#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9NS68	uniprotkb:Q13077	intact:EBI-530381|uniprotkb:Q9BXZ9|uniprotkb:Q9BY00|uniprotkb:Q9NZV2|uniprotkb:B1AM40|uniprotkb:B1AM41|ensembl:ENSP00000371693|uniprotkb:B4E2I6|uniprotkb:A8KA09|uniprotkb:A8KA26	intact:EBI-359224|uniprotkb:Q658U1|uniprotkb:Q8NF13|uniprotkb:B4DJ77|ensembl:ENSP00000362994|ensembl:ENSP00000443183	psi-mi:tnr19_human(display_long)|uniprotkb:Toxicity and JNK inducer(gene name synonym)|uniprotkb:TRADE(gene name synonym)|uniprotkb:UNQ1888/PRO4333(orf name)|uniprotkb:TNFRSF19(gene name)|psi-mi:TNFRSF19(display_short)|uniprotkb:TAJ(gene name synonym)|uniprotkb:TROY(gene name synonym)	psi-mi:traf1_human(display_long)|uniprotkb:TRAF1(gene name)|psi-mi:TRAF1(display_short)|uniprotkb:EBI6(gene name synonym)|uniprotkb:Epstein-Barr virus-induced protein 6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Eby et al. (2000)	pubmed:10809768	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-530343	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191387.1|refseq:NP_001191388.1|refseq:NP_061117.2|refseq:NP_683760.1|ensembl:ENSG00000127863(gene)|ensembl:ENST00000382258(transcript)|go:"GO:0001942"(hair follicle development)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022342|interpro:IPR034047|mint:Q9NS68|refseq:XP_011533448.1|refseq:XP_005266502.1|refseq:XP_016876140.1	refseq:NP_001177874.1|refseq:NP_001177876.1|refseq:NP_005649.1|dip:DIP-27514N|ensembl:ENSG00000056558(gene)|ensembl:ENST00000373887(transcript)|ensembl:ENST00000540010(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|mint:Q13077|rcsb pdb:3M0D|rcsb pdb:5E1T|rcsb pdb:5H10|reactome:R-HSA-5357905|reactome:R-HSA-5357956	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/04/13	2014/10/16	rogid:PgTGM9Ovs/NlXZM+4R5i/WSpgwI9606	rogid:D51RV1gTNQQjGP978+uv98Hd3Lc9606	intact-crc:845154254DB1A0C6|rigid:TtTlh84NNxA7/nTy5hyYBLJBq7s	false	flag tag:?-?|binding-associated region:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12933	uniprotkb:Q9NS68	intact:EBI-355744|uniprotkb:Q96NT2|uniprotkb:A8K107|uniprotkb:B4DPJ7|uniprotkb:Q7Z337|intact:EBI-1046651|ensembl:ENSP00000247668	intact:EBI-530381|uniprotkb:Q9BXZ9|uniprotkb:Q9BY00|uniprotkb:Q9NZV2|uniprotkb:B1AM40|uniprotkb:B1AM41|ensembl:ENSP00000371693|uniprotkb:B4E2I6|uniprotkb:A8KA09|uniprotkb:A8KA26	psi-mi:traf2_human(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:tnr19_human(display_long)|uniprotkb:Toxicity and JNK inducer(gene name synonym)|uniprotkb:TRADE(gene name synonym)|uniprotkb:UNQ1888/PRO4333(orf name)|uniprotkb:TNFRSF19(gene name)|psi-mi:TNFRSF19(display_short)|uniprotkb:TAJ(gene name synonym)|uniprotkb:TROY(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Eby et al. (2000)	pubmed:10809768	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-530352	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066961.2|refseq:XP_011517279.1|refseq:XP_011517280.1|refseq:XP_011517276.1|refseq:XP_011517277.1|refseq:XP_011517278.1|ensembl:ENSG00000127191(gene)|ensembl:ENST00000247668(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:Q12933|rcsb pdb:1CA4|rcsb pdb:1CA9|rcsb pdb:1CZY|rcsb pdb:1CZZ|rcsb pdb:1D00|rcsb pdb:1D01|rcsb pdb:1D0A|rcsb pdb:1D0J|rcsb pdb:1F3V|rcsb pdb:1QSC|rcsb pdb:3KNV|rcsb pdb:3M06|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-9693928|refseq:XP_016870584.1|dip:DIP-6223N	refseq:NP_001191387.1|refseq:NP_001191388.1|refseq:NP_061117.2|refseq:NP_683760.1|ensembl:ENSG00000127863(gene)|ensembl:ENST00000382258(transcript)|go:"GO:0001942"(hair follicle development)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022342|interpro:IPR034047|mint:Q9NS68|refseq:XP_011533448.1|refseq:XP_005266502.1|refseq:XP_016876140.1	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/04/13	2014/10/16	rogid:JhaoM5kRLh3zwhXr+BsCCRNOYa09606	rogid:PgTGM9Ovs/NlXZM+4R5i/WSpgwI9606	intact-crc:2D6FE2FB178BA5D6|rigid:Oip4R5EipTJIFprhivXGJu/zih8	false	ha tag:?-?	flag tag:?-?|binding-associated region:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00463	uniprotkb:Q9NS68	intact:EBI-523498|ensembl:ENSP00000261464|ensembl:ENSP00000336825|ensembl:ENSP00000355971|uniprotkb:Q6FHY1|uniprotkb:B4DIS9|uniprotkb:B4E0A2	intact:EBI-530381|uniprotkb:Q9BXZ9|uniprotkb:Q9BY00|uniprotkb:Q9NZV2|uniprotkb:B1AM40|uniprotkb:B1AM41|ensembl:ENSP00000371693|uniprotkb:B4E2I6|uniprotkb:A8KA09|uniprotkb:A8KA26	psi-mi:traf5_human(display_long)|uniprotkb:RING finger protein 84(gene name synonym)|uniprotkb:TRAF5(gene name)|psi-mi:TRAF5(display_short)|uniprotkb:RNF84(gene name synonym)	psi-mi:tnr19_human(display_long)|uniprotkb:Toxicity and JNK inducer(gene name synonym)|uniprotkb:TRADE(gene name synonym)|uniprotkb:UNQ1888/PRO4333(orf name)|uniprotkb:TNFRSF19(gene name)|psi-mi:TNFRSF19(display_short)|uniprotkb:TAJ(gene name synonym)|uniprotkb:TROY(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Eby et al. (2000)	pubmed:10809768	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-530364	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306136.1|refseq:XP_011508261.1|refseq:XP_011508262.1|ensembl:ENSG00000082512(gene)|ensembl:ENST00000261464(transcript)|ensembl:ENST00000336184(transcript)|ensembl:ENST00000367004(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027130|interpro:IPR043211|mint:O00463|rcsb pdb:7L3L|refseq:NP_001029082.1|refseq:NP_004610.1|refseq:NP_665702.1|refseq:XP_016857710.1	refseq:NP_001191387.1|refseq:NP_001191388.1|refseq:NP_061117.2|refseq:NP_683760.1|ensembl:ENSG00000127863(gene)|ensembl:ENST00000382258(transcript)|go:"GO:0001942"(hair follicle development)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022342|interpro:IPR034047|mint:Q9NS68|refseq:XP_011533448.1|refseq:XP_005266502.1|refseq:XP_016876140.1	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/04/13	2014/10/16	rogid:xPAQGevMJLEAPcT6eX3n304eSOw9606	rogid:PgTGM9Ovs/NlXZM+4R5i/WSpgwI9606	intact-crc:B812CADFD85244CD|rigid:7qNV38b4Fb30/SSIuKr7M1f8SHQ	false	flag tag:?-?	binding-associated region:?-?|myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)