#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P08909	uniprotkb:O55164	intact:EBI-7474723|intact:MINT-443850	intact:EBI-7401093|intact:MINT-143896|ensembl:ENSRNOP00000051321	psi-mi:5ht2c_rat(display_long)|uniprotkb:Htr2c(gene name)|psi-mi:Htr2c(display_short)|uniprotkb:5ht1c(gene name synonym)|uniprotkb:Htr1c(gene name synonym)|uniprotkb:Serotonin receptor 2C(gene name synonym)|uniprotkb:5-hydroxytryptamine receptor 1C(gene name synonym)	psi-mi:mpdz_rat(display_long)|uniprotkb:Mpdz(gene name)|psi-mi:Mpdz(display_short)|uniprotkb:Mupp1(gene name synonym)|uniprotkb:Multi-PDZ domain protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Becamel et al. (2001)	pubmed:11150294|mint:MINT-5213426	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7474764|mint:MINT-73191	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036897.2|rgd:2848|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000377(5-Hydroxytryptamine 2C receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0014054"(positive regulation of gamma-aminobutyric acid secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0031583"(phospholipase D-activating G protein-coupled receptor signaling pathway)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032098"(regulation of appetite)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043397"(regulation of corticotropin-releasing hormone secretion)|go:"GO:0045202"(synapse)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0048016"(inositol phosphate-mediated signaling)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0005886"(plasma membrane)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001662"(behavioral fear response)|rcsb pdb:2MHO|reactome:R-RNO-390666|reactome:R-RNO-416476|mint:MINT-443862(identity)	refseq:NP_062069.1|rgd:3105|ensembl:ENSRNOG00000007894(gene)|ensembl:ENSRNOT00000051028(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042552"(myelination)|go:"GO:0043220"(Schmidt-Lanterman incisure)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR015132(L27-2)|interpro:IPR032078|interpro:IPR036034|interpro:IPR036892|mint:O55164|rcsb pdb:1Y76|rcsb pdb:5DTH|mint:MINT-443867(identity)	-	comment:mint|function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system"|comment:"Stoichiometry: 1.0"	comment:mint|function:Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses|comment:"Stoichiometry: 1.0"	figure legend:F8|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:10116(rat-choroid plexus)|taxid:10116(Rattus norvegicus)	-	2005/12/06	2014/10/16	rogid:m7W0uddL6kH50Lnw130RDrCqDg810116	rogid:vn3E16p8JreR8o+dedW/axYCqEg10116	intact-crc:3358EFE130C826C1|rigid:gsb5xZR8Gnf4Dwu1CGgsvTXhPSg	false	-	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:O75970	uniprotkb:P28335	intact:EBI-821405|intact:EBI-2684724|uniprotkb:Q4LE30|uniprotkb:B7ZMI4|uniprotkb:A6NLC2|uniprotkb:O43798|uniprotkb:Q5CZ80|uniprotkb:Q5JTX3|uniprotkb:Q5JTX6|uniprotkb:Q5JTX7|uniprotkb:Q5JUC3|uniprotkb:Q5JUC4|uniprotkb:Q5VZ62|uniprotkb:Q8N790|intact:EBI-10961605|uniprotkb:B2RTS3|ensembl:ENSP00000320006	intact:EBI-994141|uniprotkb:Q5VUF8|uniprotkb:Q9NP28|ensembl:ENSP00000276198|ensembl:ENSP00000361018|ensembl:ENSP00000361019|uniprotkb:B1AMW4	psi-mi:mpdz_human(display_long)|uniprotkb:Multi-PDZ domain protein 1(gene name synonym)|uniprotkb:MPDZ(gene name)|psi-mi:MPDZ(display_short)|uniprotkb:MUPP1(gene name synonym)	psi-mi:5ht2c_human(display_long)|uniprotkb:5-hydroxytryptamine receptor 1C(gene name synonym)|uniprotkb:Serotonin receptor 2C(gene name synonym)|uniprotkb:HTR2C(gene name)|psi-mi:HTR2C(display_short)|uniprotkb:HTR1C(gene name synonym)	psi-mi:"MI:0096"(pull down)	Becamel et al. (2001)	pubmed:11150294|mint:MINT-5213426	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7474800|mint:MINT-73153	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006716948.1|refseq:XP_006716949.1|refseq:XP_006716950.1|refseq:XP_006716951.1|refseq:XP_006716952.1|refseq:XP_006716954.1|refseq:NP_003820.2|refseq:NP_001248335.1|refseq:NP_001248336.1|refseq:NP_001317566.1|refseq:XP_016870742.1|ensembl:ENSG00000107186(gene)|ensembl:ENST00000319217(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030425"(dendrite)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR015132(L27-2)|interpro:IPR032078|interpro:IPR036034|interpro:IPR036892|mint:O75970|rcsb pdb:2FCF|rcsb pdb:2FNE|rcsb pdb:2IWN|rcsb pdb:2IWO|rcsb pdb:2IWP|rcsb pdb:2IWQ|rcsb pdb:2O2T|rcsb pdb:2OPG|rcsb pdb:2QG1|mint:MINT-444065(identity)	refseq:NP_000859.1|ensembl:ENSG00000147246(gene)|ensembl:ENST00000276198(transcript)|ensembl:ENST00000371950(transcript)|ensembl:ENST00000371951(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000377(5-Hydroxytryptamine 2C receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P28335|rcsb pdb:6BQG|rcsb pdb:6BQH|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032098"(regulation of appetite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043397"(regulation of corticotropin-releasing hormone secretion)|go:"GO:0045202"(synapse)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|refseq:NP_001243690.1|refseq:NP_001243689.1|mint:MINT-444053(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/06	2014/10/16	rogid:Q5QzIDHLoL/sWqQI7r/Kb4VLSdY9606	rogid:ceYfyf8EendInDxAeD6T+az1XBE9606	intact-crc:213EA98BD08D2250|rigid:RI7yuDXV+57vSfJTtV/OrNdD8OE	false	binding-associated region:?-?(MINT-444066)	binding-associated region:369-458(MINT-444054)|glutathione s tranferase tag:?-?(MINT-444059)|mutation decreasing interaction:456-456,458-458(MINT-444056)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75970	uniprotkb:P28223	intact:EBI-821405|intact:EBI-2684724|uniprotkb:Q4LE30|uniprotkb:B7ZMI4|uniprotkb:A6NLC2|uniprotkb:O43798|uniprotkb:Q5CZ80|uniprotkb:Q5JTX3|uniprotkb:Q5JTX6|uniprotkb:Q5JTX7|uniprotkb:Q5JUC3|uniprotkb:Q5JUC4|uniprotkb:Q5VZ62|uniprotkb:Q8N790|intact:EBI-10961605|uniprotkb:B2RTS3|ensembl:ENSP00000320006	intact:EBI-6656333|ensembl:ENSP00000437737|uniprotkb:B2RAC5|uniprotkb:B4DZ79|uniprotkb:F5GWE8|uniprotkb:Q5T8C0	psi-mi:mpdz_human(display_long)|uniprotkb:Multi-PDZ domain protein 1(gene name synonym)|uniprotkb:MPDZ(gene name)|psi-mi:MPDZ(display_short)|uniprotkb:MUPP1(gene name synonym)	psi-mi:5ht2a_human(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Becamel et al. (2001)	pubmed:11150294|mint:MINT-5213426	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7474833|mint:MINT-73187	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006716948.1|refseq:XP_006716949.1|refseq:XP_006716950.1|refseq:XP_006716951.1|refseq:XP_006716952.1|refseq:XP_006716954.1|refseq:NP_003820.2|refseq:NP_001248335.1|refseq:NP_001248336.1|refseq:NP_001317566.1|refseq:XP_016870742.1|ensembl:ENSG00000107186(gene)|ensembl:ENST00000319217(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030425"(dendrite)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR015132(L27-2)|interpro:IPR032078|interpro:IPR036034|interpro:IPR036892|mint:O75970|rcsb pdb:2FCF|rcsb pdb:2FNE|rcsb pdb:2IWN|rcsb pdb:2IWO|rcsb pdb:2IWP|rcsb pdb:2IWQ|rcsb pdb:2O2T|rcsb pdb:2OPG|rcsb pdb:2QG1|mint:MINT-443916(identity)	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0007613"(memory)|go:"GO:0008219"(cell death)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030431"(sleep)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044380"(protein localization to cytoskeleton)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0007210"(serotonin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070852"(cell body fiber)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000455(5-Hydroxytryptamine 2A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6A93|rcsb pdb:6A94|rcsb pdb:6WGT|rcsb pdb:6WH4|rcsb pdb:6WHA|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051378"(serotonin binding)|refseq:NP_000612.1|refseq:NP_001159419.1|dip:DIP-41844N|mint:MINT-443906(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2C|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/06	2014/10/16	rogid:Q5QzIDHLoL/sWqQI7r/Kb4VLSdY9606	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	intact-crc:3A1B094292C12789|rigid:2dtRwq3mY5C8veqk2/Jkd7X/Z9A	false	binding-associated region:?-?(MINT-443917)	glutathione s tranferase tag:?-?(MINT-443910)|binding-associated region:380-471(MINT-443907)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P41595	uniprotkb:O75970	intact:EBI-7474947|uniprotkb:Q53TI1|uniprotkb:Q62221|uniprotkb:Q6P523|intact:MINT-444010|uniprotkb:B2R9D5|ensembl:ENSP00000258400	intact:EBI-821405|intact:EBI-2684724|uniprotkb:Q4LE30|uniprotkb:B7ZMI4|uniprotkb:A6NLC2|uniprotkb:O43798|uniprotkb:Q5CZ80|uniprotkb:Q5JTX3|uniprotkb:Q5JTX6|uniprotkb:Q5JTX7|uniprotkb:Q5JUC3|uniprotkb:Q5JUC4|uniprotkb:Q5VZ62|uniprotkb:Q8N790|intact:EBI-10961605|uniprotkb:B2RTS3|ensembl:ENSP00000320006	psi-mi:5ht2b_human(display_long)|uniprotkb:HTR2B(gene name)|psi-mi:HTR2B(display_short)|uniprotkb:Serotonin receptor 2B(gene name synonym)	psi-mi:mpdz_human(display_long)|uniprotkb:Multi-PDZ domain protein 1(gene name synonym)|uniprotkb:MPDZ(gene name)|psi-mi:MPDZ(display_short)|uniprotkb:MUPP1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Becamel et al. (2001)	pubmed:11150294|mint:MINT-5213426	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7474941|mint:MINT-73188	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001307687.1|refseq:NP_000858.3|ensembl:ENSG00000135914(gene)|ensembl:ENST00000258400(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007610"(behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014827"(intestine smooth muscle contraction)|go:"GO:0016310"(phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045202"(synapse)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071502"(cellular response to temperature stimulus)|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000482(5-Hydroxytryptamine 2B receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4IB4|rcsb pdb:4NC3|rcsb pdb:5TUD|rcsb pdb:5TVN|rcsb pdb:6DRX|rcsb pdb:6DRY|rcsb pdb:6DRZ|rcsb pdb:6DS0|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0050795"(regulation of behavior)|mint:MINT-444032(identity)	refseq:XP_006716948.1|refseq:XP_006716949.1|refseq:XP_006716950.1|refseq:XP_006716951.1|refseq:XP_006716952.1|refseq:XP_006716954.1|refseq:NP_003820.2|refseq:NP_001248335.1|refseq:NP_001248336.1|refseq:NP_001317566.1|refseq:XP_016870742.1|ensembl:ENSG00000107186(gene)|ensembl:ENST00000319217(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030425"(dendrite)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR015132(L27-2)|interpro:IPR032078|interpro:IPR036034|interpro:IPR036892|mint:O75970|rcsb pdb:2FCF|rcsb pdb:2FNE|rcsb pdb:2IWN|rcsb pdb:2IWO|rcsb pdb:2IWP|rcsb pdb:2IWQ|rcsb pdb:2O2T|rcsb pdb:2OPG|rcsb pdb:2QG1|mint:MINT-444042(identity)	-	comment:mint|function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2C|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/06	2014/10/16	rogid:PvEyuvigR2bXgqBgf+SUn6RhZTk9606	rogid:Q5QzIDHLoL/sWqQI7r/Kb4VLSdY9606	intact-crc:8DA73B9B22129F19|rigid:HIGas5/2nrGB5pZhS437KRlhC0k	false	binding-associated region:414-481(MINT-444033)|glutathione s tranferase tag:?-?(MINT-444036)	binding-associated region:?-?(MINT-444043)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O55164	uniprotkb:P08909	intact:EBI-7401093|intact:MINT-143896|ensembl:ENSRNOP00000051321	intact:EBI-7474723|intact:MINT-443850	psi-mi:mpdz_rat(display_long)|uniprotkb:Mpdz(gene name)|psi-mi:Mpdz(display_short)|uniprotkb:Mupp1(gene name synonym)|uniprotkb:Multi-PDZ domain protein 1(gene name synonym)	psi-mi:5ht2c_rat(display_long)|uniprotkb:Htr2c(gene name)|psi-mi:Htr2c(display_short)|uniprotkb:5ht1c(gene name synonym)|uniprotkb:Htr1c(gene name synonym)|uniprotkb:Serotonin receptor 2C(gene name synonym)|uniprotkb:5-hydroxytryptamine receptor 1C(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Becamel et al. (2001)	pubmed:11150294|mint:MINT-5213426	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7475068|mint:MINT-73190	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062069.1|rgd:3105|ensembl:ENSRNOG00000007894(gene)|ensembl:ENSRNOT00000051028(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042552"(myelination)|go:"GO:0043220"(Schmidt-Lanterman incisure)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR015132(L27-2)|interpro:IPR032078|interpro:IPR036034|interpro:IPR036892|mint:O55164|rcsb pdb:1Y76|rcsb pdb:5DTH|mint:MINT-443934(identity)	refseq:NP_036897.2|rgd:2848|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000377(5-Hydroxytryptamine 2C receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0014054"(positive regulation of gamma-aminobutyric acid secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0031583"(phospholipase D-activating G protein-coupled receptor signaling pathway)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032098"(regulation of appetite)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043397"(regulation of corticotropin-releasing hormone secretion)|go:"GO:0045202"(synapse)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0048016"(inositol phosphate-mediated signaling)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0005886"(plasma membrane)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001662"(behavioral fear response)|rcsb pdb:2MHO|reactome:R-RNO-390666|reactome:R-RNO-416476|mint:MINT-443929(identity)	-	comment:mint|function:Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses|comment:"Stoichiometry: 1.0"	comment:mint|function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system"|comment:"Stoichiometry: 1.0"	figure legend:F7|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:10116(rat-choroid plexus)|taxid:10116(Rattus norvegicus)	-	2005/12/06	2014/10/16	rogid:vn3E16p8JreR8o+dedW/axYCqEg10116	rogid:m7W0uddL6kH50Lnw130RDrCqDg810116	intact-crc:4C7407A5635DB157|rigid:gsb5xZR8Gnf4Dwu1CGgsvTXhPSg	false	-	-	-	-	psi-mi:"MI:0709"(polyclonal antibody immunostaining)	psi-mi:"MI:0709"(polyclonal antibody immunostaining)
uniprotkb:O75970	uniprotkb:P28335	intact:EBI-821405|intact:EBI-2684724|uniprotkb:Q4LE30|uniprotkb:B7ZMI4|uniprotkb:A6NLC2|uniprotkb:O43798|uniprotkb:Q5CZ80|uniprotkb:Q5JTX3|uniprotkb:Q5JTX6|uniprotkb:Q5JTX7|uniprotkb:Q5JUC3|uniprotkb:Q5JUC4|uniprotkb:Q5VZ62|uniprotkb:Q8N790|intact:EBI-10961605|uniprotkb:B2RTS3|ensembl:ENSP00000320006	intact:EBI-994141|uniprotkb:Q5VUF8|uniprotkb:Q9NP28|ensembl:ENSP00000276198|ensembl:ENSP00000361018|ensembl:ENSP00000361019|uniprotkb:B1AMW4	psi-mi:mpdz_human(display_long)|uniprotkb:Multi-PDZ domain protein 1(gene name synonym)|uniprotkb:MPDZ(gene name)|psi-mi:MPDZ(display_short)|uniprotkb:MUPP1(gene name synonym)	psi-mi:5ht2c_human(display_long)|uniprotkb:5-hydroxytryptamine receptor 1C(gene name synonym)|uniprotkb:Serotonin receptor 2C(gene name synonym)|uniprotkb:HTR2C(gene name)|psi-mi:HTR2C(display_short)|uniprotkb:HTR1C(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Becamel et al. (2001)	pubmed:11150294|mint:MINT-5213426	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7475091|mint:MINT-73189	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006716948.1|refseq:XP_006716949.1|refseq:XP_006716950.1|refseq:XP_006716951.1|refseq:XP_006716952.1|refseq:XP_006716954.1|refseq:NP_003820.2|refseq:NP_001248335.1|refseq:NP_001248336.1|refseq:NP_001317566.1|refseq:XP_016870742.1|ensembl:ENSG00000107186(gene)|ensembl:ENST00000319217(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030425"(dendrite)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR015132(L27-2)|interpro:IPR032078|interpro:IPR036034|interpro:IPR036892|mint:O75970|rcsb pdb:2FCF|rcsb pdb:2FNE|rcsb pdb:2IWN|rcsb pdb:2IWO|rcsb pdb:2IWP|rcsb pdb:2IWQ|rcsb pdb:2O2T|rcsb pdb:2OPG|rcsb pdb:2QG1|mint:MINT-443972(identity)	refseq:NP_000859.1|ensembl:ENSG00000147246(gene)|ensembl:ENST00000276198(transcript)|ensembl:ENST00000371950(transcript)|ensembl:ENST00000371951(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000377(5-Hydroxytryptamine 2C receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P28335|rcsb pdb:6BQG|rcsb pdb:6BQH|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032098"(regulation of appetite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043397"(regulation of corticotropin-releasing hormone secretion)|go:"GO:0045202"(synapse)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|refseq:NP_001243690.1|refseq:NP_001243689.1|mint:MINT-443963(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2005/12/06	2014/10/16	rogid:Q5QzIDHLoL/sWqQI7r/Kb4VLSdY9606	rogid:ceYfyf8EendInDxAeD6T+az1XBE9606	intact-crc:5A0D48E6C2313AAD|rigid:RI7yuDXV+57vSfJTtV/OrNdD8OE	false	tag:?-?(MINT-443973)	mutation decreasing interaction:458-458(MINT-443964)|myc tag:?-?(MINT-443966)	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:O55164	uniprotkb:P28335	intact:EBI-7401093|intact:MINT-143896|ensembl:ENSRNOP00000051321	intact:EBI-994141|uniprotkb:Q5VUF8|uniprotkb:Q9NP28|ensembl:ENSP00000276198|ensembl:ENSP00000361018|ensembl:ENSP00000361019|uniprotkb:B1AMW4	psi-mi:mpdz_rat(display_long)|uniprotkb:Mpdz(gene name)|psi-mi:Mpdz(display_short)|uniprotkb:Mupp1(gene name synonym)|uniprotkb:Multi-PDZ domain protein 1(gene name synonym)	psi-mi:5ht2c_human(display_long)|uniprotkb:5-hydroxytryptamine receptor 1C(gene name synonym)|uniprotkb:Serotonin receptor 2C(gene name synonym)|uniprotkb:HTR2C(gene name)|psi-mi:HTR2C(display_short)|uniprotkb:HTR1C(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Becamel et al. (2001)	pubmed:11150294|mint:MINT-5213426	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7475136|mint:MINT-73152	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062069.1|rgd:3105|ensembl:ENSRNOG00000007894(gene)|ensembl:ENSRNOT00000051028(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042552"(myelination)|go:"GO:0043220"(Schmidt-Lanterman incisure)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR015132(L27-2)|interpro:IPR032078|interpro:IPR036034|interpro:IPR036892|mint:O55164|rcsb pdb:1Y76|rcsb pdb:5DTH|mint:MINT-443997(identity)	refseq:NP_000859.1|ensembl:ENSG00000147246(gene)|ensembl:ENST00000276198(transcript)|ensembl:ENST00000371950(transcript)|ensembl:ENST00000371951(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000377(5-Hydroxytryptamine 2C receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P28335|rcsb pdb:6BQG|rcsb pdb:6BQH|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032098"(regulation of appetite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043397"(regulation of corticotropin-releasing hormone secretion)|go:"GO:0045202"(synapse)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|refseq:NP_001243690.1|refseq:NP_001243689.1|mint:MINT-443984(identity)	-	comment:mint|function:Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:T1 F1|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/12/06	2014/10/16	rogid:vn3E16p8JreR8o+dedW/axYCqEg10116	rogid:ceYfyf8EendInDxAeD6T+az1XBE9606	intact-crc:99E894DEC8332094|rigid:HI+ABr+xWzbH8f/IUYRX2feozbU	false	binding-associated region:1567-1718(MINT-443998)|tag:?-?(MINT-444001)	tag:?-?(MINT-443991)|binding-associated region:369-458(MINT-443985)|mutation decreasing interaction:456-456,458-458(MINT-443988)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)