#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9XTY6	uniprotkb:Q19266	intact:EBI-495781|uniprotkb:Q9BKB5|uniprotkb:Q9XTY4|ensemblmetazoa:T03D8.1a.1	intact:EBI-319158|uniprotkb:A7VJC8|ensemblmetazoa:F09E5.1.1	psi-mi:numb1_caeel(display_long)|uniprotkb:Protein kinase C adapter 1(gene name synonym)|uniprotkb:CKA1(gene name synonym)|uniprotkb:num-1(gene name)|psi-mi:num-1(display_short)|uniprotkb:cka-1(gene name synonym)|uniprotkb:T03D8.1(orf name)	psi-mi:kpc3_caeel(display_long)|uniprotkb:F09E5.1(orf name)|uniprotkb:pkc-3(gene name)|psi-mi:pkc-3(display_short)|uniprotkb:aPKC(gene name synonym)|uniprotkb:Atypical protein kinase C-3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2001)	pubmed:11134025	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-514676	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001024097.1|refseq:NP_001024098.1|refseq:NP_508021.1|wormbase:T03D8.1a|wormbase:T03D8.1b|wormbase:T03D8.1c|interpro:IPR016698(Numb/numb-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR006020(Phosphotyrosine interaction region)|reactome:R-CEL-437239|reactome:R-CEL-5610780|reactome:R-CEL-5632684|ensemblmetazoa:T03D8.1a.1(transcript)|ensemblmetazoa:WBGene00003830(gene)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0051117"(ATPase binding)	refseq:NP_495011.1|wormbase:F09E5.1|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034877|reactome:R-CEL-5218921|go:"GO:0007369"(gastrulation)|go:"GO:0007506"(gonadal mesoderm development)|go:"GO:0008104"(protein localization)|go:"GO:0008406"(gonad development)|go:"GO:0009611"(response to wounding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|go:"GO:0007338"(single fertilization)|ensemblmetazoa:F09E5.1.1(transcript)|ensemblmetazoa:WBGene00004034(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007163"(establishment or maintenance of cell polarity)|dip:DIP-24814N|reactome:R-CEL-1912408|reactome:R-CEL-9634635	-	-	-	comment:The smallest pkc-3 fragment retaining avid num-1 binding activity included AAs 212-224.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/03/03	2014/10/16	rogid:qO+DFvMBt2DE+ZS7l8axk5DMOFQ6239	rogid:ouLBmSOAJYGbW6LTfHamRpHNiAY6239	intact-crc:AA39E849E5322AB4|rigid:o32z0Fy9IvwF9sDJjUVvcfdmack	false	binding-associated region:90-231	binding-associated region:212-224	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9XTY6-1	uniprotkb:Q19266	intact:EBI-495798|ensemblmetazoa:T03D8.1a.1	intact:EBI-319158|uniprotkb:A7VJC8|ensemblmetazoa:F09E5.1.1	psi-mi:q9xty6-1(display_long)|uniprotkb:cka1(isoform synonym)|uniprotkb:num-1(gene name)|psi-mi:num-1(display_short)|uniprotkb:cka-1(gene name synonym)|uniprotkb:CKA1(gene name synonym)|uniprotkb:Protein kinase C adapter 1(gene name synonym)|uniprotkb:T03D8.1(orf name)	psi-mi:kpc3_caeel(display_long)|uniprotkb:F09E5.1(orf name)|uniprotkb:pkc-3(gene name)|psi-mi:pkc-3(display_short)|uniprotkb:aPKC(gene name synonym)|uniprotkb:Atypical protein kinase C-3(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Zhang et al. (2001)	pubmed:11134025	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-515097	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-495781(numb1_caeel)|ensemblmetazoa:T03D8.1a.1(transcript)|ensemblmetazoa:WBGene00003830(gene)	refseq:NP_495011.1|wormbase:F09E5.1|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034877|reactome:R-CEL-5218921|go:"GO:0007369"(gastrulation)|go:"GO:0007506"(gonadal mesoderm development)|go:"GO:0008104"(protein localization)|go:"GO:0008406"(gonad development)|go:"GO:0009611"(response to wounding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|go:"GO:0007338"(single fertilization)|ensemblmetazoa:F09E5.1.1(transcript)|ensemblmetazoa:WBGene00004034(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007163"(establishment or maintenance of cell polarity)|dip:DIP-24814N|reactome:R-CEL-1912408|reactome:R-CEL-9634635	-	isoform-comment:Isoform c is produced by alternative initiation at Met-45 of isoform a	-	comment:Isoform c of num-1 was coisolated with partial pkc-3 proteins that contained residues 212-227 but not by GST-pkc-3 lacking AA 219-224.	taxid:10036(mesau-av12-644)|taxid:10036(adenovirus type-12-transformed Syrian hamster subcutaneous tumor cell line)	-	2005/03/03	2014/10/16	rogid:qO+DFvMBt2DE+ZS7l8axk5DMOFQ6239	rogid:ouLBmSOAJYGbW6LTfHamRpHNiAY6239	intact-crc:0580EBD8C79801BD|rigid:o32z0Fy9IvwF9sDJjUVvcfdmack	false	binding-associated region:45-593	glutathione s tranferase tag:111-233,111-218,111-227	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q9XTY6-1	uniprotkb:Q19266	intact:EBI-495798|ensemblmetazoa:T03D8.1a.1	intact:EBI-319158|uniprotkb:A7VJC8|ensemblmetazoa:F09E5.1.1	psi-mi:q9xty6-1(display_long)|uniprotkb:cka1(isoform synonym)|uniprotkb:num-1(gene name)|psi-mi:num-1(display_short)|uniprotkb:cka-1(gene name synonym)|uniprotkb:CKA1(gene name synonym)|uniprotkb:Protein kinase C adapter 1(gene name synonym)|uniprotkb:T03D8.1(orf name)	psi-mi:kpc3_caeel(display_long)|uniprotkb:F09E5.1(orf name)|uniprotkb:pkc-3(gene name)|psi-mi:pkc-3(display_short)|uniprotkb:aPKC(gene name synonym)|uniprotkb:Atypical protein kinase C-3(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Zhang et al. (2001)	pubmed:11134025	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-515402	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-495781(numb1_caeel)|ensemblmetazoa:T03D8.1a.1(transcript)|ensemblmetazoa:WBGene00003830(gene)	refseq:NP_495011.1|wormbase:F09E5.1|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034877|reactome:R-CEL-5218921|go:"GO:0007369"(gastrulation)|go:"GO:0007506"(gonadal mesoderm development)|go:"GO:0008104"(protein localization)|go:"GO:0008406"(gonad development)|go:"GO:0009611"(response to wounding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|go:"GO:0007338"(single fertilization)|ensemblmetazoa:F09E5.1.1(transcript)|ensemblmetazoa:WBGene00004034(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007163"(establishment or maintenance of cell polarity)|dip:DIP-24814N|reactome:R-CEL-1912408|reactome:R-CEL-9634635	-	isoform-comment:Isoform c is produced by alternative initiation at Met-45 of isoform a	-	comment:"The pkc-3 fragment (AA 111-227) interacts with both isoform a and isoform c of num-1.  This interaction was inhibited by the presence of a synthetic 15mer peptide ligand."	taxid:10036(mesau-av12-644)|taxid:10036(adenovirus type-12-transformed Syrian hamster subcutaneous tumor cell line)	-	2005/03/03	2014/10/16	rogid:qO+DFvMBt2DE+ZS7l8axk5DMOFQ6239	rogid:ouLBmSOAJYGbW6LTfHamRpHNiAY6239	intact-crc:0F257A30B7725F83|rigid:o32z0Fy9IvwF9sDJjUVvcfdmack	false	-	glutathione s tranferase tag:111-227	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q19266	uniprotkb:Q9XTY6-1	intact:EBI-319158|uniprotkb:A7VJC8|ensemblmetazoa:F09E5.1.1	intact:EBI-495798|ensemblmetazoa:T03D8.1a.1	psi-mi:kpc3_caeel(display_long)|uniprotkb:F09E5.1(orf name)|uniprotkb:pkc-3(gene name)|psi-mi:pkc-3(display_short)|uniprotkb:aPKC(gene name synonym)|uniprotkb:Atypical protein kinase C-3(gene name synonym)	psi-mi:q9xty6-1(display_long)|uniprotkb:cka1(isoform synonym)|uniprotkb:num-1(gene name)|psi-mi:num-1(display_short)|uniprotkb:cka-1(gene name synonym)|uniprotkb:CKA1(gene name synonym)|uniprotkb:Protein kinase C adapter 1(gene name synonym)|uniprotkb:T03D8.1(orf name)	psi-mi:"MI:0019"(coimmunoprecipitation)	Zhang et al. (2001)	pubmed:11134025	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-515446	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_495011.1|wormbase:F09E5.1|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034877|reactome:R-CEL-5218921|go:"GO:0007369"(gastrulation)|go:"GO:0007506"(gonadal mesoderm development)|go:"GO:0008104"(protein localization)|go:"GO:0008406"(gonad development)|go:"GO:0009611"(response to wounding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|go:"GO:0007338"(single fertilization)|ensemblmetazoa:F09E5.1.1(transcript)|ensemblmetazoa:WBGene00004034(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007163"(establishment or maintenance of cell polarity)|dip:DIP-24814N|reactome:R-CEL-1912408|reactome:R-CEL-9634635	intact:EBI-495781(numb1_caeel)|ensemblmetazoa:T03D8.1a.1(transcript)|ensemblmetazoa:WBGene00003830(gene)	-	-	isoform-comment:Isoform c is produced by alternative initiation at Met-45 of isoform a	comment:"Substitution of either I-214, N-216 or F-219 with Alanine abrogated the ability of the partial (AA 111-227) pkc-3 fragment to bind with num-1 isoforms a and c."	taxid:10036(mesau-av12-644)|taxid:10036(adenovirus type-12-transformed Syrian hamster subcutaneous tumor cell line)	-	2005/03/03	2014/10/16	rogid:ouLBmSOAJYGbW6LTfHamRpHNiAY6239	rogid:qO+DFvMBt2DE+ZS7l8axk5DMOFQ6239	intact-crc:C9EB6CC69482E24D|rigid:o32z0Fy9IvwF9sDJjUVvcfdmack	false	binding-associated region:111-227|mutation decreasing interaction:214-214|mutation decreasing interaction:216-216|mutation decreasing interaction:219-219	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)