#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q28619	uniprotkb:P09619	intact:EBI-7073613|intact:MINT-148118	intact:EBI-641237|uniprotkb:Q8N5L4|uniprotkb:B5A957|ensembl:ENSP00000261799	psi-mi:nhrf1_rabit(display_long)|uniprotkb:SLC9A3R1(gene name)|psi-mi:SLC9A3R1(display_short)|uniprotkb:NHERF(gene name synonym)|uniprotkb:NHERF1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)	psi-mi:pgfrb_human(display_long)|uniprotkb:CD140 antigen-like family member B(gene name synonym)|uniprotkb:PDGFRB(gene name)|psi-mi:PDGFRB(display_short)|uniprotkb:Beta-type platelet-derived growth factor receptor(gene name synonym)|uniprotkb:PDGFR(gene name synonym)|uniprotkb:Platelet-derived growth factor receptor 1(gene name synonym)|uniprotkb:Beta platelet-derived growth factor receptor(gene name synonym)|uniprotkb:PDGFR1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Maudsley et al. (2000)	pubmed:11046132|mint:MINT-5213114|doi:10.1128/MCB.20.22.8352-8363.2000	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7419415|mint:MINT-73305	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR031199|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0030175"(filopodium)|go:"GO:0031528"(microvillus membrane)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034635"(glutathione transport)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070293"(renal absorption)|go:"GO:0071944"(cell periphery)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:2000146"(negative regulation of cell motility)|refseq:NP_001075814.1|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:MINT-432883(identity)	refseq:NP_002600.1|dip:DIP-558N|refseq:XP_011535960.1|refseq:XP_011535961.1|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0035789"(metanephric mesenchymal cell migration)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035793"(positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038091"(positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048839"(inner ear development)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060437"(lung growth)|go:"GO:0060981"(cell migration involved in coronary angiogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071670"(smooth muscle cell chemotaxis)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072262"(metanephric glomerular mesangial cell proliferation involved in metanephros development)|go:"GO:0072277"(metanephric glomerular capillary formation)|go:"GO:0072278"(metanephric comma-shaped body morphogenesis)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027288|interpro:IPR036179|mint:P09619|rcsb pdb:1GQ5|rcsb pdb:1H9O|rcsb pdb:1LWP|rcsb pdb:1SHA|rcsb pdb:2IUI|rcsb pdb:2L6W|rcsb pdb:2PLD|rcsb pdb:2PLE|rcsb pdb:3MJG|reactome:R-HSA-1257604|reactome:R-HSA-186763|reactome:R-HSA-186797|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|ensembl:ENSG00000113721(gene)|ensembl:ENST00000261799(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005017"(platelet-derived growth factor-activated receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008584"(male gonad development)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:MINT-432878(identity)	-	function:Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1D|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2005/12/13	2014/10/16	rogid:Whyx53K9mx3z81+1fNi++cEigDc9986	rogid:J3OhdjjNQKvgErBLGYg4qBmoMBg9606	intact-crc:55300460AE11AFCA|rigid:0pHjuT06ftv+PrvrSOjcnZ1E1Bw	false	ha tag:?-?(MINT-432884)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q28619	uniprotkb:P09619	intact:EBI-7073613|intact:MINT-148118	intact:EBI-641237|uniprotkb:Q8N5L4|uniprotkb:B5A957|ensembl:ENSP00000261799	psi-mi:nhrf1_rabit(display_long)|uniprotkb:SLC9A3R1(gene name)|psi-mi:SLC9A3R1(display_short)|uniprotkb:NHERF(gene name synonym)|uniprotkb:NHERF1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)	psi-mi:pgfrb_human(display_long)|uniprotkb:CD140 antigen-like family member B(gene name synonym)|uniprotkb:PDGFRB(gene name)|psi-mi:PDGFRB(display_short)|uniprotkb:Beta-type platelet-derived growth factor receptor(gene name synonym)|uniprotkb:PDGFR(gene name synonym)|uniprotkb:Platelet-derived growth factor receptor 1(gene name synonym)|uniprotkb:Beta platelet-derived growth factor receptor(gene name synonym)|uniprotkb:PDGFR1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Maudsley et al. (2000)	pubmed:11046132|mint:MINT-5213114|doi:10.1128/MCB.20.22.8352-8363.2000	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7419436|mint:MINT-73302	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR031199|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0030175"(filopodium)|go:"GO:0031528"(microvillus membrane)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034635"(glutathione transport)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070293"(renal absorption)|go:"GO:0071944"(cell periphery)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:2000146"(negative regulation of cell motility)|refseq:NP_001075814.1|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:MINT-432951(identity)	refseq:NP_002600.1|dip:DIP-558N|refseq:XP_011535960.1|refseq:XP_011535961.1|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0035789"(metanephric mesenchymal cell migration)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035793"(positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038091"(positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048839"(inner ear development)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060437"(lung growth)|go:"GO:0060981"(cell migration involved in coronary angiogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071670"(smooth muscle cell chemotaxis)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072262"(metanephric glomerular mesangial cell proliferation involved in metanephros development)|go:"GO:0072277"(metanephric glomerular capillary formation)|go:"GO:0072278"(metanephric comma-shaped body morphogenesis)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027288|interpro:IPR036179|mint:P09619|rcsb pdb:1GQ5|rcsb pdb:1H9O|rcsb pdb:1LWP|rcsb pdb:1SHA|rcsb pdb:2IUI|rcsb pdb:2L6W|rcsb pdb:2PLD|rcsb pdb:2PLE|rcsb pdb:3MJG|reactome:R-HSA-1257604|reactome:R-HSA-186763|reactome:R-HSA-186797|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|ensembl:ENSG00000113721(gene)|ensembl:ENST00000261799(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005017"(platelet-derived growth factor-activated receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008584"(male gonad development)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:MINT-432939(identity)	-	function:Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1A|kd:26 nanomolar|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/13	2014/10/16	rogid:Whyx53K9mx3z81+1fNi++cEigDc9986	rogid:J3OhdjjNQKvgErBLGYg4qBmoMBg9606	intact-crc:14925AEF92F1B1A9|rigid:0pHjuT06ftv+PrvrSOjcnZ1E1Bw	false	binding-associated region:1-151(MINT-432952)	mutation decreasing interaction:1106-1106(MINT-432943)|glutathione s tranferase tag:?-?(MINT-432945)|binding-associated region:1061-1106(MINT-432940)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q28619	uniprotkb:P07550	intact:EBI-7073613|intact:MINT-148118	intact:EBI-491169|uniprotkb:Q9UH95|uniprotkb:Q9UHA1|uniprotkb:O14823|uniprotkb:O14824|uniprotkb:O14825|uniprotkb:O14826|uniprotkb:Q4JG18|uniprotkb:Q8NEQ9|uniprotkb:Q9UMZ5|uniprotkb:Q6P4D8|uniprotkb:B0LPE4|uniprotkb:B2R7X2|uniprotkb:Q53GA6|uniprotkb:Q6GMT4|uniprotkb:Q96EC3|uniprotkb:Q9UCZ0|uniprotkb:Q9UCZ1|uniprotkb:Q9UCZ2|uniprotkb:Q9UCZ3|ensembl:ENSP00000305372	psi-mi:nhrf1_rabit(display_long)|uniprotkb:SLC9A3R1(gene name)|psi-mi:SLC9A3R1(display_short)|uniprotkb:NHERF(gene name synonym)|uniprotkb:NHERF1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)	psi-mi:adrb2_human(display_long)|uniprotkb:Beta-2 adrenoreceptor(gene name synonym)|uniprotkb:ADRB2(gene name)|psi-mi:ADRB2(display_short)|uniprotkb:ADRB2R(gene name synonym)|uniprotkb:B2AR(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Maudsley et al. (2000)	pubmed:11046132|mint:MINT-5213114|doi:10.1128/MCB.20.22.8352-8363.2000	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7419487|mint:MINT-73303	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR031199|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0030175"(filopodium)|go:"GO:0031528"(microvillus membrane)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034635"(glutathione transport)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070293"(renal absorption)|go:"GO:0071944"(cell periphery)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:2000146"(negative regulation of cell motility)|refseq:NP_001075814.1|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:MINT-432928(identity)	refseq:NP_000015.1|ensembl:ENSG00000169252(gene)|ensembl:ENST00000305988(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004941"(beta2-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009409"(response to cold)|go:"GO:0010008"(endosome membrane)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031649"(heat generation)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000332(Adrenergic receptor, beta 2)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P07550|rcsb pdb:1GQ4|rcsb pdb:2R4R|rcsb pdb:2R4S|rcsb pdb:2RH1|rcsb pdb:3D4S|rcsb pdb:3KJ6|rcsb pdb:3NY8|rcsb pdb:3NY9|rcsb pdb:3NYA|rcsb pdb:3P0G|rcsb pdb:3PDS|rcsb pdb:3SN6|rcsb pdb:4GBR|rcsb pdb:4LDE|rcsb pdb:4LDL|rcsb pdb:4LDO|rcsb pdb:4QKX|rcsb pdb:5D5A|rcsb pdb:5D5B|rcsb pdb:5D6L|rcsb pdb:5JQH|rcsb pdb:5X7D|rcsb pdb:6E67|rcsb pdb:6KR8|rcsb pdb:6MXT|rcsb pdb:6N48|rcsb pdb:6NI3|rcsb pdb:6OBA|rcsb pdb:6PRZ|rcsb pdb:6PS0|rcsb pdb:6PS1|rcsb pdb:6PS2|rcsb pdb:6PS3|rcsb pdb:6PS4|rcsb pdb:6PS5|rcsb pdb:6PS6|rcsb pdb:7BZ2|rcsb pdb:7DHI|rcsb pdb:7DHR|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-5689880|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9660821|dip:DIP-33948N|mint:MINT-432918(identity)	-	function:Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1A|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/13	2014/10/16	rogid:Whyx53K9mx3z81+1fNi++cEigDc9986	rogid:+pZmEUm9SKroeqpa7uI44Bz18zo9606	intact-crc:08A5BAC884073604|rigid:V6LLsxKltl67zGafNqFJ7lxt0cE	false	binding-associated region:1-151(MINT-432929)	glutathione s tranferase tag:?-?(MINT-432922)|binding-associated region:333-413(MINT-432919)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q28619	uniprotkb:P09619	intact:EBI-7073613|intact:MINT-148118	intact:EBI-641237|uniprotkb:Q8N5L4|uniprotkb:B5A957|ensembl:ENSP00000261799	psi-mi:nhrf1_rabit(display_long)|uniprotkb:SLC9A3R1(gene name)|psi-mi:SLC9A3R1(display_short)|uniprotkb:NHERF(gene name synonym)|uniprotkb:NHERF1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)	psi-mi:pgfrb_human(display_long)|uniprotkb:CD140 antigen-like family member B(gene name synonym)|uniprotkb:PDGFRB(gene name)|psi-mi:PDGFRB(display_short)|uniprotkb:Beta-type platelet-derived growth factor receptor(gene name synonym)|uniprotkb:PDGFR(gene name synonym)|uniprotkb:Platelet-derived growth factor receptor 1(gene name synonym)|uniprotkb:Beta platelet-derived growth factor receptor(gene name synonym)|uniprotkb:PDGFR1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Maudsley et al. (2000)	pubmed:11046132|mint:MINT-5213114|doi:10.1128/MCB.20.22.8352-8363.2000	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7419509|mint:MINT-73304	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR031199|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0030175"(filopodium)|go:"GO:0031528"(microvillus membrane)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034635"(glutathione transport)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070293"(renal absorption)|go:"GO:0071944"(cell periphery)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:2000146"(negative regulation of cell motility)|refseq:NP_001075814.1|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:MINT-432907(identity)	refseq:NP_002600.1|dip:DIP-558N|refseq:XP_011535960.1|refseq:XP_011535961.1|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0035789"(metanephric mesenchymal cell migration)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035793"(positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038091"(positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048839"(inner ear development)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060437"(lung growth)|go:"GO:0060981"(cell migration involved in coronary angiogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071670"(smooth muscle cell chemotaxis)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072262"(metanephric glomerular mesangial cell proliferation involved in metanephros development)|go:"GO:0072277"(metanephric glomerular capillary formation)|go:"GO:0072278"(metanephric comma-shaped body morphogenesis)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027288|interpro:IPR036179|mint:P09619|rcsb pdb:1GQ5|rcsb pdb:1H9O|rcsb pdb:1LWP|rcsb pdb:1SHA|rcsb pdb:2IUI|rcsb pdb:2L6W|rcsb pdb:2PLD|rcsb pdb:2PLE|rcsb pdb:3MJG|reactome:R-HSA-1257604|reactome:R-HSA-186763|reactome:R-HSA-186797|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|ensembl:ENSG00000113721(gene)|ensembl:ENST00000261799(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005017"(platelet-derived growth factor-activated receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008584"(male gonad development)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:MINT-432895(identity)	-	function:Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1B|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/13	2014/10/16	rogid:Whyx53K9mx3z81+1fNi++cEigDc9986	rogid:J3OhdjjNQKvgErBLGYg4qBmoMBg9606	intact-crc:BC0115E665083D74|rigid:0pHjuT06ftv+PrvrSOjcnZ1E1Bw	false	binding-associated region:1-151(MINT-432908)	glutathione s tranferase tag:?-?(MINT-432901)|binding-associated region:1061-1106(MINT-432896)|mutation decreasing interaction:1106-1106(MINT-432899)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)