#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P42282	uniprotkb:Q95RJ9	intact:EBI-77008|uniprotkb:A4V3Q3|uniprotkb:Q0KHY0|uniprotkb:Q1LZ43|uniprotkb:Q24313|uniprotkb:Q9V9V2|ensemblmetazoa:FBpp0085186|ensemblmetazoa:FBpp0085188|ensemblmetazoa:FBpp0085190|ensemblmetazoa:FBpp0292319	intact:EBI-421390|ensemblmetazoa:FBpp0077715|uniprotkb:Q9XZK1	psi-mi:ttka_drome(display_long)|uniprotkb:ttk(gene name)|psi-mi:ttk(display_short)|uniprotkb:FTZ-F2(gene name synonym)|uniprotkb:CG1856(orf name)|uniprotkb:Tramtrack p88(gene name synonym)|uniprotkb:Repressor protein fushi tarazu(gene name synonym)	psi-mi:ebi_drome(display_long)|uniprotkb:ebi(gene name)|psi-mi:ebi(display_short)|uniprotkb:CG4063(orf name)	psi-mi:"MI:0096"(pull down)	Boulton et al. (2000)	pubmed:11032805	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-528900	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001189329.1|refseq:NP_733443.1|refseq:NP_733444.1|refseq:NP_733445.1|flybase:FBgn0003870|ensemblmetazoa:FBgn0003870(gene)|ensemblmetazoa:FBtr0085825(transcript)|ensemblmetazoa:FBtr0085827(transcript)|ensemblmetazoa:FBtr0085829(transcript)|ensemblmetazoa:FBtr0303227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016476"(regulation of embryonic cell shape)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031208"(POZ domain binding)|go:"GO:0035001"(dorsal trunk growth, open tracheal system)|go:"GO:0035147"(branch fusion, open tracheal system)|go:"GO:0035151"(regulation of tube size, open tracheal system)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0040003"(chitin-based cuticle development)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0042682"(regulation of compound eye cone cell fate specification)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045677"(negative regulation of R7 cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048053"(R1/R6 development)|go:"GO:0048626"(myoblast fate specification)|go:"GO:0048750"(compound eye corneal lens morphogenesis)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0022416"(chaeta development)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035220"(wing disc development)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0071482"(cellular response to light stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001680(WD40 repeat)|ensemblmetazoa:FBgn0263933(gene)|ensemblmetazoa:FBtr0078055(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|refseq:NP_477329.1|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|mint:Q95RJ9|reactome:R-DME-400206|reactome:R-DME-9029569|reactome:R-DME-9707564|interpro:IPR006594(LisH dimerisation motif)|flybase:FBgn0263933	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/12	2014/10/16	rogid:k0MeF2/ch3ddqz7uLHjP8aeJwoI7227	rogid:Af8a0+hpRLwpFpdFkHfN8lEUU747227	intact-crc:7E4316E136ECA6D7|rigid:ai3msiqYK9IWQErLWn73pqgmK2U	false	radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q95RJ9	uniprotkb:P21461	intact:EBI-421390|ensemblmetazoa:FBpp0077715|uniprotkb:Q9XZK1	intact:EBI-77019|uniprotkb:A4V214|uniprotkb:Q9VVB0|ensemblmetazoa:FBpp0075091|ensemblmetazoa:FBpp0075092|ensemblmetazoa:FBpp0310636	psi-mi:ebi_drome(display_long)|uniprotkb:ebi(gene name)|psi-mi:ebi(display_short)|uniprotkb:CG4063(orf name)	psi-mi:sina_drome(display_long)|uniprotkb:sina(gene name)|psi-mi:sina(display_short)|uniprotkb:CG9949(orf name)|uniprotkb:Seven in absentia protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase sina(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boulton et al. (2000)	pubmed:11032805	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-528920	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0022416"(chaeta development)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035220"(wing disc development)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0071482"(cellular response to light stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001680(WD40 repeat)|ensemblmetazoa:FBgn0263933(gene)|ensemblmetazoa:FBtr0078055(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|refseq:NP_477329.1|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|mint:Q95RJ9|reactome:R-DME-400206|reactome:R-DME-9029569|reactome:R-DME-9707564|interpro:IPR006594(LisH dimerisation motif)|flybase:FBgn0263933	refseq:NP_476725.1|refseq:NP_730206.1|flybase:FBgn0003410|refseq:NP_001287089.1|dip:DIP-17392N|ensemblmetazoa:FBgn0003410(gene)|ensemblmetazoa:FBtr0075332(transcript)|ensemblmetazoa:FBtr0075333(transcript)|ensemblmetazoa:FBtr0344230(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007423"(sensory organ development)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045676"(regulation of R7 cell differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|reactome:R-DME-373752|reactome:R-DME-5689880|reactome:R-DME-983168	-	-	-	comment:PHYL, Sina and Ttk were co-translated.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/12	2014/10/16	rogid:Af8a0+hpRLwpFpdFkHfN8lEUU747227	rogid:GmUKLSW+fhn/1Fkti+v7o+NWs/87227	intact-crc:20DB0F740FD2E41A|rigid:5wCH1Sp2FwqLXfTwMFxtQXE3RFo	false	glutathione s tranferase tag:?-?	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q95RJ9	uniprotkb:P42282	intact:EBI-421390|ensemblmetazoa:FBpp0077715|uniprotkb:Q9XZK1	intact:EBI-77008|uniprotkb:A4V3Q3|uniprotkb:Q0KHY0|uniprotkb:Q1LZ43|uniprotkb:Q24313|uniprotkb:Q9V9V2|ensemblmetazoa:FBpp0085186|ensemblmetazoa:FBpp0085188|ensemblmetazoa:FBpp0085190|ensemblmetazoa:FBpp0292319	psi-mi:ebi_drome(display_long)|uniprotkb:ebi(gene name)|psi-mi:ebi(display_short)|uniprotkb:CG4063(orf name)	psi-mi:ttka_drome(display_long)|uniprotkb:ttk(gene name)|psi-mi:ttk(display_short)|uniprotkb:FTZ-F2(gene name synonym)|uniprotkb:CG1856(orf name)|uniprotkb:Tramtrack p88(gene name synonym)|uniprotkb:Repressor protein fushi tarazu(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boulton et al. (2000)	pubmed:11032805	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-528920	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0022416"(chaeta development)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035220"(wing disc development)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0071482"(cellular response to light stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001680(WD40 repeat)|ensemblmetazoa:FBgn0263933(gene)|ensemblmetazoa:FBtr0078055(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|refseq:NP_477329.1|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|mint:Q95RJ9|reactome:R-DME-400206|reactome:R-DME-9029569|reactome:R-DME-9707564|interpro:IPR006594(LisH dimerisation motif)|flybase:FBgn0263933	refseq:NP_001189329.1|refseq:NP_733443.1|refseq:NP_733444.1|refseq:NP_733445.1|flybase:FBgn0003870|ensemblmetazoa:FBgn0003870(gene)|ensemblmetazoa:FBtr0085825(transcript)|ensemblmetazoa:FBtr0085827(transcript)|ensemblmetazoa:FBtr0085829(transcript)|ensemblmetazoa:FBtr0303227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016476"(regulation of embryonic cell shape)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031208"(POZ domain binding)|go:"GO:0035001"(dorsal trunk growth, open tracheal system)|go:"GO:0035147"(branch fusion, open tracheal system)|go:"GO:0035151"(regulation of tube size, open tracheal system)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0040003"(chitin-based cuticle development)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0042682"(regulation of compound eye cone cell fate specification)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045677"(negative regulation of R7 cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048053"(R1/R6 development)|go:"GO:0048626"(myoblast fate specification)|go:"GO:0048750"(compound eye corneal lens morphogenesis)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	-	-	-	comment:PHYL, Sina and Ttk were co-translated.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/12	2014/10/16	rogid:Af8a0+hpRLwpFpdFkHfN8lEUU747227	rogid:k0MeF2/ch3ddqz7uLHjP8aeJwoI7227	intact-crc:20DB0F740FD2E41A|rigid:5wCH1Sp2FwqLXfTwMFxtQXE3RFo	false	glutathione s tranferase tag:?-?	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q95RJ9	uniprotkb:Q27934	intact:EBI-421390|ensemblmetazoa:FBpp0077715|uniprotkb:Q9XZK1	intact:EBI-77033|uniprotkb:Q9V721|uniprotkb:C0PV22|ensemblmetazoa:FBpp0086645	psi-mi:ebi_drome(display_long)|uniprotkb:ebi(gene name)|psi-mi:ebi(display_short)|uniprotkb:CG4063(orf name)	psi-mi:phyl_drome(display_long)|uniprotkb:phyl(gene name)|psi-mi:phyl(display_short)|uniprotkb:CG10108(orf name)	psi-mi:"MI:0096"(pull down)	Boulton et al. (2000)	pubmed:11032805	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-528920	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0022416"(chaeta development)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035220"(wing disc development)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0071482"(cellular response to light stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001680(WD40 repeat)|ensemblmetazoa:FBgn0263933(gene)|ensemblmetazoa:FBtr0078055(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|refseq:NP_477329.1|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|mint:Q95RJ9|reactome:R-DME-400206|reactome:R-DME-9029569|reactome:R-DME-9707564|interpro:IPR006594(LisH dimerisation motif)|flybase:FBgn0263933	refseq:NP_725394.1|flybase:FBgn0013725|dip:DIP-29101N|ensemblmetazoa:FBgn0013725(gene)|ensemblmetazoa:FBtr0087516(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007423"(sensory organ development)|go:"GO:0007462"(R1/R6 cell fate commitment)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008052"(sensory organ boundary specification)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D	-	-	-	comment:PHYL, Sina and Ttk were co-translated.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/12	2014/10/16	rogid:Af8a0+hpRLwpFpdFkHfN8lEUU747227	rogid:QocGYm5CUc0c4Z8raybzOGhpt1M7227	intact-crc:20DB0F740FD2E41A|rigid:5wCH1Sp2FwqLXfTwMFxtQXE3RFo	false	glutathione s tranferase tag:?-?	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q95RJ9	uniprotkb:P21461	intact:EBI-421390|ensemblmetazoa:FBpp0077715|uniprotkb:Q9XZK1	intact:EBI-77019|uniprotkb:A4V214|uniprotkb:Q9VVB0|ensemblmetazoa:FBpp0075091|ensemblmetazoa:FBpp0075092|ensemblmetazoa:FBpp0310636	psi-mi:ebi_drome(display_long)|uniprotkb:ebi(gene name)|psi-mi:ebi(display_short)|uniprotkb:CG4063(orf name)	psi-mi:sina_drome(display_long)|uniprotkb:sina(gene name)|psi-mi:sina(display_short)|uniprotkb:CG9949(orf name)|uniprotkb:Seven in absentia protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase sina(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boulton et al. (2000)	pubmed:11032805	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-528991	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0022416"(chaeta development)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035220"(wing disc development)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0071482"(cellular response to light stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001680(WD40 repeat)|ensemblmetazoa:FBgn0263933(gene)|ensemblmetazoa:FBtr0078055(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|refseq:NP_477329.1|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|mint:Q95RJ9|reactome:R-DME-400206|reactome:R-DME-9029569|reactome:R-DME-9707564|interpro:IPR006594(LisH dimerisation motif)|flybase:FBgn0263933	refseq:NP_476725.1|refseq:NP_730206.1|flybase:FBgn0003410|refseq:NP_001287089.1|dip:DIP-17392N|ensemblmetazoa:FBgn0003410(gene)|ensemblmetazoa:FBtr0075332(transcript)|ensemblmetazoa:FBtr0075333(transcript)|ensemblmetazoa:FBtr0344230(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007423"(sensory organ development)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045676"(regulation of R7 cell differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|reactome:R-DME-373752|reactome:R-DME-5689880|reactome:R-DME-983168	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/12	2014/10/16	rogid:Af8a0+hpRLwpFpdFkHfN8lEUU747227	rogid:GmUKLSW+fhn/1Fkti+v7o+NWs/87227	intact-crc:20D947368219DD18|rigid:MffZopd8T+uXVLYM+N0434NU2Gg	false	glutathione s tranferase tag:?-?	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q95RJ9	uniprotkb:Q27934	intact:EBI-421390|ensemblmetazoa:FBpp0077715|uniprotkb:Q9XZK1	intact:EBI-77033|uniprotkb:Q9V721|uniprotkb:C0PV22|ensemblmetazoa:FBpp0086645	psi-mi:ebi_drome(display_long)|uniprotkb:ebi(gene name)|psi-mi:ebi(display_short)|uniprotkb:CG4063(orf name)	psi-mi:phyl_drome(display_long)|uniprotkb:phyl(gene name)|psi-mi:phyl(display_short)|uniprotkb:CG10108(orf name)	psi-mi:"MI:0096"(pull down)	Boulton et al. (2000)	pubmed:11032805	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-528998	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0022416"(chaeta development)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035220"(wing disc development)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0071482"(cellular response to light stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001680(WD40 repeat)|ensemblmetazoa:FBgn0263933(gene)|ensemblmetazoa:FBtr0078055(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|refseq:NP_477329.1|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|mint:Q95RJ9|reactome:R-DME-400206|reactome:R-DME-9029569|reactome:R-DME-9707564|interpro:IPR006594(LisH dimerisation motif)|flybase:FBgn0263933	refseq:NP_725394.1|flybase:FBgn0013725|dip:DIP-29101N|ensemblmetazoa:FBgn0013725(gene)|ensemblmetazoa:FBtr0087516(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007423"(sensory organ development)|go:"GO:0007462"(R1/R6 cell fate commitment)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008052"(sensory organ boundary specification)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/04/12	2014/10/16	rogid:Af8a0+hpRLwpFpdFkHfN8lEUU747227	rogid:QocGYm5CUc0c4Z8raybzOGhpt1M7227	intact-crc:7493CAB0FB71556F|rigid:PwdbRq4RwdHyQ5faM6i7xN/sNT8	false	glutathione s tranferase tag:?-?	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q27934	uniprotkb:P21461	intact:EBI-77033|uniprotkb:Q9V721|uniprotkb:C0PV22|ensemblmetazoa:FBpp0086645	intact:EBI-77019|uniprotkb:A4V214|uniprotkb:Q9VVB0|ensemblmetazoa:FBpp0075091|ensemblmetazoa:FBpp0075092|ensemblmetazoa:FBpp0310636	psi-mi:phyl_drome(display_long)|uniprotkb:phyl(gene name)|psi-mi:phyl(display_short)|uniprotkb:CG10108(orf name)	psi-mi:sina_drome(display_long)|uniprotkb:sina(gene name)|psi-mi:sina(display_short)|uniprotkb:CG9949(orf name)|uniprotkb:Seven in absentia protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase sina(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boulton et al. (2000)	pubmed:11032805	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-528963	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_725394.1|flybase:FBgn0013725|dip:DIP-29101N|ensemblmetazoa:FBgn0013725(gene)|ensemblmetazoa:FBtr0087516(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007423"(sensory organ development)|go:"GO:0007462"(R1/R6 cell fate commitment)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008052"(sensory organ boundary specification)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D	refseq:NP_476725.1|refseq:NP_730206.1|flybase:FBgn0003410|refseq:NP_001287089.1|dip:DIP-17392N|ensemblmetazoa:FBgn0003410(gene)|ensemblmetazoa:FBtr0075332(transcript)|ensemblmetazoa:FBtr0075333(transcript)|ensemblmetazoa:FBtr0344230(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007423"(sensory organ development)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045676"(regulation of R7 cell differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|reactome:R-DME-373752|reactome:R-DME-5689880|reactome:R-DME-983168	-	-	-	comment:PHYL and Sina were also V5 tagged for detection.	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2005/04/12	2014/10/16	rogid:QocGYm5CUc0c4Z8raybzOGhpt1M7227	rogid:GmUKLSW+fhn/1Fkti+v7o+NWs/87227	intact-crc:D07C883B21FBDA59|rigid:/+zMRgsA2yaA/nkn52QFuwwcIWc	false	his tag:?-?|v5 tag:?-?	his tag:?-?|v5 tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q27934	uniprotkb:Q95RJ9	intact:EBI-77033|uniprotkb:Q9V721|uniprotkb:C0PV22|ensemblmetazoa:FBpp0086645	intact:EBI-421390|ensemblmetazoa:FBpp0077715|uniprotkb:Q9XZK1	psi-mi:phyl_drome(display_long)|uniprotkb:phyl(gene name)|psi-mi:phyl(display_short)|uniprotkb:CG10108(orf name)	psi-mi:ebi_drome(display_long)|uniprotkb:ebi(gene name)|psi-mi:ebi(display_short)|uniprotkb:CG4063(orf name)	psi-mi:"MI:0096"(pull down)	Boulton et al. (2000)	pubmed:11032805	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-528963	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_725394.1|flybase:FBgn0013725|dip:DIP-29101N|ensemblmetazoa:FBgn0013725(gene)|ensemblmetazoa:FBtr0087516(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007423"(sensory organ development)|go:"GO:0007462"(R1/R6 cell fate commitment)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008052"(sensory organ boundary specification)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D	go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0022416"(chaeta development)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035220"(wing disc development)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0071482"(cellular response to light stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001680(WD40 repeat)|ensemblmetazoa:FBgn0263933(gene)|ensemblmetazoa:FBtr0078055(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|refseq:NP_477329.1|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|mint:Q95RJ9|reactome:R-DME-400206|reactome:R-DME-9029569|reactome:R-DME-9707564|interpro:IPR006594(LisH dimerisation motif)|flybase:FBgn0263933	-	-	-	comment:PHYL and Sina were also V5 tagged for detection.	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2005/04/12	2014/10/16	rogid:QocGYm5CUc0c4Z8raybzOGhpt1M7227	rogid:Af8a0+hpRLwpFpdFkHfN8lEUU747227	intact-crc:D07C883B21FBDA59|rigid:/+zMRgsA2yaA/nkn52QFuwwcIWc	false	his tag:?-?|v5 tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q95RJ9	uniprotkb:P21461	intact:EBI-421390|ensemblmetazoa:FBpp0077715|uniprotkb:Q9XZK1	intact:EBI-77019|uniprotkb:A4V214|uniprotkb:Q9VVB0|ensemblmetazoa:FBpp0075091|ensemblmetazoa:FBpp0075092|ensemblmetazoa:FBpp0310636	psi-mi:ebi_drome(display_long)|uniprotkb:ebi(gene name)|psi-mi:ebi(display_short)|uniprotkb:CG4063(orf name)	psi-mi:sina_drome(display_long)|uniprotkb:sina(gene name)|psi-mi:sina(display_short)|uniprotkb:CG9949(orf name)|uniprotkb:Seven in absentia protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase sina(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boulton et al. (2000)	pubmed:11032805	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-528977	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0022416"(chaeta development)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035220"(wing disc development)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0071482"(cellular response to light stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001680(WD40 repeat)|ensemblmetazoa:FBgn0263933(gene)|ensemblmetazoa:FBtr0078055(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|refseq:NP_477329.1|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|mint:Q95RJ9|reactome:R-DME-400206|reactome:R-DME-9029569|reactome:R-DME-9707564|interpro:IPR006594(LisH dimerisation motif)|flybase:FBgn0263933	refseq:NP_476725.1|refseq:NP_730206.1|flybase:FBgn0003410|refseq:NP_001287089.1|dip:DIP-17392N|ensemblmetazoa:FBgn0003410(gene)|ensemblmetazoa:FBtr0075332(transcript)|ensemblmetazoa:FBtr0075333(transcript)|ensemblmetazoa:FBtr0344230(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007423"(sensory organ development)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045676"(regulation of R7 cell differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|reactome:R-DME-373752|reactome:R-DME-5689880|reactome:R-DME-983168	-	-	-	-	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2005/04/12	2014/10/16	rogid:Af8a0+hpRLwpFpdFkHfN8lEUU747227	rogid:GmUKLSW+fhn/1Fkti+v7o+NWs/87227	intact-crc:B08931049E6D6D5E|rigid:MffZopd8T+uXVLYM+N0434NU2Gg	false	-	his tag:?-?|v5 tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q27934	uniprotkb:Q95RJ9	intact:EBI-77033|uniprotkb:Q9V721|uniprotkb:C0PV22|ensemblmetazoa:FBpp0086645	intact:EBI-421390|ensemblmetazoa:FBpp0077715|uniprotkb:Q9XZK1	psi-mi:phyl_drome(display_long)|uniprotkb:phyl(gene name)|psi-mi:phyl(display_short)|uniprotkb:CG10108(orf name)	psi-mi:ebi_drome(display_long)|uniprotkb:ebi(gene name)|psi-mi:ebi(display_short)|uniprotkb:CG4063(orf name)	psi-mi:"MI:0096"(pull down)	Boulton et al. (2000)	pubmed:11032805	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-528983	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_725394.1|flybase:FBgn0013725|dip:DIP-29101N|ensemblmetazoa:FBgn0013725(gene)|ensemblmetazoa:FBtr0087516(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007423"(sensory organ development)|go:"GO:0007462"(R1/R6 cell fate commitment)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008052"(sensory organ boundary specification)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D	go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0022416"(chaeta development)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035220"(wing disc development)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0071482"(cellular response to light stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001680(WD40 repeat)|ensemblmetazoa:FBgn0263933(gene)|ensemblmetazoa:FBtr0078055(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|refseq:NP_477329.1|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|mint:Q95RJ9|reactome:R-DME-400206|reactome:R-DME-9029569|reactome:R-DME-9707564|interpro:IPR006594(LisH dimerisation motif)|flybase:FBgn0263933	-	-	-	-	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2005/04/12	2014/10/16	rogid:QocGYm5CUc0c4Z8raybzOGhpt1M7227	rogid:Af8a0+hpRLwpFpdFkHfN8lEUU747227	intact-crc:E7DCF440D4E0EB27|rigid:PwdbRq4RwdHyQ5faM6i7xN/sNT8	false	his tag:?-?|v5 tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)