#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P16118	uniprotkb:P35557	intact:EBI-709807|ensembl:ENSP00000364145|uniprotkb:Q5JXS5|uniprotkb:B2RA88|uniprotkb:Q99951|uniprotkb:B4DUN5	intact:EBI-709928|uniprotkb:Q05810|uniprotkb:A4D2J3|uniprotkb:A4D2J2|ensembl:ENSP00000384247	psi-mi:f261_human(display_long)|uniprotkb:6PF-2-K/Fru-2,6-P2ase liver isozyme(gene name synonym)|uniprotkb:PFKFB1(gene name)|psi-mi:PFKFB1(display_short)|uniprotkb:F6PK(gene name synonym)|uniprotkb:PFRX(gene name synonym)	psi-mi:hxk4_human(display_long)|uniprotkb:Hexokinase type IV(gene name synonym)|uniprotkb:Hexokinase-D(gene name synonym)|uniprotkb:GCK(gene name)|psi-mi:GCK(display_short)|uniprotkb:Glucokinase(gene name synonym)	psi-mi:"MI:0084"(phage display)	Baltrusch et al. (2001)	pubmed:11522786	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709993	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002616.2|ensembl:ENSG00000158571(gene)|ensembl:ENST00000375006(transcript)|go:"GO:0003873"(6-phosphofructo-2-kinase activity)|go:"GO:0004331"(fructose-2,6-bisphosphate 2-phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006003"(fructose 2,6-bisphosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032868"(response to insulin)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0033762"(response to glucagon)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043540"(6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0070095"(fructose-6-phosphate binding)|interpro:IPR001345(Phosphoglycerate/bisphosphoglycerate mutase)|interpro:IPR003094(Fructose-2,6-bisphosphatase)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR013079(6-phosphofructo-2-kinase)|interpro:IPR027417|interpro:IPR029033|rcsb pdb:1K6M|reactome:R-HSA-163358|reactome:R-HSA-163767|reactome:R-HSA-9634600|refseq:NP_001258733.1|refseq:NP_001258734.1	refseq:NP_000153.1|refseq:NP_277042.1|refseq:NP_277043.1|reactome:R-HSA-210745|reactome:R-HSA-5619073|reactome:R-HSA-5619107|reactome:R-HSA-70171|reactome:R-HSA-9615017|ensembl:ENSG00000106633(gene)|ensembl:ENST00000403799(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004340"(glucokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005536"(glucose binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006096"(glycolytic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0008865"(fructokinase activity)|go:"GO:0019158"(mannokinase activity)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0051594"(detection of glucose)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070509"(calcium ion import)|interpro:IPR001312(Hexokinase)|interpro:IPR019807|interpro:IPR022672|interpro:IPR022673|interpro:IPR039073|interpro:IPR043129|rcsb pdb:1GLK|rcsb pdb:1V4S|rcsb pdb:1V4T|rcsb pdb:3A0I|rcsb pdb:3F9M|rcsb pdb:3FGU|rcsb pdb:3FR0|rcsb pdb:3GOI|rcsb pdb:3H1V|rcsb pdb:3ID8|rcsb pdb:3IDH|rcsb pdb:3IMX|rcsb pdb:3QIC|rcsb pdb:3S41|rcsb pdb:3VEV|rcsb pdb:3VEY|rcsb pdb:3VF6|rcsb pdb:4DCH|rcsb pdb:4DHY|rcsb pdb:4ISE|rcsb pdb:4ISF|rcsb pdb:4ISG|rcsb pdb:4IWV|rcsb pdb:4IXC|rcsb pdb:4L3Q|rcsb pdb:4LC9|rcsb pdb:4MLE|rcsb pdb:4MLH|rcsb pdb:4NO7|rcsb pdb:4RCH|rcsb pdb:5V4W|rcsb pdb:5V4X|rcsb pdb:6E0E|rcsb pdb:6E0I|reactome:R-HSA-170822	-	-	-	comment:PFKFB1 identified from consensus peptide HGMKVWTLPATS	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/16	2014/10/16	rogid:PlV0xnOZK0nDHS3tfKG1B1YgyoY9606	rogid:NY0+cfFiqIntMiCxMBvjm+WWDpU9606	intact-crc:746B70665EEEF3B7|rigid:OCyzYcQPKO1DO2UEPvdtWjdasjs	false	binding-associated region:298-303	his tag:n-n	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P35557	uniprotkb:Q14397	intact:EBI-709928|uniprotkb:Q05810|uniprotkb:A4D2J3|uniprotkb:A4D2J2|ensembl:ENSP00000384247	intact:EBI-709948|uniprotkb:Q53RY6|uniprotkb:Q99522|uniprotkb:A1L4C2|uniprotkb:B4DPQ2	psi-mi:hxk4_human(display_long)|uniprotkb:Hexokinase type IV(gene name synonym)|uniprotkb:Hexokinase-D(gene name synonym)|uniprotkb:GCK(gene name)|psi-mi:GCK(display_short)|uniprotkb:Glucokinase(gene name synonym)	psi-mi:gckr_human(display_long)|uniprotkb:GCKR(gene name)|psi-mi:GCKR(display_short)	psi-mi:"MI:0084"(phage display)	Baltrusch et al. (2001)	pubmed:11522786	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-710326	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000153.1|refseq:NP_277042.1|refseq:NP_277043.1|reactome:R-HSA-210745|reactome:R-HSA-5619073|reactome:R-HSA-5619107|reactome:R-HSA-70171|reactome:R-HSA-9615017|ensembl:ENSG00000106633(gene)|ensembl:ENST00000403799(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004340"(glucokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005536"(glucose binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006096"(glycolytic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0008865"(fructokinase activity)|go:"GO:0019158"(mannokinase activity)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0051594"(detection of glucose)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070509"(calcium ion import)|interpro:IPR001312(Hexokinase)|interpro:IPR019807|interpro:IPR022672|interpro:IPR022673|interpro:IPR039073|interpro:IPR043129|rcsb pdb:1GLK|rcsb pdb:1V4S|rcsb pdb:1V4T|rcsb pdb:3A0I|rcsb pdb:3F9M|rcsb pdb:3FGU|rcsb pdb:3FR0|rcsb pdb:3GOI|rcsb pdb:3H1V|rcsb pdb:3ID8|rcsb pdb:3IDH|rcsb pdb:3IMX|rcsb pdb:3QIC|rcsb pdb:3S41|rcsb pdb:3VEV|rcsb pdb:3VEY|rcsb pdb:3VF6|rcsb pdb:4DCH|rcsb pdb:4DHY|rcsb pdb:4ISE|rcsb pdb:4ISF|rcsb pdb:4ISG|rcsb pdb:4IWV|rcsb pdb:4IXC|rcsb pdb:4L3Q|rcsb pdb:4LC9|rcsb pdb:4MLE|rcsb pdb:4MLH|rcsb pdb:4NO7|rcsb pdb:4RCH|rcsb pdb:5V4W|rcsb pdb:5V4X|rcsb pdb:6E0E|rcsb pdb:6E0I|reactome:R-HSA-170822	interpro:IPR005486(Glucokinase regulatory, conserved site)|interpro:IPR001347("Sugar isomerase (SIS)")|refseq:NP_001477.2|rcsb pdb:4LY9|rcsb pdb:4OHM|rcsb pdb:4OHO|rcsb pdb:4OHP|rcsb pdb:4PX2|rcsb pdb:4PX3|rcsb pdb:4PX5|rcsb pdb:4OHK|reactome:R-HSA-5619107|rcsb pdb:4OLH|rcsb pdb:4MQU|rcsb pdb:4MRO|reactome:R-HSA-170822|rcsb pdb:4PXS|rcsb pdb:4BB9|rcsb pdb:4BBA|rcsb pdb:4OP1|rcsb pdb:4OP2|rcsb pdb:4OP3|rcsb pdb:4MSU|interpro:IPR040190|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0009750"(response to fructose)|go:"GO:0019899"(enzyme binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0046415"(urate metabolic process)|go:"GO:0070095"(fructose-6-phosphate binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:1901135"(carbohydrate derivative metabolic process)	-	-	-	comment:Consensus peptide EYLSAIVAGPWP used as prey	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/16	2014/10/16	rogid:NY0+cfFiqIntMiCxMBvjm+WWDpU9606	rogid:L2jFFcBXpdSqsXfi4XNLClQYyXs9606	intact-crc:3EC047B5C9B67290|rigid:5MBZwyrqbWG7TIZiQ564Ek3dP/8	false	his tag:n-n	binding-associated region:182-189	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P35557	uniprotkb:Q14397	intact:EBI-709928|uniprotkb:Q05810|uniprotkb:A4D2J3|uniprotkb:A4D2J2|ensembl:ENSP00000384247	intact:EBI-709948|uniprotkb:Q53RY6|uniprotkb:Q99522|uniprotkb:A1L4C2|uniprotkb:B4DPQ2	psi-mi:hxk4_human(display_long)|uniprotkb:Hexokinase type IV(gene name synonym)|uniprotkb:Hexokinase-D(gene name synonym)|uniprotkb:GCK(gene name)|psi-mi:GCK(display_short)|uniprotkb:Glucokinase(gene name synonym)	psi-mi:gckr_human(display_long)|uniprotkb:GCKR(gene name)|psi-mi:GCKR(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Baltrusch et al. (2001)	pubmed:11522786	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-710154	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000153.1|refseq:NP_277042.1|refseq:NP_277043.1|reactome:R-HSA-210745|reactome:R-HSA-5619073|reactome:R-HSA-5619107|reactome:R-HSA-70171|reactome:R-HSA-9615017|ensembl:ENSG00000106633(gene)|ensembl:ENST00000403799(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004340"(glucokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005536"(glucose binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006096"(glycolytic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0008865"(fructokinase activity)|go:"GO:0019158"(mannokinase activity)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0051594"(detection of glucose)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070509"(calcium ion import)|interpro:IPR001312(Hexokinase)|interpro:IPR019807|interpro:IPR022672|interpro:IPR022673|interpro:IPR039073|interpro:IPR043129|rcsb pdb:1GLK|rcsb pdb:1V4S|rcsb pdb:1V4T|rcsb pdb:3A0I|rcsb pdb:3F9M|rcsb pdb:3FGU|rcsb pdb:3FR0|rcsb pdb:3GOI|rcsb pdb:3H1V|rcsb pdb:3ID8|rcsb pdb:3IDH|rcsb pdb:3IMX|rcsb pdb:3QIC|rcsb pdb:3S41|rcsb pdb:3VEV|rcsb pdb:3VEY|rcsb pdb:3VF6|rcsb pdb:4DCH|rcsb pdb:4DHY|rcsb pdb:4ISE|rcsb pdb:4ISF|rcsb pdb:4ISG|rcsb pdb:4IWV|rcsb pdb:4IXC|rcsb pdb:4L3Q|rcsb pdb:4LC9|rcsb pdb:4MLE|rcsb pdb:4MLH|rcsb pdb:4NO7|rcsb pdb:4RCH|rcsb pdb:5V4W|rcsb pdb:5V4X|rcsb pdb:6E0E|rcsb pdb:6E0I|reactome:R-HSA-170822	interpro:IPR005486(Glucokinase regulatory, conserved site)|interpro:IPR001347("Sugar isomerase (SIS)")|refseq:NP_001477.2|rcsb pdb:4LY9|rcsb pdb:4OHM|rcsb pdb:4OHO|rcsb pdb:4OHP|rcsb pdb:4PX2|rcsb pdb:4PX3|rcsb pdb:4PX5|rcsb pdb:4OHK|reactome:R-HSA-5619107|rcsb pdb:4OLH|rcsb pdb:4MQU|rcsb pdb:4MRO|reactome:R-HSA-170822|rcsb pdb:4PXS|rcsb pdb:4BB9|rcsb pdb:4BBA|rcsb pdb:4OP1|rcsb pdb:4OP2|rcsb pdb:4OP3|rcsb pdb:4MSU|interpro:IPR040190|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0009750"(response to fructose)|go:"GO:0019899"(enzyme binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0046415"(urate metabolic process)|go:"GO:0070095"(fructose-6-phosphate binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:1901135"(carbohydrate derivative metabolic process)	-	-	-	comment:Consensus peptide EYLSAIVAGPWP used as prey	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/16	2014/10/16	rogid:NY0+cfFiqIntMiCxMBvjm+WWDpU9606	rogid:L2jFFcBXpdSqsXfi4XNLClQYyXs9606	intact-crc:1196A5DB157B4103|rigid:5MBZwyrqbWG7TIZiQ564Ek3dP/8	false	his tag:n-n	binding-associated region:182-189	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P35557	uniprotkb:P16118	intact:EBI-709928|uniprotkb:Q05810|uniprotkb:A4D2J3|uniprotkb:A4D2J2|ensembl:ENSP00000384247	intact:EBI-709807|ensembl:ENSP00000364145|uniprotkb:Q5JXS5|uniprotkb:B2RA88|uniprotkb:Q99951|uniprotkb:B4DUN5	psi-mi:hxk4_human(display_long)|uniprotkb:Hexokinase type IV(gene name synonym)|uniprotkb:Hexokinase-D(gene name synonym)|uniprotkb:GCK(gene name)|psi-mi:GCK(display_short)|uniprotkb:Glucokinase(gene name synonym)	psi-mi:f261_human(display_long)|uniprotkb:6PF-2-K/Fru-2,6-P2ase liver isozyme(gene name synonym)|uniprotkb:PFKFB1(gene name)|psi-mi:PFKFB1(display_short)|uniprotkb:F6PK(gene name synonym)|uniprotkb:PFRX(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Baltrusch et al. (2001)	pubmed:11522786	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-710164	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000153.1|refseq:NP_277042.1|refseq:NP_277043.1|reactome:R-HSA-210745|reactome:R-HSA-5619073|reactome:R-HSA-5619107|reactome:R-HSA-70171|reactome:R-HSA-9615017|ensembl:ENSG00000106633(gene)|ensembl:ENST00000403799(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004340"(glucokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005536"(glucose binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006096"(glycolytic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0008865"(fructokinase activity)|go:"GO:0019158"(mannokinase activity)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0051594"(detection of glucose)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070509"(calcium ion import)|interpro:IPR001312(Hexokinase)|interpro:IPR019807|interpro:IPR022672|interpro:IPR022673|interpro:IPR039073|interpro:IPR043129|rcsb pdb:1GLK|rcsb pdb:1V4S|rcsb pdb:1V4T|rcsb pdb:3A0I|rcsb pdb:3F9M|rcsb pdb:3FGU|rcsb pdb:3FR0|rcsb pdb:3GOI|rcsb pdb:3H1V|rcsb pdb:3ID8|rcsb pdb:3IDH|rcsb pdb:3IMX|rcsb pdb:3QIC|rcsb pdb:3S41|rcsb pdb:3VEV|rcsb pdb:3VEY|rcsb pdb:3VF6|rcsb pdb:4DCH|rcsb pdb:4DHY|rcsb pdb:4ISE|rcsb pdb:4ISF|rcsb pdb:4ISG|rcsb pdb:4IWV|rcsb pdb:4IXC|rcsb pdb:4L3Q|rcsb pdb:4LC9|rcsb pdb:4MLE|rcsb pdb:4MLH|rcsb pdb:4NO7|rcsb pdb:4RCH|rcsb pdb:5V4W|rcsb pdb:5V4X|rcsb pdb:6E0E|rcsb pdb:6E0I|reactome:R-HSA-170822	refseq:NP_002616.2|ensembl:ENSG00000158571(gene)|ensembl:ENST00000375006(transcript)|go:"GO:0003873"(6-phosphofructo-2-kinase activity)|go:"GO:0004331"(fructose-2,6-bisphosphate 2-phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006003"(fructose 2,6-bisphosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032868"(response to insulin)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0033762"(response to glucagon)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043540"(6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0070095"(fructose-6-phosphate binding)|interpro:IPR001345(Phosphoglycerate/bisphosphoglycerate mutase)|interpro:IPR003094(Fructose-2,6-bisphosphatase)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR013079(6-phosphofructo-2-kinase)|interpro:IPR027417|interpro:IPR029033|rcsb pdb:1K6M|reactome:R-HSA-163358|reactome:R-HSA-163767|reactome:R-HSA-9634600|refseq:NP_001258733.1|refseq:NP_001258734.1	-	-	-	comment:Consensus peptide HGMKVWTLPATS used as prey	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/16	2014/10/16	rogid:NY0+cfFiqIntMiCxMBvjm+WWDpU9606	rogid:PlV0xnOZK0nDHS3tfKG1B1YgyoY9606	intact-crc:2FF0D18BCE996588|rigid:OCyzYcQPKO1DO2UEPvdtWjdasjs	false	his tag:n-n	binding-associated region:298-303	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q07071	uniprotkb:P35557	intact:EBI-710296|ensembl:ENSRNOP00000064260	intact:EBI-709928|uniprotkb:Q05810|uniprotkb:A4D2J3|uniprotkb:A4D2J2|ensembl:ENSP00000384247	psi-mi:gckr_rat(display_long)|uniprotkb:Gckr(gene name)|psi-mi:Gckr(display_short)	psi-mi:hxk4_human(display_long)|uniprotkb:Hexokinase type IV(gene name synonym)|uniprotkb:Hexokinase-D(gene name synonym)|uniprotkb:GCK(gene name)|psi-mi:GCK(display_short)|uniprotkb:Glucokinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Baltrusch et al. (2001)	pubmed:11522786	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-709956	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000048874(gene)|ensembl:ENSRNOT00000073228(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0009750"(response to fructose)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0046415"(urate metabolic process)|go:"GO:0051594"(detection of glucose)|go:"GO:0070095"(fructose-6-phosphate binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:1901135"(carbohydrate derivative metabolic process)|go:"GO:1903300"(negative regulation of hexokinase activity)|interpro:IPR001347("Sugar isomerase (SIS)")|interpro:IPR005486(Glucokinase regulatory, conserved site)|interpro:IPR040190|rcsb pdb:4LC9|reactome:R-RNO-170822|rgd:2671|refseq:NP_037252.1	refseq:NP_000153.1|refseq:NP_277042.1|refseq:NP_277043.1|reactome:R-HSA-210745|reactome:R-HSA-5619073|reactome:R-HSA-5619107|reactome:R-HSA-70171|reactome:R-HSA-9615017|ensembl:ENSG00000106633(gene)|ensembl:ENST00000403799(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004340"(glucokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005536"(glucose binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006096"(glycolytic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0008865"(fructokinase activity)|go:"GO:0019158"(mannokinase activity)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0051594"(detection of glucose)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070509"(calcium ion import)|interpro:IPR001312(Hexokinase)|interpro:IPR019807|interpro:IPR022672|interpro:IPR022673|interpro:IPR039073|interpro:IPR043129|rcsb pdb:1GLK|rcsb pdb:1V4S|rcsb pdb:1V4T|rcsb pdb:3A0I|rcsb pdb:3F9M|rcsb pdb:3FGU|rcsb pdb:3FR0|rcsb pdb:3GOI|rcsb pdb:3H1V|rcsb pdb:3ID8|rcsb pdb:3IDH|rcsb pdb:3IMX|rcsb pdb:3QIC|rcsb pdb:3S41|rcsb pdb:3VEV|rcsb pdb:3VEY|rcsb pdb:3VF6|rcsb pdb:4DCH|rcsb pdb:4DHY|rcsb pdb:4ISE|rcsb pdb:4ISF|rcsb pdb:4ISG|rcsb pdb:4IWV|rcsb pdb:4IXC|rcsb pdb:4L3Q|rcsb pdb:4LC9|rcsb pdb:4MLE|rcsb pdb:4MLH|rcsb pdb:4NO7|rcsb pdb:4RCH|rcsb pdb:5V4W|rcsb pdb:5V4X|rcsb pdb:6E0E|rcsb pdb:6E0I|reactome:R-HSA-170822	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/11/16	2014/10/16	rogid:Gvc8qzcUWXyZoTCp2EC3LrnPnc810116	rogid:NY0+cfFiqIntMiCxMBvjm+WWDpU9606	intact-crc:EB68685229557571|rigid:h26dfJ20nuv468yAWwErGWu3cto	false	-	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35557	uniprotkb:P07953	intact:EBI-709928|uniprotkb:Q05810|uniprotkb:A4D2J3|uniprotkb:A4D2J2|ensembl:ENSP00000384247	intact:EBI-709873|ensembl:ENSRNOP00000035212|uniprotkb:P16119	psi-mi:hxk4_human(display_long)|uniprotkb:Hexokinase type IV(gene name synonym)|uniprotkb:Hexokinase-D(gene name synonym)|uniprotkb:GCK(gene name)|psi-mi:GCK(display_short)|uniprotkb:Glucokinase(gene name synonym)	psi-mi:f261_rat(display_long)|uniprotkb:6PF-2-K/Fru-2,6-P2ase liver isozyme(gene name synonym)|uniprotkb:Pfkfb1(gene name)|psi-mi:Pfkfb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Baltrusch et al. (2001)	pubmed:11522786	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-710287	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000153.1|refseq:NP_277042.1|refseq:NP_277043.1|reactome:R-HSA-210745|reactome:R-HSA-5619073|reactome:R-HSA-5619107|reactome:R-HSA-70171|reactome:R-HSA-9615017|ensembl:ENSG00000106633(gene)|ensembl:ENST00000403799(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004340"(glucokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005536"(glucose binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006096"(glycolytic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0008865"(fructokinase activity)|go:"GO:0019158"(mannokinase activity)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0051594"(detection of glucose)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070509"(calcium ion import)|interpro:IPR001312(Hexokinase)|interpro:IPR019807|interpro:IPR022672|interpro:IPR022673|interpro:IPR039073|interpro:IPR043129|rcsb pdb:1GLK|rcsb pdb:1V4S|rcsb pdb:1V4T|rcsb pdb:3A0I|rcsb pdb:3F9M|rcsb pdb:3FGU|rcsb pdb:3FR0|rcsb pdb:3GOI|rcsb pdb:3H1V|rcsb pdb:3ID8|rcsb pdb:3IDH|rcsb pdb:3IMX|rcsb pdb:3QIC|rcsb pdb:3S41|rcsb pdb:3VEV|rcsb pdb:3VEY|rcsb pdb:3VF6|rcsb pdb:4DCH|rcsb pdb:4DHY|rcsb pdb:4ISE|rcsb pdb:4ISF|rcsb pdb:4ISG|rcsb pdb:4IWV|rcsb pdb:4IXC|rcsb pdb:4L3Q|rcsb pdb:4LC9|rcsb pdb:4MLE|rcsb pdb:4MLH|rcsb pdb:4NO7|rcsb pdb:4RCH|rcsb pdb:5V4W|rcsb pdb:5V4X|rcsb pdb:6E0E|rcsb pdb:6E0I|reactome:R-HSA-170822	interpro:IPR003094(Fructose-2,6-bisphosphatase)|rgd:3307|refseq:NP_036753.4|ensembl:ENSRNOT00000033656(transcript)|go:"GO:0003873"(6-phosphofructo-2-kinase activity)|go:"GO:0004331"(fructose-2,6-bisphosphate 2-phosphatase activity)|go:"GO:0005524"(ATP binding)|ensembl:ENSRNOG00000000165(gene)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006003"(fructose 2,6-bisphosphate metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032868"(response to insulin)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0033762"(response to glucagon)|go:"GO:0042594"(response to starvation)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0043540"(6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex)|go:"GO:0046835"(carbohydrate phosphorylation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0070095"(fructose-6-phosphate binding)|interpro:IPR001345(Phosphoglycerate/bisphosphoglycerate mutase)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR013079(6-phosphofructo-2-kinase)|interpro:IPR027417|interpro:IPR029033|rcsb pdb:1C7Z|rcsb pdb:1C80|rcsb pdb:1C81|rcsb pdb:1FBT|rcsb pdb:1TIP|reactome:R-RNO-9634600	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/11/16	2014/10/16	rogid:NY0+cfFiqIntMiCxMBvjm+WWDpU9606	rogid:rL9vZlrhsbopiNmyJQxtiv/la4E10116	intact-crc:794EEE307BD9EBB6|rigid:wdas9+jR7HUGi1qzDdXxQY9AqZI	false	his tag:n-n	binding-associated region:251..251-471..471	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07953	uniprotkb:P07953	intact:EBI-709873|ensembl:ENSRNOP00000035212|uniprotkb:P16119	intact:EBI-709873|ensembl:ENSRNOP00000035212|uniprotkb:P16119	psi-mi:f261_rat(display_long)|uniprotkb:6PF-2-K/Fru-2,6-P2ase liver isozyme(gene name synonym)|uniprotkb:Pfkfb1(gene name)|psi-mi:Pfkfb1(display_short)	psi-mi:f261_rat(display_long)|uniprotkb:6PF-2-K/Fru-2,6-P2ase liver isozyme(gene name synonym)|uniprotkb:Pfkfb1(gene name)|psi-mi:Pfkfb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Baltrusch et al. (2001)	pubmed:11522786	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-710335	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR003094(Fructose-2,6-bisphosphatase)|rgd:3307|refseq:NP_036753.4|ensembl:ENSRNOT00000033656(transcript)|go:"GO:0003873"(6-phosphofructo-2-kinase activity)|go:"GO:0004331"(fructose-2,6-bisphosphate 2-phosphatase activity)|go:"GO:0005524"(ATP binding)|ensembl:ENSRNOG00000000165(gene)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006003"(fructose 2,6-bisphosphate metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032868"(response to insulin)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0033762"(response to glucagon)|go:"GO:0042594"(response to starvation)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0043540"(6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex)|go:"GO:0046835"(carbohydrate phosphorylation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0070095"(fructose-6-phosphate binding)|interpro:IPR001345(Phosphoglycerate/bisphosphoglycerate mutase)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR013079(6-phosphofructo-2-kinase)|interpro:IPR027417|interpro:IPR029033|rcsb pdb:1C7Z|rcsb pdb:1C80|rcsb pdb:1C81|rcsb pdb:1FBT|rcsb pdb:1TIP|reactome:R-RNO-9634600	interpro:IPR003094(Fructose-2,6-bisphosphatase)|rgd:3307|refseq:NP_036753.4|ensembl:ENSRNOT00000033656(transcript)|go:"GO:0003873"(6-phosphofructo-2-kinase activity)|go:"GO:0004331"(fructose-2,6-bisphosphate 2-phosphatase activity)|go:"GO:0005524"(ATP binding)|ensembl:ENSRNOG00000000165(gene)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006003"(fructose 2,6-bisphosphate metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032868"(response to insulin)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0033762"(response to glucagon)|go:"GO:0042594"(response to starvation)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0043540"(6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex)|go:"GO:0046835"(carbohydrate phosphorylation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0070095"(fructose-6-phosphate binding)|interpro:IPR001345(Phosphoglycerate/bisphosphoglycerate mutase)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR013079(6-phosphofructo-2-kinase)|interpro:IPR027417|interpro:IPR029033|rcsb pdb:1C7Z|rcsb pdb:1C80|rcsb pdb:1C81|rcsb pdb:1FBT|rcsb pdb:1TIP|reactome:R-RNO-9634600	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/11/16	2014/10/16	rogid:rL9vZlrhsbopiNmyJQxtiv/la4E10116	rogid:rL9vZlrhsbopiNmyJQxtiv/la4E10116	intact-crc:75C3CF2C4D96F1E2|rigid:yvnKfoIwTnmMTmxg5YdRcbQrrmU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O35552	uniprotkb:P35557	intact:EBI-710340|uniprotkb:O35096|uniprotkb:O35553|uniprotkb:O35554|uniprotkb:O35555|uniprotkb:O35556|uniprotkb:O35557|uniprotkb:Q9QWQ5|uniprotkb:Q9QWQ6|ensembl:ENSRNOP00000062965	intact:EBI-709928|uniprotkb:Q05810|uniprotkb:A4D2J3|uniprotkb:A4D2J2|ensembl:ENSP00000384247	psi-mi:f263_rat(display_long)|uniprotkb:6PF-2-K/Fru-2,6-P2ase brain-type isozyme(gene name synonym)|uniprotkb:RB2K(gene name synonym)|uniprotkb:Pfkfb3(gene name)|psi-mi:Pfkfb3(display_short)	psi-mi:hxk4_human(display_long)|uniprotkb:Hexokinase type IV(gene name synonym)|uniprotkb:Hexokinase-D(gene name synonym)|uniprotkb:GCK(gene name)|psi-mi:GCK(display_short)|uniprotkb:Glucokinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Baltrusch et al. (2001)	pubmed:11522786	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-710396	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000018911(gene)|ensembl:ENSRNOT00000068354(transcript)|go:"GO:0003873"(6-phosphofructo-2-kinase activity)|go:"GO:0004331"(fructose-2,6-bisphosphate 2-phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006003"(fructose 2,6-bisphosphate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0007420"(brain development)|interpro:IPR001345(Phosphoglycerate/bisphosphoglycerate mutase)|interpro:IPR003094(Fructose-2,6-bisphosphatase)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR013079(6-phosphofructo-2-kinase)|interpro:IPR027417|interpro:IPR029033|reactome:R-RNO-9634600|rgd:619776|refseq:NP_476476.1|refseq:XP_006254254.1|refseq:XP_006254255.1|refseq:XP_006254258.1|refseq:XP_006254259.1|refseq:XP_006254260.1	refseq:NP_000153.1|refseq:NP_277042.1|refseq:NP_277043.1|reactome:R-HSA-210745|reactome:R-HSA-5619073|reactome:R-HSA-5619107|reactome:R-HSA-70171|reactome:R-HSA-9615017|ensembl:ENSG00000106633(gene)|ensembl:ENST00000403799(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004340"(glucokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005536"(glucose binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006096"(glycolytic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0008865"(fructokinase activity)|go:"GO:0019158"(mannokinase activity)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0051594"(detection of glucose)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070509"(calcium ion import)|interpro:IPR001312(Hexokinase)|interpro:IPR019807|interpro:IPR022672|interpro:IPR022673|interpro:IPR039073|interpro:IPR043129|rcsb pdb:1GLK|rcsb pdb:1V4S|rcsb pdb:1V4T|rcsb pdb:3A0I|rcsb pdb:3F9M|rcsb pdb:3FGU|rcsb pdb:3FR0|rcsb pdb:3GOI|rcsb pdb:3H1V|rcsb pdb:3ID8|rcsb pdb:3IDH|rcsb pdb:3IMX|rcsb pdb:3QIC|rcsb pdb:3S41|rcsb pdb:3VEV|rcsb pdb:3VEY|rcsb pdb:3VF6|rcsb pdb:4DCH|rcsb pdb:4DHY|rcsb pdb:4ISE|rcsb pdb:4ISF|rcsb pdb:4ISG|rcsb pdb:4IWV|rcsb pdb:4IXC|rcsb pdb:4L3Q|rcsb pdb:4LC9|rcsb pdb:4MLE|rcsb pdb:4MLH|rcsb pdb:4NO7|rcsb pdb:4RCH|rcsb pdb:5V4W|rcsb pdb:5V4X|rcsb pdb:6E0E|rcsb pdb:6E0I|reactome:R-HSA-170822	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/11/16	2014/10/16	rogid:+NT0ohNpQfdbQt57aS/1v4BOHCs10116	rogid:NY0+cfFiqIntMiCxMBvjm+WWDpU9606	intact-crc:8BD38706C9C14BCC|rigid:R/QTwFUEbebN+JtPPIG7brAaCow	false	-	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)