#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P89079 uniprotkb:Q6RHR9 intact:EBI-7401124|intact:MINT-431542 intact:EBI-7440897|uniprotkb:O54894|uniprotkb:O54893|uniprotkb:O54895|intact:MINT-150460|ensembl:ENSMUSP00000086730 psi-mi:e4or1_ade09(display_long)|uniprotkb:E4(gene name)|psi-mi:E4(display_short)|uniprotkb:Probable dUTPase E4 ORF1(gene name synonym)|uniprotkb:Early E4 14.0 kDa protein(gene name synonym)|uniprotkb:ORF1(gene name synonym) psi-mi:magi1_mouse(display_long)|uniprotkb:Magi1(gene name)|psi-mi:Magi1(display_short)|uniprotkb:Baiap1(gene name synonym)|uniprotkb:Bap1(gene name synonym)|uniprotkb:BAI1-associated protein 1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 1(gene name synonym) psi-mi:"MI:0049"(filter binding) Glaunsinger et al. (2000) pubmed:11077444|mint:MINT-5213199 taxid:10527(hadv-9)|taxid:10527(Human adenovirus D serotype 9) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7440892|mint:MINT-69666 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P89079|go:"GO:0004170"(dUTP diphosphatase activity)|go:"GO:0009117"(nucleotide metabolic process)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR029054|interpro:IPR036157|dip:DIP-44835N|mint:MINT-433998(identity) refseq:NP_034497.1|refseq:NP_001025021.1|ensembl:ENSMUSG00000045095(gene)|ensembl:ENSMUST00000089317(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0042995"(cell projection)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071944"(cell periphery)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030033|interpro:IPR036020|interpro:IPR036034|rcsb pdb:2I04|rcsb pdb:5ZYS|mint:MINT-434007(identity) - comment:mint|comment:homomint|function:Plays a key role in virus oncogenecity in animals. Binds and sequesters human MUPP1/MPDZ protein in the cytoplasm, preventing it from playing a role in cellular proliferation regulation. Induces cell transformation, probably by inactivating MPDZ protein|comment:"Stoichiometry: 1.0" comment:mint|function:May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ACCN3 currents by modulating its expression at the cell surface|comment:"Stoichiometry: 1.0" figure legend:F5A|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/11/17 2014/10/16 rogid:NtuDlTWsr1MWfNM4ARULmS3kn/U10527 rogid:mk1dW19+wMHjMLcuieBAQSHEs3U10090 intact-crc:78C84F8884C2F351|rigid:q82i177X3amg2eAyGTmBueVh6N4 false tag:?-?(MINT-434001)|mutation decreasing interaction:122-122(MINT-433999) glutathione s tranferase tag:?-?(MINT-434011)|binding-associated region:431-545(MINT-434008) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q6RHR9 uniprotkb:P89079 intact:EBI-7440897|uniprotkb:O54894|uniprotkb:O54893|uniprotkb:O54895|intact:MINT-150460|ensembl:ENSMUSP00000086730 intact:EBI-7401124|intact:MINT-431542 psi-mi:magi1_mouse(display_long)|uniprotkb:Magi1(gene name)|psi-mi:Magi1(display_short)|uniprotkb:Baiap1(gene name synonym)|uniprotkb:Bap1(gene name synonym)|uniprotkb:BAI1-associated protein 1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 1(gene name synonym) psi-mi:e4or1_ade09(display_long)|uniprotkb:E4(gene name)|psi-mi:E4(display_short)|uniprotkb:Probable dUTPase E4 ORF1(gene name synonym)|uniprotkb:Early E4 14.0 kDa protein(gene name synonym)|uniprotkb:ORF1(gene name synonym) psi-mi:"MI:0049"(filter binding) Glaunsinger et al. (2000) pubmed:11077444|mint:MINT-5213199 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10527(hadv-9)|taxid:10527(Human adenovirus D serotype 9) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7440992|mint:MINT-69667 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034497.1|refseq:NP_001025021.1|ensembl:ENSMUSG00000045095(gene)|ensembl:ENSMUST00000089317(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0042995"(cell projection)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071944"(cell periphery)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030033|interpro:IPR036020|interpro:IPR036034|rcsb pdb:2I04|rcsb pdb:5ZYS|mint:MINT-434099(identity) mint:P89079|go:"GO:0004170"(dUTP diphosphatase activity)|go:"GO:0009117"(nucleotide metabolic process)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR029054|interpro:IPR036157|dip:DIP-44835N|mint:MINT-434090(identity) - comment:mint|function:May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ACCN3 currents by modulating its expression at the cell surface|comment:"Stoichiometry: 1.0" comment:mint|comment:homomint|function:Plays a key role in virus oncogenecity in animals. Binds and sequesters human MUPP1/MPDZ protein in the cytoplasm, preventing it from playing a role in cellular proliferation regulation. Induces cell transformation, probably by inactivating MPDZ protein|comment:"Stoichiometry: 1.0" figure legend:F5A|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/11/17 2014/10/16 rogid:mk1dW19+wMHjMLcuieBAQSHEs3U10090 rogid:NtuDlTWsr1MWfNM4ARULmS3kn/U10527 intact-crc:7871F4865369D16A|rigid:q82i177X3amg2eAyGTmBueVh6N4 false glutathione s tranferase tag:?-?(MINT-434103)|binding-associated region:763-880(MINT-434100) mutation decreasing interaction:124-124(MINT-434091)|tag:?-?(MINT-434093) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P89079 uniprotkb:Q4L1J4 intact:EBI-7401124|intact:MINT-431542 intact:EBI-5259666|uniprotkb:Q4L1J5 psi-mi:e4or1_ade09(display_long)|uniprotkb:E4(gene name)|psi-mi:E4(display_short)|uniprotkb:Probable dUTPase E4 ORF1(gene name synonym)|uniprotkb:Early E4 14.0 kDa protein(gene name synonym)|uniprotkb:ORF1(gene name synonym) psi-mi:magi1_rat(display_long)|uniprotkb:Magi1(gene name)|psi-mi:Magi1(display_short)|uniprotkb:Baiap1(gene name synonym)|uniprotkb:Bap1(gene name synonym)|uniprotkb:BAI1-associated protein 1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 1(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Glaunsinger et al. (2000) pubmed:11077444|mint:MINT-5213199 taxid:10527(hadv-9)|taxid:10527(Human adenovirus D serotype 9) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7441070|mint:MINT-69670 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P89079|go:"GO:0004170"(dUTP diphosphatase activity)|go:"GO:0009117"(nucleotide metabolic process)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR029054|interpro:IPR036157|dip:DIP-44835N|mint:MINT-434033(identity) interpro:IPR030033|mint:Q4L1J4|rgd:1586025|refseq:NP_001025216.1|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR027417|interpro:IPR036020|interpro:IPR036034|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0042995"(cell projection)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071944"(cell periphery)|mint:MINT-434040(identity) - comment:mint|comment:homomint|function:Plays a key role in virus oncogenecity in animals. Binds and sequesters human MUPP1/MPDZ protein in the cytoplasm, preventing it from playing a role in cellular proliferation regulation. Induces cell transformation, probably by inactivating MPDZ protein|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F6|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:10116(rat-cref)|taxid:10116(Rattus norvegicus) - 2005/11/17 2014/10/16 rogid:NtuDlTWsr1MWfNM4ARULmS3kn/U10527 rogid:9CBhwilN2GVwCa7rk3mnHDORIU810116 intact-crc:4E089F0E551EFA6D|rigid:+3MArM6X9sSwjWCTQhn4vRVI7NY false ha tag:?-?(MINT-434034) - - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:P89079 uniprotkb:Q6RHR9-1 intact:EBI-7401124|intact:MINT-431542 intact:EBI-7441112|intact:MINT-150479|ensembl:ENSMUSP00000086730 psi-mi:e4or1_ade09(display_long)|uniprotkb:E4(gene name)|psi-mi:E4(display_short)|uniprotkb:Probable dUTPase E4 ORF1(gene name synonym)|uniprotkb:Early E4 14.0 kDa protein(gene name synonym)|uniprotkb:ORF1(gene name synonym) psi-mi:q6rhr9-1(display_long)|uniprotkb:Magi1(gene name)|psi-mi:Magi1(display_short)|uniprotkb:BAI1-associated protein 1(gene name synonym)|uniprotkb:Baiap1(gene name synonym)|uniprotkb:Bap1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 1(gene name synonym)|uniprotkb:MAGI-1c(isoform synonym)|uniprotkb:MAGI1c alpha beta2 gamma(isoform synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Glaunsinger et al. (2000) pubmed:11077444|mint:MINT-5213199 taxid:10527(hadv-9)|taxid:10527(Human adenovirus D serotype 9) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7441107|mint:MINT-69665 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P89079|go:"GO:0004170"(dUTP diphosphatase activity)|go:"GO:0009117"(nucleotide metabolic process)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR029054|interpro:IPR036157|dip:DIP-44835N|mint:MINT-434050(identity) intact:EBI-7440897(magi1_mouse)|ensembl:ENSMUSG00000045095(gene)|ensembl:ENSMUST00000089317(transcript)|mint:MINT-434058(identity) - comment:mint|comment:homomint|function:Plays a key role in virus oncogenecity in animals. Binds and sequesters human MUPP1/MPDZ protein in the cytoplasm, preventing it from playing a role in cellular proliferation regulation. Induces cell transformation, probably by inactivating MPDZ protein|comment:"Stoichiometry: 1.0" comment:mint|comment:"Stoichiometry: 1.0" figure legend:F4A|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2005/11/17 2014/10/16 rogid:NtuDlTWsr1MWfNM4ARULmS3kn/U10527 rogid:mk1dW19+wMHjMLcuieBAQSHEs3U10090 intact-crc:25002E8FF1A1DB5F|rigid:q82i177X3amg2eAyGTmBueVh6N4 false mutation decreasing interaction:123-123,124-125(MINT-434051) ha tag:?-?(MINT-434059) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q6RHR9-2 uniprotkb:P89079 intact:EBI-7441142|intact:MINT-150486 intact:EBI-7401124|intact:MINT-431542 psi-mi:q6rhr9-2(display_long)|uniprotkb:Bap1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 1(gene name synonym)|uniprotkb:MAGI-1b(isoform synonym)|uniprotkb:Magi1(gene name)|psi-mi:Magi1(display_short)|uniprotkb:BAI1-associated protein 1(gene name synonym)|uniprotkb:Baiap1(gene name synonym) psi-mi:e4or1_ade09(display_long)|uniprotkb:E4(gene name)|psi-mi:E4(display_short)|uniprotkb:Probable dUTPase E4 ORF1(gene name synonym)|uniprotkb:Early E4 14.0 kDa protein(gene name synonym)|uniprotkb:ORF1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Glaunsinger et al. (2000) pubmed:11077444|mint:MINT-5213199 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10527(hadv-9)|taxid:10527(Human adenovirus D serotype 9) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7441156|mint:MINT-69669 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7440897(magi1_mouse)|mint:MINT-434075(identity) mint:P89079|go:"GO:0004170"(dUTP diphosphatase activity)|go:"GO:0009117"(nucleotide metabolic process)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR029054|interpro:IPR036157|dip:DIP-44835N|mint:MINT-434068(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:mint|comment:homomint|function:Plays a key role in virus oncogenecity in animals. Binds and sequesters human MUPP1/MPDZ protein in the cytoplasm, preventing it from playing a role in cellular proliferation regulation. Induces cell transformation, probably by inactivating MPDZ protein|comment:"Stoichiometry: 1.0" figure legend:F5D|comment:Single PDZ domain deletions show interactions|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2005/11/17 2014/10/16 rogid:1rT8ap6nYsgW7UE/DVnjO76BJGQ10090 rogid:NtuDlTWsr1MWfNM4ARULmS3kn/U10527 intact-crc:8855C15CF32BABA1|rigid:VC9Lic0pCh6aTkzPYrMKC8aOOqY false binding-associated region:431-545,763-880(MINT-434076)|ha tag:?-?(MINT-434080) tag:?-?(MINT-434069) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0113"(western blot) uniprotkb:Q6RHR9-1 uniprotkb:P89079 intact:EBI-7441112|intact:MINT-150479|ensembl:ENSMUSP00000086730 intact:EBI-7401124|intact:MINT-431542 psi-mi:q6rhr9-1(display_long)|uniprotkb:Magi1(gene name)|psi-mi:Magi1(display_short)|uniprotkb:BAI1-associated protein 1(gene name synonym)|uniprotkb:Baiap1(gene name synonym)|uniprotkb:Bap1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 1(gene name synonym)|uniprotkb:MAGI-1c(isoform synonym)|uniprotkb:MAGI1c alpha beta2 gamma(isoform synonym) psi-mi:e4or1_ade09(display_long)|uniprotkb:E4(gene name)|psi-mi:E4(display_short)|uniprotkb:Probable dUTPase E4 ORF1(gene name synonym)|uniprotkb:Early E4 14.0 kDa protein(gene name synonym)|uniprotkb:ORF1(gene name synonym) psi-mi:"MI:0096"(pull down) Glaunsinger et al. (2000) pubmed:11077444|mint:MINT-5213199 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10527(hadv-9)|taxid:10527(Human adenovirus D serotype 9) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7441204|mint:MINT-69646 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7440897(magi1_mouse)|ensembl:ENSMUSG00000045095(gene)|ensembl:ENSMUST00000089317(transcript)|mint:MINT-434178(identity) mint:P89079|go:"GO:0004170"(dUTP diphosphatase activity)|go:"GO:0009117"(nucleotide metabolic process)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR029054|interpro:IPR036157|dip:DIP-44835N|mint:MINT-434168(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:mint|comment:homomint|function:Plays a key role in virus oncogenecity in animals. Binds and sequesters human MUPP1/MPDZ protein in the cytoplasm, preventing it from playing a role in cellular proliferation regulation. Induces cell transformation, probably by inactivating MPDZ protein|comment:"Stoichiometry: 1.0" figure legend:F2A|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/11/17 2014/10/16 rogid:mk1dW19+wMHjMLcuieBAQSHEs3U10090 rogid:NtuDlTWsr1MWfNM4ARULmS3kn/U10527 intact-crc:89CC9A572BE5FADF|rigid:q82i177X3amg2eAyGTmBueVh6N4 false ha tag:?-?(MINT-434179) glutathione s tranferase tag:?-?(MINT-434172)|mutation decreasing interaction:123-123,124-125(MINT-434169) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q6RHR9-1 uniprotkb:P04489 intact:EBI-7441112|intact:MINT-150479|ensembl:ENSMUSP00000086730 intact:EBI-6398911 psi-mi:q6rhr9-1(display_long)|uniprotkb:Magi1(gene name)|psi-mi:Magi1(display_short)|uniprotkb:BAI1-associated protein 1(gene name synonym)|uniprotkb:Baiap1(gene name synonym)|uniprotkb:Bap1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 1(gene name synonym)|uniprotkb:MAGI-1c(isoform synonym)|uniprotkb:MAGI1c alpha beta2 gamma(isoform synonym) psi-mi:e411_ade05(display_long) psi-mi:"MI:0096"(pull down) Glaunsinger et al. (2000) pubmed:11077444|mint:MINT-5213199 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7441245|mint:MINT-69659 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7440897(magi1_mouse)|ensembl:ENSMUSG00000045095(gene)|ensembl:ENSMUST00000089317(transcript)|mint:MINT-434158(identity) go:"GO:0042802"(identical protein binding)|interpro:IPR009699(Mastadenovirus E4 ORF3)|interpro:IPR038368|rcsb pdb:4DJB|mint:P04489|refseq:AP_000230.1|dip:DIP-571N|mint:MINT-434151(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2A|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/11/17 2014/10/16 rogid:mk1dW19+wMHjMLcuieBAQSHEs3U10090 rogid:QrVWoDINatBHpKYrEh2vSgBLB4c28285 intact-crc:BFB49D4140DF7CA7|rigid:m+JT0uYzlj904z4x16InprTrxtA false ha tag:?-?(MINT-434159) glutathione s tranferase tag:?-?(MINT-434152) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q6RHR9-2 uniprotkb:P89079 intact:EBI-7441142|intact:MINT-150486 intact:EBI-7401124|intact:MINT-431542 psi-mi:q6rhr9-2(display_long)|uniprotkb:Bap1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 1(gene name synonym)|uniprotkb:MAGI-1b(isoform synonym)|uniprotkb:Magi1(gene name)|psi-mi:Magi1(display_short)|uniprotkb:BAI1-associated protein 1(gene name synonym)|uniprotkb:Baiap1(gene name synonym) psi-mi:e4or1_ade09(display_long)|uniprotkb:E4(gene name)|psi-mi:E4(display_short)|uniprotkb:Probable dUTPase E4 ORF1(gene name synonym)|uniprotkb:Early E4 14.0 kDa protein(gene name synonym)|uniprotkb:ORF1(gene name synonym) psi-mi:"MI:0096"(pull down) Glaunsinger et al. (2000) pubmed:11077444|mint:MINT-5213199 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10527(hadv-9)|taxid:10527(Human adenovirus D serotype 9) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7441227|mint:MINT-69658 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7440897(magi1_mouse)|mint:MINT-434290(identity) mint:P89079|go:"GO:0004170"(dUTP diphosphatase activity)|go:"GO:0009117"(nucleotide metabolic process)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR029054|interpro:IPR036157|dip:DIP-44835N|mint:MINT-434283(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:mint|comment:homomint|function:Plays a key role in virus oncogenecity in animals. Binds and sequesters human MUPP1/MPDZ protein in the cytoplasm, preventing it from playing a role in cellular proliferation regulation. Induces cell transformation, probably by inactivating MPDZ protein|comment:"Stoichiometry: 1.0" figure legend:NFA|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/11/17 2014/10/16 rogid:1rT8ap6nYsgW7UE/DVnjO76BJGQ10090 rogid:NtuDlTWsr1MWfNM4ARULmS3kn/U10527 intact-crc:7C24715F70FE7C58|rigid:VC9Lic0pCh6aTkzPYrMKC8aOOqY false ha tag:?-?(MINT-434291) glutathione s tranferase tag:?-?(MINT-434284) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q6RHR9-1 uniprotkb:P36709 intact:EBI-7441112|intact:MINT-150479|ensembl:ENSMUSP00000086730 intact:EBI-7401351|intact:MINT-146144 psi-mi:q6rhr9-1(display_long)|uniprotkb:Magi1(gene name)|psi-mi:Magi1(display_short)|uniprotkb:BAI1-associated protein 1(gene name synonym)|uniprotkb:Baiap1(gene name synonym)|uniprotkb:Bap1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 1(gene name synonym)|uniprotkb:MAGI-1c(isoform synonym)|uniprotkb:MAGI1c alpha beta2 gamma(isoform synonym) psi-mi:e413_ade12(display_long) psi-mi:"MI:0096"(pull down) Glaunsinger et al. (2000) pubmed:11077444|mint:MINT-5213199 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:28282(ade12)|taxid:28282("Human adenovirus A serotype 12 (HAdV-12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7441277|mint:MINT-69660 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7440897(magi1_mouse)|ensembl:ENSMUSG00000045095(gene)|ensembl:ENSMUST00000089317(transcript)|mint:MINT-434141(identity) refseq:NP_040935.1|go:"GO:0039593"(suppression by virus of host exit from mitosis)|interpro:IPR008680(Mastadenovirus early E4 13 kDa)|dip:DIP-41950N|mint:MINT-434134(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:mint|comment:"Stoichiometry: 1.0" figure legend:F2A|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/11/17 2014/10/16 rogid:mk1dW19+wMHjMLcuieBAQSHEs3U10090 rogid:omXyf2NP9Ds6qvb171OfqRynBwc28282 intact-crc:DF0A666A2A82AB58|rigid:FBf02AVWdHMCFweLxgYqfc/OGSQ false ha tag:?-?(MINT-434142) glutathione s tranferase tag:?-?(MINT-434135) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q6RHR9-2 uniprotkb:P36709 intact:EBI-7441142|intact:MINT-150486 intact:EBI-7401351|intact:MINT-146144 psi-mi:q6rhr9-2(display_long)|uniprotkb:Bap1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 1(gene name synonym)|uniprotkb:MAGI-1b(isoform synonym)|uniprotkb:Magi1(gene name)|psi-mi:Magi1(display_short)|uniprotkb:BAI1-associated protein 1(gene name synonym)|uniprotkb:Baiap1(gene name synonym) psi-mi:e413_ade12(display_long) psi-mi:"MI:0096"(pull down) Glaunsinger et al. (2000) pubmed:11077444|mint:MINT-5213199 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:28282(ade12)|taxid:28282("Human adenovirus A serotype 12 (HAdV-12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7441294|mint:MINT-69661 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7440897(magi1_mouse)|mint:MINT-434213(identity) refseq:NP_040935.1|go:"GO:0039593"(suppression by virus of host exit from mitosis)|interpro:IPR008680(Mastadenovirus early E4 13 kDa)|dip:DIP-41950N|mint:MINT-434206(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:mint|comment:"Stoichiometry: 1.0" figure legend:NFA|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/11/17 2014/10/16 rogid:1rT8ap6nYsgW7UE/DVnjO76BJGQ10090 rogid:omXyf2NP9Ds6qvb171OfqRynBwc28282 intact-crc:2600C6B24EFF45A0|rigid:gFdTuq+xyfYGeSAyznioO99WAYA false ha tag:?-?(MINT-434214) glutathione s tranferase tag:?-?(MINT-434207) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P89079 uniprotkb:Q4L1J4 intact:EBI-7401124|intact:MINT-431542 intact:EBI-5259666|uniprotkb:Q4L1J5 psi-mi:e4or1_ade09(display_long)|uniprotkb:E4(gene name)|psi-mi:E4(display_short)|uniprotkb:Probable dUTPase E4 ORF1(gene name synonym)|uniprotkb:Early E4 14.0 kDa protein(gene name synonym)|uniprotkb:ORF1(gene name synonym) psi-mi:magi1_rat(display_long)|uniprotkb:Magi1(gene name)|psi-mi:Magi1(display_short)|uniprotkb:Baiap1(gene name synonym)|uniprotkb:Bap1(gene name synonym)|uniprotkb:BAI1-associated protein 1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 1(gene name synonym) psi-mi:"MI:0096"(pull down) Glaunsinger et al. (2000) pubmed:11077444|mint:MINT-5213199 taxid:10527(hadv-9)|taxid:10527(Human adenovirus D serotype 9) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7441330|mint:MINT-69663 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P89079|go:"GO:0004170"(dUTP diphosphatase activity)|go:"GO:0009117"(nucleotide metabolic process)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR029054|interpro:IPR036157|dip:DIP-44835N|mint:MINT-434322(identity) interpro:IPR030033|mint:Q4L1J4|rgd:1586025|refseq:NP_001025216.1|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR027417|interpro:IPR036020|interpro:IPR036034|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0042995"(cell projection)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071944"(cell periphery)|mint:MINT-434332(identity) - comment:mint|comment:homomint|function:Plays a key role in virus oncogenecity in animals. Binds and sequesters human MUPP1/MPDZ protein in the cytoplasm, preventing it from playing a role in cellular proliferation regulation. Induces cell transformation, probably by inactivating MPDZ protein|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2B|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/11/17 2014/10/16 rogid:NtuDlTWsr1MWfNM4ARULmS3kn/U10527 rogid:9CBhwilN2GVwCa7rk3mnHDORIU810116 intact-crc:F4450E19CE306C40|rigid:+3MArM6X9sSwjWCTQhn4vRVI7NY false mutation decreasing interaction:123-123,124-125(MINT-434323)|glutathione s tranferase tag:?-?(MINT-434326) - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0113"(western blot) uniprotkb:Q6RHR9-2 uniprotkb:P04489 intact:EBI-7441142|intact:MINT-150486 intact:EBI-6398911 psi-mi:q6rhr9-2(display_long)|uniprotkb:Bap1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 1(gene name synonym)|uniprotkb:MAGI-1b(isoform synonym)|uniprotkb:Magi1(gene name)|psi-mi:Magi1(display_short)|uniprotkb:BAI1-associated protein 1(gene name synonym)|uniprotkb:Baiap1(gene name synonym) psi-mi:e411_ade05(display_long) psi-mi:"MI:0096"(pull down) Glaunsinger et al. (2000) pubmed:11077444|mint:MINT-5213199 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7441312|mint:MINT-69662 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7440897(magi1_mouse)|mint:MINT-434195(identity) go:"GO:0042802"(identical protein binding)|interpro:IPR009699(Mastadenovirus E4 ORF3)|interpro:IPR038368|rcsb pdb:4DJB|mint:P04489|refseq:AP_000230.1|dip:DIP-571N|mint:MINT-434188(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:NFA|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/11/17 2014/10/16 rogid:1rT8ap6nYsgW7UE/DVnjO76BJGQ10090 rogid:QrVWoDINatBHpKYrEh2vSgBLB4c28285 intact-crc:A300D3CE9E63CD0C|rigid:xeR37RUDRZOD3HDNf5sFmyaDaqQ false ha tag:?-?(MINT-434196) glutathione s tranferase tag:?-?(MINT-434189) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P89079 uniprotkb:Q6RHR9-2 intact:EBI-7401124|intact:MINT-431542 intact:EBI-7441142|intact:MINT-150486 psi-mi:e4or1_ade09(display_long)|uniprotkb:E4(gene name)|psi-mi:E4(display_short)|uniprotkb:Probable dUTPase E4 ORF1(gene name synonym)|uniprotkb:Early E4 14.0 kDa protein(gene name synonym)|uniprotkb:ORF1(gene name synonym) psi-mi:q6rhr9-2(display_long)|uniprotkb:Bap1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 1(gene name synonym)|uniprotkb:MAGI-1b(isoform synonym)|uniprotkb:Magi1(gene name)|psi-mi:Magi1(display_short)|uniprotkb:BAI1-associated protein 1(gene name synonym)|uniprotkb:Baiap1(gene name synonym) psi-mi:"MI:0096"(pull down) Glaunsinger et al. (2000) pubmed:11077444|mint:MINT-5213199 taxid:10527(hadv-9)|taxid:10527(Human adenovirus D serotype 9) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7441365|mint:MINT-69668 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P89079|go:"GO:0004170"(dUTP diphosphatase activity)|go:"GO:0009117"(nucleotide metabolic process)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR029054|interpro:IPR036157|dip:DIP-44835N|mint:MINT-434261(identity) intact:EBI-7440897(magi1_mouse)|mint:MINT-434268(identity) - comment:mint|comment:homomint|function:Plays a key role in virus oncogenecity in animals. Binds and sequesters human MUPP1/MPDZ protein in the cytoplasm, preventing it from playing a role in cellular proliferation regulation. Induces cell transformation, probably by inactivating MPDZ protein|comment:"Stoichiometry: 1.0" comment:mint|comment:"Stoichiometry: 1.0" figure legend:F5C|comment:Single PDZ domain deletions show interactions|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/11/17 2014/10/16 rogid:NtuDlTWsr1MWfNM4ARULmS3kn/U10527 rogid:1rT8ap6nYsgW7UE/DVnjO76BJGQ10090 intact-crc:B1DEB06D618309D3|rigid:VC9Lic0pCh6aTkzPYrMKC8aOOqY false glutathione s tranferase tag:?-?(MINT-434262) ha tag:?-?(MINT-434273)|binding-associated region:763-880,431-545(MINT-434269) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q6RHR9-1 uniprotkb:P06463 intact:EBI-7441112|intact:MINT-150479|ensembl:ENSMUSP00000086730 intact:EBI-1186926 psi-mi:q6rhr9-1(display_long)|uniprotkb:Magi1(gene name)|psi-mi:Magi1(display_short)|uniprotkb:BAI1-associated protein 1(gene name synonym)|uniprotkb:Baiap1(gene name synonym)|uniprotkb:Bap1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 1(gene name synonym)|uniprotkb:MAGI-1c(isoform synonym)|uniprotkb:MAGI1c alpha beta2 gamma(isoform synonym) psi-mi:ve6_hpv18(display_long)|uniprotkb:E6(gene name)|psi-mi:E6(display_short) psi-mi:"MI:0096"(pull down) Glaunsinger et al. (2000) pubmed:11077444|mint:MINT-5213199 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7441390|mint:MINT-69671 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7440897(magi1_mouse)|ensembl:ENSMUSG00000045095(gene)|ensembl:ENSMUST00000089317(transcript)|mint:MINT-434312(identity) refseq:NP_040310.1|go:"GO:0003677"(DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001334(E6 early regulatory protein)|interpro:IPR038575|rcsb pdb:2I04|rcsb pdb:2I0I|rcsb pdb:2I0L|rcsb pdb:4JOR|rcsb pdb:5IC3|rcsb pdb:5K4F|rcsb pdb:6SJV|rcsb pdb:6ZFD|rcsb pdb:6ZFG|mint:P06463|dip:DIP-44730N|mint:MINT-434301(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F8|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/11/17 2014/10/16 rogid:mk1dW19+wMHjMLcuieBAQSHEs3U10090 rogid:X7TgcVayyyOKnVPXRlcbN6FVtYQ333761 intact-crc:801A30AB0AEFBDCA|rigid:cQWmURavOXbT94X5S/0vqsX7ex8 false ha tag:?-?(MINT-434313) glutathione s tranferase tag:?-?(MINT-434306)|mutation decreasing interaction:158-158(MINT-434304)|binding-associated region:143-158(MINT-434302) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q6RHR9-1 uniprotkb:P06463 intact:EBI-7441112|intact:MINT-150479|ensembl:ENSMUSP00000086730 intact:EBI-1186926 psi-mi:q6rhr9-1(display_long)|uniprotkb:Magi1(gene name)|psi-mi:Magi1(display_short)|uniprotkb:BAI1-associated protein 1(gene name synonym)|uniprotkb:Baiap1(gene name synonym)|uniprotkb:Bap1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 1(gene name synonym)|uniprotkb:MAGI-1c(isoform synonym)|uniprotkb:MAGI1c alpha beta2 gamma(isoform synonym) psi-mi:ve6_hpv18(display_long)|uniprotkb:E6(gene name)|psi-mi:E6(display_short) psi-mi:"MI:0096"(pull down) Glaunsinger et al. (2000) pubmed:11077444|mint:MINT-5213199 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7441430|mint:MINT-69673 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7440897(magi1_mouse)|ensembl:ENSMUSG00000045095(gene)|ensembl:ENSMUST00000089317(transcript)|mint:MINT-434121(identity) refseq:NP_040310.1|go:"GO:0003677"(DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001334(E6 early regulatory protein)|interpro:IPR038575|rcsb pdb:2I04|rcsb pdb:2I0I|rcsb pdb:2I0L|rcsb pdb:4JOR|rcsb pdb:5IC3|rcsb pdb:5K4F|rcsb pdb:6SJV|rcsb pdb:6ZFD|rcsb pdb:6ZFG|mint:P06463|dip:DIP-44730N|mint:MINT-434114(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F10B|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/11/17 2014/10/16 rogid:mk1dW19+wMHjMLcuieBAQSHEs3U10090 rogid:X7TgcVayyyOKnVPXRlcbN6FVtYQ333761 intact-crc:F1332B3EF220BB3F|rigid:cQWmURavOXbT94X5S/0vqsX7ex8 false binding-associated region:425-1471(MINT-434122)|ha tag:?-?(MINT-434125) glutathione s tranferase tag:?-?(MINT-434115) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q6RHR9-1 uniprotkb:P03126 intact:EBI-7441112|intact:MINT-150479|ensembl:ENSMUSP00000086730 intact:EBI-1177242|uniprotkb:Q71BI7 psi-mi:q6rhr9-1(display_long)|uniprotkb:Magi1(gene name)|psi-mi:Magi1(display_short)|uniprotkb:BAI1-associated protein 1(gene name synonym)|uniprotkb:Baiap1(gene name synonym)|uniprotkb:Bap1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 1(gene name synonym)|uniprotkb:MAGI-1c(isoform synonym)|uniprotkb:MAGI1c alpha beta2 gamma(isoform synonym) psi-mi:ve6_hpv16(display_long)|uniprotkb:E6(gene name)|psi-mi:E6(display_short) psi-mi:"MI:0096"(pull down) Glaunsinger et al. (2000) pubmed:11077444|mint:MINT-5213199 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7441452|mint:MINT-69674 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7440897(magi1_mouse)|ensembl:ENSMUSG00000045095(gene)|ensembl:ENSMUST00000089317(transcript)|mint:MINT-434251(identity) refseq:NP_041325.1|go:"GO:0003677"(DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR001334(E6 early regulatory protein)|interpro:IPR038575|rcsb pdb:1VZN|rcsb pdb:2FK4|rcsb pdb:2KPL|rcsb pdb:2LJX|rcsb pdb:2LJY|rcsb pdb:2LJZ|rcsb pdb:4GIZ|rcsb pdb:4JOP|rcsb pdb:4XR8|rcsb pdb:6HKS|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|mint:P03126|dip:DIP-44706N|mint:MINT-434244(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F8|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/11/17 2014/10/16 rogid:mk1dW19+wMHjMLcuieBAQSHEs3U10090 rogid:m9USUwG2VskhrMAdtZ9gSULmGBY333760 intact-crc:4DB890FCCA2E333F|rigid:bm0RGHRSt2E4NZZl45vmd2mNXn8 false ha tag:?-?(MINT-434252) glutathione s tranferase tag:?-?(MINT-434245) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P89079 uniprotkb:Q6RHR9-1 intact:EBI-7401124|intact:MINT-431542 intact:EBI-7441112|intact:MINT-150479|ensembl:ENSMUSP00000086730 psi-mi:e4or1_ade09(display_long)|uniprotkb:E4(gene name)|psi-mi:E4(display_short)|uniprotkb:Probable dUTPase E4 ORF1(gene name synonym)|uniprotkb:Early E4 14.0 kDa protein(gene name synonym)|uniprotkb:ORF1(gene name synonym) psi-mi:q6rhr9-1(display_long)|uniprotkb:Magi1(gene name)|psi-mi:Magi1(display_short)|uniprotkb:BAI1-associated protein 1(gene name synonym)|uniprotkb:Baiap1(gene name synonym)|uniprotkb:Bap1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 1(gene name synonym)|uniprotkb:MAGI-1c(isoform synonym)|uniprotkb:MAGI1c alpha beta2 gamma(isoform synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Glaunsinger et al. (2000) pubmed:11077444|mint:MINT-5213199 taxid:10527(hadv-9)|taxid:10527(Human adenovirus D serotype 9) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7441515|mint:MINT-69664 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P89079|go:"GO:0004170"(dUTP diphosphatase activity)|go:"GO:0009117"(nucleotide metabolic process)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR029054|interpro:IPR036157|dip:DIP-44835N|mint:MINT-434226(identity) intact:EBI-7440897(magi1_mouse)|ensembl:ENSMUSG00000045095(gene)|ensembl:ENSMUST00000089317(transcript)|mint:MINT-434234(identity) - comment:mint|comment:homomint|function:Plays a key role in virus oncogenecity in animals. Binds and sequesters human MUPP1/MPDZ protein in the cytoplasm, preventing it from playing a role in cellular proliferation regulation. Induces cell transformation, probably by inactivating MPDZ protein|comment:"Stoichiometry: 1.0" comment:mint|comment:"Stoichiometry: 1.0" figure legend:F4A|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2005/11/17 2014/10/16 rogid:NtuDlTWsr1MWfNM4ARULmS3kn/U10527 rogid:mk1dW19+wMHjMLcuieBAQSHEs3U10090 intact-crc:BE789FF233B4F7AA|rigid:q82i177X3amg2eAyGTmBueVh6N4 false mutation decreasing interaction:124-125,123-123(MINT-434227) ha tag:?-?(MINT-434235) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0078"(nucleotide sequence identification)