#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P02340	uniprotkb:P03070	intact:EBI-474016|uniprotkb:Q9QUP3|ensembl:ENSMUSP00000104298	intact:EBI-617698	psi-mi:p53_mouse(display_long)|uniprotkb:Tp53(gene name)|psi-mi:Tp53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Trp53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)	psi-mi:lt_sv40(display_long)	psi-mi:"MI:0231"(mammalian protein protein interaction trap)	Eyckerman et al. (2001)	pubmed:11781573|mint:MINT-6731380	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:1891767(sv40)|taxid:1891767(sv40)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-617704	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000059552(gene)|ensembl:ENSMUST00000108658(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903205"(regulation of hydrogen peroxide-induced cell death)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|mint:P02340|rcsb pdb:1HU8|rcsb pdb:2GEQ|rcsb pdb:2IOI|rcsb pdb:2IOM|rcsb pdb:2IOO|rcsb pdb:2P52|rcsb pdb:3EXJ|rcsb pdb:3EXL|reactome:R-MMU-2559580|reactome:R-MMU-2559584|reactome:R-MMU-2559585|reactome:R-MMU-2559586|reactome:R-MMU-349425|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-5693565|reactome:R-MMU-6804754|reactome:R-MMU-6804756|reactome:R-MMU-6804757|reactome:R-MMU-6804758|reactome:R-MMU-6804759|reactome:R-MMU-6804760|reactome:R-MMU-6811555|reactome:R-MMU-69473|reactome:R-MMU-69481|reactome:R-MMU-69541|reactome:R-MMU-69895|reactome:R-MMU-8852276|reactome:R-MMU-8941855|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007569"(cell aging)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009411"(response to UV)|go:"GO:0009651"(response to salt stress)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010038"(response to metal ion)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033552"(response to vitamin B3)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043200"(response to amino acid)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045471"(response to ethanol)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051276"(chromosome organization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070243"(regulation of thymocyte apoptotic process)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0034644"(cellular response to UV)|refseq:NP_001120705.1|refseq:NP_035770.2|refseq:XP_006533220.1|dip:DIP-369N	go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039576"(suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039686"(bidirectional double-stranded viral DNA replication)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR003133(T antigen, Ori-binding)|interpro:IPR010932(Large T antigen, polyomavirus,  C-terminus)|interpro:IPR016392(Large T antigen, polyomaviridae)|interpro:IPR017910|interpro:IPR027417|interpro:IPR036869|rcsb pdb:1EJL|rcsb pdb:1GH6|rcsb pdb:1N25|rcsb pdb:1Q1S|rcsb pdb:1Q1T|rcsb pdb:1SVL|rcsb pdb:1SVM|rcsb pdb:1SVO|rcsb pdb:1TBD|rcsb pdb:1Z1D|rcsb pdb:2FUF|rcsb pdb:2H1L|rcsb pdb:2IF9|rcsb pdb:2IPR|rcsb pdb:2ITJ|rcsb pdb:2ITL|rcsb pdb:2NL8|rcsb pdb:2NTC|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|rcsb pdb:2TBD|rcsb pdb:3QK2|rcsb pdb:3QN2|rcsb pdb:4E2I|rcsb pdb:4FGN|rcsb pdb:4GDF|rcsb pdb:4RXH|rcsb pdb:5D9I|refseq:YP_003708382.1|mint:P03070|dip:DIP-24251N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/07/08	2019/10/18	rogid:ZU1071LBVm95uqzi6RBNluw8wFo10090	rogid:IMcAp2PRxZXkbJ1eiXhJU9rD2JM1891767	intact-crc:959E8C83EECD20FC|rigid:QldzDSwqOxBPFxZmWq/ncYr1wNw	false	binding-associated region:76-318	binding-associated region:261-708	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62225	uniprotkb:P19235	intact:EBI-617489|ensembl:ENSMUSP00000082183|uniprotkb:Q3TC70	intact:EBI-617321|uniprotkb:Q15443|uniprotkb:Q2M205|uniprotkb:B2RCG4|ensembl:ENSP00000222139	psi-mi:cish_mouse(display_long)|uniprotkb:CIS-1(gene name synonym)|uniprotkb:Suppressor of cytokine signaling(gene name synonym)|uniprotkb:Cish(gene name)|psi-mi:Cish(display_short)|uniprotkb:Cis(gene name synonym)	psi-mi:epor_human(display_long)|uniprotkb:EPOR(gene name)|psi-mi:EPOR(display_short)	psi-mi:"MI:0231"(mammalian protein protein interaction trap)	Eyckerman et al. (2001)	pubmed:11781573|mint:MINT-6731380	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-617720	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000032578(gene)|ensembl:ENSMUST00000085102(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028425|interpro:IPR035887|interpro:IPR036036|interpro:IPR036860|mint:Q62225|reactome:R-MMU-8951664|refseq:NP_034025.1|refseq:NP_001304283.1|dip:DIP-907N	refseq:NP_000112.1|dip:DIP-5732N|rcsb pdb:1ERN|rcsb pdb:2JIX|rcsb pdb:2MV6|rcsb pdb:4Y5V|rcsb pdb:4Y5X|rcsb pdb:4Y5Y|rcsb pdb:6E2Q|rcsb pdb:6MOE|rcsb pdb:6MOF|rcsb pdb:6MOH|rcsb pdb:6MOI|rcsb pdb:6MOJ|rcsb pdb:6MOK|rcsb pdb:6MOL|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|ensembl:ENSG00000187266(gene)|ensembl:ENST00000222139(transcript)|go:"GO:0004900"(erythropoietin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0046697"(decidualization)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR009167(Erythropoietin receptor)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR036116|mint:P19235|rcsb pdb:1CN4|rcsb pdb:1EBA|rcsb pdb:1EBP|rcsb pdb:1EER	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/07/08	2014/10/16	rogid:6VsFfr+LOZZOI8gwptkglukw3Mo10090	rogid:tQiA0I1YOgo0qGcgBDNJKvzkvMg9606	intact-crc:03D45BA294CBDBF9|rigid:PbHqVPuTwjytsp9jknFmiB94k5A	false	-	mutation decreasing interaction:426-426|binding-associated region:369-453	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19235	uniprotkb:O14508	intact:EBI-617321|uniprotkb:Q15443|uniprotkb:Q2M205|uniprotkb:B2RCG4|ensembl:ENSP00000222139	intact:EBI-617737|ensembl:ENSP00000339428|ensembl:ENSP00000442898|ensembl:ENSP00000447161|ensembl:ENSP00000448815|ensembl:ENSP00000449227|ensembl:ENSP00000481249|uniprotkb:O14542|uniprotkb:O95102|uniprotkb:Q9UKS5|uniprotkb:A8K3D1	psi-mi:epor_human(display_long)|uniprotkb:EPOR(gene name)|psi-mi:EPOR(display_short)	psi-mi:socs2_human(display_long)|uniprotkb:Cytokine-inducible SH2 protein 2(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 2(gene name synonym)|uniprotkb:CIS2(gene name synonym)|uniprotkb:SSI2(gene name synonym)|uniprotkb:STATI2(gene name synonym)|uniprotkb:SOCS2(gene name)|psi-mi:SOCS2(display_short)	psi-mi:"MI:0231"(mammalian protein protein interaction trap)	Eyckerman et al. (2001)	pubmed:11781573|mint:MINT-6731380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-617778	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000112.1|dip:DIP-5732N|rcsb pdb:1ERN|rcsb pdb:2JIX|rcsb pdb:2MV6|rcsb pdb:4Y5V|rcsb pdb:4Y5X|rcsb pdb:4Y5Y|rcsb pdb:6E2Q|rcsb pdb:6MOE|rcsb pdb:6MOF|rcsb pdb:6MOH|rcsb pdb:6MOI|rcsb pdb:6MOJ|rcsb pdb:6MOK|rcsb pdb:6MOL|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|ensembl:ENSG00000187266(gene)|ensembl:ENST00000222139(transcript)|go:"GO:0004900"(erythropoietin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0046697"(decidualization)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR009167(Erythropoietin receptor)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR036116|mint:P19235|rcsb pdb:1CN4|rcsb pdb:1EBA|rcsb pdb:1EBP|rcsb pdb:1EER	ensembl:ENSG00000120833(gene)|ensembl:ENST00000340600(transcript)|ensembl:ENST00000536696(transcript)|ensembl:ENST00000549122(transcript)|ensembl:ENST00000551556(transcript)|ensembl:ENST00000622746(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007595"(lactation)|go:"GO:0008269"(JAK pathway signal transduction adaptor activity)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060749"(mammary gland alveolus development)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028410|interpro:IPR035862|interpro:IPR036036|interpro:IPR036860|mint:O14508|ensembl:ENST00000549206(transcript)|rcsb pdb:2C9W|rcsb pdb:4JGH|rcsb pdb:5BO4|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|reactome:R-HSA-1266695|reactome:R-HSA-8951664|reactome:R-HSA-9706369|reactome:R-HSA-982772|refseq:NP_003868.1|refseq:NP_001257396.1|refseq:NP_001257397.1|refseq:NP_001257398.1|refseq:NP_001257399.1|refseq:NP_001257400.1|refseq:XP_016875645.1|dip:DIP-29569N	-	-	-	caution:SOCS2 described as fragment but no detail given|agonist:Erythropoietin|resulting-ptm:Phosphorylation of SOCS2 - dependent on treatment of cells with erythropoietin|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/07/08	2014/10/16	rogid:tQiA0I1YOgo0qGcgBDNJKvzkvMg9606	rogid:vh/FSp+KisXm9YDUkf26UU7ucgI9606	intact-crc:14785CF149AAF1B7|rigid:Tn9xQqsqZBGBJREHYrDBIQ6iWok	false	binding-associated region:369-453|mutation decreasing interaction:426-426	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14508	uniprotkb:P19235	intact:EBI-617737|ensembl:ENSP00000339428|ensembl:ENSP00000442898|ensembl:ENSP00000447161|ensembl:ENSP00000448815|ensembl:ENSP00000449227|ensembl:ENSP00000481249|uniprotkb:O14542|uniprotkb:O95102|uniprotkb:Q9UKS5|uniprotkb:A8K3D1	intact:EBI-617321|uniprotkb:Q15443|uniprotkb:Q2M205|uniprotkb:B2RCG4|ensembl:ENSP00000222139	psi-mi:socs2_human(display_long)|uniprotkb:Cytokine-inducible SH2 protein 2(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 2(gene name synonym)|uniprotkb:CIS2(gene name synonym)|uniprotkb:SSI2(gene name synonym)|uniprotkb:STATI2(gene name synonym)|uniprotkb:SOCS2(gene name)|psi-mi:SOCS2(display_short)	psi-mi:epor_human(display_long)|uniprotkb:EPOR(gene name)|psi-mi:EPOR(display_short)	psi-mi:"MI:0231"(mammalian protein protein interaction trap)	Eyckerman et al. (2001)	pubmed:11781573|mint:MINT-6731380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-617821	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000120833(gene)|ensembl:ENST00000340600(transcript)|ensembl:ENST00000536696(transcript)|ensembl:ENST00000549122(transcript)|ensembl:ENST00000551556(transcript)|ensembl:ENST00000622746(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007595"(lactation)|go:"GO:0008269"(JAK pathway signal transduction adaptor activity)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060749"(mammary gland alveolus development)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028410|interpro:IPR035862|interpro:IPR036036|interpro:IPR036860|mint:O14508|ensembl:ENST00000549206(transcript)|rcsb pdb:2C9W|rcsb pdb:4JGH|rcsb pdb:5BO4|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|reactome:R-HSA-1266695|reactome:R-HSA-8951664|reactome:R-HSA-9706369|reactome:R-HSA-982772|refseq:NP_003868.1|refseq:NP_001257396.1|refseq:NP_001257397.1|refseq:NP_001257398.1|refseq:NP_001257399.1|refseq:NP_001257400.1|refseq:XP_016875645.1|dip:DIP-29569N	refseq:NP_000112.1|dip:DIP-5732N|rcsb pdb:1ERN|rcsb pdb:2JIX|rcsb pdb:2MV6|rcsb pdb:4Y5V|rcsb pdb:4Y5X|rcsb pdb:4Y5Y|rcsb pdb:6E2Q|rcsb pdb:6MOE|rcsb pdb:6MOF|rcsb pdb:6MOH|rcsb pdb:6MOI|rcsb pdb:6MOJ|rcsb pdb:6MOK|rcsb pdb:6MOL|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|ensembl:ENSG00000187266(gene)|ensembl:ENST00000222139(transcript)|go:"GO:0004900"(erythropoietin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0046697"(decidualization)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR009167(Erythropoietin receptor)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR036116|mint:P19235|rcsb pdb:1CN4|rcsb pdb:1EBA|rcsb pdb:1EBP|rcsb pdb:1EER	-	-	-	caution:SOCS2 described as fragment but no detail given|agonist:Erythropoietin|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/07/08	2014/10/16	rogid:vh/FSp+KisXm9YDUkf26UU7ucgI9606	rogid:tQiA0I1YOgo0qGcgBDNJKvzkvMg9606	intact-crc:49F89E94F325520C|rigid:Tn9xQqsqZBGBJREHYrDBIQ6iWok	false	-	binding-associated region:369-453	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O14508	uniprotkb:P19235	intact:EBI-617737|ensembl:ENSP00000339428|ensembl:ENSP00000442898|ensembl:ENSP00000447161|ensembl:ENSP00000448815|ensembl:ENSP00000449227|ensembl:ENSP00000481249|uniprotkb:O14542|uniprotkb:O95102|uniprotkb:Q9UKS5|uniprotkb:A8K3D1	intact:EBI-617321|uniprotkb:Q15443|uniprotkb:Q2M205|uniprotkb:B2RCG4|ensembl:ENSP00000222139	psi-mi:socs2_human(display_long)|uniprotkb:Cytokine-inducible SH2 protein 2(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 2(gene name synonym)|uniprotkb:CIS2(gene name synonym)|uniprotkb:SSI2(gene name synonym)|uniprotkb:STATI2(gene name synonym)|uniprotkb:SOCS2(gene name)|psi-mi:SOCS2(display_short)	psi-mi:epor_human(display_long)|uniprotkb:EPOR(gene name)|psi-mi:EPOR(display_short)	psi-mi:"MI:0231"(mammalian protein protein interaction trap)	Eyckerman et al. (2001)	pubmed:11781573|mint:MINT-6731380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-617845	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000120833(gene)|ensembl:ENST00000340600(transcript)|ensembl:ENST00000536696(transcript)|ensembl:ENST00000549122(transcript)|ensembl:ENST00000551556(transcript)|ensembl:ENST00000622746(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007595"(lactation)|go:"GO:0008269"(JAK pathway signal transduction adaptor activity)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060749"(mammary gland alveolus development)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028410|interpro:IPR035862|interpro:IPR036036|interpro:IPR036860|mint:O14508|ensembl:ENST00000549206(transcript)|rcsb pdb:2C9W|rcsb pdb:4JGH|rcsb pdb:5BO4|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|reactome:R-HSA-1266695|reactome:R-HSA-8951664|reactome:R-HSA-9706369|reactome:R-HSA-982772|refseq:NP_003868.1|refseq:NP_001257396.1|refseq:NP_001257397.1|refseq:NP_001257398.1|refseq:NP_001257399.1|refseq:NP_001257400.1|refseq:XP_016875645.1|dip:DIP-29569N	refseq:NP_000112.1|dip:DIP-5732N|rcsb pdb:1ERN|rcsb pdb:2JIX|rcsb pdb:2MV6|rcsb pdb:4Y5V|rcsb pdb:4Y5X|rcsb pdb:4Y5Y|rcsb pdb:6E2Q|rcsb pdb:6MOE|rcsb pdb:6MOF|rcsb pdb:6MOH|rcsb pdb:6MOI|rcsb pdb:6MOJ|rcsb pdb:6MOK|rcsb pdb:6MOL|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|ensembl:ENSG00000187266(gene)|ensembl:ENST00000222139(transcript)|go:"GO:0004900"(erythropoietin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0046697"(decidualization)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR009167(Erythropoietin receptor)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR036116|mint:P19235|rcsb pdb:1CN4|rcsb pdb:1EBA|rcsb pdb:1EBP|rcsb pdb:1EER	-	-	-	agonist:Erythropoietin|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-tf1)|taxid:9606(Human erythroleukaemia TF1 cells)	-	2005/07/08	2014/10/16	rogid:vh/FSp+KisXm9YDUkf26UU7ucgI9606	rogid:tQiA0I1YOgo0qGcgBDNJKvzkvMg9606	intact-crc:FC08F6C4C669B8BC|rigid:Tn9xQqsqZBGBJREHYrDBIQ6iWok	false	-	binding-associated region:369-453	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NSE2	uniprotkb:P19235	intact:EBI-617866|uniprotkb:Q9NS38|uniprotkb:Q9Y5R1|uniprotkb:B2R9N1|uniprotkb:G5E9R1|ensembl:ENSP00000294173	intact:EBI-617321|uniprotkb:Q15443|uniprotkb:Q2M205|uniprotkb:B2RCG4|ensembl:ENSP00000222139	psi-mi:cish_human(display_long)|uniprotkb:CIS-1(gene name synonym)|uniprotkb:Suppressor of cytokine signaling(gene name synonym)|uniprotkb:Protein G18(gene name synonym)|uniprotkb:CISH(gene name)|psi-mi:CISH(display_short)|uniprotkb:G18(gene name synonym)	psi-mi:epor_human(display_long)|uniprotkb:EPOR(gene name)|psi-mi:EPOR(display_short)	psi-mi:"MI:0231"(mammalian protein protein interaction trap)	Eyckerman et al. (2001)	pubmed:11781573|mint:MINT-6731380	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-617859	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_037456.5|refseq:NP_659508.1|refseq:XP_011531631.1|ensembl:ENSG00000114737(gene)|ensembl:ENST00000348721(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028425|interpro:IPR035887|interpro:IPR036036|interpro:IPR036860|mint:Q9NSE2|reactome:R-HSA-1266695|reactome:R-HSA-8951664|reactome:R-HSA-982772	refseq:NP_000112.1|dip:DIP-5732N|rcsb pdb:1ERN|rcsb pdb:2JIX|rcsb pdb:2MV6|rcsb pdb:4Y5V|rcsb pdb:4Y5X|rcsb pdb:4Y5Y|rcsb pdb:6E2Q|rcsb pdb:6MOE|rcsb pdb:6MOF|rcsb pdb:6MOH|rcsb pdb:6MOI|rcsb pdb:6MOJ|rcsb pdb:6MOK|rcsb pdb:6MOL|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|ensembl:ENSG00000187266(gene)|ensembl:ENST00000222139(transcript)|go:"GO:0004900"(erythropoietin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0046697"(decidualization)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR009167(Erythropoietin receptor)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR036116|mint:P19235|rcsb pdb:1CN4|rcsb pdb:1EBA|rcsb pdb:1EBP|rcsb pdb:1EER	-	-	-	agonist:Erythropoietin|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-tf1)|taxid:9606(Human erythroleukaemia TF1 cells)	-	2005/07/08	2014/10/16	rogid:NnfVh2fsTGqxfR+nBBPR4xtdHZg9606	rogid:tQiA0I1YOgo0qGcgBDNJKvzkvMg9606	intact-crc:7C5F841216A11CBC|rigid:DwO5I+3bwvU14Pi3E/ynRnwvZrM	false	-	binding-associated region:369-453	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)