#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9DE30 uniprotkb:O42579 intact:EBI-7989725|intact:MINT-216462 intact:EBI-7989741|intact:MINT-216470 psi-mi:q9de30_xenla(display_long)|uniprotkb:gipc1.L(gene name)|psi-mi:gipc1.L(display_short)|uniprotkb:Kermit(gene name synonym)|uniprotkb:gipc1(gene name synonym)|uniprotkb:XELAEV_18018952mg(orf name) psi-mi:fzd3_xenla(display_long)|uniprotkb:fzd3(gene name)|psi-mi:fzd3(display_short)|uniprotkb:fz3(gene name synonym) psi-mi:"MI:0096"(pull down) Tan et al. (2001) pubmed:11585793|mint:MINT-5214638 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7989735|mint:MINT-62464 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_018106303.1|refseq:NP_001082063.1|interpro:IPR017379(Uncharacterised conserved protein UCP038083, PDZ)|interpro:IPR036034|interpro:IPR001478(PDZ/DHR/GLGF)|mint:MINT-590902(identity) refseq:NP_001083918.1|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026553|interpro:IPR036790|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0007399"(nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0014036"(neural crest cell fate specification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042813"(Wnt-activated receptor activity)|interpro:IPR000539(Frizzled protein)|interpro:IPR041769|mint:MINT-590911(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt8|comment:"Stoichiometry: 1.0" figure legend:F5A|comment:"The same experiments showed that Kermit binds weaklyto the C terminus of Xfz7 confirming the Two hybrids results reported in the same paper (mint_ 62454)"|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/09/16 2014/10/16 rogid:2IjLXDSKHgUDvLdsBTqHnSglPBM8355 rogid:gy45UesPRCdw3shpcMbY3EKGctY8355 intact-crc:0EA6057417F484FA|rigid:DrCgMLp1nDO3wiu43g3RCcfxdQk false binding-associated region:128-217(MINT-590903)|tag:?-?(MINT-590906) binding-associated region:499-664(MINT-590912)|tag:?-?(MINT-590915) - - psi-mi:"MI:0056"(full identification by DNA sequencing) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9DE30 uniprotkb:O42579 intact:EBI-7989725|intact:MINT-216462 intact:EBI-7989741|intact:MINT-216470 psi-mi:q9de30_xenla(display_long)|uniprotkb:gipc1.L(gene name)|psi-mi:gipc1.L(display_short)|uniprotkb:Kermit(gene name synonym)|uniprotkb:gipc1(gene name synonym)|uniprotkb:XELAEV_18018952mg(orf name) psi-mi:fzd3_xenla(display_long)|uniprotkb:fzd3(gene name)|psi-mi:fzd3(display_short)|uniprotkb:fz3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tan et al. (2001) pubmed:11585793|mint:MINT-5214638 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7989854|mint:MINT-62465 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_018106303.1|refseq:NP_001082063.1|interpro:IPR017379(Uncharacterised conserved protein UCP038083, PDZ)|interpro:IPR036034|interpro:IPR001478(PDZ/DHR/GLGF)|mint:MINT-590927(identity) refseq:NP_001083918.1|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026553|interpro:IPR036790|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0007399"(nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0014036"(neural crest cell fate specification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042813"(Wnt-activated receptor activity)|interpro:IPR000539(Frizzled protein)|interpro:IPR041769|mint:MINT-590936(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt8|comment:"Stoichiometry: 1.0" figure legend:F5B|comment:Kermit was myc tagged, Fz3 was GST tagged.
Both proteins were co-expressed in Xenopus embryos.|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/09/16 2014/10/16 rogid:2IjLXDSKHgUDvLdsBTqHnSglPBM8355 rogid:gy45UesPRCdw3shpcMbY3EKGctY8355 intact-crc:464497856DC27821|rigid:DrCgMLp1nDO3wiu43g3RCcfxdQk false tag:?-?(MINT-590931)|binding-associated region:128-217(MINT-590928) binding-associated region:499-664(MINT-590937)|tag:?-?(MINT-590940) - - psi-mi:"MI:0056"(full identification by DNA sequencing) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:O42579 uniprotkb:Q9DE30 intact:EBI-7989741|intact:MINT-216470 intact:EBI-7989725|intact:MINT-216462 psi-mi:fzd3_xenla(display_long)|uniprotkb:fzd3(gene name)|psi-mi:fzd3(display_short)|uniprotkb:fz3(gene name synonym) psi-mi:q9de30_xenla(display_long)|uniprotkb:gipc1.L(gene name)|psi-mi:gipc1.L(display_short)|uniprotkb:Kermit(gene name synonym)|uniprotkb:gipc1(gene name synonym)|uniprotkb:XELAEV_18018952mg(orf name) psi-mi:"MI:0018"(two hybrid) Tan et al. (2001) pubmed:11585793|mint:MINT-5214638 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7989904|mint:MINT-62454 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001083918.1|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026553|interpro:IPR036790|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0007399"(nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0014036"(neural crest cell fate specification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042813"(Wnt-activated receptor activity)|interpro:IPR000539(Frizzled protein)|interpro:IPR041769|mint:MINT-590961(identity) refseq:XP_018106303.1|refseq:NP_001082063.1|interpro:IPR017379(Uncharacterised conserved protein UCP038083, PDZ)|interpro:IPR036034|interpro:IPR001478(PDZ/DHR/GLGF)|mint:MINT-590952(identity) - comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt8|comment:"Stoichiometry: 1.0" comment:mint|comment:"Stoichiometry: 1.0" figure legend:F4|comment:"Kermit distinguishes between frizzled C-termini, since it interacts (decribed in this entry) more strongly with Xfz3 than Xfz7 C terminus, and not at all with Xfz8 C terminus."|comment:"growth speed: +++"|comment:mint taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2005/09/16 2014/10/16 rogid:gy45UesPRCdw3shpcMbY3EKGctY8355 rogid:2IjLXDSKHgUDvLdsBTqHnSglPBM8355 intact-crc:4B765A5680EB15F0|rigid:DrCgMLp1nDO3wiu43g3RCcfxdQk false binding-associated region:499-664(MINT-590962)|tag:?-?(MINT-590965) tag:?-?(MINT-590956)|binding-associated region:128-217(MINT-590953) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O42579 uniprotkb:Q9DE30 intact:EBI-7989741|intact:MINT-216470 intact:EBI-7989725|intact:MINT-216462 psi-mi:fzd3_xenla(display_long)|uniprotkb:fzd3(gene name)|psi-mi:fzd3(display_short)|uniprotkb:fz3(gene name synonym) psi-mi:q9de30_xenla(display_long)|uniprotkb:gipc1.L(gene name)|psi-mi:gipc1.L(display_short)|uniprotkb:Kermit(gene name synonym)|uniprotkb:gipc1(gene name synonym)|uniprotkb:XELAEV_18018952mg(orf name) psi-mi:"MI:0018"(two hybrid) Tan et al. (2001) pubmed:11585793|mint:MINT-5214638 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7989932|mint:MINT-62455 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001083918.1|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026553|interpro:IPR036790|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0007399"(nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0014036"(neural crest cell fate specification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042813"(Wnt-activated receptor activity)|interpro:IPR000539(Frizzled protein)|interpro:IPR041769|mint:MINT-590985(identity) refseq:XP_018106303.1|refseq:NP_001082063.1|interpro:IPR017379(Uncharacterised conserved protein UCP038083, PDZ)|interpro:IPR036034|interpro:IPR001478(PDZ/DHR/GLGF)|mint:MINT-590976(identity) - comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt8|comment:"Stoichiometry: 1.0" comment:mint|comment:"Stoichiometry: 1.0" figure legend:F4A|comment:mint taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2005/09/16 2014/10/16 rogid:gy45UesPRCdw3shpcMbY3EKGctY8355 rogid:2IjLXDSKHgUDvLdsBTqHnSglPBM8355 intact-crc:BF01A942FCF5EA92|rigid:DrCgMLp1nDO3wiu43g3RCcfxdQk false binding-associated region:499-664(MINT-590986)|tag:?-?(MINT-590989) binding-associated region:128-217(MINT-590977)|tag:?-?(MINT-590980) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)