|rigid:aTC6w5QHFn1/1uAoZq56ja2kVeU	false	flag tag:?-?|35s radiolabel:?-?|necessary binding region:188-226	necessary binding region:383-550|35s radiolabel:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)