#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P08588	uniprotkb:Q86UL8	intact:EBI-991009|uniprotkb:Q9UKG7|uniprotkb:Q9UKG8|ensembl:ENSP00000358301|uniprotkb:B0LPE2|uniprotkb:Q5T5Y4	intact:EBI-311035|uniprotkb:O60434|uniprotkb:O60510|uniprotkb:Q86UI7|uniprotkb:Q9NP44|uniprotkb:Q9UDQ5|uniprotkb:Q9UDU1|uniprotkb:A4D1C1|uniprotkb:A7E2C3|intact:EBI-28973920|ensembl:ENSP00000346151	psi-mi:adrb1_human(display_long)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)|uniprotkb:ADRB1(gene name)|psi-mi:ADRB1(display_short)|uniprotkb:ADRB1R(gene name synonym)|uniprotkb:B1AR(gene name synonym)	psi-mi:magi2_human(display_long)|uniprotkb:MAGI2(gene name)|psi-mi:MAGI2(display_short)|uniprotkb:KIAA0705(gene name synonym)|uniprotkb:ACVRINP1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)|uniprotkb:Atrophin-1-interacting protein A(gene name synonym)|uniprotkb:AIP1(gene name synonym)	psi-mi:"MI:0045"(experimental interaction detection)	Xu et al. (2001)	pubmed:11526121|mint:MINT-5214450	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7941357|mint:MINT-58358	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000675.1|ensembl:ENSG00000043591(gene)|ensembl:ENST00000369295(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0009409"(response to cold)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042596"(fear response)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2LSQ|rcsb pdb:7BTS|rcsb pdb:7BU6|rcsb pdb:7BU7|rcsb pdb:7BVQ|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821|dip:DIP-36294N|mint:MINT-585877(identity)	ensembl:ENSP00000346151|ensembl:ENST00000419488|ensembl:ENSP00000405766|refseq:NP_036433.2|refseq:NP_001288057.1|ensembl:ENSG00000187391(gene)|ensembl:ENST00000354212(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003402"(planar cell polarity pathway involved in axis elongation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030036|interpro:IPR036020|interpro:IPR036034|mint:Q86UL8|rcsb pdb:1UEP|rcsb pdb:1UEQ|rcsb pdb:1UEW|rcsb pdb:1UJV|rcsb pdb:1WFV|reactome:R-HSA-373753|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043113"(receptor clustering)|mint:MINT-585867(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2D|kd:10 nanomolar|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/05/12	2014/10/16	rogid:WwGqJMzG+4OiJNDRpX2GJ/HPV449606	rogid:/uTMSMqB1wrlyHj2P9OVVBCpWcY9606	intact-crc:5353C65C484734D8|rigid:ydRzigsmpv88IgICJqz2pVWePKU	false	binding-associated region:377-477(MINT-585878)|tag:?-?(MINT-585881)	tag:?-?(MINT-585872)|binding-associated region:420-559(MINT-585868)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P08588	uniprotkb:Q86UL8	intact:EBI-991009|uniprotkb:Q9UKG7|uniprotkb:Q9UKG8|ensembl:ENSP00000358301|uniprotkb:B0LPE2|uniprotkb:Q5T5Y4	intact:EBI-311035|uniprotkb:O60434|uniprotkb:O60510|uniprotkb:Q86UI7|uniprotkb:Q9NP44|uniprotkb:Q9UDQ5|uniprotkb:Q9UDU1|uniprotkb:A4D1C1|uniprotkb:A7E2C3|intact:EBI-28973920|ensembl:ENSP00000346151	psi-mi:adrb1_human(display_long)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)|uniprotkb:ADRB1(gene name)|psi-mi:ADRB1(display_short)|uniprotkb:ADRB1R(gene name synonym)|uniprotkb:B1AR(gene name synonym)	psi-mi:magi2_human(display_long)|uniprotkb:MAGI2(gene name)|psi-mi:MAGI2(display_short)|uniprotkb:KIAA0705(gene name synonym)|uniprotkb:ACVRINP1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)|uniprotkb:Atrophin-1-interacting protein A(gene name synonym)|uniprotkb:AIP1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Xu et al. (2001)	pubmed:11526121|mint:MINT-5214450	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7941457|mint:MINT-58357	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000675.1|ensembl:ENSG00000043591(gene)|ensembl:ENST00000369295(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0009409"(response to cold)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042596"(fear response)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2LSQ|rcsb pdb:7BTS|rcsb pdb:7BU6|rcsb pdb:7BU7|rcsb pdb:7BVQ|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821|dip:DIP-36294N|mint:MINT-585931(identity)	ensembl:ENSP00000346151|ensembl:ENST00000419488|ensembl:ENSP00000405766|refseq:NP_036433.2|refseq:NP_001288057.1|ensembl:ENSG00000187391(gene)|ensembl:ENST00000354212(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003402"(planar cell polarity pathway involved in axis elongation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030036|interpro:IPR036020|interpro:IPR036034|mint:Q86UL8|rcsb pdb:1UEP|rcsb pdb:1UEQ|rcsb pdb:1UEW|rcsb pdb:1UJV|rcsb pdb:1WFV|reactome:R-HSA-373753|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043113"(receptor clustering)|mint:MINT-585921(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:"GST tagged Betha receptor<br><br>His Tagged Magi<br><br><br><br>see also PMID: 10995758<br><br>These studies were carried out in conjunction with yeast two-hybrid screens of a brain cDNA library utilizing the 1AR-CT as bait. The yeast two-hybrid screens, as previously described (PMID: 10995758), yielded two interacting clones corresponding to overlapping regions of PSD-95, a brain-specific protein of 95 kDa."|figure legend:F1 F2A|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/05/12	2014/10/16	rogid:WwGqJMzG+4OiJNDRpX2GJ/HPV449606	rogid:/uTMSMqB1wrlyHj2P9OVVBCpWcY9606	intact-crc:6B510BD06A644C75|rigid:ydRzigsmpv88IgICJqz2pVWePKU	false	binding-associated region:377-477(MINT-585932)|tag:?-?(MINT-585935)	tag:?-?(MINT-585926)|binding-associated region:420-559(MINT-585922)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q86UL8	uniprotkb:P08588	intact:EBI-311035|uniprotkb:O60434|uniprotkb:O60510|uniprotkb:Q86UI7|uniprotkb:Q9NP44|uniprotkb:Q9UDQ5|uniprotkb:Q9UDU1|uniprotkb:A4D1C1|uniprotkb:A7E2C3|intact:EBI-28973920|ensembl:ENSP00000346151	intact:EBI-991009|uniprotkb:Q9UKG7|uniprotkb:Q9UKG8|ensembl:ENSP00000358301|uniprotkb:B0LPE2|uniprotkb:Q5T5Y4	psi-mi:magi2_human(display_long)|uniprotkb:MAGI2(gene name)|psi-mi:MAGI2(display_short)|uniprotkb:KIAA0705(gene name synonym)|uniprotkb:ACVRINP1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)|uniprotkb:Atrophin-1-interacting protein A(gene name synonym)|uniprotkb:AIP1(gene name synonym)	psi-mi:adrb1_human(display_long)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)|uniprotkb:ADRB1(gene name)|psi-mi:ADRB1(display_short)|uniprotkb:ADRB1R(gene name synonym)|uniprotkb:B1AR(gene name synonym)	psi-mi:"MI:0096"(pull down)	Xu et al. (2001)	pubmed:11526121|mint:MINT-5214450	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7941535|mint:MINT-58359	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000346151|ensembl:ENST00000419488|ensembl:ENSP00000405766|refseq:NP_036433.2|refseq:NP_001288057.1|ensembl:ENSG00000187391(gene)|ensembl:ENST00000354212(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003402"(planar cell polarity pathway involved in axis elongation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030036|interpro:IPR036020|interpro:IPR036034|mint:Q86UL8|rcsb pdb:1UEP|rcsb pdb:1UEQ|rcsb pdb:1UEW|rcsb pdb:1UJV|rcsb pdb:1WFV|reactome:R-HSA-373753|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043113"(receptor clustering)|mint:MINT-585893(identity)	refseq:NP_000675.1|ensembl:ENSG00000043591(gene)|ensembl:ENST00000369295(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0009409"(response to cold)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042596"(fear response)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2LSQ|rcsb pdb:7BTS|rcsb pdb:7BU6|rcsb pdb:7BU7|rcsb pdb:7BVQ|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821|dip:DIP-36294N|mint:MINT-585903(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3|comment:MAGI-2 is His tagged|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/05/12	2014/10/16	rogid:/uTMSMqB1wrlyHj2P9OVVBCpWcY9606	rogid:WwGqJMzG+4OiJNDRpX2GJ/HPV449606	intact-crc:E97A2829608C9605|rigid:ydRzigsmpv88IgICJqz2pVWePKU	false	binding-associated region:420-559(MINT-585894)|tag:?-?(MINT-585898)	tag:?-?(MINT-585911)|mutation decreasing interaction:475-475,477-477,476-476(MINT-585907)|binding-associated region:472-477(MINT-585904)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q86UL8	uniprotkb:P08588	intact:EBI-311035|uniprotkb:O60434|uniprotkb:O60510|uniprotkb:Q86UI7|uniprotkb:Q9NP44|uniprotkb:Q9UDQ5|uniprotkb:Q9UDU1|uniprotkb:A4D1C1|uniprotkb:A7E2C3|intact:EBI-28973920|ensembl:ENSP00000346151	intact:EBI-991009|uniprotkb:Q9UKG7|uniprotkb:Q9UKG8|ensembl:ENSP00000358301|uniprotkb:B0LPE2|uniprotkb:Q5T5Y4	psi-mi:magi2_human(display_long)|uniprotkb:MAGI2(gene name)|psi-mi:MAGI2(display_short)|uniprotkb:KIAA0705(gene name synonym)|uniprotkb:ACVRINP1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)|uniprotkb:Atrophin-1-interacting protein A(gene name synonym)|uniprotkb:AIP1(gene name synonym)	psi-mi:adrb1_human(display_long)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)|uniprotkb:ADRB1(gene name)|psi-mi:ADRB1(display_short)|uniprotkb:ADRB1R(gene name synonym)|uniprotkb:B1AR(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Xu et al. (2001)	pubmed:11526121|mint:MINT-5214450	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7941657|mint:MINT-58361	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000346151|ensembl:ENST00000419488|ensembl:ENSP00000405766|refseq:NP_036433.2|refseq:NP_001288057.1|ensembl:ENSG00000187391(gene)|ensembl:ENST00000354212(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003402"(planar cell polarity pathway involved in axis elongation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030036|interpro:IPR036020|interpro:IPR036034|mint:Q86UL8|rcsb pdb:1UEP|rcsb pdb:1UEQ|rcsb pdb:1UEW|rcsb pdb:1UJV|rcsb pdb:1WFV|reactome:R-HSA-373753|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043113"(receptor clustering)|mint:MINT-585947(identity)	refseq:NP_000675.1|ensembl:ENSG00000043591(gene)|ensembl:ENST00000369295(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0009409"(response to cold)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042596"(fear response)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2LSQ|rcsb pdb:7BTS|rcsb pdb:7BU6|rcsb pdb:7BU7|rcsb pdb:7BVQ|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821|dip:DIP-36294N|mint:MINT-585954(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5|comment:homomint|comment:mint	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/05/12	2014/10/16	rogid:/uTMSMqB1wrlyHj2P9OVVBCpWcY9606	rogid:WwGqJMzG+4OiJNDRpX2GJ/HPV449606	intact-crc:9BFBE3F53086D436|rigid:ydRzigsmpv88IgICJqz2pVWePKU	false	tag:?-?(MINT-585948)	tag:?-?(MINT-585955)	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)
uniprotkb:P08588	uniprotkb:Q86UL8	intact:EBI-991009|uniprotkb:Q9UKG7|uniprotkb:Q9UKG8|ensembl:ENSP00000358301|uniprotkb:B0LPE2|uniprotkb:Q5T5Y4	intact:EBI-311035|uniprotkb:O60434|uniprotkb:O60510|uniprotkb:Q86UI7|uniprotkb:Q9NP44|uniprotkb:Q9UDQ5|uniprotkb:Q9UDU1|uniprotkb:A4D1C1|uniprotkb:A7E2C3|intact:EBI-28973920|ensembl:ENSP00000346151	psi-mi:adrb1_human(display_long)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)|uniprotkb:ADRB1(gene name)|psi-mi:ADRB1(display_short)|uniprotkb:ADRB1R(gene name synonym)|uniprotkb:B1AR(gene name synonym)	psi-mi:magi2_human(display_long)|uniprotkb:MAGI2(gene name)|psi-mi:MAGI2(display_short)|uniprotkb:KIAA0705(gene name synonym)|uniprotkb:ACVRINP1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)|uniprotkb:Atrophin-1-interacting protein A(gene name synonym)|uniprotkb:AIP1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xu et al. (2001)	pubmed:11526121|mint:MINT-5214450	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7941722|mint:MINT-58360	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000675.1|ensembl:ENSG00000043591(gene)|ensembl:ENST00000369295(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0009409"(response to cold)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042596"(fear response)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2LSQ|rcsb pdb:7BTS|rcsb pdb:7BU6|rcsb pdb:7BU7|rcsb pdb:7BVQ|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821|dip:DIP-36294N|mint:MINT-585977(identity)	ensembl:ENSP00000346151|ensembl:ENST00000419488|ensembl:ENSP00000405766|refseq:NP_036433.2|refseq:NP_001288057.1|ensembl:ENSG00000187391(gene)|ensembl:ENST00000354212(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003402"(planar cell polarity pathway involved in axis elongation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030036|interpro:IPR036020|interpro:IPR036034|mint:Q86UL8|rcsb pdb:1UEP|rcsb pdb:1UEQ|rcsb pdb:1UEW|rcsb pdb:1UJV|rcsb pdb:1WFV|reactome:R-HSA-373753|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043113"(receptor clustering)|mint:MINT-585967(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4|comment:flag tagged betha receptor<br><br>His tagged MAGI-2|comment:homomint|comment:mint	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/05/12	2014/10/16	rogid:WwGqJMzG+4OiJNDRpX2GJ/HPV449606	rogid:/uTMSMqB1wrlyHj2P9OVVBCpWcY9606	intact-crc:64D1C580753FC0E5|rigid:ydRzigsmpv88IgICJqz2pVWePKU	false	binding-associated region:472-477(MINT-585978)|tag:?-?(MINT-585981)	tag:?-?(MINT-585972)|binding-associated region:420-559(MINT-585968)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)