#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9WU22	uniprotkb:Q61625	intact:EBI-7249866|intact:MINT-126937|uniprotkb:G5E8E7|ensembl:ENSMUSP00000067614	intact:EBI-2794106|uniprotkb:A4QPG1|ensembl:ENSMUSP00000093536	psi-mi:ptn4_mouse(display_long)|uniprotkb:Ptpn4(gene name)|psi-mi:Ptpn4(display_short)|uniprotkb:Testis-enriched protein tyrosine phosphatase(gene name synonym)	psi-mi:grid2_mouse(display_long)|uniprotkb:Grid2(gene name)|psi-mi:Grid2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hironaka et al. (2000)	pubmed:10748123|mint:MINT-5212410	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7249862|mint:MINT-72710	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064317.2|ensembl:ENSMUSG00000026384(gene)|ensembl:ENSMUST00000064091(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:MINT-414873(identity)	refseq:NP_032193.1|ensembl:ENSMUST00000095852(transcript)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|ensembl:ENSMUSG00000071424(gene)|mint:MINT-414880(identity)	-	comment:mint|function:May act at junctions between the membrane and the cytoskeleton|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4D|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|partial coverage:partial coverage	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/25	2014/10/16	rogid:f0q7V4YMwX+v4tFgx3DePzQc3X010090	rogid:tGtRvPYFWLcS2DY+O/nGFFgt5/k10090	intact-crc:6EE8AED659A05FF0|rigid:HmMXmMBnVab5xdCpsmCBBSAGNCU	false	myc tag:?-?(MINT-414874)	mutation decreasing interaction:1004-1007,983-1007,1007-1007(MINT-414881)|flag tag:?-?(MINT-414885)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q12879	uniprotkb:Q9WU22	intact:EBI-7249937|uniprotkb:Q17RZ6|uniprotkb:O00669|intact:MINT-414776|ensembl:ENSP00000332549|ensembl:ENSP00000379818	intact:EBI-7249866|intact:MINT-126937|uniprotkb:G5E8E7|ensembl:ENSMUSP00000067614	psi-mi:nmde1_human(display_long)|uniprotkb:GRIN2A(gene name)|psi-mi:GRIN2A(display_short)|uniprotkb:NMDAR2A(gene name synonym)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-1(gene name synonym)|uniprotkb:N-methyl D-aspartate receptor subtype 2A(gene name synonym)	psi-mi:ptn4_mouse(display_long)|uniprotkb:Ptpn4(gene name)|psi-mi:Ptpn4(display_short)|uniprotkb:Testis-enriched protein tyrosine phosphatase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hironaka et al. (2000)	pubmed:10748123|mint:MINT-5212410	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7249932|mint:MINT-72712	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011520763.1|refseq:NP_000824.1|refseq:NP_001127880.1|refseq:NP_001127879.1|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|ensembl:ENSG00000183454(gene)|go:"GO:0030431"(sleep)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0033058"(directional locomotion)|go:"GO:0038023"(signaling receptor activity)|ensembl:ENST00000330684(transcript)|ensembl:ENST00000396573(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0001964"(startle response)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0001975"(response to amphetamine)|go:"GO:0043197"(dendritic spine)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0045471"(response to ethanol)|go:"GO:0007420"(brain development)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022008"(neurogenesis)|go:"GO:0098976"(excitatory chemical synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1903539"(protein localization to postsynaptic membrane)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|mint:Q12879|rcsb pdb:3NFL|rcsb pdb:5H8F|rcsb pdb:5H8H|rcsb pdb:5H8N|rcsb pdb:5H8Q|rcsb pdb:5I2K|rcsb pdb:5I2N|rcsb pdb:5KCJ|rcsb pdb:5KDT|rcsb pdb:5TP9|rcsb pdb:5TPA|rcsb pdb:6IRA|rcsb pdb:6IRF|rcsb pdb:6IRG|rcsb pdb:6IRH|rcsb pdb:7EOQ|rcsb pdb:7EOR|rcsb pdb:7EOS|rcsb pdb:7EOT|rcsb pdb:7EOU|reactome:R-HSA-438066|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9022699|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|go:"GO:0098839"(postsynaptic density membrane)|dip:DIP-40798N|mint:MINT-414802(identity)	refseq:NP_064317.2|ensembl:ENSMUSG00000026384(gene)|ensembl:ENSMUST00000064091(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:MINT-414795(identity)	-	comment:mint|function:NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits|comment:"Stoichiometry: 1.0"	comment:mint|function:May act at junctions between the membrane and the cytoskeleton|comment:"Stoichiometry: 1.0"	figure legend:F5A|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|partial coverage:partial coverage	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/25	2014/10/16	rogid:TgxknLgEUv+HeST8sJLtK2pYoEM9606	rogid:f0q7V4YMwX+v4tFgx3DePzQc3X010090	intact-crc:96E2FDE9D3190729|rigid:3WUvIGn31o4hEJY5AEeQam/zaE4	false	-	myc tag:?-?(MINT-414796)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q12879	uniprotkb:Q9WU22	intact:EBI-7249937|uniprotkb:Q17RZ6|uniprotkb:O00669|intact:MINT-414776|ensembl:ENSP00000332549|ensembl:ENSP00000379818	intact:EBI-7249866|intact:MINT-126937|uniprotkb:G5E8E7|ensembl:ENSMUSP00000067614	psi-mi:nmde1_human(display_long)|uniprotkb:GRIN2A(gene name)|psi-mi:GRIN2A(display_short)|uniprotkb:NMDAR2A(gene name synonym)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-1(gene name synonym)|uniprotkb:N-methyl D-aspartate receptor subtype 2A(gene name synonym)	psi-mi:ptn4_mouse(display_long)|uniprotkb:Ptpn4(gene name)|psi-mi:Ptpn4(display_short)|uniprotkb:Testis-enriched protein tyrosine phosphatase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hironaka et al. (2000)	pubmed:10748123|mint:MINT-5212410	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7250057|mint:MINT-72716	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011520763.1|refseq:NP_000824.1|refseq:NP_001127880.1|refseq:NP_001127879.1|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|ensembl:ENSG00000183454(gene)|go:"GO:0030431"(sleep)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0033058"(directional locomotion)|go:"GO:0038023"(signaling receptor activity)|ensembl:ENST00000330684(transcript)|ensembl:ENST00000396573(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0001964"(startle response)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0001975"(response to amphetamine)|go:"GO:0043197"(dendritic spine)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0045471"(response to ethanol)|go:"GO:0007420"(brain development)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022008"(neurogenesis)|go:"GO:0098976"(excitatory chemical synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1903539"(protein localization to postsynaptic membrane)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|mint:Q12879|rcsb pdb:3NFL|rcsb pdb:5H8F|rcsb pdb:5H8H|rcsb pdb:5H8N|rcsb pdb:5H8Q|rcsb pdb:5I2K|rcsb pdb:5I2N|rcsb pdb:5KCJ|rcsb pdb:5KDT|rcsb pdb:5TP9|rcsb pdb:5TPA|rcsb pdb:6IRA|rcsb pdb:6IRF|rcsb pdb:6IRG|rcsb pdb:6IRH|rcsb pdb:7EOQ|rcsb pdb:7EOR|rcsb pdb:7EOS|rcsb pdb:7EOT|rcsb pdb:7EOU|reactome:R-HSA-438066|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9022699|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|go:"GO:0098839"(postsynaptic density membrane)|dip:DIP-40798N|mint:MINT-414942(identity)	refseq:NP_064317.2|ensembl:ENSMUSG00000026384(gene)|ensembl:ENSMUST00000064091(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:MINT-414935(identity)	-	comment:mint|function:NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits|comment:"Stoichiometry: 1.0"	comment:mint|function:May act at junctions between the membrane and the cytoskeleton|comment:"Stoichiometry: 1.0"	figure legend:F5E|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|partial coverage:partial coverage	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/25	2014/10/16	rogid:TgxknLgEUv+HeST8sJLtK2pYoEM9606	rogid:f0q7V4YMwX+v4tFgx3DePzQc3X010090	intact-crc:14BCC9F5C5EA5CAA|rigid:3WUvIGn31o4hEJY5AEeQam/zaE4	false	binding-associated region:768-1116(MINT-414943)|ha tag:?-?(MINT-414947)|mutation decreasing interaction:1464-1464(MINT-414945)	myc tag:?-?(MINT-414936)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q12879	uniprotkb:Q9WU22	intact:EBI-7249937|uniprotkb:Q17RZ6|uniprotkb:O00669|intact:MINT-414776|ensembl:ENSP00000332549|ensembl:ENSP00000379818	intact:EBI-7249866|intact:MINT-126937|uniprotkb:G5E8E7|ensembl:ENSMUSP00000067614	psi-mi:nmde1_human(display_long)|uniprotkb:GRIN2A(gene name)|psi-mi:GRIN2A(display_short)|uniprotkb:NMDAR2A(gene name synonym)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-1(gene name synonym)|uniprotkb:N-methyl D-aspartate receptor subtype 2A(gene name synonym)	psi-mi:ptn4_mouse(display_long)|uniprotkb:Ptpn4(gene name)|psi-mi:Ptpn4(display_short)|uniprotkb:Testis-enriched protein tyrosine phosphatase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hironaka et al. (2000)	pubmed:10748123|mint:MINT-5212410	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7250020|mint:MINT-72715	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011520763.1|refseq:NP_000824.1|refseq:NP_001127880.1|refseq:NP_001127879.1|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|ensembl:ENSG00000183454(gene)|go:"GO:0030431"(sleep)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0033058"(directional locomotion)|go:"GO:0038023"(signaling receptor activity)|ensembl:ENST00000330684(transcript)|ensembl:ENST00000396573(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0001964"(startle response)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0001975"(response to amphetamine)|go:"GO:0043197"(dendritic spine)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0045471"(response to ethanol)|go:"GO:0007420"(brain development)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022008"(neurogenesis)|go:"GO:0098976"(excitatory chemical synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1903539"(protein localization to postsynaptic membrane)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|mint:Q12879|rcsb pdb:3NFL|rcsb pdb:5H8F|rcsb pdb:5H8H|rcsb pdb:5H8N|rcsb pdb:5H8Q|rcsb pdb:5I2K|rcsb pdb:5I2N|rcsb pdb:5KCJ|rcsb pdb:5KDT|rcsb pdb:5TP9|rcsb pdb:5TPA|rcsb pdb:6IRA|rcsb pdb:6IRF|rcsb pdb:6IRG|rcsb pdb:6IRH|rcsb pdb:7EOQ|rcsb pdb:7EOR|rcsb pdb:7EOS|rcsb pdb:7EOT|rcsb pdb:7EOU|reactome:R-HSA-438066|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9022699|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|go:"GO:0098839"(postsynaptic density membrane)|dip:DIP-40798N|mint:MINT-414927(identity)	refseq:NP_064317.2|ensembl:ENSMUSG00000026384(gene)|ensembl:ENSMUST00000064091(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:MINT-414917(identity)	-	comment:mint|function:NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits|comment:"Stoichiometry: 1.0"	comment:mint|function:May act at junctions between the membrane and the cytoskeleton|comment:"Stoichiometry: 1.0"	figure legend:F5D|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|partial coverage:partial coverage	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/11/25	2014/10/16	rogid:TgxknLgEUv+HeST8sJLtK2pYoEM9606	rogid:f0q7V4YMwX+v4tFgx3DePzQc3X010090	intact-crc:D2D7BFB044B79A16|rigid:3WUvIGn31o4hEJY5AEeQam/zaE4	false	-	myc tag:?-?(MINT-414921)|binding-associated region:517-925(MINT-414918)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WU22	uniprotkb:Q61625	intact:EBI-7249866|intact:MINT-126937|uniprotkb:G5E8E7|ensembl:ENSMUSP00000067614	intact:EBI-2794106|uniprotkb:A4QPG1|ensembl:ENSMUSP00000093536	psi-mi:ptn4_mouse(display_long)|uniprotkb:Ptpn4(gene name)|psi-mi:Ptpn4(display_short)|uniprotkb:Testis-enriched protein tyrosine phosphatase(gene name synonym)	psi-mi:grid2_mouse(display_long)|uniprotkb:Grid2(gene name)|psi-mi:Grid2(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Hironaka et al. (2000)	pubmed:10748123|mint:MINT-5212410	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7250094|mint:MINT-72707	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064317.2|ensembl:ENSMUSG00000026384(gene)|ensembl:ENSMUST00000064091(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:MINT-414813(identity)	refseq:NP_032193.1|ensembl:ENSMUST00000095852(transcript)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|ensembl:ENSMUSG00000071424(gene)|mint:MINT-414818(identity)	-	comment:mint|function:May act at junctions between the membrane and the cytoskeleton|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3B|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|partial coverage:partial coverage	taxid:10090(mouse-brain-cerebellum)|taxid:10090(Mus musculus brain cerebellum)	-	2005/11/25	2014/10/16	rogid:f0q7V4YMwX+v4tFgx3DePzQc3X010090	rogid:tGtRvPYFWLcS2DY+O/nGFFgt5/k10090	intact-crc:0773F3E8C0E22337|rigid:HmMXmMBnVab5xdCpsmCBBSAGNCU	false	-	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q9WU22	uniprotkb:Q61625	intact:EBI-7249866|intact:MINT-126937|uniprotkb:G5E8E7|ensembl:ENSMUSP00000067614	intact:EBI-2794106|uniprotkb:A4QPG1|ensembl:ENSMUSP00000093536	psi-mi:ptn4_mouse(display_long)|uniprotkb:Ptpn4(gene name)|psi-mi:Ptpn4(display_short)|uniprotkb:Testis-enriched protein tyrosine phosphatase(gene name synonym)	psi-mi:grid2_mouse(display_long)|uniprotkb:Grid2(gene name)|psi-mi:Grid2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hironaka et al. (2000)	pubmed:10748123|mint:MINT-5212410	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7250200|mint:MINT-72709	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064317.2|ensembl:ENSMUSG00000026384(gene)|ensembl:ENSMUST00000064091(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:MINT-414828(identity)	refseq:NP_032193.1|ensembl:ENSMUST00000095852(transcript)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|ensembl:ENSMUSG00000071424(gene)|mint:MINT-414835(identity)	-	comment:mint|function:May act at junctions between the membrane and the cytoskeleton|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|partial coverage:partial coverage	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/11/25	2014/10/16	rogid:f0q7V4YMwX+v4tFgx3DePzQc3X010090	rogid:tGtRvPYFWLcS2DY+O/nGFFgt5/k10090	intact-crc:D50AD01B0ADECE3F|rigid:HmMXmMBnVab5xdCpsmCBBSAGNCU	false	myc tag:?-?(MINT-414829)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q9WU22	uniprotkb:Q12879	intact:EBI-7249866|intact:MINT-126937|uniprotkb:G5E8E7|ensembl:ENSMUSP00000067614	intact:EBI-7249937|uniprotkb:Q17RZ6|uniprotkb:O00669|intact:MINT-414776|ensembl:ENSP00000332549|ensembl:ENSP00000379818	psi-mi:ptn4_mouse(display_long)|uniprotkb:Ptpn4(gene name)|psi-mi:Ptpn4(display_short)|uniprotkb:Testis-enriched protein tyrosine phosphatase(gene name synonym)	psi-mi:nmde1_human(display_long)|uniprotkb:GRIN2A(gene name)|psi-mi:GRIN2A(display_short)|uniprotkb:NMDAR2A(gene name synonym)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-1(gene name synonym)|uniprotkb:N-methyl D-aspartate receptor subtype 2A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hironaka et al. (2000)	pubmed:10748123|mint:MINT-5212410	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7250271|mint:MINT-72713	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064317.2|ensembl:ENSMUSG00000026384(gene)|ensembl:ENSMUST00000064091(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:MINT-414847(identity)	refseq:XP_011520763.1|refseq:NP_000824.1|refseq:NP_001127880.1|refseq:NP_001127879.1|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|ensembl:ENSG00000183454(gene)|go:"GO:0030431"(sleep)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0033058"(directional locomotion)|go:"GO:0038023"(signaling receptor activity)|ensembl:ENST00000330684(transcript)|ensembl:ENST00000396573(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0001964"(startle response)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0001975"(response to amphetamine)|go:"GO:0043197"(dendritic spine)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0045471"(response to ethanol)|go:"GO:0007420"(brain development)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022008"(neurogenesis)|go:"GO:0098976"(excitatory chemical synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1903539"(protein localization to postsynaptic membrane)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|mint:Q12879|rcsb pdb:3NFL|rcsb pdb:5H8F|rcsb pdb:5H8H|rcsb pdb:5H8N|rcsb pdb:5H8Q|rcsb pdb:5I2K|rcsb pdb:5I2N|rcsb pdb:5KCJ|rcsb pdb:5KDT|rcsb pdb:5TP9|rcsb pdb:5TPA|rcsb pdb:6IRA|rcsb pdb:6IRF|rcsb pdb:6IRG|rcsb pdb:6IRH|rcsb pdb:7EOQ|rcsb pdb:7EOR|rcsb pdb:7EOS|rcsb pdb:7EOT|rcsb pdb:7EOU|reactome:R-HSA-438066|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9022699|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|go:"GO:0098839"(postsynaptic density membrane)|dip:DIP-40798N|mint:MINT-414852(identity)	-	comment:mint|function:May act at junctions between the membrane and the cytoskeleton|comment:"Stoichiometry: 1.0"	comment:mint|function:NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits|comment:"Stoichiometry: 1.0"	figure legend:F5B|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|partial coverage:partial coverage	taxid:10090(mouse-telencephalon)|taxid:10090(Mus musculus)	-	2005/11/25	2014/10/16	rogid:f0q7V4YMwX+v4tFgx3DePzQc3X010090	rogid:TgxknLgEUv+HeST8sJLtK2pYoEM9606	intact-crc:008ADD94E54441D7|rigid:3WUvIGn31o4hEJY5AEeQam/zaE4	false	-	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q9WU22	uniprotkb:Q12879	intact:EBI-7249866|intact:MINT-126937|uniprotkb:G5E8E7|ensembl:ENSMUSP00000067614	intact:EBI-7249937|uniprotkb:Q17RZ6|uniprotkb:O00669|intact:MINT-414776|ensembl:ENSP00000332549|ensembl:ENSP00000379818	psi-mi:ptn4_mouse(display_long)|uniprotkb:Ptpn4(gene name)|psi-mi:Ptpn4(display_short)|uniprotkb:Testis-enriched protein tyrosine phosphatase(gene name synonym)	psi-mi:nmde1_human(display_long)|uniprotkb:GRIN2A(gene name)|psi-mi:GRIN2A(display_short)|uniprotkb:NMDAR2A(gene name synonym)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-1(gene name synonym)|uniprotkb:N-methyl D-aspartate receptor subtype 2A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hironaka et al. (2000)	pubmed:10748123|mint:MINT-5212410	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7250282|mint:MINT-72714	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064317.2|ensembl:ENSMUSG00000026384(gene)|ensembl:ENSMUST00000064091(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:MINT-414860(identity)	refseq:XP_011520763.1|refseq:NP_000824.1|refseq:NP_001127880.1|refseq:NP_001127879.1|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|ensembl:ENSG00000183454(gene)|go:"GO:0030431"(sleep)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0033058"(directional locomotion)|go:"GO:0038023"(signaling receptor activity)|ensembl:ENST00000330684(transcript)|ensembl:ENST00000396573(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0001964"(startle response)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0001975"(response to amphetamine)|go:"GO:0043197"(dendritic spine)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0045471"(response to ethanol)|go:"GO:0007420"(brain development)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022008"(neurogenesis)|go:"GO:0098976"(excitatory chemical synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1903539"(protein localization to postsynaptic membrane)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|mint:Q12879|rcsb pdb:3NFL|rcsb pdb:5H8F|rcsb pdb:5H8H|rcsb pdb:5H8N|rcsb pdb:5H8Q|rcsb pdb:5I2K|rcsb pdb:5I2N|rcsb pdb:5KCJ|rcsb pdb:5KDT|rcsb pdb:5TP9|rcsb pdb:5TPA|rcsb pdb:6IRA|rcsb pdb:6IRF|rcsb pdb:6IRG|rcsb pdb:6IRH|rcsb pdb:7EOQ|rcsb pdb:7EOR|rcsb pdb:7EOS|rcsb pdb:7EOT|rcsb pdb:7EOU|reactome:R-HSA-438066|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9022699|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|go:"GO:0098839"(postsynaptic density membrane)|dip:DIP-40798N|mint:MINT-414865(identity)	-	comment:mint|function:May act at junctions between the membrane and the cytoskeleton|comment:"Stoichiometry: 1.0"	comment:mint|function:NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits|comment:"Stoichiometry: 1.0"	figure legend:F5B|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|partial coverage:partial coverage	taxid:10090(mouse-telencephalon)|taxid:10090(Mus musculus)	-	2005/11/25	2014/10/16	rogid:f0q7V4YMwX+v4tFgx3DePzQc3X010090	rogid:TgxknLgEUv+HeST8sJLtK2pYoEM9606	intact-crc:B51508D6B74C2E1F|rigid:3WUvIGn31o4hEJY5AEeQam/zaE4	false	-	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q9WU22	uniprotkb:Q61625	intact:EBI-7249866|intact:MINT-126937|uniprotkb:G5E8E7|ensembl:ENSMUSP00000067614	intact:EBI-2794106|uniprotkb:A4QPG1|ensembl:ENSMUSP00000093536	psi-mi:ptn4_mouse(display_long)|uniprotkb:Ptpn4(gene name)|psi-mi:Ptpn4(display_short)|uniprotkb:Testis-enriched protein tyrosine phosphatase(gene name synonym)	psi-mi:grid2_mouse(display_long)|uniprotkb:Grid2(gene name)|psi-mi:Grid2(display_short)	psi-mi:"MI:0018"(two hybrid)	Hironaka et al. (2000)	pubmed:10748123|mint:MINT-5212410	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7250305|mint:MINT-72890	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064317.2|ensembl:ENSMUSG00000026384(gene)|ensembl:ENSMUST00000064091(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:MINT-414896(identity)	refseq:NP_032193.1|ensembl:ENSMUST00000095852(transcript)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|ensembl:ENSMUSG00000071424(gene)|mint:MINT-414905(identity)	-	comment:mint|function:May act at junctions between the membrane and the cytoskeleton|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1A F1B|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|partial coverage:partial coverage	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/11/25	2014/10/16	rogid:f0q7V4YMwX+v4tFgx3DePzQc3X010090	rogid:tGtRvPYFWLcS2DY+O/nGFFgt5/k10090	intact-crc:365C7EE5804924F8|rigid:HmMXmMBnVab5xdCpsmCBBSAGNCU	false	tag:?-?(MINT-414899)|binding-associated region:408-925(MINT-414897)	binding-associated region:922-1007(MINT-414906)|tag:?-?(MINT-414908)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)