#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9JIL4	uniprotkb:Q60825	intact:EBI-7420331|uniprotkb:Q8CDP5|uniprotkb:Q9CQ72|uniprotkb:Q8R4G2|intact:MINT-148595	intact:EBI-7454990|uniprotkb:Q62116|uniprotkb:Q62115|intact:MINT-152214|uniprotkb:Q62110|uniprotkb:E9QKA0|uniprotkb:Q62112|uniprotkb:Q62564|uniprotkb:Q62113|uniprotkb:Q62114|uniprotkb:Q62111	psi-mi:nhrf3_mouse(display_long)|uniprotkb:Pdzk1(gene name)|psi-mi:Pdzk1(display_short)|uniprotkb:Cap70(gene name synonym)|uniprotkb:Nherf3(gene name synonym)|uniprotkb:PDZ domain-containing protein 1(gene name synonym)|uniprotkb:CFTR-associated protein of 70 kDa(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 3(gene name synonym)|uniprotkb:"Na(+)/H(+) exchanger regulatory factor 3"(gene name synonym)|uniprotkb:Na/Pi cotransporter C-terminal-associated protein 1(gene name synonym)	psi-mi:npt2a_mouse(display_long)|uniprotkb:Slc34a1(gene name)|psi-mi:Slc34a1(display_short)|uniprotkb:Npt2(gene name synonym)|uniprotkb:Slc17a2(gene name synonym)|uniprotkb:"Na(+)-dependent phosphate cotransporter 2A"(gene name synonym)|uniprotkb:Sodium/phosphate cotransporter 2A(gene name synonym)|uniprotkb:NaPi-7(gene name synonym)|uniprotkb:Solute carrier family 34 member 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Gisler et al. (2001)	pubmed:11099500|mint:MINT-5213271	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455020|mint:MINT-73095	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q9JIL4|refseq:XP_011238480.1|refseq:NP_001139473.1|refseq:NP_067492.2|interpro:IPR001478(PDZ/DHR/GLGF)|refseq:XP_017175164.1|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005124"(scavenger receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0015879"(carnitine transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1904064"(positive regulation of cation transmembrane transport)|go:"GO:1905477"(positive regulation of protein localization to membrane)|rcsb pdb:2D90|rcsb pdb:2EDZ|rcsb pdb:3NGH|rcsb pdb:3R68|rcsb pdb:3R69|rcsb pdb:4F8K|rcsb pdb:4R2Z|interpro:IPR036034|refseq:XP_006501896.1|mint:MINT-441344(identity)	interpro:IPR029848|interpro:IPR003841(Na+/Pi-cotransporter)|go:"GO:0005436"("sodium:phosphate symporter activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044341"(sodium-dependent phosphate transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046849"(bone remodeling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:1901684"(arsenate ion transmembrane transport)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:2000187"(positive regulation of phosphate transmembrane transport)|reactome:R-MMU-427589|reactome:R-MMU-5683826|mint:MINT-441333(identity)	-	comment:mint|function:"A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism (By similarity). May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function"|comment:"Stoichiometry: 1.0"	comment:mint|function:"May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx"|comment:"Stoichiometry: 1.0"	figure legend:T1 T2 F4A|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/12/05	2014/10/16	rogid:BJgdvpSO4jt9gOQ4q7csJ928GKI10090	rogid:A0ztjbHNwl2aAWx7rsPFVb8T9sI10090	intact-crc:91A84597FB20C7D0|rigid:Do/qGyDHlngdGgHwNZwa3ihIUy8	false	binding-associated region:217-359(MINT-441345)|tag:?-?(MINT-441348)	binding-associated region:563-637(MINT-441334)|tag:?-?(MINT-441338)|mutation decreasing interaction:635-637(MINT-441336)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99MJ6	uniprotkb:Q60825	intact:EBI-7455069|uniprotkb:Q8BWE5|intact:MINT-152467	intact:EBI-7454990|uniprotkb:Q62116|uniprotkb:Q62115|intact:MINT-152214|uniprotkb:Q62110|uniprotkb:E9QKA0|uniprotkb:Q62112|uniprotkb:Q62564|uniprotkb:Q62113|uniprotkb:Q62114|uniprotkb:Q62111	psi-mi:nhrf4_mouse(display_long)|uniprotkb:Pdzd3(gene name)|psi-mi:Pdzd3(display_short)|uniprotkb:Pdzk2(gene name synonym)|uniprotkb:Nherf4(gene name synonym)|uniprotkb:PDZ domain-containing protein 3(gene name synonym)|uniprotkb:PDZ domain-containing protein 2(gene name synonym)|uniprotkb:Natrium-phosphate cotransporter IIa C-terminal-associated protein 2(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 4(gene name synonym)	psi-mi:npt2a_mouse(display_long)|uniprotkb:Slc34a1(gene name)|psi-mi:Slc34a1(display_short)|uniprotkb:Npt2(gene name synonym)|uniprotkb:Slc17a2(gene name synonym)|uniprotkb:"Na(+)-dependent phosphate cotransporter 2A"(gene name synonym)|uniprotkb:Sodium/phosphate cotransporter 2A(gene name synonym)|uniprotkb:NaPi-7(gene name synonym)|uniprotkb:Solute carrier family 34 member 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Gisler et al. (2001)	pubmed:11099500|mint:MINT-5213271	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455065|mint:MINT-73096	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR031200|interpro:IPR036034|interpro:IPR001478(PDZ/DHR/GLGF)|refseq:NP_573489.2|go:"GO:0005737"(cytoplasm)|go:"GO:0005903"(brush border)|go:"GO:0006811"(ion transport)|go:"GO:0007168"(receptor guanylyl cyclase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030251"(guanylate cyclase inhibitor activity)|go:"GO:0043296"(apical junction complex)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1990381"(ubiquitin-specific protease binding)|mint:MINT-441196(identity)	interpro:IPR029848|interpro:IPR003841(Na+/Pi-cotransporter)|go:"GO:0005436"("sodium:phosphate symporter activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044341"(sodium-dependent phosphate transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046849"(bone remodeling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:1901684"(arsenate ion transmembrane transport)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:2000187"(positive regulation of phosphate transmembrane transport)|reactome:R-MMU-427589|reactome:R-MMU-5683826|mint:MINT-441185(identity)	-	comment:mint|function:Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation|comment:"Stoichiometry: 1.0"	comment:mint|function:"May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx"|comment:"Stoichiometry: 1.0"	figure legend:T1 T2 F4A|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/12/05	2014/10/16	rogid:Nlz4RzwY4ilDwdPQALP7wG4HjEk10090	rogid:A0ztjbHNwl2aAWx7rsPFVb8T9sI10090	intact-crc:9B49022B20AA17AA|rigid:XEyovhlR04P7GFsrdQsZyTYzLL8	false	tag:?-?(MINT-441200)|binding-associated region:243-377(MINT-441197)	mutation decreasing interaction:635-637(MINT-441188)|tag:?-?(MINT-441190)|binding-associated region:563-637(MINT-441186)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60825	uniprotkb:P70441	intact:EBI-7454990|uniprotkb:Q62116|uniprotkb:Q62115|intact:MINT-152214|uniprotkb:Q62110|uniprotkb:E9QKA0|uniprotkb:Q62112|uniprotkb:Q62564|uniprotkb:Q62113|uniprotkb:Q62114|uniprotkb:Q62111	intact:EBI-1184085|uniprotkb:Q8BYD8|ensembl:ENSMUSP00000021077	psi-mi:npt2a_mouse(display_long)|uniprotkb:Slc34a1(gene name)|psi-mi:Slc34a1(display_short)|uniprotkb:Npt2(gene name synonym)|uniprotkb:Slc17a2(gene name synonym)|uniprotkb:"Na(+)-dependent phosphate cotransporter 2A"(gene name synonym)|uniprotkb:Sodium/phosphate cotransporter 2A(gene name synonym)|uniprotkb:NaPi-7(gene name synonym)|uniprotkb:Solute carrier family 34 member 1(gene name synonym)	psi-mi:nhrf1_mouse(display_long)|uniprotkb:Slc9a3r1(gene name)|psi-mi:Slc9a3r1(display_short)|uniprotkb:Nherf(gene name synonym)|uniprotkb:Nherf1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Gisler et al. (2001)	pubmed:11099500|mint:MINT-5213271	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455132|mint:MINT-73097	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR029848|interpro:IPR003841(Na+/Pi-cotransporter)|go:"GO:0005436"("sodium:phosphate symporter activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044341"(sodium-dependent phosphate transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046849"(bone remodeling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:1901684"(arsenate ion transmembrane transport)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:2000187"(positive regulation of phosphate transmembrane transport)|reactome:R-MMU-427589|reactome:R-MMU-5683826|mint:MINT-441457(identity)	refseq:NP_036160.1|ensembl:ENSMUSG00000020733(gene)|ensembl:ENSMUST00000021077(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003096"(renal sodium ion transport)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015185"(gamma-aminobutyric acid transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034635"(glutathione transport)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0032416"("negative regulation of sodium:proton antiporter activity")|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044062"(regulation of excretion)|go:"GO:0044782"(cilium organization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045159"(myosin II binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050780"(dopamine receptor binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051939"(gamma-aminobutyric acid import)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0070293"(renal absorption)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:0098739"(import across plasma membrane)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031199|interpro:IPR036034|mint:P70441|mint:MINT-441468(identity)	-	comment:mint|function:"May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:T1 T2 F5A|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/12/05	2014/10/16	rogid:A0ztjbHNwl2aAWx7rsPFVb8T9sI10090	rogid:0Tz5KKGiYYEbcyP2lx4RrXUc76o10090	intact-crc:2E31EDB5BC7D0C02|rigid:C3JdGHGIZx0abS5q3znZvjnTjdE	false	tag:?-?(MINT-441462)|mutation decreasing interaction:635-637(MINT-441460)|binding-associated region:563-637(MINT-441458)	tag:?-?(MINT-441472)|binding-associated region:1-129(MINT-441469)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9DC04	uniprotkb:Q60825	intact:EBI-7455167|uniprotkb:Q8VI25|uniprotkb:Q925G9|uniprotkb:Q9JL23|intact:MINT-152808|uniprotkb:Q5SRB1|uniprotkb:Q9JL22|uniprotkb:Q5SRB4|uniprotkb:Q8CEE3|uniprotkb:Q5SRB8|uniprotkb:Q9QXA2|ensembl:ENSMUSP00000081569	intact:EBI-7454990|uniprotkb:Q62116|uniprotkb:Q62115|intact:MINT-152214|uniprotkb:Q62110|uniprotkb:E9QKA0|uniprotkb:Q62112|uniprotkb:Q62564|uniprotkb:Q62113|uniprotkb:Q62114|uniprotkb:Q62111	psi-mi:rgs3_mouse(display_long)|uniprotkb:Rgs3(gene name)|psi-mi:Rgs3(display_short)|uniprotkb:C2PA(gene name synonym)	psi-mi:npt2a_mouse(display_long)|uniprotkb:Slc34a1(gene name)|psi-mi:Slc34a1(display_short)|uniprotkb:Npt2(gene name synonym)|uniprotkb:Slc17a2(gene name synonym)|uniprotkb:"Na(+)-dependent phosphate cotransporter 2A"(gene name synonym)|uniprotkb:Sodium/phosphate cotransporter 2A(gene name synonym)|uniprotkb:NaPi-7(gene name synonym)|uniprotkb:Solute carrier family 34 member 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Gisler et al. (2001)	pubmed:11099500|mint:MINT-5213271	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455162|mint:MINT-73098	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297635.1|refseq:NP_062365.2|refseq:NP_001075119.1|refseq:NP_599018.3|refseq:XP_017175797.1|refseq:XP_006538130.1|refseq:XP_006538131.1|refseq:XP_006538132.1|refseq:XP_006538133.1|ensembl:ENSMUSG00000059810(gene)|ensembl:ENSMUST00000084521(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR034951|interpro:IPR036034|interpro:IPR036305|rcsb pdb:1WHD|reactome:R-MMU-416476|reactome:R-MMU-418594|mint:MINT-441425(identity)	interpro:IPR029848|interpro:IPR003841(Na+/Pi-cotransporter)|go:"GO:0005436"("sodium:phosphate symporter activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044341"(sodium-dependent phosphate transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046849"(bone remodeling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:1901684"(arsenate ion transmembrane transport)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:2000187"(positive regulation of phosphate transmembrane transport)|reactome:R-MMU-427589|reactome:R-MMU-5683826|mint:MINT-441414(identity)	-	comment:mint|function:Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases|comment:"Stoichiometry: 1.0"	comment:mint|function:"May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx"|comment:"Stoichiometry: 1.0"	figure legend:T1 T2 F5A|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/12/05	2014/10/16	rogid:XoMK1ccXFxmIN2eVjDw1jDHcFAI10090	rogid:A0ztjbHNwl2aAWx7rsPFVb8T9sI10090	intact-crc:5F632008F4BEE1BD|rigid:12MoTl951HZM7lYf68ui+EbOEBY	false	binding-associated region:195-375(MINT-441426)|tag:?-?(MINT-441429)	tag:?-?(MINT-441419)|mutation decreasing interaction:635-637(MINT-441417)|binding-associated region:563-637(MINT-441415)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60825	uniprotkb:Q9JHL1	intact:EBI-7454990|uniprotkb:Q62116|uniprotkb:Q62115|intact:MINT-152214|uniprotkb:Q62110|uniprotkb:E9QKA0|uniprotkb:Q62112|uniprotkb:Q62564|uniprotkb:Q62113|uniprotkb:Q62114|uniprotkb:Q62111	intact:EBI-538451|uniprotkb:Q3TDR3|uniprotkb:Q6P074|uniprotkb:Q8BGL9|uniprotkb:Q8BW05|uniprotkb:Q9DCR6	psi-mi:npt2a_mouse(display_long)|uniprotkb:Slc34a1(gene name)|psi-mi:Slc34a1(display_short)|uniprotkb:Npt2(gene name synonym)|uniprotkb:Slc17a2(gene name synonym)|uniprotkb:"Na(+)-dependent phosphate cotransporter 2A"(gene name synonym)|uniprotkb:Sodium/phosphate cotransporter 2A(gene name synonym)|uniprotkb:NaPi-7(gene name synonym)|uniprotkb:Solute carrier family 34 member 1(gene name synonym)	psi-mi:nhrf2_mouse(display_long)|uniprotkb:Tyrosine kinase activator protein 1(gene name synonym)|uniprotkb:SRY-interacting protein 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 2(gene name synonym)|uniprotkb:NHE3 kinase A regulatory protein E3KARP(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 2(gene name synonym)|uniprotkb:Octs2(gene name synonym)|uniprotkb:Slc9a3r2(gene name)|psi-mi:Slc9a3r2(display_short)|uniprotkb:Nherf2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Gisler et al. (2001)	pubmed:11099500|mint:MINT-5213271	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455300|mint:MINT-73099	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR029848|interpro:IPR003841(Na+/Pi-cotransporter)|go:"GO:0005436"("sodium:phosphate symporter activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044341"(sodium-dependent phosphate transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046849"(bone remodeling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:1901684"(arsenate ion transmembrane transport)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:2000187"(positive regulation of phosphate transmembrane transport)|reactome:R-MMU-427589|reactome:R-MMU-5683826|mint:MINT-441314(identity)	refseq:NP_075542.2|refseq:NP_075938.2|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR031197|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|mint:Q9JHL1|mint:MINT-441323(identity)	-	comment:mint|function:"May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:T1 T2|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/12/05	2014/10/16	rogid:A0ztjbHNwl2aAWx7rsPFVb8T9sI10090	rogid:479nbF0TYY11Q1dSVT26LwYoyiA10090	intact-crc:150FF033DE2529D5|rigid:DXZcih0dRD+jCMTEMDmGJlplYRQ	false	binding-associated region:563-637(MINT-441315)|tag:?-?(MINT-441317)	tag:?-?(MINT-441324)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60825	uniprotkb:Q80YW5	intact:EBI-7454990|uniprotkb:Q62116|uniprotkb:Q62115|intact:MINT-152214|uniprotkb:Q62110|uniprotkb:E9QKA0|uniprotkb:Q62112|uniprotkb:Q62564|uniprotkb:Q62113|uniprotkb:Q62114|uniprotkb:Q62111	intact:EBI-7455360|uniprotkb:Q9ER70|uniprotkb:Q8BZF0|intact:MINT-152245|uniprotkb:Q99KV7|uniprotkb:Q3TU74|ensembl:ENSMUSP00000103073	psi-mi:npt2a_mouse(display_long)|uniprotkb:Slc34a1(gene name)|psi-mi:Slc34a1(display_short)|uniprotkb:Npt2(gene name synonym)|uniprotkb:Slc17a2(gene name synonym)|uniprotkb:"Na(+)-dependent phosphate cotransporter 2A"(gene name synonym)|uniprotkb:Sodium/phosphate cotransporter 2A(gene name synonym)|uniprotkb:NaPi-7(gene name synonym)|uniprotkb:Solute carrier family 34 member 1(gene name synonym)	psi-mi:bspry_mouse(display_long)|uniprotkb:Bspry(gene name)|psi-mi:Bspry(display_short)	psi-mi:"MI:0018"(two hybrid)	Gisler et al. (2001)	pubmed:11099500|mint:MINT-5213271	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455389|mint:MINT-73100	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR029848|interpro:IPR003841(Na+/Pi-cotransporter)|go:"GO:0005436"("sodium:phosphate symporter activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044341"(sodium-dependent phosphate transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046849"(bone remodeling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:1901684"(arsenate ion transmembrane transport)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:2000187"(positive regulation of phosphate transmembrane transport)|reactome:R-MMU-427589|reactome:R-MMU-5683826|mint:MINT-441438(identity)	refseq:NP_619594.1|ensembl:ENSMUSG00000028392(gene)|ensembl:ENSMUST00000107449(transcript)|go:"GO:0005499"(vitamin D binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006816"(calcium ion transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031252"(cell leading edge)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR043136|mint:MINT-441447(identity)	-	comment:mint|function:"May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx"|comment:"Stoichiometry: 1.0"	comment:mint|function:May regulate epithelial calcium transport by inhibiting TRPV5 activity|comment:"Stoichiometry: 1.0"	figure legend:T1 T2|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/12/05	2014/10/16	rogid:A0ztjbHNwl2aAWx7rsPFVb8T9sI10090	rogid:wHKBQ6+DCilL1fdVBcv9dDtyg2Y10090	intact-crc:15882FF70F7C4ACA|rigid:9DOZfzz2owp66sPa99ju0ui+nfY	false	tag:?-?(MINT-441441)|binding-associated region:563-637(MINT-441439)	tag:?-?(MINT-441448)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P11499	uniprotkb:Q60825	intact:EBI-492813|uniprotkb:O89078|uniprotkb:Q3UIQ7|ensembl:ENSMUSP00000024739	intact:EBI-7454990|uniprotkb:Q62116|uniprotkb:Q62115|intact:MINT-152214|uniprotkb:Q62110|uniprotkb:E9QKA0|uniprotkb:Q62112|uniprotkb:Q62564|uniprotkb:Q62113|uniprotkb:Q62114|uniprotkb:Q62111	psi-mi:hs90b_mouse(display_long)|uniprotkb:Heat shock 84 kDa(gene name synonym)|uniprotkb:Tumor-specific transplantation 84 kDa antigen(gene name synonym)|uniprotkb:Hsp90ab1(gene name)|psi-mi:Hsp90ab1(display_short)|uniprotkb:Hsp84(gene name synonym)|uniprotkb:Hsp84-1(gene name synonym)|uniprotkb:Hspcb(gene name synonym)	psi-mi:npt2a_mouse(display_long)|uniprotkb:Slc34a1(gene name)|psi-mi:Slc34a1(display_short)|uniprotkb:Npt2(gene name synonym)|uniprotkb:Slc17a2(gene name synonym)|uniprotkb:"Na(+)-dependent phosphate cotransporter 2A"(gene name synonym)|uniprotkb:Sodium/phosphate cotransporter 2A(gene name synonym)|uniprotkb:NaPi-7(gene name synonym)|uniprotkb:Solute carrier family 34 member 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Gisler et al. (2001)	pubmed:11099500|mint:MINT-5213271	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455410|mint:MINT-73101	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032328.2|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P11499|reactome:R-MMU-168928|reactome:R-MMU-2029482|reactome:R-MMU-3371497|reactome:R-MMU-3371511|reactome:R-MMU-3371568|reactome:R-MMU-3371571|reactome:R-MMU-399954|reactome:R-MMU-6798695|reactome:R-MMU-844456|reactome:R-MMU-8852276|reactome:R-MMU-8937144|reactome:R-MMU-8939211|reactome:R-MMU-9013418|reactome:R-MMU-9018519|ensembl:ENSMUSG00000023944(gene)|ensembl:ENSMUST00000024739(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|dip:DIP-461N|mint:MINT-441156(identity)	interpro:IPR029848|interpro:IPR003841(Na+/Pi-cotransporter)|go:"GO:0005436"("sodium:phosphate symporter activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044341"(sodium-dependent phosphate transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046849"(bone remodeling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:1901684"(arsenate ion transmembrane transport)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:2000187"(positive regulation of phosphate transmembrane transport)|reactome:R-MMU-427589|reactome:R-MMU-5683826|mint:MINT-441147(identity)	-	comment:"Stoichiometry: 1.0"	comment:mint|function:"May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx"|comment:"Stoichiometry: 1.0"	figure legend:T1 T2|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/12/05	2014/10/16	rogid:5/MXDESVXdwuWna0s87Ap19aLMA10090	rogid:A0ztjbHNwl2aAWx7rsPFVb8T9sI10090	intact-crc:D3CD1F02675AF11D|rigid:NTZBvqx4i7/SotUUBJEBVg8ZCEY	false	tag:?-?(MINT-441157)	tag:?-?(MINT-441150)|binding-associated region:563-637(MINT-441148)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60825	uniprotkb:P07901	intact:EBI-7454990|uniprotkb:Q62116|uniprotkb:Q62115|intact:MINT-152214|uniprotkb:Q62110|uniprotkb:E9QKA0|uniprotkb:Q62112|uniprotkb:Q62564|uniprotkb:Q62113|uniprotkb:Q62114|uniprotkb:Q62111	intact:EBI-78930|ensembl:ENSMUSP00000021698|ensembl:ENSMUSP00000091921	psi-mi:npt2a_mouse(display_long)|uniprotkb:Slc34a1(gene name)|psi-mi:Slc34a1(display_short)|uniprotkb:Npt2(gene name synonym)|uniprotkb:Slc17a2(gene name synonym)|uniprotkb:"Na(+)-dependent phosphate cotransporter 2A"(gene name synonym)|uniprotkb:Sodium/phosphate cotransporter 2A(gene name synonym)|uniprotkb:NaPi-7(gene name synonym)|uniprotkb:Solute carrier family 34 member 1(gene name synonym)	psi-mi:hs90a_mouse(display_long)|uniprotkb:Hsp90aa1(gene name)|psi-mi:Hsp90aa1(display_short)|uniprotkb:Hsp86(gene name synonym)|uniprotkb:Hsp86-1(gene name synonym)|uniprotkb:Hspca(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Tumor-specific transplantation 86 kDa antigen(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Gisler et al. (2001)	pubmed:11099500|mint:MINT-5213271	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455458|mint:MINT-73102	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR029848|interpro:IPR003841(Na+/Pi-cotransporter)|go:"GO:0005436"("sodium:phosphate symporter activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044341"(sodium-dependent phosphate transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046849"(bone remodeling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:1901684"(arsenate ion transmembrane transport)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:2000187"(positive regulation of phosphate transmembrane transport)|reactome:R-MMU-427589|reactome:R-MMU-5683826|mint:MINT-441109(identity)	refseq:NP_034610.1|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045585"(positive regulation of cytotoxic T cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097226"(sperm mitochondrial sheath)|go:"GO:0097524"(sperm plasma membrane)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07901|rcsb pdb:5H22|reactome:R-MMU-1227986|reactome:R-MMU-1474151|reactome:R-MMU-168928|reactome:R-MMU-2029482|reactome:R-MMU-203615|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-3371511|reactome:R-MMU-3371568|reactome:R-MMU-3371571|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-399954|reactome:R-MMU-4420097|reactome:R-MMU-5218920|reactome:R-MMU-5620912|reactome:R-MMU-5675482|reactome:R-MMU-6798695|reactome:R-MMU-8852276|reactome:R-MMU-8854518|reactome:R-MMU-8863795|reactome:R-MMU-8939211|reactome:R-MMU-9009391|reactome:R-MMU-9013418|reactome:R-MMU-9018519|reactome:R-MMU-9652282|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032564"(dATP binding)|go:"GO:0032728"(positive regulation of interferon-beta production)|ensembl:ENSMUSG00000021270(gene)|ensembl:ENSMUST00000021698(transcript)|ensembl:ENSMUST00000094361(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0036126"(sperm flagellum)|go:"GO:0042026"(protein refolding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|dip:DIP-30975N|mint:MINT-441118(identity)	-	comment:mint|function:"May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:T1 T2|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/12/05	2014/10/16	rogid:A0ztjbHNwl2aAWx7rsPFVb8T9sI10090	rogid:t9XAeXdXezYOtJX0wp3IY9/ZMkQ10090	intact-crc:C000A5E6C5F48C1A|rigid:zq757ji84YYDEgJd7nqJD0hURXM	false	tag:?-?(MINT-441112)|binding-associated region:563-637(MINT-441110)	tag:?-?(MINT-441119)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60825	uniprotkb:O70433	intact:EBI-7454990|uniprotkb:Q62116|uniprotkb:Q62115|intact:MINT-152214|uniprotkb:Q62110|uniprotkb:E9QKA0|uniprotkb:Q62112|uniprotkb:Q62564|uniprotkb:Q62113|uniprotkb:Q62114|uniprotkb:Q62111	intact:EBI-299379|ensembl:ENSMUSP00000008280|ensembl:ENSMUSP00000141170|uniprotkb:P97448	psi-mi:npt2a_mouse(display_long)|uniprotkb:Slc34a1(gene name)|psi-mi:Slc34a1(display_short)|uniprotkb:Npt2(gene name synonym)|uniprotkb:Slc17a2(gene name synonym)|uniprotkb:"Na(+)-dependent phosphate cotransporter 2A"(gene name synonym)|uniprotkb:Sodium/phosphate cotransporter 2A(gene name synonym)|uniprotkb:NaPi-7(gene name synonym)|uniprotkb:Solute carrier family 34 member 1(gene name synonym)	psi-mi:fhl2_mouse(display_long)|uniprotkb:Fhl2(gene name)|psi-mi:Fhl2(display_short)|uniprotkb:Skeletal muscle LIM-protein 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Gisler et al. (2001)	pubmed:11099500|mint:MINT-5213271	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455585|mint:MINT-73104	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR029848|interpro:IPR003841(Na+/Pi-cotransporter)|go:"GO:0005436"("sodium:phosphate symporter activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044341"(sodium-dependent phosphate transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046849"(bone remodeling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:1901684"(arsenate ion transmembrane transport)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:2000187"(positive regulation of phosphate transmembrane transport)|reactome:R-MMU-427589|reactome:R-MMU-5683826|mint:MINT-441090(identity)	ensembl:ENSMUSG00000008136(gene)|ensembl:ENSMUST00000008280(transcript)|ensembl:ENSMUST00000185893(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009725"(response to hormone)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR037987|refseq:NP_034342.1|refseq:XP_011236736.1|refseq:NP_001276462.1|mint:MINT-441099(identity)	-	comment:mint|function:"May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:T1 T2|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/12/05	2014/10/16	rogid:A0ztjbHNwl2aAWx7rsPFVb8T9sI10090	rogid:F/ksOc8Ay71/DwSdKCK0mehHCCs10090	intact-crc:BA66CAE3712ACF2F|rigid:Hkija8XCN5ZsctAosLsP4ekXs3U	false	tag:?-?(MINT-441093)|binding-associated region:563-637(MINT-441091)	tag:?-?(MINT-441100)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60825	uniprotkb:Q60592	intact:EBI-7454990|uniprotkb:Q62116|uniprotkb:Q62115|intact:MINT-152214|uniprotkb:Q62110|uniprotkb:E9QKA0|uniprotkb:Q62112|uniprotkb:Q62564|uniprotkb:Q62113|uniprotkb:Q62114|uniprotkb:Q62111	intact:EBI-493888|uniprotkb:Q6P9M1|uniprotkb:Q8CHD1	psi-mi:npt2a_mouse(display_long)|uniprotkb:Slc34a1(gene name)|psi-mi:Slc34a1(display_short)|uniprotkb:Npt2(gene name synonym)|uniprotkb:Slc17a2(gene name synonym)|uniprotkb:"Na(+)-dependent phosphate cotransporter 2A"(gene name synonym)|uniprotkb:Sodium/phosphate cotransporter 2A(gene name synonym)|uniprotkb:NaPi-7(gene name synonym)|uniprotkb:Solute carrier family 34 member 1(gene name synonym)	psi-mi:mast2_mouse(display_long)|uniprotkb:Mast205(gene name synonym)|uniprotkb:Mast2(gene name)|psi-mi:Mast2(display_short)	psi-mi:"MI:0018"(two hybrid)	Gisler et al. (2001)	pubmed:11099500|mint:MINT-5213271	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455497|mint:MINT-73103	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR029848|interpro:IPR003841(Na+/Pi-cotransporter)|go:"GO:0005436"("sodium:phosphate symporter activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044341"(sodium-dependent phosphate transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046849"(bone remodeling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:1901684"(arsenate ion transmembrane transport)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:2000187"(positive regulation of phosphate transmembrane transport)|reactome:R-MMU-427589|reactome:R-MMU-5683826|mint:MINT-441395(identity)	refseq:NP_001036208.1|refseq:NP_032667.2|interpro:IPR028779|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015022(Region of unknown function DUF1908)|interpro:IPR023142|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|refseq:XP_017175507.1|interpro:IPR037711|interpro:IPR036034|interpro:IPR041489|mint:MINT-441404(identity)	-	comment:mint|function:"May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:T1 T2|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/12/05	2014/10/16	rogid:A0ztjbHNwl2aAWx7rsPFVb8T9sI10090	rogid:daKhgytpVxuFTpdmnVqscn+e43010090	intact-crc:C45E71DC6C2EF8CB|rigid:XqeqdPw/TeT+7jjlKg/qsXvkqYs	false	tag:?-?(MINT-441398)|binding-associated region:563-637(MINT-441396)	tag:?-?(MINT-441405)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60825	uniprotkb:Q91XB7	intact:EBI-7454990|uniprotkb:Q62116|uniprotkb:Q62115|intact:MINT-152214|uniprotkb:Q62110|uniprotkb:E9QKA0|uniprotkb:Q62112|uniprotkb:Q62564|uniprotkb:Q62113|uniprotkb:Q62114|uniprotkb:Q62111	intact:EBI-7455606|intact:MINT-152722|uniprotkb:Q9CWB2|ensembl:ENSMUSP00000025811	psi-mi:npt2a_mouse(display_long)|uniprotkb:Slc34a1(gene name)|psi-mi:Slc34a1(display_short)|uniprotkb:Npt2(gene name synonym)|uniprotkb:Slc17a2(gene name synonym)|uniprotkb:"Na(+)-dependent phosphate cotransporter 2A"(gene name synonym)|uniprotkb:Sodium/phosphate cotransporter 2A(gene name synonym)|uniprotkb:NaPi-7(gene name synonym)|uniprotkb:Solute carrier family 34 member 1(gene name synonym)	psi-mi:yif1a_mouse(display_long)|uniprotkb:Yif1a(gene name)|psi-mi:Yif1a(display_short)|uniprotkb:YIP1-interacting factor homolog A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Gisler et al. (2001)	pubmed:11099500|mint:MINT-5213271	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455626|mint:MINT-73105	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR029848|interpro:IPR003841(Na+/Pi-cotransporter)|go:"GO:0005436"("sodium:phosphate symporter activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044341"(sodium-dependent phosphate transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046849"(bone remodeling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:1901684"(arsenate ion transmembrane transport)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:2000187"(positive regulation of phosphate transmembrane transport)|reactome:R-MMU-427589|reactome:R-MMU-5683826|mint:MINT-441166(identity)	refseq:NP_080829.1|ensembl:ENSMUST00000025811(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|ensembl:ENSMUSG00000024875(gene)|go:"GO:0015031"(protein transport)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR005578(Hrf1)|mint:MINT-441175(identity)	-	comment:mint|function:"May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx"|comment:"Stoichiometry: 1.0"	comment:mint|function:Possible role in transport between endoplasmic reticulum and Golgi|comment:"Stoichiometry: 1.0"	figure legend:T1 T2|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/12/05	2014/10/16	rogid:A0ztjbHNwl2aAWx7rsPFVb8T9sI10090	rogid:HS9q4iJb3cXF5FKygB/0+zRahLU10090	intact-crc:ABAD615D8AC053ED|rigid:4GLxEqCJehghTm/l+YBCGwssbs8	false	binding-associated region:563-637(MINT-441167)|tag:?-?(MINT-441169)	tag:?-?(MINT-441176)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JIL4	uniprotkb:Q61983	intact:EBI-7420331|uniprotkb:Q8CDP5|uniprotkb:Q9CQ72|uniprotkb:Q8R4G2|intact:MINT-148595	intact:EBI-7455670|intact:MINT-152357|uniprotkb:A9Z1Z4|uniprotkb:Q91YA1|ensembl:ENSMUSP00000006785|ensembl:ENSMUSP00000106043	psi-mi:nhrf3_mouse(display_long)|uniprotkb:Pdzk1(gene name)|psi-mi:Pdzk1(display_short)|uniprotkb:Cap70(gene name synonym)|uniprotkb:Nherf3(gene name synonym)|uniprotkb:PDZ domain-containing protein 1(gene name synonym)|uniprotkb:CFTR-associated protein of 70 kDa(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 3(gene name synonym)|uniprotkb:"Na(+)/H(+) exchanger regulatory factor 3"(gene name synonym)|uniprotkb:Na/Pi cotransporter C-terminal-associated protein 1(gene name synonym)	psi-mi:npt1_mouse(display_long)|uniprotkb:Slc17a1(gene name)|psi-mi:Slc17a1(display_short)|uniprotkb:Npt1(gene name synonym)|uniprotkb:Sodium/phosphate cotransporter 1(gene name synonym)|uniprotkb:"Na(+)/PI cotransporter 1"(gene name synonym)|uniprotkb:Solute carrier family 17 member 1(gene name synonym)|uniprotkb:Renal sodium-dependent phosphate transport protein 1(gene name synonym)|uniprotkb:"Renal Na(+)-dependent phosphate cotransporter 1"(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Gisler et al. (2001)	pubmed:11099500|mint:MINT-5213271	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455699|mint:MINT-73106	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q9JIL4|refseq:XP_011238480.1|refseq:NP_001139473.1|refseq:NP_067492.2|interpro:IPR001478(PDZ/DHR/GLGF)|refseq:XP_017175164.1|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005124"(scavenger receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0015879"(carnitine transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1904064"(positive regulation of cation transmembrane transport)|go:"GO:1905477"(positive regulation of protein localization to membrane)|rcsb pdb:2D90|rcsb pdb:2EDZ|rcsb pdb:3NGH|rcsb pdb:3R68|rcsb pdb:3R69|rcsb pdb:4F8K|rcsb pdb:4R2Z|interpro:IPR036034|refseq:XP_006501896.1|mint:MINT-441304(identity)	refseq:NP_033224.3|refseq:NP_001164109.1|ensembl:ENSMUSG00000021335(gene)|ensembl:ENSMUST00000006785(transcript)|ensembl:ENSMUST00000110413(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006820"(anion transport)|go:"GO:0015114"(phosphate ion transmembrane transporter activity)|go:"GO:0015136"(sialic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015739"(sialic acid transport)|go:"GO:0015747"(urate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0046415"(urate metabolic process)|interpro:IPR004745("Na(+)-dependent inorganic phosphate cotransporter")|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR036259|reactome:R-MMU-428643|mint:MINT-441295(identity)	-	comment:mint|function:"A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism (By similarity). May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function"|comment:"Stoichiometry: 1.0"	comment:mint|function:"Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane"|comment:"Stoichiometry: 1.0"	figure legend:T2|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/12/05	2014/10/16	rogid:BJgdvpSO4jt9gOQ4q7csJ928GKI10090	rogid:qEYGH6d7NBjLdyIs1rJn5D87ZW410090	intact-crc:CCA22D8BEFC71A28|rigid:9HSLN8NnSYtjwXPsA8XQ+WNdd2E	false	tag:?-?(MINT-441305)	tag:?-?(MINT-441298)|binding-associated region:443-465(MINT-441296)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99MJ6	uniprotkb:Q61983	intact:EBI-7455069|uniprotkb:Q8BWE5|intact:MINT-152467	intact:EBI-7455670|intact:MINT-152357|uniprotkb:A9Z1Z4|uniprotkb:Q91YA1|ensembl:ENSMUSP00000006785|ensembl:ENSMUSP00000106043	psi-mi:nhrf4_mouse(display_long)|uniprotkb:Pdzd3(gene name)|psi-mi:Pdzd3(display_short)|uniprotkb:Pdzk2(gene name synonym)|uniprotkb:Nherf4(gene name synonym)|uniprotkb:PDZ domain-containing protein 3(gene name synonym)|uniprotkb:PDZ domain-containing protein 2(gene name synonym)|uniprotkb:Natrium-phosphate cotransporter IIa C-terminal-associated protein 2(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 4(gene name synonym)	psi-mi:npt1_mouse(display_long)|uniprotkb:Slc17a1(gene name)|psi-mi:Slc17a1(display_short)|uniprotkb:Npt1(gene name synonym)|uniprotkb:Sodium/phosphate cotransporter 1(gene name synonym)|uniprotkb:"Na(+)/PI cotransporter 1"(gene name synonym)|uniprotkb:Solute carrier family 17 member 1(gene name synonym)|uniprotkb:Renal sodium-dependent phosphate transport protein 1(gene name synonym)|uniprotkb:"Renal Na(+)-dependent phosphate cotransporter 1"(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Gisler et al. (2001)	pubmed:11099500|mint:MINT-5213271	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455773|mint:MINT-73107	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR031200|interpro:IPR036034|interpro:IPR001478(PDZ/DHR/GLGF)|refseq:NP_573489.2|go:"GO:0005737"(cytoplasm)|go:"GO:0005903"(brush border)|go:"GO:0006811"(ion transport)|go:"GO:0007168"(receptor guanylyl cyclase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030251"(guanylate cyclase inhibitor activity)|go:"GO:0043296"(apical junction complex)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1990381"(ubiquitin-specific protease binding)|mint:MINT-441490(identity)	refseq:NP_033224.3|refseq:NP_001164109.1|ensembl:ENSMUSG00000021335(gene)|ensembl:ENSMUST00000006785(transcript)|ensembl:ENSMUST00000110413(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006820"(anion transport)|go:"GO:0015114"(phosphate ion transmembrane transporter activity)|go:"GO:0015136"(sialic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015739"(sialic acid transport)|go:"GO:0015747"(urate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0046415"(urate metabolic process)|interpro:IPR004745("Na(+)-dependent inorganic phosphate cotransporter")|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR036259|reactome:R-MMU-428643|mint:MINT-441481(identity)	-	comment:mint|function:Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation|comment:"Stoichiometry: 1.0"	comment:mint|function:"Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane"|comment:"Stoichiometry: 1.0"	figure legend:T2|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/12/05	2014/10/16	rogid:Nlz4RzwY4ilDwdPQALP7wG4HjEk10090	rogid:qEYGH6d7NBjLdyIs1rJn5D87ZW410090	intact-crc:0EF93F42781522C1|rigid:CwFC93vKU+QFdpvcSiqntrsMlPU	false	tag:?-?(MINT-441491)	tag:?-?(MINT-441484)|binding-associated region:443-465(MINT-441482)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61983	uniprotkb:P70441	intact:EBI-7455670|intact:MINT-152357|uniprotkb:A9Z1Z4|uniprotkb:Q91YA1|ensembl:ENSMUSP00000006785|ensembl:ENSMUSP00000106043	intact:EBI-1184085|uniprotkb:Q8BYD8|ensembl:ENSMUSP00000021077	psi-mi:npt1_mouse(display_long)|uniprotkb:Slc17a1(gene name)|psi-mi:Slc17a1(display_short)|uniprotkb:Npt1(gene name synonym)|uniprotkb:Sodium/phosphate cotransporter 1(gene name synonym)|uniprotkb:"Na(+)/PI cotransporter 1"(gene name synonym)|uniprotkb:Solute carrier family 17 member 1(gene name synonym)|uniprotkb:Renal sodium-dependent phosphate transport protein 1(gene name synonym)|uniprotkb:"Renal Na(+)-dependent phosphate cotransporter 1"(gene name synonym)	psi-mi:nhrf1_mouse(display_long)|uniprotkb:Slc9a3r1(gene name)|psi-mi:Slc9a3r1(display_short)|uniprotkb:Nherf(gene name synonym)|uniprotkb:Nherf1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Gisler et al. (2001)	pubmed:11099500|mint:MINT-5213271	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455793|mint:MINT-73108	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033224.3|refseq:NP_001164109.1|ensembl:ENSMUSG00000021335(gene)|ensembl:ENSMUST00000006785(transcript)|ensembl:ENSMUST00000110413(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006820"(anion transport)|go:"GO:0015114"(phosphate ion transmembrane transporter activity)|go:"GO:0015136"(sialic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015739"(sialic acid transport)|go:"GO:0015747"(urate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0046415"(urate metabolic process)|interpro:IPR004745("Na(+)-dependent inorganic phosphate cotransporter")|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR036259|reactome:R-MMU-428643|mint:MINT-441357(identity)	refseq:NP_036160.1|ensembl:ENSMUSG00000020733(gene)|ensembl:ENSMUST00000021077(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003096"(renal sodium ion transport)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015185"(gamma-aminobutyric acid transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034635"(glutathione transport)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0032416"("negative regulation of sodium:proton antiporter activity")|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044062"(regulation of excretion)|go:"GO:0044782"(cilium organization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045159"(myosin II binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050780"(dopamine receptor binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051939"(gamma-aminobutyric acid import)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0070293"(renal absorption)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:0098739"(import across plasma membrane)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031199|interpro:IPR036034|mint:P70441|mint:MINT-441366(identity)	-	comment:mint|function:"Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:T2|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/12/05	2014/10/16	rogid:qEYGH6d7NBjLdyIs1rJn5D87ZW410090	rogid:0Tz5KKGiYYEbcyP2lx4RrXUc76o10090	intact-crc:93B818EAED315698|rigid:7ISjVXvzbmgkqtfaD6+1dykEcqw	false	tag:?-?(MINT-441360)|binding-associated region:443-465(MINT-441358)	tag:?-?(MINT-441367)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61983	uniprotkb:Q60592	intact:EBI-7455670|intact:MINT-152357|uniprotkb:A9Z1Z4|uniprotkb:Q91YA1|ensembl:ENSMUSP00000006785|ensembl:ENSMUSP00000106043	intact:EBI-493888|uniprotkb:Q6P9M1|uniprotkb:Q8CHD1	psi-mi:npt1_mouse(display_long)|uniprotkb:Slc17a1(gene name)|psi-mi:Slc17a1(display_short)|uniprotkb:Npt1(gene name synonym)|uniprotkb:Sodium/phosphate cotransporter 1(gene name synonym)|uniprotkb:"Na(+)/PI cotransporter 1"(gene name synonym)|uniprotkb:Solute carrier family 17 member 1(gene name synonym)|uniprotkb:Renal sodium-dependent phosphate transport protein 1(gene name synonym)|uniprotkb:"Renal Na(+)-dependent phosphate cotransporter 1"(gene name synonym)	psi-mi:mast2_mouse(display_long)|uniprotkb:Mast205(gene name synonym)|uniprotkb:Mast2(gene name)|psi-mi:Mast2(display_short)	psi-mi:"MI:0018"(two hybrid)	Gisler et al. (2001)	pubmed:11099500|mint:MINT-5213271	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455814|mint:MINT-73109	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033224.3|refseq:NP_001164109.1|ensembl:ENSMUSG00000021335(gene)|ensembl:ENSMUST00000006785(transcript)|ensembl:ENSMUST00000110413(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006820"(anion transport)|go:"GO:0015114"(phosphate ion transmembrane transporter activity)|go:"GO:0015136"(sialic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015739"(sialic acid transport)|go:"GO:0015747"(urate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0046415"(urate metabolic process)|interpro:IPR004745("Na(+)-dependent inorganic phosphate cotransporter")|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR036259|reactome:R-MMU-428643|mint:MINT-441209(identity)	refseq:NP_001036208.1|refseq:NP_032667.2|interpro:IPR028779|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015022(Region of unknown function DUF1908)|interpro:IPR023142|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|refseq:XP_017175507.1|interpro:IPR037711|interpro:IPR036034|interpro:IPR041489|mint:MINT-441218(identity)	-	comment:mint|function:"Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:T2|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/12/05	2014/10/16	rogid:qEYGH6d7NBjLdyIs1rJn5D87ZW410090	rogid:daKhgytpVxuFTpdmnVqscn+e43010090	intact-crc:E5200F967146A811|rigid:mZmPqLO2VIJjhRRm/axMca72NFU	false	tag:?-?(MINT-441212)|binding-associated region:443-465(MINT-441210)	tag:?-?(MINT-441219)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JIL4	uniprotkb:P26433	intact:EBI-7420331|uniprotkb:Q8CDP5|uniprotkb:Q9CQ72|uniprotkb:Q8R4G2|intact:MINT-148595	intact:EBI-961694	psi-mi:nhrf3_mouse(display_long)|uniprotkb:Pdzk1(gene name)|psi-mi:Pdzk1(display_short)|uniprotkb:Cap70(gene name synonym)|uniprotkb:Nherf3(gene name synonym)|uniprotkb:PDZ domain-containing protein 1(gene name synonym)|uniprotkb:CFTR-associated protein of 70 kDa(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 3(gene name synonym)|uniprotkb:"Na(+)/H(+) exchanger regulatory factor 3"(gene name synonym)|uniprotkb:Na/Pi cotransporter C-terminal-associated protein 1(gene name synonym)	psi-mi:sl9a3_rat(display_long)|uniprotkb:Slc9a3(gene name)|psi-mi:Slc9a3(display_short)|uniprotkb:Nhe3(gene name synonym)|uniprotkb:"Na(+)/H(+) exchanger 3"(gene name synonym)|uniprotkb:Solute carrier family 9 member 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Gisler et al. (2001)	pubmed:11099500|mint:MINT-5213271	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455834|mint:MINT-73110	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q9JIL4|refseq:XP_011238480.1|refseq:NP_001139473.1|refseq:NP_067492.2|interpro:IPR001478(PDZ/DHR/GLGF)|refseq:XP_017175164.1|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005124"(scavenger receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0015879"(carnitine transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1904064"(positive regulation of cation transmembrane transport)|go:"GO:1905477"(positive regulation of protein localization to membrane)|rcsb pdb:2D90|rcsb pdb:2EDZ|rcsb pdb:3NGH|rcsb pdb:3R68|rcsb pdb:3R69|rcsb pdb:4F8K|rcsb pdb:4R2Z|interpro:IPR036034|refseq:XP_006501896.1|mint:MINT-441137(identity)	go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006885"(regulation of pH)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0015385"("sodium:proton antiporter activity")|go:"GO:0015386"("potassium:proton antiporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0031982"(vesicle)|rgd:3720|refseq:NP_036786.1|interpro:IPR006153(Sodium/hydrogen exchanger)|interpro:IPR018422|interpro:IPR018410|interpro:IPR004709(Sodium/hydrogen exchanger subfamily)|reactome:R-RNO-425986|mint:MINT-441128(identity)	-	comment:mint|function:"A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism (By similarity). May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:T2|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/12/05	2014/10/16	rogid:BJgdvpSO4jt9gOQ4q7csJ928GKI10090	rogid:7bSUDMNq7pX8lDlSPsoOAmVipD810116	intact-crc:F92AF957BE8954CA|rigid:4FOKWrkjqFHdrFDq0OxYMLs9kgM	false	tag:?-?(MINT-441138)	binding-associated region:447-831(MINT-441129)|tag:?-?(MINT-441131)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26433	uniprotkb:P70441	intact:EBI-961694	intact:EBI-1184085|uniprotkb:Q8BYD8|ensembl:ENSMUSP00000021077	psi-mi:sl9a3_rat(display_long)|uniprotkb:Slc9a3(gene name)|psi-mi:Slc9a3(display_short)|uniprotkb:Nhe3(gene name synonym)|uniprotkb:"Na(+)/H(+) exchanger 3"(gene name synonym)|uniprotkb:Solute carrier family 9 member 3(gene name synonym)	psi-mi:nhrf1_mouse(display_long)|uniprotkb:Slc9a3r1(gene name)|psi-mi:Slc9a3r1(display_short)|uniprotkb:Nherf(gene name synonym)|uniprotkb:Nherf1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Gisler et al. (2001)	pubmed:11099500|mint:MINT-5213271	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455871|mint:MINT-73111	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006885"(regulation of pH)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0015385"("sodium:proton antiporter activity")|go:"GO:0015386"("potassium:proton antiporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0031982"(vesicle)|rgd:3720|refseq:NP_036786.1|interpro:IPR006153(Sodium/hydrogen exchanger)|interpro:IPR018422|interpro:IPR018410|interpro:IPR004709(Sodium/hydrogen exchanger subfamily)|reactome:R-RNO-425986|mint:MINT-441376(identity)	refseq:NP_036160.1|ensembl:ENSMUSG00000020733(gene)|ensembl:ENSMUST00000021077(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003096"(renal sodium ion transport)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015185"(gamma-aminobutyric acid transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034635"(glutathione transport)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0032416"("negative regulation of sodium:proton antiporter activity")|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044062"(regulation of excretion)|go:"GO:0044782"(cilium organization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045159"(myosin II binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050780"(dopamine receptor binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051939"(gamma-aminobutyric acid import)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0070293"(renal absorption)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:0098739"(import across plasma membrane)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031199|interpro:IPR036034|mint:P70441|mint:MINT-441385(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:T2|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/12/05	2014/10/16	rogid:7bSUDMNq7pX8lDlSPsoOAmVipD810116	rogid:0Tz5KKGiYYEbcyP2lx4RrXUc76o10090	intact-crc:A630CC36BC7F187A|rigid:naGCavsfkTsMoSSta9wko2cGaVY	false	tag:?-?(MINT-441379)|binding-associated region:447-831(MINT-441377)	tag:?-?(MINT-441386)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JIL4	uniprotkb:Q60825	intact:EBI-7420331|uniprotkb:Q8CDP5|uniprotkb:Q9CQ72|uniprotkb:Q8R4G2|intact:MINT-148595	intact:EBI-7454990|uniprotkb:Q62116|uniprotkb:Q62115|intact:MINT-152214|uniprotkb:Q62110|uniprotkb:E9QKA0|uniprotkb:Q62112|uniprotkb:Q62564|uniprotkb:Q62113|uniprotkb:Q62114|uniprotkb:Q62111	psi-mi:nhrf3_mouse(display_long)|uniprotkb:Pdzk1(gene name)|psi-mi:Pdzk1(display_short)|uniprotkb:Cap70(gene name synonym)|uniprotkb:Nherf3(gene name synonym)|uniprotkb:PDZ domain-containing protein 1(gene name synonym)|uniprotkb:CFTR-associated protein of 70 kDa(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 3(gene name synonym)|uniprotkb:"Na(+)/H(+) exchanger regulatory factor 3"(gene name synonym)|uniprotkb:Na/Pi cotransporter C-terminal-associated protein 1(gene name synonym)	psi-mi:npt2a_mouse(display_long)|uniprotkb:Slc34a1(gene name)|psi-mi:Slc34a1(display_short)|uniprotkb:Npt2(gene name synonym)|uniprotkb:Slc17a2(gene name synonym)|uniprotkb:"Na(+)-dependent phosphate cotransporter 2A"(gene name synonym)|uniprotkb:Sodium/phosphate cotransporter 2A(gene name synonym)|uniprotkb:NaPi-7(gene name synonym)|uniprotkb:Solute carrier family 34 member 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Gisler et al. (2001)	pubmed:11099500|mint:MINT-5213271	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455900|mint:MINT-73112	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q9JIL4|refseq:XP_011238480.1|refseq:NP_001139473.1|refseq:NP_067492.2|interpro:IPR001478(PDZ/DHR/GLGF)|refseq:XP_017175164.1|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005124"(scavenger receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0015879"(carnitine transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1904064"(positive regulation of cation transmembrane transport)|go:"GO:1905477"(positive regulation of protein localization to membrane)|rcsb pdb:2D90|rcsb pdb:2EDZ|rcsb pdb:3NGH|rcsb pdb:3R68|rcsb pdb:3R69|rcsb pdb:4F8K|rcsb pdb:4R2Z|interpro:IPR036034|refseq:XP_006501896.1|mint:MINT-441276(identity)	interpro:IPR029848|interpro:IPR003841(Na+/Pi-cotransporter)|go:"GO:0005436"("sodium:phosphate symporter activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044341"(sodium-dependent phosphate transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046849"(bone remodeling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:1901684"(arsenate ion transmembrane transport)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:2000187"(positive regulation of phosphate transmembrane transport)|reactome:R-MMU-427589|reactome:R-MMU-5683826|mint:MINT-441286(identity)	-	comment:mint|function:"A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism (By similarity). May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function"|comment:"Stoichiometry: 1.0"	comment:mint|function:"May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx"|comment:"Stoichiometry: 1.0"	figure legend:F1|comment:Interaction occurs also with X. laevis lysates overexpressing murine Type IIa Na/Pi|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/05	2014/10/16	rogid:BJgdvpSO4jt9gOQ4q7csJ928GKI10090	rogid:A0ztjbHNwl2aAWx7rsPFVb8T9sI10090	intact-crc:B508BD8C059BA800|rigid:Do/qGyDHlngdGgHwNZwa3ihIUy8	false	binding-associated region:217-359(MINT-441277)|glutathione s tranferase tag:?-?(MINT-441280)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q60825	uniprotkb:P70441	intact:EBI-7454990|uniprotkb:Q62116|uniprotkb:Q62115|intact:MINT-152214|uniprotkb:Q62110|uniprotkb:E9QKA0|uniprotkb:Q62112|uniprotkb:Q62564|uniprotkb:Q62113|uniprotkb:Q62114|uniprotkb:Q62111	intact:EBI-1184085|uniprotkb:Q8BYD8|ensembl:ENSMUSP00000021077	psi-mi:npt2a_mouse(display_long)|uniprotkb:Slc34a1(gene name)|psi-mi:Slc34a1(display_short)|uniprotkb:Npt2(gene name synonym)|uniprotkb:Slc17a2(gene name synonym)|uniprotkb:"Na(+)-dependent phosphate cotransporter 2A"(gene name synonym)|uniprotkb:Sodium/phosphate cotransporter 2A(gene name synonym)|uniprotkb:NaPi-7(gene name synonym)|uniprotkb:Solute carrier family 34 member 1(gene name synonym)	psi-mi:nhrf1_mouse(display_long)|uniprotkb:Slc9a3r1(gene name)|psi-mi:Slc9a3r1(display_short)|uniprotkb:Nherf(gene name synonym)|uniprotkb:Nherf1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Gisler et al. (2001)	pubmed:11099500|mint:MINT-5213271	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455934|mint:MINT-73114	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR029848|interpro:IPR003841(Na+/Pi-cotransporter)|go:"GO:0005436"("sodium:phosphate symporter activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044341"(sodium-dependent phosphate transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046849"(bone remodeling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:1901684"(arsenate ion transmembrane transport)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:2000187"(positive regulation of phosphate transmembrane transport)|reactome:R-MMU-427589|reactome:R-MMU-5683826|mint:MINT-441252(identity)	refseq:NP_036160.1|ensembl:ENSMUSG00000020733(gene)|ensembl:ENSMUST00000021077(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003096"(renal sodium ion transport)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015185"(gamma-aminobutyric acid transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034635"(glutathione transport)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0032416"("negative regulation of sodium:proton antiporter activity")|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044062"(regulation of excretion)|go:"GO:0044782"(cilium organization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045159"(myosin II binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050780"(dopamine receptor binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051939"(gamma-aminobutyric acid import)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0070293"(renal absorption)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:0098739"(import across plasma membrane)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031199|interpro:IPR036034|mint:P70441|mint:MINT-441245(identity)	-	comment:mint|function:"May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/05	2014/10/16	rogid:A0ztjbHNwl2aAWx7rsPFVb8T9sI10090	rogid:0Tz5KKGiYYEbcyP2lx4RrXUc76o10090	intact-crc:AF1543B5C7EE9D1C|rigid:C3JdGHGIZx0abS5q3znZvjnTjdE	false	-	glutathione s tranferase tag:?-?(MINT-441246)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60825	uniprotkb:Q99MJ6	intact:EBI-7454990|uniprotkb:Q62116|uniprotkb:Q62115|intact:MINT-152214|uniprotkb:Q62110|uniprotkb:E9QKA0|uniprotkb:Q62112|uniprotkb:Q62564|uniprotkb:Q62113|uniprotkb:Q62114|uniprotkb:Q62111	intact:EBI-7455069|uniprotkb:Q8BWE5|intact:MINT-152467	psi-mi:npt2a_mouse(display_long)|uniprotkb:Slc34a1(gene name)|psi-mi:Slc34a1(display_short)|uniprotkb:Npt2(gene name synonym)|uniprotkb:Slc17a2(gene name synonym)|uniprotkb:"Na(+)-dependent phosphate cotransporter 2A"(gene name synonym)|uniprotkb:Sodium/phosphate cotransporter 2A(gene name synonym)|uniprotkb:NaPi-7(gene name synonym)|uniprotkb:Solute carrier family 34 member 1(gene name synonym)	psi-mi:nhrf4_mouse(display_long)|uniprotkb:Pdzd3(gene name)|psi-mi:Pdzd3(display_short)|uniprotkb:Pdzk2(gene name synonym)|uniprotkb:Nherf4(gene name synonym)|uniprotkb:PDZ domain-containing protein 3(gene name synonym)|uniprotkb:PDZ domain-containing protein 2(gene name synonym)|uniprotkb:Natrium-phosphate cotransporter IIa C-terminal-associated protein 2(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Gisler et al. (2001)	pubmed:11099500|mint:MINT-5213271	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455920|mint:MINT-73113	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR029848|interpro:IPR003841(Na+/Pi-cotransporter)|go:"GO:0005436"("sodium:phosphate symporter activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044341"(sodium-dependent phosphate transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046849"(bone remodeling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:1901684"(arsenate ion transmembrane transport)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:2000187"(positive regulation of phosphate transmembrane transport)|reactome:R-MMU-427589|reactome:R-MMU-5683826|mint:MINT-441267(identity)	interpro:IPR031200|interpro:IPR036034|interpro:IPR001478(PDZ/DHR/GLGF)|refseq:NP_573489.2|go:"GO:0005737"(cytoplasm)|go:"GO:0005903"(brush border)|go:"GO:0006811"(ion transport)|go:"GO:0007168"(receptor guanylyl cyclase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030251"(guanylate cyclase inhibitor activity)|go:"GO:0043296"(apical junction complex)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1990381"(ubiquitin-specific protease binding)|mint:MINT-441260(identity)	-	comment:mint|function:"May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx"|comment:"Stoichiometry: 1.0"	comment:mint|function:Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation|comment:"Stoichiometry: 1.0"	figure legend:F1|comment:Interaction occurs also with X. laevis lysates overexpressing murine Type IIa Na/Pi|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/05	2014/10/16	rogid:A0ztjbHNwl2aAWx7rsPFVb8T9sI10090	rogid:Nlz4RzwY4ilDwdPQALP7wG4HjEk10090	intact-crc:C1832B36956C51AD|rigid:XEyovhlR04P7GFsrdQsZyTYzLL8	false	-	glutathione s tranferase tag:?-?(MINT-441261)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60825	uniprotkb:Q9JHL1	intact:EBI-7454990|uniprotkb:Q62116|uniprotkb:Q62115|intact:MINT-152214|uniprotkb:Q62110|uniprotkb:E9QKA0|uniprotkb:Q62112|uniprotkb:Q62564|uniprotkb:Q62113|uniprotkb:Q62114|uniprotkb:Q62111	intact:EBI-538451|uniprotkb:Q3TDR3|uniprotkb:Q6P074|uniprotkb:Q8BGL9|uniprotkb:Q8BW05|uniprotkb:Q9DCR6	psi-mi:npt2a_mouse(display_long)|uniprotkb:Slc34a1(gene name)|psi-mi:Slc34a1(display_short)|uniprotkb:Npt2(gene name synonym)|uniprotkb:Slc17a2(gene name synonym)|uniprotkb:"Na(+)-dependent phosphate cotransporter 2A"(gene name synonym)|uniprotkb:Sodium/phosphate cotransporter 2A(gene name synonym)|uniprotkb:NaPi-7(gene name synonym)|uniprotkb:Solute carrier family 34 member 1(gene name synonym)	psi-mi:nhrf2_mouse(display_long)|uniprotkb:Tyrosine kinase activator protein 1(gene name synonym)|uniprotkb:SRY-interacting protein 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 2(gene name synonym)|uniprotkb:NHE3 kinase A regulatory protein E3KARP(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 2(gene name synonym)|uniprotkb:Octs2(gene name synonym)|uniprotkb:Slc9a3r2(gene name)|psi-mi:Slc9a3r2(display_short)|uniprotkb:Nherf2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Gisler et al. (2001)	pubmed:11099500|mint:MINT-5213271	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455948|mint:MINT-73115	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR029848|interpro:IPR003841(Na+/Pi-cotransporter)|go:"GO:0005436"("sodium:phosphate symporter activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044341"(sodium-dependent phosphate transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046849"(bone remodeling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:1901684"(arsenate ion transmembrane transport)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:2000187"(positive regulation of phosphate transmembrane transport)|reactome:R-MMU-427589|reactome:R-MMU-5683826|mint:MINT-441237(identity)	refseq:NP_075542.2|refseq:NP_075938.2|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR031197|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|mint:Q9JHL1|mint:MINT-441230(identity)	-	comment:mint|function:"May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/05	2014/10/16	rogid:A0ztjbHNwl2aAWx7rsPFVb8T9sI10090	rogid:479nbF0TYY11Q1dSVT26LwYoyiA10090	intact-crc:6D1551B65E197618|rigid:DXZcih0dRD+jCMTEMDmGJlplYRQ	false	-	glutathione s tranferase tag:?-?(MINT-441231)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)