#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P24588	uniprotkb:P35561	intact:EBI-703640|uniprotkb:A2RRB8|ensembl:ENSP00000315615|ensembl:ENSP00000378207	intact:EBI-703793|ensembl:ENSMUSP00000037192	psi-mi:akap5_human(display_long)|uniprotkb:A-kinase anchor protein 79 kDa(gene name synonym)|uniprotkb:cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein(gene name synonym)|uniprotkb:H21(gene name synonym)|uniprotkb:AKAP5(gene name)|psi-mi:AKAP5(display_short)|uniprotkb:AKAP79(gene name synonym)	psi-mi:kcnj2_mouse(display_long)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 2(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir2.1"(gene name synonym)|uniprotkb:Kcnj2(gene name)|psi-mi:Kcnj2(display_short)|uniprotkb:Irk1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Dart et al. (2001)	pubmed:11287423	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-703636	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004848.3|dip:DIP-186N|ensembl:ENSG00000179841(gene)|ensembl:ENST00000320636(transcript)|ensembl:ENST00000394718(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098837"(postsynaptic recycling endosome)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905751"(positive regulation of endosome to plasma membrane protein transport)|interpro:IPR001573(Protein kinase A anchoring region)|interpro:IPR042375|mint:P24588|rcsb pdb:2H9R|rcsb pdb:3LL8|rcsb pdb:5NIN|reactome:R-HSA-381676|reactome:R-HSA-399719|reactome:R-HSA-9010642	refseq:NP_032451.1|ensembl:ENSMUSG00000041695(gene)|ensembl:ENSMUST00000042970(transcript)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0014704"(intercalated disc)|go:"GO:0014861"(regulation of skeletal muscle contraction via regulation of action potential)|go:"GO:0015693"(magnesium ion transport)|go:"GO:0030315"(T-tubule)|go:"GO:0030425"(dendrite)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086001"(cardiac muscle cell action potential)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086008"(voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization)|go:"GO:0086011"(membrane repolarization during action potential)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090076"(relaxation of skeletal muscle)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR003271(Potassium channel, inwardly rectifying, Kir2.1)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR013673(Potassium channel, inwardly rectifying, Kir, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|mint:P35561|rcsb pdb:1U4F|rcsb pdb:2GIX|rcsb pdb:2XKY|reactome:R-MMU-1296041|reactome:R-MMU-1296053|reactome:R-MMU-5576886|reactome:R-MMU-997272	-	-	-	comment:The HA tag is inserted into the extracellular loop of kir2.1 at amino-acid 117.|comment:Both proteins are overexpressed	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2005/10/26	2014/10/16	rogid:sprVt4+r5Bkdl+FVefWWqs783y09606	rogid:g9tvgEkng4AEzSRbx9ujR4nPPrQ10090	intact-crc:14F256DB749995E6|rigid:7gf9A63KI9ECTXjR0zQuae/p1/s	false	-	ha tag:117-117	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35561	uniprotkb:P24588	intact:EBI-703793|ensembl:ENSMUSP00000037192	intact:EBI-703640|uniprotkb:A2RRB8|ensembl:ENSP00000315615|ensembl:ENSP00000378207	psi-mi:kcnj2_mouse(display_long)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 2(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir2.1"(gene name synonym)|uniprotkb:Kcnj2(gene name)|psi-mi:Kcnj2(display_short)|uniprotkb:Irk1(gene name synonym)	psi-mi:akap5_human(display_long)|uniprotkb:A-kinase anchor protein 79 kDa(gene name synonym)|uniprotkb:cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein(gene name synonym)|uniprotkb:H21(gene name synonym)|uniprotkb:AKAP5(gene name)|psi-mi:AKAP5(display_short)|uniprotkb:AKAP79(gene name synonym)	psi-mi:"MI:0096"(pull down)	Dart et al. (2001)	pubmed:11287423	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-703659	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032451.1|ensembl:ENSMUSG00000041695(gene)|ensembl:ENSMUST00000042970(transcript)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0014704"(intercalated disc)|go:"GO:0014861"(regulation of skeletal muscle contraction via regulation of action potential)|go:"GO:0015693"(magnesium ion transport)|go:"GO:0030315"(T-tubule)|go:"GO:0030425"(dendrite)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086001"(cardiac muscle cell action potential)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086008"(voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization)|go:"GO:0086011"(membrane repolarization during action potential)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090076"(relaxation of skeletal muscle)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR003271(Potassium channel, inwardly rectifying, Kir2.1)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR013673(Potassium channel, inwardly rectifying, Kir, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|mint:P35561|rcsb pdb:1U4F|rcsb pdb:2GIX|rcsb pdb:2XKY|reactome:R-MMU-1296041|reactome:R-MMU-1296053|reactome:R-MMU-5576886|reactome:R-MMU-997272	refseq:NP_004848.3|dip:DIP-186N|ensembl:ENSG00000179841(gene)|ensembl:ENST00000320636(transcript)|ensembl:ENST00000394718(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098837"(postsynaptic recycling endosome)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905751"(positive regulation of endosome to plasma membrane protein transport)|interpro:IPR001573(Protein kinase A anchoring region)|interpro:IPR042375|mint:P24588|rcsb pdb:2H9R|rcsb pdb:3LL8|rcsb pdb:5NIN|reactome:R-HSA-381676|reactome:R-HSA-399719|reactome:R-HSA-9010642	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/10/26	2014/10/16	rogid:g9tvgEkng4AEzSRbx9ujR4nPPrQ10090	rogid:sprVt4+r5Bkdl+FVefWWqs783y09606	intact-crc:D9AEAC3611C9E2B6|rigid:7gf9A63KI9ECTXjR0zQuae/p1/s	false	sufficient binding region:1-71|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P63252	uniprotkb:P24588	intact:EBI-703457|uniprotkb:O15110|uniprotkb:P48049|ensembl:ENSP00000243457|ensembl:ENSP00000441848	intact:EBI-703640|uniprotkb:A2RRB8|ensembl:ENSP00000315615|ensembl:ENSP00000378207	psi-mi:kcnj2_human(display_long)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 2(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir2.1"(gene name synonym)|uniprotkb:Cardiac inward rectifier potassium channel(gene name synonym)|uniprotkb:IRK1(gene name synonym)|uniprotkb:KCNJ2(gene name)|psi-mi:KCNJ2(display_short)	psi-mi:akap5_human(display_long)|uniprotkb:A-kinase anchor protein 79 kDa(gene name synonym)|uniprotkb:cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein(gene name synonym)|uniprotkb:H21(gene name synonym)|uniprotkb:AKAP5(gene name)|psi-mi:AKAP5(display_short)|uniprotkb:AKAP79(gene name synonym)	psi-mi:"MI:0096"(pull down)	Dart et al. (2001)	pubmed:11287423	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-703667	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000882.1|ensembl:ENSG00000123700(gene)|ensembl:ENST00000243457(transcript)|ensembl:ENST00000535240(transcript)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0014704"(intercalated disc)|go:"GO:0014861"(regulation of skeletal muscle contraction via regulation of action potential)|go:"GO:0015693"(magnesium ion transport)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086008"(voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization)|go:"GO:0086011"(membrane repolarization during action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090076"(relaxation of skeletal muscle)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR003271(Potassium channel, inwardly rectifying, Kir2.1)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR013673(Potassium channel, inwardly rectifying, Kir, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|rcsb pdb:6SPZ|reactome:R-HSA-1296041|reactome:R-HSA-1296053|reactome:R-HSA-5576886|reactome:R-HSA-997272	refseq:NP_004848.3|dip:DIP-186N|ensembl:ENSG00000179841(gene)|ensembl:ENST00000320636(transcript)|ensembl:ENST00000394718(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098837"(postsynaptic recycling endosome)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905751"(positive regulation of endosome to plasma membrane protein transport)|interpro:IPR001573(Protein kinase A anchoring region)|interpro:IPR042375|mint:P24588|rcsb pdb:2H9R|rcsb pdb:3LL8|rcsb pdb:5NIN|reactome:R-HSA-381676|reactome:R-HSA-399719|reactome:R-HSA-9010642	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/10/26	2014/10/16	rogid:uGsmRzyUuB9KQ53a7lTB90mvi/89606	rogid:sprVt4+r5Bkdl+FVefWWqs783y09606	intact-crc:373A40C6E26369ED|rigid:LNlbVRoXgd98ZPgw6udGWPqM28E	false	sufficient binding region:?-?|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)