#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13573	uniprotkb:Q06330	intact:EBI-632715|uniprotkb:Q13483|uniprotkb:Q32N03|uniprotkb:Q5D0D6|uniprotkb:A8K8A9|ensembl:ENSP00000261531	intact:EBI-632552|uniprotkb:Q5XKH9|uniprotkb:Q6P1N3|ensembl:ENSP00000345206|ensembl:ENSP00000354528|ensembl:ENSP00000423644|uniprotkb:B4DY22	psi-mi:snw1_human(display_long)|uniprotkb:Nuclear protein SkiP(gene name synonym)|uniprotkb:Ski-interacting protein(gene name synonym)|uniprotkb:Nuclear receptor coactivator NCoA-62(gene name synonym)|uniprotkb:SKIIP(gene name synonym)|uniprotkb:SKIP(gene name synonym)|uniprotkb:SNW1(gene name)|psi-mi:SNW1(display_short)	psi-mi:suh_human(display_long)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym)|uniprotkb:CBF-1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-30(gene name synonym)|uniprotkb:RBPJ(gene name)|psi-mi:RBPJ(display_short)|uniprotkb:IGKJRB(gene name synonym)|uniprotkb:IGKJRB1(gene name synonym)|uniprotkb:RBPJK(gene name synonym)|uniprotkb:RBPSUH(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhou et al. (2000)	pubmed:10713164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-632732	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036377.1|ensembl:ENSG00000100603(gene)|ensembl:ENST00000261531(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048385"(regulation of retinoic acid receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070562"(regulation of vitamin D receptor signaling pathway)|go:"GO:0070564"(positive regulation of vitamin D receptor signaling pathway)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071300"(cellular response to retinoic acid)|interpro:IPR004015(SKIP/SNW)|interpro:IPR017862|mint:Q13573|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z58|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-72163|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|dip:DIP-34800N	refseq:NP_005340.2|refseq:NP_976028.1|refseq:NP_976029.1|refseq:NP_056958.3|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|go:"GO:0030183"(B cell differentiation)|rcsb pdb:2F8X|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:6PY8|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2197563|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000168214(gene)|ensembl:ENST00000342295(transcript)|ensembl:ENST00000361572(transcript)|ensembl:ENST00000512671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|refseq:XP_005248218.1|refseq:XP_011512142.1|refseq:XP_016863661.1|refseq:XP_016863662.1|refseq:XP_016863663.1|refseq:XP_016863664.1|dip:DIP-33326N	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/08/11	2014/10/16	rogid:DwdpE5FIS2KfI0GOFt9IbAvjm/Y9606	rogid:K86zd5i5jYfKx0hGupxu8rA8rDM9606	intact-crc:255B8F42ED9F73B4|rigid:P8AfUzOvqNgNRSn5xxeqPu+4DLo	false	-	-	-	-	psi-mi:"MI:0056"(full identification by DNA sequencing)	psi-mi:"MI:0056"(full identification by DNA sequencing)
uniprotkb:Q06330	uniprotkb:Q13573	intact:EBI-632552|uniprotkb:Q5XKH9|uniprotkb:Q6P1N3|ensembl:ENSP00000345206|ensembl:ENSP00000354528|ensembl:ENSP00000423644|uniprotkb:B4DY22	intact:EBI-632715|uniprotkb:Q13483|uniprotkb:Q32N03|uniprotkb:Q5D0D6|uniprotkb:A8K8A9|ensembl:ENSP00000261531	psi-mi:suh_human(display_long)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym)|uniprotkb:CBF-1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-30(gene name synonym)|uniprotkb:RBPJ(gene name)|psi-mi:RBPJ(display_short)|uniprotkb:IGKJRB(gene name synonym)|uniprotkb:IGKJRB1(gene name synonym)|uniprotkb:RBPJK(gene name synonym)|uniprotkb:RBPSUH(gene name synonym)	psi-mi:snw1_human(display_long)|uniprotkb:Nuclear protein SkiP(gene name synonym)|uniprotkb:Ski-interacting protein(gene name synonym)|uniprotkb:Nuclear receptor coactivator NCoA-62(gene name synonym)|uniprotkb:SKIIP(gene name synonym)|uniprotkb:SKIP(gene name synonym)|uniprotkb:SNW1(gene name)|psi-mi:SNW1(display_short)	psi-mi:"MI:0096"(pull down)	Zhou et al. (2000)	pubmed:10713164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-632777	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005340.2|refseq:NP_976028.1|refseq:NP_976029.1|refseq:NP_056958.3|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|go:"GO:0030183"(B cell differentiation)|rcsb pdb:2F8X|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:6PY8|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2197563|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000168214(gene)|ensembl:ENST00000342295(transcript)|ensembl:ENST00000361572(transcript)|ensembl:ENST00000512671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|refseq:XP_005248218.1|refseq:XP_011512142.1|refseq:XP_016863661.1|refseq:XP_016863662.1|refseq:XP_016863663.1|refseq:XP_016863664.1|dip:DIP-33326N	refseq:NP_036377.1|ensembl:ENSG00000100603(gene)|ensembl:ENST00000261531(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048385"(regulation of retinoic acid receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070562"(regulation of vitamin D receptor signaling pathway)|go:"GO:0070564"(positive regulation of vitamin D receptor signaling pathway)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071300"(cellular response to retinoic acid)|interpro:IPR004015(SKIP/SNW)|interpro:IPR017862|mint:Q13573|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z58|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-72163|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|dip:DIP-34800N	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/08/11	2014/10/16	rogid:K86zd5i5jYfKx0hGupxu8rA8rDM9606	rogid:DwdpE5FIS2KfI0GOFt9IbAvjm/Y9606	intact-crc:2005C0BE55635566|rigid:P8AfUzOvqNgNRSn5xxeqPu+4DLo	false	glutathione s tranferase tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P39736	uniprotkb:Q06330	intact:EBI-93732|uniprotkb:Q9W390|ensemblmetazoa:FBpp0071285|ensemblmetazoa:FBpp0305943	intact:EBI-632552|uniprotkb:Q5XKH9|uniprotkb:Q6P1N3|ensembl:ENSP00000345206|ensembl:ENSP00000354528|ensembl:ENSP00000423644|uniprotkb:B4DY22	psi-mi:bx42_drome(display_long)|uniprotkb:Bx42(gene name)|psi-mi:Bx42(display_short)|uniprotkb:CG8264(orf name)	psi-mi:suh_human(display_long)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym)|uniprotkb:CBF-1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-30(gene name synonym)|uniprotkb:RBPJ(gene name)|psi-mi:RBPJ(display_short)|uniprotkb:IGKJRB(gene name synonym)|uniprotkb:IGKJRB1(gene name synonym)|uniprotkb:RBPJK(gene name synonym)|uniprotkb:RBPSUH(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhou et al. (2000)	pubmed:10713164	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-636277	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_511093.2|flybase:FBgn0004856|ensemblmetazoa:FBgn0004856(gene)|ensemblmetazoa:FBtr0071350(transcript)|ensemblmetazoa:FBtr0333809(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0003677"(DNA binding)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR004015(SKIP/SNW)|interpro:IPR017862|reactome:R-DME-2173796|reactome:R-DME-72163|refseq:NP_001259370.1|dip:DIP-17877N	refseq:NP_005340.2|refseq:NP_976028.1|refseq:NP_976029.1|refseq:NP_056958.3|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|go:"GO:0030183"(B cell differentiation)|rcsb pdb:2F8X|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:6PY8|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2197563|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000168214(gene)|ensembl:ENST00000342295(transcript)|ensembl:ENST00000361572(transcript)|ensembl:ENST00000512671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|refseq:XP_005248218.1|refseq:XP_011512142.1|refseq:XP_016863661.1|refseq:XP_016863662.1|refseq:XP_016863663.1|refseq:XP_016863664.1|dip:DIP-33326N	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/08/11	2014/10/16	rogid:vKGJIAu9IZPjKBeqb0QTkx+O4d47227	rogid:K86zd5i5jYfKx0hGupxu8rA8rDM9606	intact-crc:DFB00A5CD8931D60|rigid:SVtoK9gLWbC/3L73HUJb8mq+SF8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q06330	uniprotkb:Q22836	intact:EBI-632552|uniprotkb:Q5XKH9|uniprotkb:Q6P1N3|ensembl:ENSP00000345206|ensembl:ENSP00000354528|ensembl:ENSP00000423644|uniprotkb:B4DY22	intact:EBI-322121|ensemblmetazoa:T27F2.1.1	psi-mi:suh_human(display_long)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym)|uniprotkb:CBF-1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-30(gene name synonym)|uniprotkb:RBPJ(gene name)|psi-mi:RBPJ(display_short)|uniprotkb:IGKJRB(gene name synonym)|uniprotkb:IGKJRB1(gene name synonym)|uniprotkb:RBPJK(gene name synonym)|uniprotkb:RBPSUH(gene name synonym)	psi-mi:ygh1_caeel(display_long)|uniprotkb:T27F2.1(orf name)	psi-mi:"MI:0018"(two hybrid)	Zhou et al. (2000)	pubmed:10713164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-636281	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005340.2|refseq:NP_976028.1|refseq:NP_976029.1|refseq:NP_056958.3|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|go:"GO:0030183"(B cell differentiation)|rcsb pdb:2F8X|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:6PY8|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2197563|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000168214(gene)|ensembl:ENST00000342295(transcript)|ensembl:ENST00000361572(transcript)|ensembl:ENST00000512671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|refseq:XP_005248218.1|refseq:XP_011512142.1|refseq:XP_016863661.1|refseq:XP_016863662.1|refseq:XP_016863663.1|refseq:XP_016863664.1|dip:DIP-33326N	refseq:NP_505950.1|wormbase:T27F2.1|ensemblmetazoa:T27F2.1.1(transcript)|ensemblmetazoa:WBGene00004806(gene)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0002119"(nematode larval development)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0007281"(germ cell development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0018991"(oviposition)|go:"GO:0040011"(locomotion)|go:"GO:0040025"(vulval development)|go:"GO:0042303"(molting cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060065"(uterus development)|interpro:IPR004015(SKIP/SNW)|interpro:IPR017862|reactome:R-CEL-2173796|reactome:R-CEL-72163|dip:DIP-26404N	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/08/11	2014/10/16	rogid:K86zd5i5jYfKx0hGupxu8rA8rDM9606	rogid:xyzwY1zrYyPbLhIScFWPH6d3UiU6239	intact-crc:B50D11C3154C0154|rigid:n2ekcRHklpr0p5OUdlgqDvlKfPo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13573	uniprotkb:Q9Y618	intact:EBI-632715|uniprotkb:Q13483|uniprotkb:Q32N03|uniprotkb:Q5D0D6|uniprotkb:A8K8A9|ensembl:ENSP00000261531	intact:EBI-80830|uniprotkb:Q9Y5U0|uniprotkb:O00613|uniprotkb:O15416|uniprotkb:Q13354|uniprotkb:O15421|intact:EBI-28976851|uniprotkb:Q56D06|uniprotkb:Q59GM0|ensembl:ENSP00000384018	psi-mi:snw1_human(display_long)|uniprotkb:Nuclear protein SkiP(gene name synonym)|uniprotkb:Ski-interacting protein(gene name synonym)|uniprotkb:Nuclear receptor coactivator NCoA-62(gene name synonym)|uniprotkb:SKIIP(gene name synonym)|uniprotkb:SKIP(gene name synonym)|uniprotkb:SNW1(gene name)|psi-mi:SNW1(display_short)	psi-mi:ncor2_human(display_long)|uniprotkb:NCOR2(gene name)|psi-mi:NCOR2(display_short)|uniprotkb:CTG26(gene name synonym)|uniprotkb:Silencing mediator of retinoic acid and thyroid hormone receptor(gene name synonym)|uniprotkb:Thyroid-, retinoic-acid-receptor-associated corepressor(gene name synonym)|uniprotkb:T3 receptor-associating factor(gene name synonym)|uniprotkb:CTG repeat protein 26(gene name synonym)|uniprotkb:SMAP270(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhou et al. (2000)	pubmed:10713164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-636316	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036377.1|ensembl:ENSG00000100603(gene)|ensembl:ENST00000261531(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048385"(regulation of retinoic acid receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070562"(regulation of vitamin D receptor signaling pathway)|go:"GO:0070564"(positive regulation of vitamin D receptor signaling pathway)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071300"(cellular response to retinoic acid)|interpro:IPR004015(SKIP/SNW)|interpro:IPR017862|mint:Q13573|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z58|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-72163|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|dip:DIP-34800N	ensembl:ENSP00000384018|refseq:NP_001070729.2|refseq:NP_001193583.1|refseq:NP_006303.4|dip:DIP-951N|ensembl:ENSG00000196498(gene)|ensembl:ENST00000405201(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007595"(lactation)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010565"(regulation of cellular ketone metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:Q9Y618|rcsb pdb:1KKQ|rcsb pdb:1R2B|rcsb pdb:1XC5|rcsb pdb:2GPV|rcsb pdb:2L5G|rcsb pdb:2LTP|rcsb pdb:2ODD|rcsb pdb:2RT5|rcsb pdb:3R29|rcsb pdb:3R2A|rcsb pdb:4A69|rcsb pdb:4OAR|rcsb pdb:5X8Q|rcsb pdb:5X8X|rcsb pdb:5ZOO|rcsb pdb:5ZOP|rcsb pdb:6A22|rcsb pdb:6IVX|rcsb pdb:6PDZ|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2173795|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564	-	-	-	-	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2005/08/11	2018/09/18	rogid:DwdpE5FIS2KfI0GOFt9IbAvjm/Y9606	rogid:58SZfHIXN3dZN93fsiVHbbEwD0g9606	intact-crc:8DF6F8CEF6B1239B|rigid:BpVOHb4XvJ2xp648VWHnuRR//94	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y618	uniprotkb:Q13573	intact:EBI-80830|uniprotkb:Q9Y5U0|uniprotkb:O00613|uniprotkb:O15416|uniprotkb:Q13354|uniprotkb:O15421|intact:EBI-28976851|uniprotkb:Q56D06|uniprotkb:Q59GM0|ensembl:ENSP00000384018	intact:EBI-632715|uniprotkb:Q13483|uniprotkb:Q32N03|uniprotkb:Q5D0D6|uniprotkb:A8K8A9|ensembl:ENSP00000261531	psi-mi:ncor2_human(display_long)|uniprotkb:NCOR2(gene name)|psi-mi:NCOR2(display_short)|uniprotkb:CTG26(gene name synonym)|uniprotkb:Silencing mediator of retinoic acid and thyroid hormone receptor(gene name synonym)|uniprotkb:Thyroid-, retinoic-acid-receptor-associated corepressor(gene name synonym)|uniprotkb:T3 receptor-associating factor(gene name synonym)|uniprotkb:CTG repeat protein 26(gene name synonym)|uniprotkb:SMAP270(gene name synonym)	psi-mi:snw1_human(display_long)|uniprotkb:Nuclear protein SkiP(gene name synonym)|uniprotkb:Ski-interacting protein(gene name synonym)|uniprotkb:Nuclear receptor coactivator NCoA-62(gene name synonym)|uniprotkb:SKIIP(gene name synonym)|uniprotkb:SKIP(gene name synonym)|uniprotkb:SNW1(gene name)|psi-mi:SNW1(display_short)	psi-mi:"MI:0018"(two hybrid)	Zhou et al. (2000)	pubmed:10713164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-636319	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000384018|refseq:NP_001070729.2|refseq:NP_001193583.1|refseq:NP_006303.4|dip:DIP-951N|ensembl:ENSG00000196498(gene)|ensembl:ENST00000405201(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007595"(lactation)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010565"(regulation of cellular ketone metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:Q9Y618|rcsb pdb:1KKQ|rcsb pdb:1R2B|rcsb pdb:1XC5|rcsb pdb:2GPV|rcsb pdb:2L5G|rcsb pdb:2LTP|rcsb pdb:2ODD|rcsb pdb:2RT5|rcsb pdb:3R29|rcsb pdb:3R2A|rcsb pdb:4A69|rcsb pdb:4OAR|rcsb pdb:5X8Q|rcsb pdb:5X8X|rcsb pdb:5ZOO|rcsb pdb:5ZOP|rcsb pdb:6A22|rcsb pdb:6IVX|rcsb pdb:6PDZ|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2173795|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564	refseq:NP_036377.1|ensembl:ENSG00000100603(gene)|ensembl:ENST00000261531(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048385"(regulation of retinoic acid receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070562"(regulation of vitamin D receptor signaling pathway)|go:"GO:0070564"(positive regulation of vitamin D receptor signaling pathway)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071300"(cellular response to retinoic acid)|interpro:IPR004015(SKIP/SNW)|interpro:IPR017862|mint:Q13573|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z58|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-72163|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|dip:DIP-34800N	-	-	-	-	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2005/08/11	2018/09/18	rogid:58SZfHIXN3dZN93fsiVHbbEwD0g9606	rogid:DwdpE5FIS2KfI0GOFt9IbAvjm/Y9606	intact-crc:6930DD3CD57A019E|rigid:BpVOHb4XvJ2xp648VWHnuRR//94	false	-	sufficient binding region:1-536	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q06330	uniprotkb:Q9Y618	intact:EBI-632552|uniprotkb:Q5XKH9|uniprotkb:Q6P1N3|ensembl:ENSP00000345206|ensembl:ENSP00000354528|ensembl:ENSP00000423644|uniprotkb:B4DY22	intact:EBI-80830|uniprotkb:Q9Y5U0|uniprotkb:O00613|uniprotkb:O15416|uniprotkb:Q13354|uniprotkb:O15421|intact:EBI-28976851|uniprotkb:Q56D06|uniprotkb:Q59GM0|ensembl:ENSP00000384018	psi-mi:suh_human(display_long)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym)|uniprotkb:CBF-1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-30(gene name synonym)|uniprotkb:RBPJ(gene name)|psi-mi:RBPJ(display_short)|uniprotkb:IGKJRB(gene name synonym)|uniprotkb:IGKJRB1(gene name synonym)|uniprotkb:RBPJK(gene name synonym)|uniprotkb:RBPSUH(gene name synonym)	psi-mi:ncor2_human(display_long)|uniprotkb:NCOR2(gene name)|psi-mi:NCOR2(display_short)|uniprotkb:CTG26(gene name synonym)|uniprotkb:Silencing mediator of retinoic acid and thyroid hormone receptor(gene name synonym)|uniprotkb:Thyroid-, retinoic-acid-receptor-associated corepressor(gene name synonym)|uniprotkb:T3 receptor-associating factor(gene name synonym)|uniprotkb:CTG repeat protein 26(gene name synonym)|uniprotkb:SMAP270(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhou et al. (2000)	pubmed:10713164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-636331	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005340.2|refseq:NP_976028.1|refseq:NP_976029.1|refseq:NP_056958.3|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|go:"GO:0030183"(B cell differentiation)|rcsb pdb:2F8X|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:6PY8|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2197563|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000168214(gene)|ensembl:ENST00000342295(transcript)|ensembl:ENST00000361572(transcript)|ensembl:ENST00000512671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|refseq:XP_005248218.1|refseq:XP_011512142.1|refseq:XP_016863661.1|refseq:XP_016863662.1|refseq:XP_016863663.1|refseq:XP_016863664.1|dip:DIP-33326N	ensembl:ENSP00000384018|refseq:NP_001070729.2|refseq:NP_001193583.1|refseq:NP_006303.4|dip:DIP-951N|ensembl:ENSG00000196498(gene)|ensembl:ENST00000405201(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007595"(lactation)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010565"(regulation of cellular ketone metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:Q9Y618|rcsb pdb:1KKQ|rcsb pdb:1R2B|rcsb pdb:1XC5|rcsb pdb:2GPV|rcsb pdb:2L5G|rcsb pdb:2LTP|rcsb pdb:2ODD|rcsb pdb:2RT5|rcsb pdb:3R29|rcsb pdb:3R2A|rcsb pdb:4A69|rcsb pdb:4OAR|rcsb pdb:5X8Q|rcsb pdb:5X8X|rcsb pdb:5ZOO|rcsb pdb:5ZOP|rcsb pdb:6A22|rcsb pdb:6IVX|rcsb pdb:6PDZ|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2173795|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/08/11	2018/09/18	rogid:K86zd5i5jYfKx0hGupxu8rA8rDM9606	rogid:58SZfHIXN3dZN93fsiVHbbEwD0g9606	intact-crc:EA28598DBA81CE23|rigid:U7v87LsV5W7+tr5fvHFQ6S9Mmqw	false	mutation decreasing interaction strength:233-235	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13573	uniprotkb:P46531	intact:EBI-632715|uniprotkb:Q13483|uniprotkb:Q32N03|uniprotkb:Q5D0D6|uniprotkb:A8K8A9|ensembl:ENSP00000261531	intact:EBI-636374|uniprotkb:Q59ED8|uniprotkb:Q5SXM3|intact:EBI-28989124|ensembl:ENSP00000498587	psi-mi:snw1_human(display_long)|uniprotkb:Nuclear protein SkiP(gene name synonym)|uniprotkb:Ski-interacting protein(gene name synonym)|uniprotkb:Nuclear receptor coactivator NCoA-62(gene name synonym)|uniprotkb:SKIIP(gene name synonym)|uniprotkb:SKIP(gene name synonym)|uniprotkb:SNW1(gene name)|psi-mi:SNW1(display_short)	psi-mi:notc1_human(display_long)|uniprotkb:Translocation-associated notch protein TAN-1(gene name synonym)|uniprotkb:NOTCH1(gene name)|psi-mi:NOTCH1(display_short)|uniprotkb:TAN1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Zhou et al. (2000)	pubmed:10713164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-636394	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036377.1|ensembl:ENSG00000100603(gene)|ensembl:ENST00000261531(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048385"(regulation of retinoic acid receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070562"(regulation of vitamin D receptor signaling pathway)|go:"GO:0070564"(positive regulation of vitamin D receptor signaling pathway)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071300"(cellular response to retinoic acid)|interpro:IPR004015(SKIP/SNW)|interpro:IPR017862|mint:Q13573|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z58|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-72163|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|dip:DIP-34800N	refseq:NP_060087.3|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0005912"(adherens junction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|go:"GO:0070986"(left/right axis specification)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR035993|interpro:IPR036770|mint:P46531|rcsb pdb:1PB5|rcsb pdb:1TOZ|rcsb pdb:1YYH|rcsb pdb:2F8X|rcsb pdb:2F8Y|rcsb pdb:2HE0|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|rcsb pdb:2VJ3|rcsb pdb:3ETO|rcsb pdb:3I08|rcsb pdb:3L95|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:4CUD|rcsb pdb:4CUE|rcsb pdb:4CUF|rcsb pdb:4D0E|rcsb pdb:4D0F|rcsb pdb:5FM9|rcsb pdb:5FMA|rcsb pdb:5KZO|rcsb pdb:5L0R|rcsb pdb:5UB5|rcsb pdb:6IDF|rcsb pdb:6PY8|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000148400(gene)|ensembl:ENST00000651671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|dip:DIP-29919N|ensembl:ENSP00000498587	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/08/11	2014/10/16	rogid:DwdpE5FIS2KfI0GOFt9IbAvjm/Y9606	rogid:yRAjMjynnyZ7ANlk2eulodpS4P09606	intact-crc:435DB25171FF0B9A|rigid:SZC76ZnnS9DYiAQcrUMArDPvBL0	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P39736	uniprotkb:P46531	intact:EBI-93732|uniprotkb:Q9W390|ensemblmetazoa:FBpp0071285|ensemblmetazoa:FBpp0305943	intact:EBI-636374|uniprotkb:Q59ED8|uniprotkb:Q5SXM3|intact:EBI-28989124|ensembl:ENSP00000498587	psi-mi:bx42_drome(display_long)|uniprotkb:Bx42(gene name)|psi-mi:Bx42(display_short)|uniprotkb:CG8264(orf name)	psi-mi:notc1_human(display_long)|uniprotkb:Translocation-associated notch protein TAN-1(gene name synonym)|uniprotkb:NOTCH1(gene name)|psi-mi:NOTCH1(display_short)|uniprotkb:TAN1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhou et al. (2000)	pubmed:10713164	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-636407	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_511093.2|flybase:FBgn0004856|ensemblmetazoa:FBgn0004856(gene)|ensemblmetazoa:FBtr0071350(transcript)|ensemblmetazoa:FBtr0333809(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0003677"(DNA binding)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR004015(SKIP/SNW)|interpro:IPR017862|reactome:R-DME-2173796|reactome:R-DME-72163|refseq:NP_001259370.1|dip:DIP-17877N	refseq:NP_060087.3|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0005912"(adherens junction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|go:"GO:0070986"(left/right axis specification)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR035993|interpro:IPR036770|mint:P46531|rcsb pdb:1PB5|rcsb pdb:1TOZ|rcsb pdb:1YYH|rcsb pdb:2F8X|rcsb pdb:2F8Y|rcsb pdb:2HE0|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|rcsb pdb:2VJ3|rcsb pdb:3ETO|rcsb pdb:3I08|rcsb pdb:3L95|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:4CUD|rcsb pdb:4CUE|rcsb pdb:4CUF|rcsb pdb:4D0E|rcsb pdb:4D0F|rcsb pdb:5FM9|rcsb pdb:5FMA|rcsb pdb:5KZO|rcsb pdb:5L0R|rcsb pdb:5UB5|rcsb pdb:6IDF|rcsb pdb:6PY8|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000148400(gene)|ensembl:ENST00000651671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|dip:DIP-29919N|ensembl:ENSP00000498587	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/08/11	2014/10/16	rogid:vKGJIAu9IZPjKBeqb0QTkx+O4d47227	rogid:yRAjMjynnyZ7ANlk2eulodpS4P09606	intact-crc:D8160DF3D9B36BA4|rigid:VjNmZAaEZSkHw4cDDG0mgVXie7A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46531	uniprotkb:Q22836	intact:EBI-636374|uniprotkb:Q59ED8|uniprotkb:Q5SXM3|intact:EBI-28989124|ensembl:ENSP00000498587	intact:EBI-322121|ensemblmetazoa:T27F2.1.1	psi-mi:notc1_human(display_long)|uniprotkb:Translocation-associated notch protein TAN-1(gene name synonym)|uniprotkb:NOTCH1(gene name)|psi-mi:NOTCH1(display_short)|uniprotkb:TAN1(gene name synonym)	psi-mi:ygh1_caeel(display_long)|uniprotkb:T27F2.1(orf name)	psi-mi:"MI:0018"(two hybrid)	Zhou et al. (2000)	pubmed:10713164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-636411	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060087.3|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0005912"(adherens junction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|go:"GO:0070986"(left/right axis specification)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR035993|interpro:IPR036770|mint:P46531|rcsb pdb:1PB5|rcsb pdb:1TOZ|rcsb pdb:1YYH|rcsb pdb:2F8X|rcsb pdb:2F8Y|rcsb pdb:2HE0|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|rcsb pdb:2VJ3|rcsb pdb:3ETO|rcsb pdb:3I08|rcsb pdb:3L95|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:4CUD|rcsb pdb:4CUE|rcsb pdb:4CUF|rcsb pdb:4D0E|rcsb pdb:4D0F|rcsb pdb:5FM9|rcsb pdb:5FMA|rcsb pdb:5KZO|rcsb pdb:5L0R|rcsb pdb:5UB5|rcsb pdb:6IDF|rcsb pdb:6PY8|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000148400(gene)|ensembl:ENST00000651671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|dip:DIP-29919N|ensembl:ENSP00000498587	refseq:NP_505950.1|wormbase:T27F2.1|ensemblmetazoa:T27F2.1.1(transcript)|ensemblmetazoa:WBGene00004806(gene)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0002119"(nematode larval development)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0007281"(germ cell development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0018991"(oviposition)|go:"GO:0040011"(locomotion)|go:"GO:0040025"(vulval development)|go:"GO:0042303"(molting cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060065"(uterus development)|interpro:IPR004015(SKIP/SNW)|interpro:IPR017862|reactome:R-CEL-2173796|reactome:R-CEL-72163|dip:DIP-26404N	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/08/11	2014/10/16	rogid:yRAjMjynnyZ7ANlk2eulodpS4P09606	rogid:xyzwY1zrYyPbLhIScFWPH6d3UiU6239	intact-crc:35C358EDA555AAAE|rigid:XZgNLo7pX+R2DAvFrVHYgTUVFl0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46531	uniprotkb:Q13573	intact:EBI-636374|uniprotkb:Q59ED8|uniprotkb:Q5SXM3|intact:EBI-28989124|ensembl:ENSP00000498587	intact:EBI-632715|uniprotkb:Q13483|uniprotkb:Q32N03|uniprotkb:Q5D0D6|uniprotkb:A8K8A9|ensembl:ENSP00000261531	psi-mi:notc1_human(display_long)|uniprotkb:Translocation-associated notch protein TAN-1(gene name synonym)|uniprotkb:NOTCH1(gene name)|psi-mi:NOTCH1(display_short)|uniprotkb:TAN1(gene name synonym)	psi-mi:snw1_human(display_long)|uniprotkb:Nuclear protein SkiP(gene name synonym)|uniprotkb:Ski-interacting protein(gene name synonym)|uniprotkb:Nuclear receptor coactivator NCoA-62(gene name synonym)|uniprotkb:SKIIP(gene name synonym)|uniprotkb:SKIP(gene name synonym)|uniprotkb:SNW1(gene name)|psi-mi:SNW1(display_short)	psi-mi:"MI:0018"(two hybrid)	Zhou et al. (2000)	pubmed:10713164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-636469	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060087.3|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0005912"(adherens junction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|go:"GO:0070986"(left/right axis specification)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR035993|interpro:IPR036770|mint:P46531|rcsb pdb:1PB5|rcsb pdb:1TOZ|rcsb pdb:1YYH|rcsb pdb:2F8X|rcsb pdb:2F8Y|rcsb pdb:2HE0|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|rcsb pdb:2VJ3|rcsb pdb:3ETO|rcsb pdb:3I08|rcsb pdb:3L95|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:4CUD|rcsb pdb:4CUE|rcsb pdb:4CUF|rcsb pdb:4D0E|rcsb pdb:4D0F|rcsb pdb:5FM9|rcsb pdb:5FMA|rcsb pdb:5KZO|rcsb pdb:5L0R|rcsb pdb:5UB5|rcsb pdb:6IDF|rcsb pdb:6PY8|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000148400(gene)|ensembl:ENST00000651671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|dip:DIP-29919N|ensembl:ENSP00000498587	refseq:NP_036377.1|ensembl:ENSG00000100603(gene)|ensembl:ENST00000261531(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048385"(regulation of retinoic acid receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070562"(regulation of vitamin D receptor signaling pathway)|go:"GO:0070564"(positive regulation of vitamin D receptor signaling pathway)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071300"(cellular response to retinoic acid)|interpro:IPR004015(SKIP/SNW)|interpro:IPR017862|mint:Q13573|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z58|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-72163|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|dip:DIP-34800N	-	-	-	comment:"NotchIC was expressed as a fusion to the transactivation domain and nuclear localization signal of EBV-EBNA2. Two variants were used where NotchIC either still contained its RAM domain (the CBF-1 interaction domain) or it was deleted. The experiment showed that the RAM domain was neither sufficient or necessary for NotchIC interaction with SKIP."	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/08/11	2014/10/16	rogid:yRAjMjynnyZ7ANlk2eulodpS4P09606	rogid:DwdpE5FIS2KfI0GOFt9IbAvjm/Y9606	intact-crc:A0CC975B17FE0ECF|rigid:SZC76ZnnS9DYiAQcrUMArDPvBL0	false	fusion protein:?-?	sufficient binding region:1-536	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46531	uniprotkb:Q06330	intact:EBI-636374|uniprotkb:Q59ED8|uniprotkb:Q5SXM3|intact:EBI-28989124|ensembl:ENSP00000498587	intact:EBI-632552|uniprotkb:Q5XKH9|uniprotkb:Q6P1N3|ensembl:ENSP00000345206|ensembl:ENSP00000354528|ensembl:ENSP00000423644|uniprotkb:B4DY22	psi-mi:notc1_human(display_long)|uniprotkb:Translocation-associated notch protein TAN-1(gene name synonym)|uniprotkb:NOTCH1(gene name)|psi-mi:NOTCH1(display_short)|uniprotkb:TAN1(gene name synonym)	psi-mi:suh_human(display_long)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym)|uniprotkb:CBF-1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-30(gene name synonym)|uniprotkb:RBPJ(gene name)|psi-mi:RBPJ(display_short)|uniprotkb:IGKJRB(gene name synonym)|uniprotkb:IGKJRB1(gene name synonym)|uniprotkb:RBPJK(gene name synonym)|uniprotkb:RBPSUH(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhou et al. (2000)	pubmed:10713164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-636557	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060087.3|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0005912"(adherens junction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|go:"GO:0070986"(left/right axis specification)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR035993|interpro:IPR036770|mint:P46531|rcsb pdb:1PB5|rcsb pdb:1TOZ|rcsb pdb:1YYH|rcsb pdb:2F8X|rcsb pdb:2F8Y|rcsb pdb:2HE0|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|rcsb pdb:2VJ3|rcsb pdb:3ETO|rcsb pdb:3I08|rcsb pdb:3L95|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:4CUD|rcsb pdb:4CUE|rcsb pdb:4CUF|rcsb pdb:4D0E|rcsb pdb:4D0F|rcsb pdb:5FM9|rcsb pdb:5FMA|rcsb pdb:5KZO|rcsb pdb:5L0R|rcsb pdb:5UB5|rcsb pdb:6IDF|rcsb pdb:6PY8|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000148400(gene)|ensembl:ENST00000651671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|dip:DIP-29919N|ensembl:ENSP00000498587	refseq:NP_005340.2|refseq:NP_976028.1|refseq:NP_976029.1|refseq:NP_056958.3|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|go:"GO:0030183"(B cell differentiation)|rcsb pdb:2F8X|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:6PY8|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2197563|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000168214(gene)|ensembl:ENST00000342295(transcript)|ensembl:ENST00000361572(transcript)|ensembl:ENST00000512671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|refseq:XP_005248218.1|refseq:XP_011512142.1|refseq:XP_016863661.1|refseq:XP_016863662.1|refseq:XP_016863663.1|refseq:XP_016863664.1|dip:DIP-33326N	-	-	-	comment:"The addition of SMRT (Q9Y618) abolished NotchIC activation - indicating that SMRT and NotchIC compete to bind CBF1 (Q06330)."|comment:"SKIIP (Q13573) had a small positive effect on NotchIC activation of the transcription reporter indicating that it might facilitate the NotchIC-CBF-1 interaction."	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/08/11	2014/10/16	rogid:yRAjMjynnyZ7ANlk2eulodpS4P09606	rogid:K86zd5i5jYfKx0hGupxu8rA8rDM9606	intact-crc:3E3EA4109825E17A|rigid:g0Dn1hoTVnarsXuNso0HzIsIpnk	false	-	sufficient binding region:1-500	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46531	uniprotkb:Q06330	intact:EBI-636374|uniprotkb:Q59ED8|uniprotkb:Q5SXM3|intact:EBI-28989124|ensembl:ENSP00000498587	intact:EBI-632552|uniprotkb:Q5XKH9|uniprotkb:Q6P1N3|ensembl:ENSP00000345206|ensembl:ENSP00000354528|ensembl:ENSP00000423644|uniprotkb:B4DY22	psi-mi:notc1_human(display_long)|uniprotkb:Translocation-associated notch protein TAN-1(gene name synonym)|uniprotkb:NOTCH1(gene name)|psi-mi:NOTCH1(display_short)|uniprotkb:TAN1(gene name synonym)	psi-mi:suh_human(display_long)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym)|uniprotkb:CBF-1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-30(gene name synonym)|uniprotkb:RBPJ(gene name)|psi-mi:RBPJ(display_short)|uniprotkb:IGKJRB(gene name synonym)|uniprotkb:IGKJRB1(gene name synonym)|uniprotkb:RBPJK(gene name synonym)|uniprotkb:RBPSUH(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Zhou et al. (2000)	pubmed:10713164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-638058	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060087.3|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0005912"(adherens junction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|go:"GO:0070986"(left/right axis specification)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR035993|interpro:IPR036770|mint:P46531|rcsb pdb:1PB5|rcsb pdb:1TOZ|rcsb pdb:1YYH|rcsb pdb:2F8X|rcsb pdb:2F8Y|rcsb pdb:2HE0|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|rcsb pdb:2VJ3|rcsb pdb:3ETO|rcsb pdb:3I08|rcsb pdb:3L95|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:4CUD|rcsb pdb:4CUE|rcsb pdb:4CUF|rcsb pdb:4D0E|rcsb pdb:4D0F|rcsb pdb:5FM9|rcsb pdb:5FMA|rcsb pdb:5KZO|rcsb pdb:5L0R|rcsb pdb:5UB5|rcsb pdb:6IDF|rcsb pdb:6PY8|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000148400(gene)|ensembl:ENST00000651671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|dip:DIP-29919N|ensembl:ENSP00000498587	refseq:NP_005340.2|refseq:NP_976028.1|refseq:NP_976029.1|refseq:NP_056958.3|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|go:"GO:0030183"(B cell differentiation)|rcsb pdb:2F8X|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:6PY8|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2197563|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000168214(gene)|ensembl:ENST00000342295(transcript)|ensembl:ENST00000361572(transcript)|ensembl:ENST00000512671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|refseq:XP_005248218.1|refseq:XP_011512142.1|refseq:XP_016863661.1|refseq:XP_016863662.1|refseq:XP_016863663.1|refseq:XP_016863664.1|dip:DIP-33326N	-	-	-	comment:"A mutation within the fourth ankyrin repeat (AA to EF) did not effect the interaction."	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/08/11	2014/10/16	rogid:yRAjMjynnyZ7ANlk2eulodpS4P09606	rogid:K86zd5i5jYfKx0hGupxu8rA8rDM9606	intact-crc:11946E4B7CCD1F4E|rigid:g0Dn1hoTVnarsXuNso0HzIsIpnk	false	binding-associated region:1746-2530	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13573	uniprotkb:P46531	intact:EBI-632715|uniprotkb:Q13483|uniprotkb:Q32N03|uniprotkb:Q5D0D6|uniprotkb:A8K8A9|ensembl:ENSP00000261531	intact:EBI-636374|uniprotkb:Q59ED8|uniprotkb:Q5SXM3|intact:EBI-28989124|ensembl:ENSP00000498587	psi-mi:snw1_human(display_long)|uniprotkb:Nuclear protein SkiP(gene name synonym)|uniprotkb:Ski-interacting protein(gene name synonym)|uniprotkb:Nuclear receptor coactivator NCoA-62(gene name synonym)|uniprotkb:SKIIP(gene name synonym)|uniprotkb:SKIP(gene name synonym)|uniprotkb:SNW1(gene name)|psi-mi:SNW1(display_short)	psi-mi:notc1_human(display_long)|uniprotkb:Translocation-associated notch protein TAN-1(gene name synonym)|uniprotkb:NOTCH1(gene name)|psi-mi:NOTCH1(display_short)|uniprotkb:TAN1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Zhou et al. (2000)	pubmed:10713164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-638096	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036377.1|ensembl:ENSG00000100603(gene)|ensembl:ENST00000261531(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048385"(regulation of retinoic acid receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070562"(regulation of vitamin D receptor signaling pathway)|go:"GO:0070564"(positive regulation of vitamin D receptor signaling pathway)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071300"(cellular response to retinoic acid)|interpro:IPR004015(SKIP/SNW)|interpro:IPR017862|mint:Q13573|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z58|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-72163|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|dip:DIP-34800N	refseq:NP_060087.3|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0005912"(adherens junction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|go:"GO:0070986"(left/right axis specification)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR035993|interpro:IPR036770|mint:P46531|rcsb pdb:1PB5|rcsb pdb:1TOZ|rcsb pdb:1YYH|rcsb pdb:2F8X|rcsb pdb:2F8Y|rcsb pdb:2HE0|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|rcsb pdb:2VJ3|rcsb pdb:3ETO|rcsb pdb:3I08|rcsb pdb:3L95|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:4CUD|rcsb pdb:4CUE|rcsb pdb:4CUF|rcsb pdb:4D0E|rcsb pdb:4D0F|rcsb pdb:5FM9|rcsb pdb:5FMA|rcsb pdb:5KZO|rcsb pdb:5L0R|rcsb pdb:5UB5|rcsb pdb:6IDF|rcsb pdb:6PY8|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000148400(gene)|ensembl:ENST00000651671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|dip:DIP-29919N|ensembl:ENSP00000498587	-	-	-	caution:The mutant Notch1 protein used in this interaction had a AA to EF mutation within the fourth ankyrin repeat. There are two AA within this region - at positions 2036-2038 and 2044-2045, it is uncertain which set were mutated, even though 2044-2045AA were used in the feature.	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2005/08/11	2014/10/16	rogid:DwdpE5FIS2KfI0GOFt9IbAvjm/Y9606	rogid:yRAjMjynnyZ7ANlk2eulodpS4P09606	intact-crc:20AD2160066C65EF|rigid:SZC76ZnnS9DYiAQcrUMArDPvBL0	false	flag tag:?-?	binding-associated region:1746-2530|mutation decreasing interaction:2043-2044	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)