#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O61667	uniprotkb:P41958	intact:EBI-495949|uniprotkb:Q7JLC9|ensemblmetazoa:F23B12.9.1	intact:EBI-494110|ensemblmetazoa:T07C4.8.1	psi-mi:egl1_caeel(display_long)|uniprotkb:Egg-laying defective protein 1(gene name synonym)|uniprotkb:egl-1(gene name)|psi-mi:egl-1(display_short)|uniprotkb:F23B12.9(orf name)	psi-mi:ced9_caeel(display_long)|uniprotkb:Cell death protein 9(gene name synonym)|uniprotkb:ced-9(gene name)|psi-mi:ced-9(display_short)|uniprotkb:T07C4.8(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	del et al. (2000)	pubmed:10846174|imex:IM-25114	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-496045|imex:IM-25114-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_506575.2|wormbase:F23B12.9|interpro:IPR021543|rcsb pdb:1TY4|ensemblmetazoa:F23B12.9.1(transcript)|ensemblmetazoa:WBGene00001170(gene)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0018991"(oviposition)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0098793"(presynapse)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)	refseq:NP_499284.1|wormbase:T07C4.8|ensemblmetazoa:T07C4.8.1(transcript)|ensemblmetazoa:WBGene00000423(gene)|go:"GO:0000422"(autophagy of mitochondrion)|reactome:R-CEL-9648002|dip:DIP-250N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031090"(organelle membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0090727"(positive regulation of brood size)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098793"(presynapse)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR020717|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1OHU|rcsb pdb:1TY4|rcsb pdb:2A5Y	-	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/02/28	2016/04/21	rogid:M1NJ7kcUPROwBXN7H90MiFEYvh46239	rogid:0nKuipvqQOKHVeaoNXbSFYJNPhM6239	intact-crc:27185C85A3A94222|rigid:J6TqE3VgwAsc774cEVYHZCJEca0	false	flag tag:?-?	ha tag:?-?|mutation with no effect:169-169	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P30429	uniprotkb:P41958	intact:EBI-494118|uniprotkb:Q5BHI5|ensemblmetazoa:C35D10.9b.1|ensemblmetazoa:C35D10.9b.2	intact:EBI-494110|ensemblmetazoa:T07C4.8.1	psi-mi:ced4_caeel(display_long)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)|uniprotkb:C35D10.9(orf name)	psi-mi:ced9_caeel(display_long)|uniprotkb:Cell death protein 9(gene name synonym)|uniprotkb:ced-9(gene name)|psi-mi:ced-9(display_short)|uniprotkb:T07C4.8(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	del et al. (2000)	pubmed:10846174|imex:IM-25114	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-496086|imex:IM-25114-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001021202.1|refseq:NP_001021203.1|wormbase:C35D10.9a|wormbase:C35D10.9b|dip:DIP-1016N|ensemblmetazoa:C35D10.9b.1(transcript)|ensemblmetazoa:C35D10.9b.2(transcript)|ensemblmetazoa:WBGene00000418(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051432"(BH1 domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002182(NB-ARC)|interpro:IPR011029(DEATH-like)|interpro:IPR016854(Apoptosis regulator, Ced-4)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2A5Y|rcsb pdb:3LQQ|rcsb pdb:3LQR|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|go:"GO:0030155"(regulation of cell adhesion)	refseq:NP_499284.1|wormbase:T07C4.8|ensemblmetazoa:T07C4.8.1(transcript)|ensemblmetazoa:WBGene00000423(gene)|go:"GO:0000422"(autophagy of mitochondrion)|reactome:R-CEL-9648002|dip:DIP-250N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031090"(organelle membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0090727"(positive regulation of brood size)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098793"(presynapse)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR020717|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1OHU|rcsb pdb:1TY4|rcsb pdb:2A5Y	-	-	-	figure legend:Fig. 2A|inhibition:"The association between wild type ced-9 and ced-4 proteins is disrupted in the presence of the egl-1 protein.  The egl-1 protein did not effect the interaction between mutant ced-9 (G169E) (gly169glu) and wild type ced-4 proteins."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/02/28	2014/10/16	rogid:nrCvl4N8Vx6zKbAnnOseTjz1RmA6239	rogid:0nKuipvqQOKHVeaoNXbSFYJNPhM6239	intact-crc:B8B9BC9FFE0EE555|rigid:IkyWahKhsCIdno2wk72lKUjK5kQ	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P41958	uniprotkb:P30429	intact:EBI-494110|ensemblmetazoa:T07C4.8.1	intact:EBI-494118|uniprotkb:Q5BHI5|ensemblmetazoa:C35D10.9b.1|ensemblmetazoa:C35D10.9b.2	psi-mi:ced9_caeel(display_long)|uniprotkb:Cell death protein 9(gene name synonym)|uniprotkb:ced-9(gene name)|psi-mi:ced-9(display_short)|uniprotkb:T07C4.8(orf name)	psi-mi:ced4_caeel(display_long)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)|uniprotkb:C35D10.9(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	del et al. (2000)	pubmed:10846174|imex:IM-25114	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-496093|imex:IM-25114-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_499284.1|wormbase:T07C4.8|ensemblmetazoa:T07C4.8.1(transcript)|ensemblmetazoa:WBGene00000423(gene)|go:"GO:0000422"(autophagy of mitochondrion)|reactome:R-CEL-9648002|dip:DIP-250N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031090"(organelle membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0090727"(positive regulation of brood size)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098793"(presynapse)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR020717|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1OHU|rcsb pdb:1TY4|rcsb pdb:2A5Y	refseq:NP_001021202.1|refseq:NP_001021203.1|wormbase:C35D10.9a|wormbase:C35D10.9b|dip:DIP-1016N|ensemblmetazoa:C35D10.9b.1(transcript)|ensemblmetazoa:C35D10.9b.2(transcript)|ensemblmetazoa:WBGene00000418(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051432"(BH1 domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002182(NB-ARC)|interpro:IPR011029(DEATH-like)|interpro:IPR016854(Apoptosis regulator, Ced-4)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2A5Y|rcsb pdb:3LQQ|rcsb pdb:3LQR|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|go:"GO:0030155"(regulation of cell adhesion)	-	-	-	figure legend:Fig. 2B|inhibition:"The association between wild type ced-9 and ced-4 proteins is disrupted in the presence of the egl-i protein.  The egl-1 protein did not effect the interaction between mutant ced-9 (G169E) (gly169glu) and ced-4 proteins."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/02/28	2014/10/16	rogid:0nKuipvqQOKHVeaoNXbSFYJNPhM6239	rogid:nrCvl4N8Vx6zKbAnnOseTjz1RmA6239	intact-crc:85090FFE2BEE0F9F|rigid:IkyWahKhsCIdno2wk72lKUjK5kQ	false	ha tag:?-?|mutation with no effect:169-169	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P30429	uniprotkb:O61667	intact:EBI-494118|uniprotkb:Q5BHI5|ensemblmetazoa:C35D10.9b.1|ensemblmetazoa:C35D10.9b.2	intact:EBI-495949|uniprotkb:Q7JLC9|ensemblmetazoa:F23B12.9.1	psi-mi:ced4_caeel(display_long)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)|uniprotkb:C35D10.9(orf name)	psi-mi:egl1_caeel(display_long)|uniprotkb:Egg-laying defective protein 1(gene name synonym)|uniprotkb:egl-1(gene name)|psi-mi:egl-1(display_short)|uniprotkb:F23B12.9(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	del et al. (2000)	pubmed:10846174|imex:IM-25114	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11688070|imex:IM-25114-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001021202.1|refseq:NP_001021203.1|wormbase:C35D10.9a|wormbase:C35D10.9b|dip:DIP-1016N|ensemblmetazoa:C35D10.9b.1(transcript)|ensemblmetazoa:C35D10.9b.2(transcript)|ensemblmetazoa:WBGene00000418(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051432"(BH1 domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002182(NB-ARC)|interpro:IPR011029(DEATH-like)|interpro:IPR016854(Apoptosis regulator, Ced-4)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2A5Y|rcsb pdb:3LQQ|rcsb pdb:3LQR|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|go:"GO:0030155"(regulation of cell adhesion)	refseq:NP_506575.2|wormbase:F23B12.9|interpro:IPR021543|rcsb pdb:1TY4|ensemblmetazoa:F23B12.9.1(transcript)|ensemblmetazoa:WBGene00001170(gene)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0018991"(oviposition)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0098793"(presynapse)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)	-	-	-	figure legend:Fig. 2A|inhibition:"The association between wild type ced-9 and ced-4 proteins is disrupted in the presence of the egl-i protein.  The egl-1 protein did not effect the interaction between mutant ced-9 (G169E) (gly169glu) and ced-4 proteins."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/02/28	2016/04/21	rogid:nrCvl4N8Vx6zKbAnnOseTjz1RmA6239	rogid:M1NJ7kcUPROwBXN7H90MiFEYvh46239	rigid:CfEmuNwEZjH+nxbeQhCJ9x1KOZE	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P30429	uniprotkb:P41958	intact:EBI-494118|uniprotkb:Q5BHI5|ensemblmetazoa:C35D10.9b.1|ensemblmetazoa:C35D10.9b.2	intact:EBI-494110|ensemblmetazoa:T07C4.8.1	psi-mi:ced4_caeel(display_long)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)|uniprotkb:C35D10.9(orf name)	psi-mi:ced9_caeel(display_long)|uniprotkb:Cell death protein 9(gene name synonym)|uniprotkb:ced-9(gene name)|psi-mi:ced-9(display_short)|uniprotkb:T07C4.8(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	del et al. (2000)	pubmed:10846174|imex:IM-25114	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11688070|imex:IM-25114-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001021202.1|refseq:NP_001021203.1|wormbase:C35D10.9a|wormbase:C35D10.9b|dip:DIP-1016N|ensemblmetazoa:C35D10.9b.1(transcript)|ensemblmetazoa:C35D10.9b.2(transcript)|ensemblmetazoa:WBGene00000418(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051432"(BH1 domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002182(NB-ARC)|interpro:IPR011029(DEATH-like)|interpro:IPR016854(Apoptosis regulator, Ced-4)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2A5Y|rcsb pdb:3LQQ|rcsb pdb:3LQR|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|go:"GO:0030155"(regulation of cell adhesion)	refseq:NP_499284.1|wormbase:T07C4.8|ensemblmetazoa:T07C4.8.1(transcript)|ensemblmetazoa:WBGene00000423(gene)|go:"GO:0000422"(autophagy of mitochondrion)|reactome:R-CEL-9648002|dip:DIP-250N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031090"(organelle membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0090727"(positive regulation of brood size)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098793"(presynapse)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR020717|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1OHU|rcsb pdb:1TY4|rcsb pdb:2A5Y	-	-	-	figure legend:Fig. 2A|inhibition:"The association between wild type ced-9 and ced-4 proteins is disrupted in the presence of the egl-i protein.  The egl-1 protein did not effect the interaction between mutant ced-9 (G169E) (gly169glu) and ced-4 proteins."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/02/28	2016/04/21	rogid:nrCvl4N8Vx6zKbAnnOseTjz1RmA6239	rogid:0nKuipvqQOKHVeaoNXbSFYJNPhM6239	rigid:CfEmuNwEZjH+nxbeQhCJ9x1KOZE	false	myc tag:?-?	ha tag:?-?|mutation:169-169	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P41958	uniprotkb:O61667	intact:EBI-494110|ensemblmetazoa:T07C4.8.1	intact:EBI-495949|uniprotkb:Q7JLC9|ensemblmetazoa:F23B12.9.1	psi-mi:ced9_caeel(display_long)|uniprotkb:Cell death protein 9(gene name synonym)|uniprotkb:ced-9(gene name)|psi-mi:ced-9(display_short)|uniprotkb:T07C4.8(orf name)	psi-mi:egl1_caeel(display_long)|uniprotkb:Egg-laying defective protein 1(gene name synonym)|uniprotkb:egl-1(gene name)|psi-mi:egl-1(display_short)|uniprotkb:F23B12.9(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	del et al. (2000)	pubmed:10846174|imex:IM-25114	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-496056|imex:IM-25114-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_499284.1|wormbase:T07C4.8|ensemblmetazoa:T07C4.8.1(transcript)|ensemblmetazoa:WBGene00000423(gene)|go:"GO:0000422"(autophagy of mitochondrion)|reactome:R-CEL-9648002|dip:DIP-250N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031090"(organelle membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0090727"(positive regulation of brood size)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098793"(presynapse)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR020717|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1OHU|rcsb pdb:1TY4|rcsb pdb:2A5Y	refseq:NP_506575.2|wormbase:F23B12.9|interpro:IPR021543|rcsb pdb:1TY4|ensemblmetazoa:F23B12.9.1(transcript)|ensemblmetazoa:WBGene00001170(gene)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0018991"(oviposition)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0098793"(presynapse)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)	-	-	-	comment:"The ced-9 (Gly169Glu) mutant displays reduced binding affinty for the egl-1 protein compared to the wild type ced-9 protein"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/02/28	2016/04/21	rogid:0nKuipvqQOKHVeaoNXbSFYJNPhM6239	rogid:M1NJ7kcUPROwBXN7H90MiFEYvh46239	intact-crc:858E2B3D0B69733A|rigid:J6TqE3VgwAsc774cEVYHZCJEca0	false	radiolabel:?-?|ha tag:?-?|mutation decreasing interaction strength:169-169	tag:?-?|flag tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P41958	uniprotkb:P30429	intact:EBI-494110|ensemblmetazoa:T07C4.8.1	intact:EBI-494118|uniprotkb:Q5BHI5|ensemblmetazoa:C35D10.9b.1|ensemblmetazoa:C35D10.9b.2	psi-mi:ced9_caeel(display_long)|uniprotkb:Cell death protein 9(gene name synonym)|uniprotkb:ced-9(gene name)|psi-mi:ced-9(display_short)|uniprotkb:T07C4.8(orf name)	psi-mi:ced4_caeel(display_long)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)|uniprotkb:C35D10.9(orf name)	psi-mi:"MI:0416"(fluorescence microscopy)	del et al. (2000)	pubmed:10846174|imex:IM-25114	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11688232|imex:IM-25114-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_499284.1|wormbase:T07C4.8|ensemblmetazoa:T07C4.8.1(transcript)|ensemblmetazoa:WBGene00000423(gene)|go:"GO:0000422"(autophagy of mitochondrion)|reactome:R-CEL-9648002|dip:DIP-250N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031090"(organelle membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0090727"(positive regulation of brood size)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098793"(presynapse)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR020717|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1OHU|rcsb pdb:1TY4|rcsb pdb:2A5Y	refseq:NP_001021202.1|refseq:NP_001021203.1|wormbase:C35D10.9a|wormbase:C35D10.9b|dip:DIP-1016N|ensemblmetazoa:C35D10.9b.1(transcript)|ensemblmetazoa:C35D10.9b.2(transcript)|ensemblmetazoa:WBGene00000418(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051432"(BH1 domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002182(NB-ARC)|interpro:IPR011029(DEATH-like)|interpro:IPR016854(Apoptosis regulator, Ced-4)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2A5Y|rcsb pdb:3LQQ|rcsb pdb:3LQR|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|go:"GO:0030155"(regulation of cell adhesion)	-	-	-	figure legend:Fig. 3B|comment:the expression of EGL-1 in the presence of wild type CED-9 changed the CED-4 labeling pattern from granular to diffuse|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/02/28	2016/04/21	rogid:0nKuipvqQOKHVeaoNXbSFYJNPhM6239	rogid:nrCvl4N8Vx6zKbAnnOseTjz1RmA6239	rigid:IkyWahKhsCIdno2wk72lKUjK5kQ	false	ha tag:?-?|mutation with no effect:169-169	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O61667	uniprotkb:P41958	intact:EBI-495949|uniprotkb:Q7JLC9|ensemblmetazoa:F23B12.9.1	intact:EBI-494110|ensemblmetazoa:T07C4.8.1	psi-mi:egl1_caeel(display_long)|uniprotkb:Egg-laying defective protein 1(gene name synonym)|uniprotkb:egl-1(gene name)|psi-mi:egl-1(display_short)|uniprotkb:F23B12.9(orf name)	psi-mi:ced9_caeel(display_long)|uniprotkb:Cell death protein 9(gene name synonym)|uniprotkb:ced-9(gene name)|psi-mi:ced-9(display_short)|uniprotkb:T07C4.8(orf name)	psi-mi:"MI:0416"(fluorescence microscopy)	del et al. (2000)	pubmed:10846174|imex:IM-25114	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11688244|imex:IM-25114-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_506575.2|wormbase:F23B12.9|interpro:IPR021543|rcsb pdb:1TY4|ensemblmetazoa:F23B12.9.1(transcript)|ensemblmetazoa:WBGene00001170(gene)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0018991"(oviposition)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0098793"(presynapse)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)	refseq:NP_499284.1|wormbase:T07C4.8|ensemblmetazoa:T07C4.8.1(transcript)|ensemblmetazoa:WBGene00000423(gene)|go:"GO:0000422"(autophagy of mitochondrion)|reactome:R-CEL-9648002|dip:DIP-250N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031090"(organelle membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0090727"(positive regulation of brood size)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098793"(presynapse)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR020717|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1OHU|rcsb pdb:1TY4|rcsb pdb:2A5Y	-	-	-	figure legend:Fig. 3A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/02/28	2016/04/21	rogid:M1NJ7kcUPROwBXN7H90MiFEYvh46239	rogid:0nKuipvqQOKHVeaoNXbSFYJNPhM6239	rigid:J6TqE3VgwAsc774cEVYHZCJEca0	false	flag tag:?-?	ha tag:?-?|mutation with no effect:169-169	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)