#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P39428	uniprotkb:Q9UNE0	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	intact:EBI-529289|uniprotkb:Q52LL5|uniprotkb:Q9UND9|uniprotkb:D3DX74|ensembl:ENSP00000258443|uniprotkb:B2R9H2|uniprotkb:B4DLC5|uniprotkb:E9PC98	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:edar_human(display_long)|uniprotkb:Anhidrotic ectodysplasin receptor 1(gene name synonym)|uniprotkb:Ectodysplasin-A receptor(gene name synonym)|uniprotkb:EDA-A1 receptor(gene name synonym)|uniprotkb:Ectodermal dysplasia receptor(gene name synonym)|uniprotkb:Downless homolog(gene name synonym)|uniprotkb:EDAR(gene name)|psi-mi:EDAR(display_short)|uniprotkb:DL(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kumar et al. (2001)	pubmed:11035039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-529308	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	refseq:XP_006712267.1|refseq:NP_071731.1|ensembl:ENSG00000135960(gene)|ensembl:ENST00000258443(transcript)|go:"GO:0001942"(hair follicle development)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008544"(epidermis development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043473"(pigmentation)|go:"GO:0045177"(apical part of cell)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR011029(DEATH-like)|interpro:IPR034052|reactome:R-HSA-5669034	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/04/12	2014/10/16	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	rogid:ObK942+1oBEblE0eDhYFlPi2dFs9606	intact-crc:FFAAA52005C32FCC|rigid:abW+s1kQhPFkINZNegClBmk3v8I	false	ha tag:?-?	binding-associated region:21-225|flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P39429	uniprotkb:Q9UNE0	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	intact:EBI-529289|uniprotkb:Q52LL5|uniprotkb:Q9UND9|uniprotkb:D3DX74|ensembl:ENSP00000258443|uniprotkb:B2R9H2|uniprotkb:B4DLC5|uniprotkb:E9PC98	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:edar_human(display_long)|uniprotkb:Anhidrotic ectodysplasin receptor 1(gene name synonym)|uniprotkb:Ectodysplasin-A receptor(gene name synonym)|uniprotkb:EDA-A1 receptor(gene name synonym)|uniprotkb:Ectodermal dysplasia receptor(gene name synonym)|uniprotkb:Downless homolog(gene name synonym)|uniprotkb:EDAR(gene name)|psi-mi:EDAR(display_short)|uniprotkb:DL(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kumar et al. (2001)	pubmed:11035039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-529337	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	refseq:XP_006712267.1|refseq:NP_071731.1|ensembl:ENSG00000135960(gene)|ensembl:ENST00000258443(transcript)|go:"GO:0001942"(hair follicle development)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008544"(epidermis development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043473"(pigmentation)|go:"GO:0045177"(apical part of cell)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR011029(DEATH-like)|interpro:IPR034052|reactome:R-HSA-5669034	-	-	-	caution:Authors noted, but did not present data in the referenced paper, that both GST pulldown and yeast-2-hybrid analysis had failed to detect an interaction between the cytoplasmic domain of EDAR and the TRAF2 protein.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/04/12	2014/10/16	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rogid:ObK942+1oBEblE0eDhYFlPi2dFs9606	intact-crc:8B678A946FD89B06|rigid:byAc6NwvQtsNmUUlAUn8QT9dH70	false	ha tag:?-?	binding-associated region:21-448|flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13114	uniprotkb:Q9UNE0	intact:EBI-357631|uniprotkb:Q12990|uniprotkb:Q13076|uniprotkb:Q13947|uniprotkb:Q6AZX1|uniprotkb:Q9UNL1|ensembl:ENSP00000376500|ensembl:ENSP00000454207|uniprotkb:B7Z8C4	intact:EBI-529289|uniprotkb:Q52LL5|uniprotkb:Q9UND9|uniprotkb:D3DX74|ensembl:ENSP00000258443|uniprotkb:B2R9H2|uniprotkb:B4DLC5|uniprotkb:E9PC98	psi-mi:traf3_human(display_long)|uniprotkb:TRAF3(gene name)|psi-mi:TRAF3(display_short)|uniprotkb:CAP1(gene name synonym)|uniprotkb:CRAF1(gene name synonym)|uniprotkb:CD40 receptor-associated factor 1(gene name synonym)|uniprotkb:CD40-binding protein(gene name synonym)|uniprotkb:LMP1-associated protein 1(gene name synonym)|uniprotkb:CAP-1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF3(gene name synonym)	psi-mi:edar_human(display_long)|uniprotkb:Anhidrotic ectodysplasin receptor 1(gene name synonym)|uniprotkb:Ectodysplasin-A receptor(gene name synonym)|uniprotkb:EDA-A1 receptor(gene name synonym)|uniprotkb:Ectodermal dysplasia receptor(gene name synonym)|uniprotkb:Downless homolog(gene name synonym)|uniprotkb:EDAR(gene name)|psi-mi:EDAR(display_short)|uniprotkb:DL(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kumar et al. (2001)	pubmed:11035039	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-529350	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000131323(gene)|ensembl:ENST00000392745(transcript)|ensembl:ENST00000560371(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|refseq:NP_001186356.1|refseq:NP_003291.2|refseq:NP_663777.1|refseq:NP_663778.1|go:"GO:0007165"(signal transduction)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050688"(regulation of defense response to virus)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027128|interpro:IPR037304|interpro:IPR043211|mint:Q13114|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:1FLK|rcsb pdb:1FLL|rcsb pdb:1L0A|rcsb pdb:1RF3|rcsb pdb:1ZMS|rcsb pdb:2ECY|rcsb pdb:2GKW|rcsb pdb:1KZZ|refseq:XP_011535420.1|reactome:R-HSA-5668541|reactome:R-HSA-5676594|reactome:R-HSA-5689896|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-5602571|refseq:XP_016877106.1|refseq:XP_016877107.1|dip:DIP-6222N	refseq:XP_006712267.1|refseq:NP_071731.1|ensembl:ENSG00000135960(gene)|ensembl:ENST00000258443(transcript)|go:"GO:0001942"(hair follicle development)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008544"(epidermis development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043473"(pigmentation)|go:"GO:0045177"(apical part of cell)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR011029(DEATH-like)|interpro:IPR034052|reactome:R-HSA-5669034	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/04/12	2014/10/16	rogid:9Tjx/USypDBBrPVyFOsLzM/bwzA9606	rogid:ObK942+1oBEblE0eDhYFlPi2dFs9606	intact-crc:91118DE5A7FFC6FA|rigid:CkSrdmJqDJsrFTlVpKADfOoTFeo	false	ha tag:?-?	flag tag:?-?|binding-associated region:21-448	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UNE0	uniprotkb:Q99558	intact:EBI-529289|uniprotkb:Q52LL5|uniprotkb:Q9UND9|uniprotkb:D3DX74|ensembl:ENSP00000258443|uniprotkb:B2R9H2|uniprotkb:B4DLC5|uniprotkb:E9PC98	intact:EBI-358011|uniprotkb:Q8IYN1|uniprotkb:A8K2D8|uniprotkb:D3DX67|ensembl:ENSP00000478552|ensembl:ENSP00000480974|ensembl:ENSP00000482657	psi-mi:edar_human(display_long)|uniprotkb:Anhidrotic ectodysplasin receptor 1(gene name synonym)|uniprotkb:Ectodysplasin-A receptor(gene name synonym)|uniprotkb:EDA-A1 receptor(gene name synonym)|uniprotkb:Ectodermal dysplasia receptor(gene name synonym)|uniprotkb:Downless homolog(gene name synonym)|uniprotkb:EDAR(gene name)|psi-mi:EDAR(display_short)|uniprotkb:DL(gene name synonym)	psi-mi:m3k14_human(display_long)|uniprotkb:MAP3K14(gene name)|psi-mi:MAP3K14(display_short)|uniprotkb:NIK(gene name synonym)|uniprotkb:Serine/threonine-protein kinase NIK(gene name synonym)|uniprotkb:NF-kappa-beta-inducing kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kumar et al. (2001)	pubmed:11035039	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-529386	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006712267.1|refseq:NP_071731.1|ensembl:ENSG00000135960(gene)|ensembl:ENST00000258443(transcript)|go:"GO:0001942"(hair follicle development)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008544"(epidermis development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043473"(pigmentation)|go:"GO:0045177"(apical part of cell)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR011029(DEATH-like)|interpro:IPR034052|reactome:R-HSA-5669034	refseq:NP_003945.2|refseq:XP_011523743.1|dip:DIP-27522N|ensembl:ENSG00000006062(gene)|ensembl:ENST00000344686(transcript)|ensembl:ENST00000376926(transcript)|ensembl:ENST00000617331(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017425(Mitogen-activated protein kinase kinase kinase 14)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042787|mint:Q99558|rcsb pdb:4DN5|rcsb pdb:4G3D|rcsb pdb:4IDT|rcsb pdb:4IDV|rcsb pdb:6WPP|rcsb pdb:6Z1Q|rcsb pdb:6Z1T|reactome:R-HSA-389357|reactome:R-HSA-5607761|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5676594	-	-	-	caution:Authors noted, but did not present data in the referenced paper, that both GST pulldown and yeast-2-hybrid analysis had failed to detect an interaction between the cytoplasmic domain of EDAR and the NIK protein.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/04/12	2014/10/16	rogid:ObK942+1oBEblE0eDhYFlPi2dFs9606	rogid:GBmoUEm+pGubNnnauGgKgMyeiqA9606	intact-crc:2D19B335C1466D3F|rigid:hprb/MNk9ou3B7P+EihE0apNntE	false	flag tag:?-?|binding-associated region:21-448	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UNE0	uniprotkb:Q92838	intact:EBI-529289|uniprotkb:Q52LL5|uniprotkb:Q9UND9|uniprotkb:D3DX74|ensembl:ENSP00000258443|uniprotkb:B2R9H2|uniprotkb:B4DLC5|uniprotkb:E9PC98	intact:EBI-529425|uniprotkb:A0AUZ2|uniprotkb:A2A337|uniprotkb:O75910|uniprotkb:Q5JS00|uniprotkb:Q5JUM7|uniprotkb:Q9UP77|uniprotkb:Q9Y6L0|uniprotkb:Q9Y6L1|uniprotkb:Q9Y6L2|uniprotkb:Q9Y6L3|uniprotkb:Q9Y6L4|uniprotkb:B7ZLU2|uniprotkb:B7ZLU4|ensembl:ENSP00000363680	psi-mi:edar_human(display_long)|uniprotkb:Anhidrotic ectodysplasin receptor 1(gene name synonym)|uniprotkb:Ectodysplasin-A receptor(gene name synonym)|uniprotkb:EDA-A1 receptor(gene name synonym)|uniprotkb:Ectodermal dysplasia receptor(gene name synonym)|uniprotkb:Downless homolog(gene name synonym)|uniprotkb:EDAR(gene name)|psi-mi:EDAR(display_short)|uniprotkb:DL(gene name synonym)	psi-mi:eda_human(display_long)|uniprotkb:Ectodermal dysplasia protein(gene name synonym)|uniprotkb:EDA(gene name)|psi-mi:EDA(display_short)|uniprotkb:ED1(gene name synonym)|uniprotkb:EDA2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kumar et al. (2001)	pubmed:11035039	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-529482	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006712267.1|refseq:NP_071731.1|ensembl:ENSG00000135960(gene)|ensembl:ENST00000258443(transcript)|go:"GO:0001942"(hair follicle development)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008544"(epidermis development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043473"(pigmentation)|go:"GO:0045177"(apical part of cell)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR011029(DEATH-like)|interpro:IPR034052|reactome:R-HSA-5669034	refseq:NP_001005609.1|refseq:NP_001005610.2|refseq:NP_001005612.2|refseq:NP_001005613.1|refseq:NP_001390.1|ensembl:ENSG00000158813(gene)|ensembl:ENST00000374552(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0038177"(death receptor agonist activity)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043473"(pigmentation)|go:"GO:0045177"(apical part of cell)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048513"(animal organ development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0061153"(trachea gland development)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:1RJ7|rcsb pdb:1RJ8|reactome:R-HSA-5669034	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/04/12	2014/10/16	rogid:ObK942+1oBEblE0eDhYFlPi2dFs9606	rogid:eonj4+AITQKuO8trfPnhiVYqwoo9606	intact-crc:22AC361C9CAE5741|rigid:VM6N4i7xJr/dwTpSZRjGLCk5ovM	false	binding-associated region:21-448|flag tag:?-?	binding-associated region:134-391|myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)