#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9QZ06	uniprotkb:Q61730	intact:EBI-74272|uniprotkb:Q543N1|uniprotkb:Q9D5P5|ensembl:ENSMUSP00000001950	intact:EBI-525035|uniprotkb:Q8VCB9|uniprotkb:Q3UVZ1|ensembl:ENSMUSP00000023156	psi-mi:tolip_mouse(display_long)|uniprotkb:Tollip(gene name)|psi-mi:Tollip(display_short)	psi-mi:il1ap_mouse(display_long)|uniprotkb:Il1rap(gene name)|psi-mi:Il1rap(display_short)|uniprotkb:Interleukin-33 receptot beta chain(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Burns et al. (2000)	pubmed:10854325	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-525059	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076253.1|ensembl:ENSMUSG00000025139(gene)|ensembl:ENSMUST00000001950(transcript)|go:"GO:0005150"(interleukin-1, type I receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0016310"(phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0019900"(kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR009060(UBA-like)|interpro:IPR035892|interpro:IPR037301|interpro:IPR041799|mint:Q9QZ06|reactome:R-MMU-6798695|reactome:R-MMU-9020702	refseq:NP_032390.1|refseq:NP_598864.1|refseq:NP_001152790.1|ensembl:ENSMUSG00000022514(gene)|ensembl:ENSMUST00000023156(transcript)|go:"GO:0002114"(interleukin-33 receptor activity)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038172"(interleukin-33-mediated signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099545"(trans-synaptic signaling by trans-synaptic complex)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|interpro:IPR041416|rcsb pdb:4YFD|rcsb pdb:5VI4|reactome:R-MMU-1257604|reactome:R-MMU-388844|reactome:R-MMU-6811558|reactome:R-MMU-9014826|reactome:R-MMU-9014843|reactome:R-MMU-9020702|dip:DIP-296N	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/04/04	2014/10/16	rogid:l31YAZvuxJMK48wHqwvgPu8lVUs10090	rogid:t6go1Z8XGGOANmCmvimPb/wwc2g10090	intact-crc:F8B9991AFA522BFE|rigid:CXJI74VS6qUGREAcLX24yvY8t8E	false	-	binding-associated region:385-570	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QZ06	uniprotkb:Q61730	intact:EBI-74272|uniprotkb:Q543N1|uniprotkb:Q9D5P5|ensembl:ENSMUSP00000001950	intact:EBI-525035|uniprotkb:Q8VCB9|uniprotkb:Q3UVZ1|ensembl:ENSMUSP00000023156	psi-mi:tolip_mouse(display_long)|uniprotkb:Tollip(gene name)|psi-mi:Tollip(display_short)	psi-mi:il1ap_mouse(display_long)|uniprotkb:Il1rap(gene name)|psi-mi:Il1rap(display_short)|uniprotkb:Interleukin-33 receptot beta chain(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Burns et al. (2000)	pubmed:10854325	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-525064	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076253.1|ensembl:ENSMUSG00000025139(gene)|ensembl:ENSMUST00000001950(transcript)|go:"GO:0005150"(interleukin-1, type I receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0016310"(phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0019900"(kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR009060(UBA-like)|interpro:IPR035892|interpro:IPR037301|interpro:IPR041799|mint:Q9QZ06|reactome:R-MMU-6798695|reactome:R-MMU-9020702	refseq:NP_032390.1|refseq:NP_598864.1|refseq:NP_001152790.1|ensembl:ENSMUSG00000022514(gene)|ensembl:ENSMUST00000023156(transcript)|go:"GO:0002114"(interleukin-33 receptor activity)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038172"(interleukin-33-mediated signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099545"(trans-synaptic signaling by trans-synaptic complex)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|interpro:IPR041416|rcsb pdb:4YFD|rcsb pdb:5VI4|reactome:R-MMU-1257604|reactome:R-MMU-388844|reactome:R-MMU-6811558|reactome:R-MMU-9014826|reactome:R-MMU-9014843|reactome:R-MMU-9020702|dip:DIP-296N	-	-	-	-	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/04/04	2014/10/16	rogid:l31YAZvuxJMK48wHqwvgPu8lVUs10090	rogid:t6go1Z8XGGOANmCmvimPb/wwc2g10090	intact-crc:A1F944DC1BD497A3|rigid:CXJI74VS6qUGREAcLX24yvY8t8E	false	tag:?-?|binding-associated region:47-274	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QZ06	uniprotkb:Q62406	intact:EBI-74272|uniprotkb:Q543N1|uniprotkb:Q9D5P5|ensembl:ENSMUSP00000001950	intact:EBI-448533|uniprotkb:Q6Y3Z5|uniprotkb:Q6Y3Z6|uniprotkb:B1AUW4|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:tolip_mouse(display_long)|uniprotkb:Tollip(gene name)|psi-mi:Tollip(display_short)	psi-mi:irak1_mouse(display_long)|uniprotkb:Pelle-like protein kinase(gene name synonym)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Burns et al. (2000)	pubmed:10854325	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-525192	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076253.1|ensembl:ENSMUSG00000025139(gene)|ensembl:ENSMUST00000001950(transcript)|go:"GO:0005150"(interleukin-1, type I receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0016310"(phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0019900"(kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR009060(UBA-like)|interpro:IPR035892|interpro:IPR037301|interpro:IPR041799|mint:Q9QZ06|reactome:R-MMU-6798695|reactome:R-MMU-9020702	refseq:NP_001171447.1|refseq:NP_032389.2|refseq:NP_001171445.1|dip:DIP-31491N|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)|go:"GO:0001959"(regulation of cytokine-mediated signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035533|interpro:IPR035536|mint:Q62406|reactome:R-MMU-1257604|reactome:R-MMU-168638|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-445989|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-450321|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-975144|reactome:R-MMU-450302	-	-	-	inhibition:Tollip binding to the N terminal region of IRAK1 prevents phosphorylation of IRAK1|comment:"The 293T cells expressed murine Interleukin receptor 1 (IL-1R1)."	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/04/04	2014/10/16	rogid:l31YAZvuxJMK48wHqwvgPu8lVUs10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:731EF1ADFD8E0F24|rigid:wnEXKNx1mN/Y1dLTq1YGC09+xH4	false	tag:?-?|binding-associated region:47-274	binding-associated region:1-208|mutation decreasing interaction:66-66|flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62406	uniprotkb:P22366	intact:EBI-448533|uniprotkb:Q6Y3Z5|uniprotkb:Q6Y3Z6|uniprotkb:B1AUW4|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	intact:EBI-525108|uniprotkb:O35916|ensembl:ENSMUSP00000035092	psi-mi:irak1_mouse(display_long)|uniprotkb:Pelle-like protein kinase(gene name synonym)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)	psi-mi:myd88_mouse(display_long)|uniprotkb:Myd88(gene name)|psi-mi:Myd88(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Burns et al. (2000)	pubmed:10854325	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-525209	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171447.1|refseq:NP_032389.2|refseq:NP_001171445.1|dip:DIP-31491N|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)|go:"GO:0001959"(regulation of cytokine-mediated signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035533|interpro:IPR035536|mint:Q62406|reactome:R-MMU-1257604|reactome:R-MMU-168638|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-445989|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-450321|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-975144|reactome:R-MMU-450302	refseq:NP_034981.1|dip:DIP-34957N|ensembl:ENSMUSG00000032508(gene)|ensembl:ENSMUST00000035092(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005121"(Toll binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:P22366|go:"GO:0042832"(defense response to protozoan)|reactome:R-MMU-1810476|reactome:R-MMU-209543|reactome:R-MMU-3134963|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-1257604	-	-	-	inhibition:Tollip binding to the N terminal region of IRAK1 prevents phosphorylation of IRAK1	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/04/04	2014/10/16	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	rogid:4bHizxwWAnvXGR+Uos99jAL3iDU10090	intact-crc:4EA1E1EA0D12A806|rigid:1lx6v94tCfUxZT/JUOgDeI3crAg	false	mutation:66-66	binding-associated region:1-172(IPR000488)|flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13504	uniprotkb:Q9QZ06	intact:EBI-1782675|ensembl:ENSMUSP00000027241	intact:EBI-74272|uniprotkb:Q543N1|uniprotkb:Q9D5P5|ensembl:ENSMUSP00000001950	psi-mi:il1r1_mouse(display_long)|uniprotkb:Il1r1(gene name)|psi-mi:Il1r1(display_short)|uniprotkb:Il-1r1(gene name synonym)|uniprotkb:Il1ra(gene name synonym)|uniprotkb:Interleukin-1 receptor type I(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:CD121 antigen-like family member A(gene name synonym)|uniprotkb:Interleukin-1 receptor alpha(gene name synonym)	psi-mi:tolip_mouse(display_long)|uniprotkb:Tollip(gene name)|psi-mi:Tollip(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Burns et al. (2000)	pubmed:10854325	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-525104	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032388.1|refseq:XP_006495776.1|dip:DIP-40669N|ensembl:ENSMUSG00000026072(gene)|ensembl:ENSMUST00000027241(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0004909"(interleukin-1, type I, activating receptor activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0006954"(inflammatory response)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010286"(heat acclimation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030424"(axon)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000661"(positive regulation of interleukin-1-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR004076(Interleukin-1 receptor IL1R)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|interpro:IPR041416|rcsb pdb:1OU3|reactome:R-MMU-9020702	refseq:NP_076253.1|ensembl:ENSMUSG00000025139(gene)|ensembl:ENSMUST00000001950(transcript)|go:"GO:0005150"(interleukin-1, type I receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0016310"(phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0019900"(kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR009060(UBA-like)|interpro:IPR035892|interpro:IPR037301|interpro:IPR041799|mint:Q9QZ06|reactome:R-MMU-6798695|reactome:R-MMU-9020702	-	-	-	comment:"Association between the Interleukin-1 receptor-like 1 precursor  (IL-1R1) and the Toll-interacting protein (Tollip) was detected 2 minutes after treatment of EL4 cells with Interleukin 1 and was undetectable after 5 minutes treatment."	taxid:10090(mouse-el4)|taxid:10090(Mus musculus)	-	2005/04/04	2014/10/16	rogid:C1dNhiQL96zOX0NoYggax/CpIYE10090	rogid:l31YAZvuxJMK48wHqwvgPu8lVUs10090	intact-crc:DF837E6EE4AE2B6D|rigid:QpgzHH9cW1a1sv5amzjXQ55lc3I	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13504	uniprotkb:P22366	intact:EBI-1782675|ensembl:ENSMUSP00000027241	intact:EBI-525108|uniprotkb:O35916|ensembl:ENSMUSP00000035092	psi-mi:il1r1_mouse(display_long)|uniprotkb:Il1r1(gene name)|psi-mi:Il1r1(display_short)|uniprotkb:Il-1r1(gene name synonym)|uniprotkb:Il1ra(gene name synonym)|uniprotkb:Interleukin-1 receptor type I(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:CD121 antigen-like family member A(gene name synonym)|uniprotkb:Interleukin-1 receptor alpha(gene name synonym)	psi-mi:myd88_mouse(display_long)|uniprotkb:Myd88(gene name)|psi-mi:Myd88(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Burns et al. (2000)	pubmed:10854325	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-525124	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032388.1|refseq:XP_006495776.1|dip:DIP-40669N|ensembl:ENSMUSG00000026072(gene)|ensembl:ENSMUST00000027241(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0004909"(interleukin-1, type I, activating receptor activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0006954"(inflammatory response)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010286"(heat acclimation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030424"(axon)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000661"(positive regulation of interleukin-1-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR004076(Interleukin-1 receptor IL1R)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|interpro:IPR041416|rcsb pdb:1OU3|reactome:R-MMU-9020702	refseq:NP_034981.1|dip:DIP-34957N|ensembl:ENSMUSG00000032508(gene)|ensembl:ENSMUST00000035092(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005121"(Toll binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:P22366|go:"GO:0042832"(defense response to protozoan)|reactome:R-MMU-1810476|reactome:R-MMU-209543|reactome:R-MMU-3134963|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-1257604	-	-	-	comment:"Association between the Interleukin-1 receptor-like 1 precursor  (IL-1R1) and the Myeloid differentiation primary response protein (MyD88) occurred 30 seconds after treatment of EL4 cells with Interleukin 1 and was detected at all timepoints thereafter."	taxid:10090(mouse-el4)|taxid:10090(Mus musculus)	-	2005/04/04	2014/10/16	rogid:C1dNhiQL96zOX0NoYggax/CpIYE10090	rogid:4bHizxwWAnvXGR+Uos99jAL3iDU10090	intact-crc:1321AF0AE5A5337A|rigid:VcQRfNb13t/HLf+LqFdqUVLWZdc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13504	uniprotkb:Q62406-2	intact:EBI-1782675|ensembl:ENSMUSP00000027241	intact:EBI-488317|ensembl:ENSMUSP00000110000	psi-mi:il1r1_mouse(display_long)|uniprotkb:Il1r1(gene name)|psi-mi:Il1r1(display_short)|uniprotkb:Il-1r1(gene name synonym)|uniprotkb:Il1ra(gene name synonym)|uniprotkb:Interleukin-1 receptor type I(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:CD121 antigen-like family member A(gene name synonym)|uniprotkb:Interleukin-1 receptor alpha(gene name synonym)	psi-mi:q62406-2(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Burns et al. (2000)	pubmed:10854325	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-525131	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032388.1|refseq:XP_006495776.1|dip:DIP-40669N|ensembl:ENSMUSG00000026072(gene)|ensembl:ENSMUST00000027241(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0004909"(interleukin-1, type I, activating receptor activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0006954"(inflammatory response)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010286"(heat acclimation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030424"(axon)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000661"(positive regulation of interleukin-1-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR004076(Interleukin-1 receptor IL1R)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|interpro:IPR041416|rcsb pdb:1OU3|reactome:R-MMU-9020702	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000114360(transcript)	-	-	-	comment:"Association between the Interleukin-1 receptor-like 1 precursor  (IL-1R1) and the Interleukin-1 receptor-associated kinase 1 (IRAK1) occurred 30 seconds after treatment of EL4 cells with Interleukin 1 and was detected at all timepoints thereafter."	taxid:10090(mouse-el4)|taxid:10090(Mus musculus)	-	2005/04/04	2014/10/16	rogid:C1dNhiQL96zOX0NoYggax/CpIYE10090	rogid:kygg4kjQf2Be37xSg+Dvs/9G1GQ10090	intact-crc:893E42143DE58DB1|rigid:oNr4XJs3AaZ8+IzqGM1W1AxC18M	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QZ06	uniprotkb:Q62406	intact:EBI-74272|uniprotkb:Q543N1|uniprotkb:Q9D5P5|ensembl:ENSMUSP00000001950	intact:EBI-448533|uniprotkb:Q6Y3Z5|uniprotkb:Q6Y3Z6|uniprotkb:B1AUW4|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:tolip_mouse(display_long)|uniprotkb:Tollip(gene name)|psi-mi:Tollip(display_short)	psi-mi:irak1_mouse(display_long)|uniprotkb:Pelle-like protein kinase(gene name synonym)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Burns et al. (2000)	pubmed:10854325	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-525224	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076253.1|ensembl:ENSMUSG00000025139(gene)|ensembl:ENSMUST00000001950(transcript)|go:"GO:0005150"(interleukin-1, type I receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0016310"(phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0019900"(kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR009060(UBA-like)|interpro:IPR035892|interpro:IPR037301|interpro:IPR041799|mint:Q9QZ06|reactome:R-MMU-6798695|reactome:R-MMU-9020702	refseq:NP_001171447.1|refseq:NP_032389.2|refseq:NP_001171445.1|dip:DIP-31491N|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)|go:"GO:0001959"(regulation of cytokine-mediated signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035533|interpro:IPR035536|mint:Q62406|reactome:R-MMU-1257604|reactome:R-MMU-168638|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-445989|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-450321|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-975144|reactome:R-MMU-450302	-	-	-	comment:"The interaction between Interleukin-1 receptor-associated kinase 1(IRAK1) and the  Toll-interacting protein was only detected in EL-4 cells which were not stimulated with Interleukin-1"	taxid:10090(mouse-el4)|taxid:10090(Mus musculus)	-	2005/04/04	2014/10/16	rogid:l31YAZvuxJMK48wHqwvgPu8lVUs10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:3F98F7C19B67AB16|rigid:wnEXKNx1mN/Y1dLTq1YGC09+xH4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)