#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9NQS3 uniprotkb:P55196 intact:EBI-2826725|uniprotkb:Q8WVU4|uniprotkb:Q6NVZ3|uniprotkb:Q9Y412|uniprotkb:Q9BVA9|ensembl:ENSP00000418070|uniprotkb:E9PFR0|uniprotkb:Q8NC05 intact:EBI-365875|uniprotkb:O75089|uniprotkb:Q5TIG6|uniprotkb:O75087|uniprotkb:O75088|uniprotkb:Q9NSN7|uniprotkb:Q9NU92|uniprotkb:Q5TIG7|uniprotkb:Q59FP0|ensembl:ENSP00000404595 psi-mi:nect3_human(display_long)|uniprotkb:NECTIN3(gene name)|psi-mi:NECTIN3(display_short)|uniprotkb:CDw113(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 3(gene name synonym)|uniprotkb:PRR3(gene name synonym)|uniprotkb:PVRL3(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 3(gene name synonym) psi-mi:afad_human(display_long)|uniprotkb:AFDN(gene name)|psi-mi:AFDN(display_short)|uniprotkb:AF6(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 6 protein(gene name synonym)|uniprotkb:Afadin adherens junction formation factor(gene name synonym)|uniprotkb:MLLT4(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Reymond et al. (2000) pubmed:11024295|mint:MINT-5213063 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7408138|mint:MINT-73129 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001230215.1|refseq:NP_056295.1|ensembl:ENSG00000177707(gene)|ensembl:ENST00000485303(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007286"(spermatid development)|go:"GO:0009566"(fertilization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|reactome:R-HSA-420597|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033319|interpro:IPR036179|rcsb pdb:4FOM|reactome:R-HSA-418990|refseq:NP_001230217.1|dip:DIP-41491N|mint:MINT-432405(identity) refseq:NP_001035089.1|refseq:NP_001193937.1|refseq:XP_005267053.1|ensembl:ENST00000392108|ensembl:ENSP00000375956|ensembl:ENST00000392112|ensembl:ENSP00000375960|ensembl:ENST00000400822|ensembl:ENSP00000383623|ensembl:ENSP00000404595|refseq:NP_001278893.1|ensembl:ENSG00000130396(gene)|ensembl:ENST00000447894(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045296"(cadherin binding)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0070160"(tight junction)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000159(Ras-association)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR002710(Dilute)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR029071|interpro:IPR036034|interpro:IPR037977|mint:P55196|rcsb pdb:1T2M|rcsb pdb:1XZ9|rcsb pdb:2AIN|rcsb pdb:2EXG|rcsb pdb:5A6C|reactome:R-HSA-418990|go:"GO:0022409"(positive regulation of cell-cell adhesion)|mint:MINT-432412(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F4B|comment:homomint|comment:mint taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2005/12/05 2014/10/16 rogid:lzSScehKhxTPj0E6EmL+P+XXjB09606 rogid:x7kK5K1+wAFZFdVopvQ/l496J5U9606 intact-crc:6C5BA400B9CC7413|rigid:8OrMw1G0/713HnQAgg5XqjTZcJE false flag tag:?-?(MINT-432406) - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:Q9NQS3 uniprotkb:P55196 intact:EBI-2826725|uniprotkb:Q8WVU4|uniprotkb:Q6NVZ3|uniprotkb:Q9Y412|uniprotkb:Q9BVA9|ensembl:ENSP00000418070|uniprotkb:E9PFR0|uniprotkb:Q8NC05 intact:EBI-365875|uniprotkb:O75089|uniprotkb:Q5TIG6|uniprotkb:O75087|uniprotkb:O75088|uniprotkb:Q9NSN7|uniprotkb:Q9NU92|uniprotkb:Q5TIG7|uniprotkb:Q59FP0|ensembl:ENSP00000404595 psi-mi:nect3_human(display_long)|uniprotkb:NECTIN3(gene name)|psi-mi:NECTIN3(display_short)|uniprotkb:CDw113(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 3(gene name synonym)|uniprotkb:PRR3(gene name synonym)|uniprotkb:PVRL3(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 3(gene name synonym) psi-mi:afad_human(display_long)|uniprotkb:AFDN(gene name)|psi-mi:AFDN(display_short)|uniprotkb:AF6(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 6 protein(gene name synonym)|uniprotkb:Afadin adherens junction formation factor(gene name synonym)|uniprotkb:MLLT4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Reymond et al. (2000) pubmed:11024295|mint:MINT-5213063 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7408180|mint:MINT-73128 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001230215.1|refseq:NP_056295.1|ensembl:ENSG00000177707(gene)|ensembl:ENST00000485303(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007286"(spermatid development)|go:"GO:0009566"(fertilization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|reactome:R-HSA-420597|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033319|interpro:IPR036179|rcsb pdb:4FOM|reactome:R-HSA-418990|refseq:NP_001230217.1|dip:DIP-41491N|mint:MINT-432422(identity) refseq:NP_001035089.1|refseq:NP_001193937.1|refseq:XP_005267053.1|ensembl:ENST00000392108|ensembl:ENSP00000375956|ensembl:ENST00000392112|ensembl:ENSP00000375960|ensembl:ENST00000400822|ensembl:ENSP00000383623|ensembl:ENSP00000404595|refseq:NP_001278893.1|ensembl:ENSG00000130396(gene)|ensembl:ENST00000447894(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045296"(cadherin binding)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0070160"(tight junction)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000159(Ras-association)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR002710(Dilute)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR029071|interpro:IPR036034|interpro:IPR037977|mint:P55196|rcsb pdb:1T2M|rcsb pdb:1XZ9|rcsb pdb:2AIN|rcsb pdb:2EXG|rcsb pdb:5A6C|reactome:R-HSA-418990|go:"GO:0022409"(positive regulation of cell-cell adhesion)|mint:MINT-432429(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F4A|comment:homomint|comment:mint taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2005/12/05 2014/10/16 rogid:lzSScehKhxTPj0E6EmL+P+XXjB09606 rogid:x7kK5K1+wAFZFdVopvQ/l496J5U9606 intact-crc:274CD7285CF4F2A3|rigid:8OrMw1G0/713HnQAgg5XqjTZcJE false flag tag:?-?(MINT-432423) - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0072"(monoclonal antibody western blot)