#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P18011	uniprotkb:P16070	intact:EBI-490239|ensemblbacteria:AAL72352	intact:EBI-490245|uniprotkb:P22511|uniprotkb:Q04858|uniprotkb:Q13419|uniprotkb:Q13957|uniprotkb:Q13958|uniprotkb:Q13959|uniprotkb:Q13960|uniprotkb:Q13961|uniprotkb:Q13967|uniprotkb:Q13968|uniprotkb:Q13980|uniprotkb:Q15861|uniprotkb:Q16064|uniprotkb:Q16065|uniprotkb:Q16066|uniprotkb:Q16208|uniprotkb:Q16522|uniprotkb:Q86T72|uniprotkb:Q86Z27|uniprotkb:Q8N694|uniprotkb:Q92493|uniprotkb:Q96J24|uniprotkb:Q9UJ36|uniprotkb:Q9H5A5|uniprotkb:A5YRN9|uniprotkb:Q9UC28|uniprotkb:Q9UC29|uniprotkb:Q9UC30|uniprotkb:Q9UCB0|uniprotkb:D3DR12|uniprotkb:D3DR13|uniprotkb:B6EAT9|uniprotkb:O95370|ensembl:ENSP00000398632	psi-mi:ipab_shifl(display_long)|uniprotkb:62 kDa antigen(gene name synonym)|uniprotkb:ipaB(gene name)|psi-mi:ipaB(display_short)|uniprotkb:CP0128(locus name)	psi-mi:cd44_human(display_long)|uniprotkb:Epican(gene name synonym)|uniprotkb:CDw44(gene name synonym)|uniprotkb:Phagocytic glycoprotein I(gene name synonym)|uniprotkb:Extracellular matrix receptor III(gene name synonym)|uniprotkb:HUTCH-I(gene name synonym)|uniprotkb:Phagocytic glycoprotein 1(gene name synonym)|uniprotkb:GP90 lymphocyte homing/adhesion receptor(gene name synonym)|uniprotkb:Hermes antigen(gene name synonym)|uniprotkb:Hyaluronate receptor(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan(gene name synonym)|uniprotkb:CD44(gene name)|psi-mi:CD44(display_short)|uniprotkb:LHR(gene name synonym)|uniprotkb:MDU2(gene name synonym)|uniprotkb:MDU3(gene name synonym)|uniprotkb:MIC4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Skoudy et al. (2000)	pubmed:11207560	taxid:623(shifl)|taxid:623(Shigella flexneri)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-490284	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_858261.1|refseq:YP_009062485.1|refseq:WP_010921663.1|refseq:NP_085290.1|ensemblbacteria:AAL72352(transcript)|ensemblbacteria:SF_p0128(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0042025"(host cell nucleus)|interpro:IPR003895(Salmonella/Shigella invasin protein B)|interpro:IPR006972("Secretion system effector C (SseC) like protein")|interpro:IPR032391|rcsb pdb:3GZ1|rcsb pdb:3GZ2|rcsb pdb:3U0C|rcsb pdb:5WKQ|rcsb pdb:6KEA|dip:DIP-45233N	refseq:NP_000601.3|refseq:NP_001001389.1|refseq:NP_001001390.1|refseq:NP_001001391.1|refseq:NP_001001392.1|refseq:NP_001189484.1|refseq:NP_001189485.1|refseq:NP_001189486.1|refseq:XP_011518790.1|ensembl:ENSG00000026508(gene)|ensembl:ENST00000428726(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000392"(regulation of lamellipodium morphogenesis)|interpro:IPR000538(Link)|interpro:IPR001231(CD44 antigen)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR043210|rcsb pdb:1POZ|rcsb pdb:1UUH|rcsb pdb:2I83|rcsb pdb:4PZ3|rcsb pdb:4PZ4|rcsb pdb:6TXS|reactome:R-HSA-1474228|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-2160916|reactome:R-HSA-6798695|reactome:R-HSA-877300|dip:DIP-1121N	go:"GO:0051701"(biological process involved in interaction with host)	-	-	inhibition:Competitive inhibition of this interaction is observed when GST-complexes are incubated with anti-cd44 antibodies.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/02/02	2014/10/16	rogid:+VZIF6Bf6eIW6pUUylqTLn/yfW4623	rogid:QOb28rF7/ryqfz/ylJFTyL3aoAc9606	intact-crc:F342AA1385CDCB51|rigid:LWK+BhJLs1q7Z6mPqCg7YX+mNLg	false	glutathione s tranferase tag:c-c	tag:?-?	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P18011	uniprotkb:P16070	intact:EBI-490239|ensemblbacteria:AAL72352	intact:EBI-490245|uniprotkb:P22511|uniprotkb:Q04858|uniprotkb:Q13419|uniprotkb:Q13957|uniprotkb:Q13958|uniprotkb:Q13959|uniprotkb:Q13960|uniprotkb:Q13961|uniprotkb:Q13967|uniprotkb:Q13968|uniprotkb:Q13980|uniprotkb:Q15861|uniprotkb:Q16064|uniprotkb:Q16065|uniprotkb:Q16066|uniprotkb:Q16208|uniprotkb:Q16522|uniprotkb:Q86T72|uniprotkb:Q86Z27|uniprotkb:Q8N694|uniprotkb:Q92493|uniprotkb:Q96J24|uniprotkb:Q9UJ36|uniprotkb:Q9H5A5|uniprotkb:A5YRN9|uniprotkb:Q9UC28|uniprotkb:Q9UC29|uniprotkb:Q9UC30|uniprotkb:Q9UCB0|uniprotkb:D3DR12|uniprotkb:D3DR13|uniprotkb:B6EAT9|uniprotkb:O95370|ensembl:ENSP00000398632	psi-mi:ipab_shifl(display_long)|uniprotkb:62 kDa antigen(gene name synonym)|uniprotkb:ipaB(gene name)|psi-mi:ipaB(display_short)|uniprotkb:CP0128(locus name)	psi-mi:cd44_human(display_long)|uniprotkb:Epican(gene name synonym)|uniprotkb:CDw44(gene name synonym)|uniprotkb:Phagocytic glycoprotein I(gene name synonym)|uniprotkb:Extracellular matrix receptor III(gene name synonym)|uniprotkb:HUTCH-I(gene name synonym)|uniprotkb:Phagocytic glycoprotein 1(gene name synonym)|uniprotkb:GP90 lymphocyte homing/adhesion receptor(gene name synonym)|uniprotkb:Hermes antigen(gene name synonym)|uniprotkb:Hyaluronate receptor(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan(gene name synonym)|uniprotkb:CD44(gene name)|psi-mi:CD44(display_short)|uniprotkb:LHR(gene name synonym)|uniprotkb:MDU2(gene name synonym)|uniprotkb:MDU3(gene name synonym)|uniprotkb:MIC4(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Skoudy et al. (2000)	pubmed:11207560	taxid:623(shifl)|taxid:623(Shigella flexneri)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-490532	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_858261.1|refseq:YP_009062485.1|refseq:WP_010921663.1|refseq:NP_085290.1|ensemblbacteria:AAL72352(transcript)|ensemblbacteria:SF_p0128(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0042025"(host cell nucleus)|interpro:IPR003895(Salmonella/Shigella invasin protein B)|interpro:IPR006972("Secretion system effector C (SseC) like protein")|interpro:IPR032391|rcsb pdb:3GZ1|rcsb pdb:3GZ2|rcsb pdb:3U0C|rcsb pdb:5WKQ|rcsb pdb:6KEA|dip:DIP-45233N	refseq:NP_000601.3|refseq:NP_001001389.1|refseq:NP_001001390.1|refseq:NP_001001391.1|refseq:NP_001001392.1|refseq:NP_001189484.1|refseq:NP_001189485.1|refseq:NP_001189486.1|refseq:XP_011518790.1|ensembl:ENSG00000026508(gene)|ensembl:ENST00000428726(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000392"(regulation of lamellipodium morphogenesis)|interpro:IPR000538(Link)|interpro:IPR001231(CD44 antigen)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR043210|rcsb pdb:1POZ|rcsb pdb:1UUH|rcsb pdb:2I83|rcsb pdb:4PZ3|rcsb pdb:4PZ4|rcsb pdb:6TXS|reactome:R-HSA-1474228|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-2160916|reactome:R-HSA-6798695|reactome:R-HSA-877300|dip:DIP-1121N	go:"GO:0051701"(biological process involved in interaction with host)	-	-	kinetics:IC50=150+/- 25nM	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/02/02	2014/10/16	rogid:+VZIF6Bf6eIW6pUUylqTLn/yfW4623	rogid:QOb28rF7/ryqfz/ylJFTyL3aoAc9606	intact-crc:B324418C4F4913A5|rigid:LWK+BhJLs1q7Z6mPqCg7YX+mNLg	false	glutathione s tranferase tag:c-c	tag:?-?|binding-associated region:1-670	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P18011	uniprotkb:P16070	intact:EBI-490239|ensemblbacteria:AAL72352	intact:EBI-490245|uniprotkb:P22511|uniprotkb:Q04858|uniprotkb:Q13419|uniprotkb:Q13957|uniprotkb:Q13958|uniprotkb:Q13959|uniprotkb:Q13960|uniprotkb:Q13961|uniprotkb:Q13967|uniprotkb:Q13968|uniprotkb:Q13980|uniprotkb:Q15861|uniprotkb:Q16064|uniprotkb:Q16065|uniprotkb:Q16066|uniprotkb:Q16208|uniprotkb:Q16522|uniprotkb:Q86T72|uniprotkb:Q86Z27|uniprotkb:Q8N694|uniprotkb:Q92493|uniprotkb:Q96J24|uniprotkb:Q9UJ36|uniprotkb:Q9H5A5|uniprotkb:A5YRN9|uniprotkb:Q9UC28|uniprotkb:Q9UC29|uniprotkb:Q9UC30|uniprotkb:Q9UCB0|uniprotkb:D3DR12|uniprotkb:D3DR13|uniprotkb:B6EAT9|uniprotkb:O95370|ensembl:ENSP00000398632	psi-mi:ipab_shifl(display_long)|uniprotkb:62 kDa antigen(gene name synonym)|uniprotkb:ipaB(gene name)|psi-mi:ipaB(display_short)|uniprotkb:CP0128(locus name)	psi-mi:cd44_human(display_long)|uniprotkb:Epican(gene name synonym)|uniprotkb:CDw44(gene name synonym)|uniprotkb:Phagocytic glycoprotein I(gene name synonym)|uniprotkb:Extracellular matrix receptor III(gene name synonym)|uniprotkb:HUTCH-I(gene name synonym)|uniprotkb:Phagocytic glycoprotein 1(gene name synonym)|uniprotkb:GP90 lymphocyte homing/adhesion receptor(gene name synonym)|uniprotkb:Hermes antigen(gene name synonym)|uniprotkb:Hyaluronate receptor(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan(gene name synonym)|uniprotkb:CD44(gene name)|psi-mi:CD44(display_short)|uniprotkb:LHR(gene name synonym)|uniprotkb:MDU2(gene name synonym)|uniprotkb:MDU3(gene name synonym)|uniprotkb:MIC4(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skoudy et al. (2000)	pubmed:11207560	taxid:623(shifl)|taxid:623(Shigella flexneri)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-490583	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_858261.1|refseq:YP_009062485.1|refseq:WP_010921663.1|refseq:NP_085290.1|ensemblbacteria:AAL72352(transcript)|ensemblbacteria:SF_p0128(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0042025"(host cell nucleus)|interpro:IPR003895(Salmonella/Shigella invasin protein B)|interpro:IPR006972("Secretion system effector C (SseC) like protein")|interpro:IPR032391|rcsb pdb:3GZ1|rcsb pdb:3GZ2|rcsb pdb:3U0C|rcsb pdb:5WKQ|rcsb pdb:6KEA|dip:DIP-45233N	refseq:NP_000601.3|refseq:NP_001001389.1|refseq:NP_001001390.1|refseq:NP_001001391.1|refseq:NP_001001392.1|refseq:NP_001189484.1|refseq:NP_001189485.1|refseq:NP_001189486.1|refseq:XP_011518790.1|ensembl:ENSG00000026508(gene)|ensembl:ENST00000428726(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000392"(regulation of lamellipodium morphogenesis)|interpro:IPR000538(Link)|interpro:IPR001231(CD44 antigen)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR043210|rcsb pdb:1POZ|rcsb pdb:1UUH|rcsb pdb:2I83|rcsb pdb:4PZ3|rcsb pdb:4PZ4|rcsb pdb:6TXS|reactome:R-HSA-1474228|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-2160916|reactome:R-HSA-6798695|reactome:R-HSA-877300|dip:DIP-1121N	go:"GO:0051701"(biological process involved in interaction with host)	-	-	kinetics:"The binding of bioin CD44-ig to IpaB-gst is inhibated by CD44-ig with a half maximum inhibitory concentration of (IC50=) 175+/- 20nM"|kinetics:The binding of CD44-ig to IpaB-gst is saturable with a half maximal binding concentration of 150 +/- 25nM	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/02/02	2014/10/16	rogid:+VZIF6Bf6eIW6pUUylqTLn/yfW4623	rogid:QOb28rF7/ryqfz/ylJFTyL3aoAc9606	intact-crc:2703F7AEDA898ACF|rigid:LWK+BhJLs1q7Z6mPqCg7YX+mNLg	false	glutathione s tranferase tag:c-c	tag:?-?|binding-associated region:1-670	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P18011	uniprotkb:P16070	intact:EBI-490239|ensemblbacteria:AAL72352	intact:EBI-490245|uniprotkb:P22511|uniprotkb:Q04858|uniprotkb:Q13419|uniprotkb:Q13957|uniprotkb:Q13958|uniprotkb:Q13959|uniprotkb:Q13960|uniprotkb:Q13961|uniprotkb:Q13967|uniprotkb:Q13968|uniprotkb:Q13980|uniprotkb:Q15861|uniprotkb:Q16064|uniprotkb:Q16065|uniprotkb:Q16066|uniprotkb:Q16208|uniprotkb:Q16522|uniprotkb:Q86T72|uniprotkb:Q86Z27|uniprotkb:Q8N694|uniprotkb:Q92493|uniprotkb:Q96J24|uniprotkb:Q9UJ36|uniprotkb:Q9H5A5|uniprotkb:A5YRN9|uniprotkb:Q9UC28|uniprotkb:Q9UC29|uniprotkb:Q9UC30|uniprotkb:Q9UCB0|uniprotkb:D3DR12|uniprotkb:D3DR13|uniprotkb:B6EAT9|uniprotkb:O95370|ensembl:ENSP00000398632	psi-mi:ipab_shifl(display_long)|uniprotkb:62 kDa antigen(gene name synonym)|uniprotkb:ipaB(gene name)|psi-mi:ipaB(display_short)|uniprotkb:CP0128(locus name)	psi-mi:cd44_human(display_long)|uniprotkb:Epican(gene name synonym)|uniprotkb:CDw44(gene name synonym)|uniprotkb:Phagocytic glycoprotein I(gene name synonym)|uniprotkb:Extracellular matrix receptor III(gene name synonym)|uniprotkb:HUTCH-I(gene name synonym)|uniprotkb:Phagocytic glycoprotein 1(gene name synonym)|uniprotkb:GP90 lymphocyte homing/adhesion receptor(gene name synonym)|uniprotkb:Hermes antigen(gene name synonym)|uniprotkb:Hyaluronate receptor(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan(gene name synonym)|uniprotkb:CD44(gene name)|psi-mi:CD44(display_short)|uniprotkb:LHR(gene name synonym)|uniprotkb:MDU2(gene name synonym)|uniprotkb:MDU3(gene name synonym)|uniprotkb:MIC4(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Skoudy et al. (2000)	pubmed:11207560	taxid:623(shifl)|taxid:623(Shigella flexneri)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-490613	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_858261.1|refseq:YP_009062485.1|refseq:WP_010921663.1|refseq:NP_085290.1|ensemblbacteria:AAL72352(transcript)|ensemblbacteria:SF_p0128(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0042025"(host cell nucleus)|interpro:IPR003895(Salmonella/Shigella invasin protein B)|interpro:IPR006972("Secretion system effector C (SseC) like protein")|interpro:IPR032391|rcsb pdb:3GZ1|rcsb pdb:3GZ2|rcsb pdb:3U0C|rcsb pdb:5WKQ|rcsb pdb:6KEA|dip:DIP-45233N	refseq:NP_000601.3|refseq:NP_001001389.1|refseq:NP_001001390.1|refseq:NP_001001391.1|refseq:NP_001001392.1|refseq:NP_001189484.1|refseq:NP_001189485.1|refseq:NP_001189486.1|refseq:XP_011518790.1|ensembl:ENSG00000026508(gene)|ensembl:ENST00000428726(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000392"(regulation of lamellipodium morphogenesis)|interpro:IPR000538(Link)|interpro:IPR001231(CD44 antigen)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR043210|rcsb pdb:1POZ|rcsb pdb:1UUH|rcsb pdb:2I83|rcsb pdb:4PZ3|rcsb pdb:4PZ4|rcsb pdb:6TXS|reactome:R-HSA-1474228|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-2160916|reactome:R-HSA-6798695|reactome:R-HSA-877300|dip:DIP-1121N	go:"GO:0051701"(biological process involved in interaction with host)	-	-	inhibition:Competitive inhibition of this interaction is observed when Hela cells are incubated with anti-cd44 antibodies during the shigella infection. Immunofluorescence show that this antibody treatment inhibit shigella internalisation.|comment:IpaB-CD44 interaction is required in the early steps of shigella invasion.|comment:The CoIp is carried out after shigella infection of the Hela cells.	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2005/02/02	2014/10/16	rogid:+VZIF6Bf6eIW6pUUylqTLn/yfW4623	rogid:QOb28rF7/ryqfz/ylJFTyL3aoAc9606	intact-crc:41398703437516E9|rigid:LWK+BhJLs1q7Z6mPqCg7YX+mNLg	false	-	-	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)