#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q80TH2	uniprotkb:P70424	intact:EBI-7320461|uniprotkb:Q8K171|uniprotkb:E9QND6|uniprotkb:Q8CE41|uniprotkb:Q8BQ14|uniprotkb:Q9JI47|intact:MINT-138078|uniprotkb:Q99JU3|ensembl:ENSMUSP00000088813	intact:EBI-2945468|ensembl:ENSMUSP00000053897|uniprotkb:Q61525|uniprotkb:Q6ZPE0	psi-mi:erbin_mouse(display_long)|uniprotkb:Erbin(gene name)|psi-mi:Erbin(display_short)|uniprotkb:Densin-180-like protein(gene name synonym)|uniprotkb:Erbb2-interacting protein(gene name synonym)|uniprotkb:Erbb2ip(gene name synonym)|uniprotkb:Kiaa1225(gene name synonym)|uniprotkb:Lap2(gene name synonym)|uniprotkb:Protein LAP2(gene name synonym)	psi-mi:erbb2_mouse(display_long)|uniprotkb:Erbb2(gene name)|psi-mi:Erbb2(display_short)|uniprotkb:Kiaa3023(gene name synonym)|uniprotkb:Neu(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:p185erbB2(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Borg et al. (2000)	pubmed:10878805|mint:MINT-5212725	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7320494|mint:MINT-72831	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000021709(gene)|ensembl:ENSMUST00000091269(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR032927|interpro:IPR036034|reactome:R-MMU-1227986|reactome:R-MMU-8863795|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-9652282|refseq:NP_001005868.1|refseq:NP_001276402.1|refseq:NP_001276403.1|refseq:NP_001276404.1|mint:MINT-420867(identity)	ensembl:ENSMUSG00000062312(gene)|ensembl:ENSMUST00000058295(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010008"(endosome membrane)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043219"(lateral loop)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048678"(response to axon injury)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|reactome:R-MMU-1227986|reactome:R-MMU-1250196|reactome:R-MMU-1257604|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-416572|reactome:R-MMU-5673001|reactome:R-MMU-6785631|reactome:R-MMU-6811558|reactome:R-MMU-8847993|reactome:R-MMU-8863795|reactome:R-MMU-9652282|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|refseq:NP_001003817.1|dip:DIP-40912N|mint:MINT-420872(identity)	-	comment:mint|function:Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ERBB2 'Tyr-1248' receptor, it may contribute to stabilize this unphosphorylated state|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4D|comment:homomint|comment:mint	taxid:9606(human-caco)|taxid:9606(Homo sapiens)	-	2005/11/28	2014/10/16	rogid:8/YYmKxiql+Xa8+qsF+qTgYSU0M10090	rogid:+lOIwIPXJnyC0pwki4J6+7mk1+w10090	intact-crc:06B05A1AA9DA63CE|rigid:FoNp4qCH4ImbJjypLRkq7gwkIHE	false	-	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q80TH2	uniprotkb:P70424	intact:EBI-7320461|uniprotkb:Q8K171|uniprotkb:E9QND6|uniprotkb:Q8CE41|uniprotkb:Q8BQ14|uniprotkb:Q9JI47|intact:MINT-138078|uniprotkb:Q99JU3|ensembl:ENSMUSP00000088813	intact:EBI-2945468|ensembl:ENSMUSP00000053897|uniprotkb:Q61525|uniprotkb:Q6ZPE0	psi-mi:erbin_mouse(display_long)|uniprotkb:Erbin(gene name)|psi-mi:Erbin(display_short)|uniprotkb:Densin-180-like protein(gene name synonym)|uniprotkb:Erbb2-interacting protein(gene name synonym)|uniprotkb:Erbb2ip(gene name synonym)|uniprotkb:Kiaa1225(gene name synonym)|uniprotkb:Lap2(gene name synonym)|uniprotkb:Protein LAP2(gene name synonym)	psi-mi:erbb2_mouse(display_long)|uniprotkb:Erbb2(gene name)|psi-mi:Erbb2(display_short)|uniprotkb:Kiaa3023(gene name synonym)|uniprotkb:Neu(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:p185erbB2(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Borg et al. (2000)	pubmed:10878805|mint:MINT-5212725	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7320587|mint:MINT-72824	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000021709(gene)|ensembl:ENSMUST00000091269(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR032927|interpro:IPR036034|reactome:R-MMU-1227986|reactome:R-MMU-8863795|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-9652282|refseq:NP_001005868.1|refseq:NP_001276402.1|refseq:NP_001276403.1|refseq:NP_001276404.1|mint:MINT-420882(identity)	ensembl:ENSMUSG00000062312(gene)|ensembl:ENSMUST00000058295(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010008"(endosome membrane)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043219"(lateral loop)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048678"(response to axon injury)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|reactome:R-MMU-1227986|reactome:R-MMU-1250196|reactome:R-MMU-1257604|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-416572|reactome:R-MMU-5673001|reactome:R-MMU-6785631|reactome:R-MMU-6811558|reactome:R-MMU-8847993|reactome:R-MMU-8863795|reactome:R-MMU-9652282|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|refseq:NP_001003817.1|dip:DIP-40912N|mint:MINT-420892(identity)	-	comment:mint|function:Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ERBB2 'Tyr-1248' receptor, it may contribute to stabilize this unphosphorylated state|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1E|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/28	2014/10/16	rogid:8/YYmKxiql+Xa8+qsF+qTgYSU0M10090	rogid:+lOIwIPXJnyC0pwki4J6+7mk1+w10090	intact-crc:B400FE5B3FED4FA4|rigid:FoNp4qCH4ImbJjypLRkq7gwkIHE	false	glutathione s tranferase tag:?-?(MINT-420886)|binding-associated region:1240-1371(MINT-420883)	binding-associated region:1248-1256(MINT-420893)|glutathione s tranferase tag:?-?(MINT-420896)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q80TH2	uniprotkb:P70424	intact:EBI-7320461|uniprotkb:Q8K171|uniprotkb:E9QND6|uniprotkb:Q8CE41|uniprotkb:Q8BQ14|uniprotkb:Q9JI47|intact:MINT-138078|uniprotkb:Q99JU3|ensembl:ENSMUSP00000088813	intact:EBI-2945468|ensembl:ENSMUSP00000053897|uniprotkb:Q61525|uniprotkb:Q6ZPE0	psi-mi:erbin_mouse(display_long)|uniprotkb:Erbin(gene name)|psi-mi:Erbin(display_short)|uniprotkb:Densin-180-like protein(gene name synonym)|uniprotkb:Erbb2-interacting protein(gene name synonym)|uniprotkb:Erbb2ip(gene name synonym)|uniprotkb:Kiaa1225(gene name synonym)|uniprotkb:Lap2(gene name synonym)|uniprotkb:Protein LAP2(gene name synonym)	psi-mi:erbb2_mouse(display_long)|uniprotkb:Erbb2(gene name)|psi-mi:Erbb2(display_short)|uniprotkb:Kiaa3023(gene name synonym)|uniprotkb:Neu(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:p185erbB2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Borg et al. (2000)	pubmed:10878805|mint:MINT-5212725	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7320622|mint:MINT-72820	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000021709(gene)|ensembl:ENSMUST00000091269(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR032927|interpro:IPR036034|reactome:R-MMU-1227986|reactome:R-MMU-8863795|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-9652282|refseq:NP_001005868.1|refseq:NP_001276402.1|refseq:NP_001276403.1|refseq:NP_001276404.1|mint:MINT-420976(identity)	ensembl:ENSMUSG00000062312(gene)|ensembl:ENSMUST00000058295(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010008"(endosome membrane)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043219"(lateral loop)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048678"(response to axon injury)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|reactome:R-MMU-1227986|reactome:R-MMU-1250196|reactome:R-MMU-1257604|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-416572|reactome:R-MMU-5673001|reactome:R-MMU-6785631|reactome:R-MMU-6811558|reactome:R-MMU-8847993|reactome:R-MMU-8863795|reactome:R-MMU-9652282|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|refseq:NP_001003817.1|dip:DIP-40912N|mint:MINT-420986(identity)	-	comment:mint|function:Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ERBB2 'Tyr-1248' receptor, it may contribute to stabilize this unphosphorylated state|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1D|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/28	2014/10/16	rogid:8/YYmKxiql+Xa8+qsF+qTgYSU0M10090	rogid:+lOIwIPXJnyC0pwki4J6+7mk1+w10090	intact-crc:53DC9472946C2B7D|rigid:FoNp4qCH4ImbJjypLRkq7gwkIHE	false	binding-associated region:1240-1371(MINT-420977)|glutathione s tranferase tag:?-?(MINT-420980)	tag:?-?(MINT-420987)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q80TH2	uniprotkb:P70424	intact:EBI-7320461|uniprotkb:Q8K171|uniprotkb:E9QND6|uniprotkb:Q8CE41|uniprotkb:Q8BQ14|uniprotkb:Q9JI47|intact:MINT-138078|uniprotkb:Q99JU3|ensembl:ENSMUSP00000088813	intact:EBI-2945468|ensembl:ENSMUSP00000053897|uniprotkb:Q61525|uniprotkb:Q6ZPE0	psi-mi:erbin_mouse(display_long)|uniprotkb:Erbin(gene name)|psi-mi:Erbin(display_short)|uniprotkb:Densin-180-like protein(gene name synonym)|uniprotkb:Erbb2-interacting protein(gene name synonym)|uniprotkb:Erbb2ip(gene name synonym)|uniprotkb:Kiaa1225(gene name synonym)|uniprotkb:Lap2(gene name synonym)|uniprotkb:Protein LAP2(gene name synonym)	psi-mi:erbb2_mouse(display_long)|uniprotkb:Erbb2(gene name)|psi-mi:Erbb2(display_short)|uniprotkb:Kiaa3023(gene name synonym)|uniprotkb:Neu(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:p185erbB2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Borg et al. (2000)	pubmed:10878805|mint:MINT-5212725	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7320644|mint:MINT-72828	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000021709(gene)|ensembl:ENSMUST00000091269(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR032927|interpro:IPR036034|reactome:R-MMU-1227986|reactome:R-MMU-8863795|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-9652282|refseq:NP_001005868.1|refseq:NP_001276402.1|refseq:NP_001276403.1|refseq:NP_001276404.1|mint:MINT-420907(identity)	ensembl:ENSMUSG00000062312(gene)|ensembl:ENSMUST00000058295(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010008"(endosome membrane)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043219"(lateral loop)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048678"(response to axon injury)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|reactome:R-MMU-1227986|reactome:R-MMU-1250196|reactome:R-MMU-1257604|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-416572|reactome:R-MMU-5673001|reactome:R-MMU-6785631|reactome:R-MMU-6811558|reactome:R-MMU-8847993|reactome:R-MMU-8863795|reactome:R-MMU-9652282|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|refseq:NP_001003817.1|dip:DIP-40912N|mint:MINT-420919(identity)	-	comment:mint|function:Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ERBB2 'Tyr-1248' receptor, it may contribute to stabilize this unphosphorylated state|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1G|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/28	2014/10/16	rogid:8/YYmKxiql+Xa8+qsF+qTgYSU0M10090	rogid:+lOIwIPXJnyC0pwki4J6+7mk1+w10090	intact-crc:CC73EFF29386DC5C|rigid:FoNp4qCH4ImbJjypLRkq7gwkIHE	false	mutation decreasing interaction:1378-1379(MINT-420911)|binding-associated region:1240-1371(MINT-420908)|glutathione s tranferase tag:?-?(MINT-420913)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q80TH2	uniprotkb:P70424	intact:EBI-7320461|uniprotkb:Q8K171|uniprotkb:E9QND6|uniprotkb:Q8CE41|uniprotkb:Q8BQ14|uniprotkb:Q9JI47|intact:MINT-138078|uniprotkb:Q99JU3|ensembl:ENSMUSP00000088813	intact:EBI-2945468|ensembl:ENSMUSP00000053897|uniprotkb:Q61525|uniprotkb:Q6ZPE0	psi-mi:erbin_mouse(display_long)|uniprotkb:Erbin(gene name)|psi-mi:Erbin(display_short)|uniprotkb:Densin-180-like protein(gene name synonym)|uniprotkb:Erbb2-interacting protein(gene name synonym)|uniprotkb:Erbb2ip(gene name synonym)|uniprotkb:Kiaa1225(gene name synonym)|uniprotkb:Lap2(gene name synonym)|uniprotkb:Protein LAP2(gene name synonym)	psi-mi:erbb2_mouse(display_long)|uniprotkb:Erbb2(gene name)|psi-mi:Erbb2(display_short)|uniprotkb:Kiaa3023(gene name synonym)|uniprotkb:Neu(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:p185erbB2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Borg et al. (2000)	pubmed:10878805|mint:MINT-5212725	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7320687|mint:MINT-72832	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000021709(gene)|ensembl:ENSMUST00000091269(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR032927|interpro:IPR036034|reactome:R-MMU-1227986|reactome:R-MMU-8863795|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-9652282|refseq:NP_001005868.1|refseq:NP_001276402.1|refseq:NP_001276403.1|refseq:NP_001276404.1|mint:MINT-421012(identity)	ensembl:ENSMUSG00000062312(gene)|ensembl:ENSMUST00000058295(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010008"(endosome membrane)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043219"(lateral loop)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048678"(response to axon injury)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|reactome:R-MMU-1227986|reactome:R-MMU-1250196|reactome:R-MMU-1257604|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-416572|reactome:R-MMU-5673001|reactome:R-MMU-6785631|reactome:R-MMU-6811558|reactome:R-MMU-8847993|reactome:R-MMU-8863795|reactome:R-MMU-9652282|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|refseq:NP_001003817.1|dip:DIP-40912N|mint:MINT-421022(identity)	-	comment:mint|function:Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ERBB2 'Tyr-1248' receptor, it may contribute to stabilize this unphosphorylated state|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3C|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/11/28	2014/10/16	rogid:8/YYmKxiql+Xa8+qsF+qTgYSU0M10090	rogid:+lOIwIPXJnyC0pwki4J6+7mk1+w10090	intact-crc:06DFBFB7DC675013|rigid:FoNp4qCH4ImbJjypLRkq7gwkIHE	false	glutathione s tranferase tag:?-?(MINT-421016)|binding-associated region:1313-1397(MINT-421013)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q80TH2	uniprotkb:P70424	intact:EBI-7320461|uniprotkb:Q8K171|uniprotkb:E9QND6|uniprotkb:Q8CE41|uniprotkb:Q8BQ14|uniprotkb:Q9JI47|intact:MINT-138078|uniprotkb:Q99JU3|ensembl:ENSMUSP00000088813	intact:EBI-2945468|ensembl:ENSMUSP00000053897|uniprotkb:Q61525|uniprotkb:Q6ZPE0	psi-mi:erbin_mouse(display_long)|uniprotkb:Erbin(gene name)|psi-mi:Erbin(display_short)|uniprotkb:Densin-180-like protein(gene name synonym)|uniprotkb:Erbb2-interacting protein(gene name synonym)|uniprotkb:Erbb2ip(gene name synonym)|uniprotkb:Kiaa1225(gene name synonym)|uniprotkb:Lap2(gene name synonym)|uniprotkb:Protein LAP2(gene name synonym)	psi-mi:erbb2_mouse(display_long)|uniprotkb:Erbb2(gene name)|psi-mi:Erbb2(display_short)|uniprotkb:Kiaa3023(gene name synonym)|uniprotkb:Neu(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:p185erbB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Borg et al. (2000)	pubmed:10878805|mint:MINT-5212725	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7320731|mint:MINT-72764	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000021709(gene)|ensembl:ENSMUST00000091269(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR032927|interpro:IPR036034|reactome:R-MMU-1227986|reactome:R-MMU-8863795|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-9652282|refseq:NP_001005868.1|refseq:NP_001276402.1|refseq:NP_001276403.1|refseq:NP_001276404.1|mint:MINT-420929(identity)	ensembl:ENSMUSG00000062312(gene)|ensembl:ENSMUST00000058295(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010008"(endosome membrane)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043219"(lateral loop)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048678"(response to axon injury)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|reactome:R-MMU-1227986|reactome:R-MMU-1250196|reactome:R-MMU-1257604|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-416572|reactome:R-MMU-5673001|reactome:R-MMU-6785631|reactome:R-MMU-6811558|reactome:R-MMU-8847993|reactome:R-MMU-8863795|reactome:R-MMU-9652282|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|refseq:NP_001003817.1|dip:DIP-40912N|mint:MINT-420940(identity)	-	comment:mint|function:Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ERBB2 'Tyr-1248' receptor, it may contribute to stabilize this unphosphorylated state|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/11/28	2014/10/16	rogid:8/YYmKxiql+Xa8+qsF+qTgYSU0M10090	rogid:+lOIwIPXJnyC0pwki4J6+7mk1+w10090	intact-crc:DFD80F8EFB877516|rigid:FoNp4qCH4ImbJjypLRkq7gwkIHE	false	binding-associated region:1240-1371(MINT-420930)|tag:?-?(MINT-420934)	mutation decreasing interaction:1252-1252,1254-1254(MINT-420944)|tag:?-?(MINT-420947)|binding-associated region:1248-1256(MINT-420941)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q80TH2	uniprotkb:P70424	intact:EBI-7320461|uniprotkb:Q8K171|uniprotkb:E9QND6|uniprotkb:Q8CE41|uniprotkb:Q8BQ14|uniprotkb:Q9JI47|intact:MINT-138078|uniprotkb:Q99JU3|ensembl:ENSMUSP00000088813	intact:EBI-2945468|ensembl:ENSMUSP00000053897|uniprotkb:Q61525|uniprotkb:Q6ZPE0	psi-mi:erbin_mouse(display_long)|uniprotkb:Erbin(gene name)|psi-mi:Erbin(display_short)|uniprotkb:Densin-180-like protein(gene name synonym)|uniprotkb:Erbb2-interacting protein(gene name synonym)|uniprotkb:Erbb2ip(gene name synonym)|uniprotkb:Kiaa1225(gene name synonym)|uniprotkb:Lap2(gene name synonym)|uniprotkb:Protein LAP2(gene name synonym)	psi-mi:erbb2_mouse(display_long)|uniprotkb:Erbb2(gene name)|psi-mi:Erbb2(display_short)|uniprotkb:Kiaa3023(gene name synonym)|uniprotkb:Neu(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:p185erbB2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Borg et al. (2000)	pubmed:10878805|mint:MINT-5212725	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7320792|mint:MINT-72903	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000021709(gene)|ensembl:ENSMUST00000091269(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR032927|interpro:IPR036034|reactome:R-MMU-1227986|reactome:R-MMU-8863795|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-9652282|refseq:NP_001005868.1|refseq:NP_001276402.1|refseq:NP_001276403.1|refseq:NP_001276404.1|mint:MINT-420958(identity)	ensembl:ENSMUSG00000062312(gene)|ensembl:ENSMUST00000058295(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010008"(endosome membrane)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043219"(lateral loop)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048678"(response to axon injury)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|reactome:R-MMU-1227986|reactome:R-MMU-1250196|reactome:R-MMU-1257604|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-416572|reactome:R-MMU-5673001|reactome:R-MMU-6785631|reactome:R-MMU-6811558|reactome:R-MMU-8847993|reactome:R-MMU-8863795|reactome:R-MMU-9652282|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|refseq:NP_001003817.1|dip:DIP-40912N|mint:MINT-420968(identity)	-	comment:mint|function:Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ERBB2 'Tyr-1248' receptor, it may contribute to stabilize this unphosphorylated state|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3G|comment:homomint|comment:mint	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2005/11/28	2014/10/16	rogid:8/YYmKxiql+Xa8+qsF+qTgYSU0M10090	rogid:+lOIwIPXJnyC0pwki4J6+7mk1+w10090	intact-crc:36FB89B1C0548982|rigid:FoNp4qCH4ImbJjypLRkq7gwkIHE	false	binding-associated region:1313-1397(MINT-420959)|myc tag:?-?(MINT-420962)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q80TH2	uniprotkb:P70424	intact:EBI-7320461|uniprotkb:Q8K171|uniprotkb:E9QND6|uniprotkb:Q8CE41|uniprotkb:Q8BQ14|uniprotkb:Q9JI47|intact:MINT-138078|uniprotkb:Q99JU3|ensembl:ENSMUSP00000088813	intact:EBI-2945468|ensembl:ENSMUSP00000053897|uniprotkb:Q61525|uniprotkb:Q6ZPE0	psi-mi:erbin_mouse(display_long)|uniprotkb:Erbin(gene name)|psi-mi:Erbin(display_short)|uniprotkb:Densin-180-like protein(gene name synonym)|uniprotkb:Erbb2-interacting protein(gene name synonym)|uniprotkb:Erbb2ip(gene name synonym)|uniprotkb:Kiaa1225(gene name synonym)|uniprotkb:Lap2(gene name synonym)|uniprotkb:Protein LAP2(gene name synonym)	psi-mi:erbb2_mouse(display_long)|uniprotkb:Erbb2(gene name)|psi-mi:Erbb2(display_short)|uniprotkb:Kiaa3023(gene name synonym)|uniprotkb:Neu(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:p185erbB2(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Borg et al. (2000)	pubmed:10878805|mint:MINT-5212725	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7320885|mint:MINT-72830	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000021709(gene)|ensembl:ENSMUST00000091269(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR032927|interpro:IPR036034|reactome:R-MMU-1227986|reactome:R-MMU-8863795|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-9652282|refseq:NP_001005868.1|refseq:NP_001276402.1|refseq:NP_001276403.1|refseq:NP_001276404.1|mint:MINT-420998(identity)	ensembl:ENSMUSG00000062312(gene)|ensembl:ENSMUST00000058295(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010008"(endosome membrane)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043219"(lateral loop)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048678"(response to axon injury)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|reactome:R-MMU-1227986|reactome:R-MMU-1250196|reactome:R-MMU-1257604|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-416572|reactome:R-MMU-5673001|reactome:R-MMU-6785631|reactome:R-MMU-6811558|reactome:R-MMU-8847993|reactome:R-MMU-8863795|reactome:R-MMU-9652282|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|refseq:NP_001003817.1|dip:DIP-40912N|mint:MINT-421003(identity)	-	comment:mint|function:Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ERBB2 'Tyr-1248' receptor, it may contribute to stabilize this unphosphorylated state|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:Erbin and ERBB2 co-localize to the basolateral epithelia.|figure legend:F4B F5|comment:homomint|comment:mint	taxid:9606(human-caco)|taxid:9606(Homo sapiens)	-	2005/11/28	2014/10/16	rogid:8/YYmKxiql+Xa8+qsF+qTgYSU0M10090	rogid:+lOIwIPXJnyC0pwki4J6+7mk1+w10090	intact-crc:F9644587D32CDFC4|rigid:FoNp4qCH4ImbJjypLRkq7gwkIHE	false	-	-	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)