#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O88339	uniprotkb:P49951	intact:EBI-7066728|intact:MINT-101104	intact:EBI-448355|ensembl:ENSBTAP00000060092	psi-mi:epn1_rat(display_long)|uniprotkb:Epn1(gene name)|psi-mi:Epn1(display_short)|uniprotkb:EPS-15-interacting protein 1(gene name synonym)	psi-mi:clh1_bovin(display_long)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)	psi-mi:"MI:0096"(pull down)	Drake et al. (2000)	pubmed:10692452|mint:MINT-5212271	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7202719|mint:MINT-58292	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:O88339|go:"GO:1905445"(positive regulation of clathrin coat assembly)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|rcsb pdb:1EDU|rcsb pdb:1EYH|rcsb pdb:1H0A|rcsb pdb:1KY6|reactome:R-RNO-182971|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0090148"(membrane fission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|rgd:619772|refseq:NP_476477.1|dip:DIP-40738N|mint:MINT-412729(identity)	refseq:NP_776448.1|dip:DIP-31603N|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:P49951|rcsb pdb:1B89|rcsb pdb:1UTC|rcsb pdb:1XI4|rcsb pdb:1XI5|rcsb pdb:3GC3|rcsb pdb:3GD1|rcsb pdb:3IYV|rcsb pdb:3LVH|rcsb pdb:3QIL|rcsb pdb:5M5R|rcsb pdb:5M5S|rcsb pdb:5M5T|rcsb pdb:5M5U|rcsb pdb:5M5V|rcsb pdb:5M61|rcsb pdb:6WCJ|rcsb pdb:3LVG|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0033572"(transferrin transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|ensembl:ENSBTAG00000016708(gene)|ensembl:ENSBTAT00000077192(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|mint:MINT-412721(identity)	-	comment:mint|function:"Binds to membranes enriched in phosphatidylinositol-4,5-biphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. Regulates receptor-mediated endocytosis"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5|comment:GST pull-down is from rat brain cytosol.|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/05/04	2014/10/16	rogid:HSxImXvS6/UJyI9kGWz36B0oxiM10116	rogid:wpLSa4t2I+sHqUBOftWeW3eCayU9913	intact-crc:3654BB19926985F3|rigid:pFvy0EkVqyD9Z1Xa/pwsyR6ZOyA	false	-	binding-associated region:1-579(MINT-412722)|tag:?-?(MINT-412724)	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P18484	uniprotkb:P49951	intact:EBI-539360	intact:EBI-448355|ensembl:ENSBTAP00000060092	psi-mi:ap2a2_rat(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-2(gene name synonym)|uniprotkb:Alpha2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit(gene name synonym)|uniprotkb:Alpha-adaptin C(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-C large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein C(gene name synonym)|uniprotkb:Ap2a2(gene name)|psi-mi:Ap2a2(display_short)|uniprotkb:Adtab(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-2(gene name synonym)	psi-mi:clh1_bovin(display_long)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)	psi-mi:"MI:0096"(pull down)	Drake et al. (2000)	pubmed:10692452|mint:MINT-5212271	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7202755|mint:MINT-58294	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:71015|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|rcsb pdb:2VGL|rcsb pdb:2XA7|go:"GO:0008021"(synaptic vesicle)|rcsb pdb:4NEE|rcsb pdb:4UQI|rcsb pdb:6OWT|rcsb pdb:6QH5|rcsb pdb:6QH6|rcsb pdb:6QH7|go:"GO:0019900"(kinase binding)|rcsb pdb:6URI|rcsb pdb:6YAE|rcsb pdb:6YAF|rcsb pdb:6YAH|reactome:R-RNO-177504|reactome:R-RNO-2132295|reactome:R-RNO-416993|reactome:R-RNO-437239|reactome:R-RNO-5099900|reactome:R-RNO-5140745|reactome:R-RNO-6798695|reactome:R-RNO-8856825|go:"GO:0019901"(protein kinase binding)|reactome:R-RNO-8856828|go:"GO:0019904"(protein domain specific binding)|reactome:R-RNO-8866427|reactome:R-RNO-8964038|go:"GO:0030117"(membrane coat)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140312"(cargo adaptor activity)|mint:P18484|dip:DIP-29765N|mint:MINT-412539(identity)	refseq:NP_776448.1|dip:DIP-31603N|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:P49951|rcsb pdb:1B89|rcsb pdb:1UTC|rcsb pdb:1XI4|rcsb pdb:1XI5|rcsb pdb:3GC3|rcsb pdb:3GD1|rcsb pdb:3IYV|rcsb pdb:3LVH|rcsb pdb:3QIL|rcsb pdb:5M5R|rcsb pdb:5M5S|rcsb pdb:5M5T|rcsb pdb:5M5U|rcsb pdb:5M5V|rcsb pdb:5M61|rcsb pdb:6WCJ|rcsb pdb:3LVG|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0033572"(transferrin transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|ensembl:ENSBTAG00000016708(gene)|ensembl:ENSBTAT00000077192(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|mint:MINT-412531(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5|comment:GST pull-down is from rat brain cytosol.|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/05/04	2014/10/16	rogid:/3UaX0n3j6Lo0w7GMn0uWzL5GI010116	rogid:wpLSa4t2I+sHqUBOftWeW3eCayU9913	intact-crc:AE9D9BAC1F246B2F|rigid:wKm66pt+z0G7LY6hvgI2pLnzyxs	false	-	tag:?-?(MINT-412534)|binding-associated region:1-579(MINT-412532)	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49951	uniprotkb:P84092	intact:EBI-448355|ensembl:ENSBTAP00000060092	intact:EBI-297693|uniprotkb:P53679|uniprotkb:P20172|ensembl:ENSRNOP00000070202	psi-mi:clh1_bovin(display_long)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)	psi-mi:ap2m1_rat(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit mu(gene name synonym)|uniprotkb:AP-2 mu chain(gene name synonym)|uniprotkb:Ap2m1(gene name)|psi-mi:Ap2m1(display_short)|uniprotkb:Mu2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor AP-2 50 kDa protein(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP50(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP50(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 mu medium chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit mu(gene name synonym)	psi-mi:"MI:0096"(pull down)	Drake et al. (2000)	pubmed:10692452|mint:MINT-5212271	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7202737|mint:MINT-58293	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776448.1|dip:DIP-31603N|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:P49951|rcsb pdb:1B89|rcsb pdb:1UTC|rcsb pdb:1XI4|rcsb pdb:1XI5|rcsb pdb:3GC3|rcsb pdb:3GD1|rcsb pdb:3IYV|rcsb pdb:3LVH|rcsb pdb:3QIL|rcsb pdb:5M5R|rcsb pdb:5M5S|rcsb pdb:5M5T|rcsb pdb:5M5U|rcsb pdb:5M5V|rcsb pdb:5M61|rcsb pdb:6WCJ|rcsb pdb:3LVG|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0033572"(transferrin transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|ensembl:ENSBTAG00000016708(gene)|ensembl:ENSBTAT00000077192(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|mint:MINT-412563(identity)	go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR022775|interpro:IPR028565|interpro:IPR036168|interpro:IPR043512|interpro:IPR043532|mint:P84092|rcsb pdb:1BW8|rcsb pdb:1BXX|rcsb pdb:1HES|rcsb pdb:1I31|rcsb pdb:2BP5|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2PR9|rcsb pdb:2VGL|rcsb pdb:2XA7|rcsb pdb:3H85|rcsb pdb:3ML6|rcsb pdb:4UQI|rcsb pdb:5C7Z|rcsb pdb:5FPI|rcsb pdb:5WRK|go:"GO:0097718"(disordered domain specific binding)|rcsb pdb:5WRL|rcsb pdb:5WRM|rcsb pdb:6QH5|rcsb pdb:6QH6|rcsb pdb:6RH6|rcsb pdb:6YAE|rcsb pdb:6YAF|rcsb pdb:6YAH|reactome:R-RNO-177504|reactome:R-RNO-190873|reactome:R-RNO-196025|reactome:R-RNO-2132295|reactome:R-RNO-416993|reactome:R-RNO-437239|reactome:R-RNO-5099900|reactome:R-RNO-5140745|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8866427|reactome:R-RNO-8964038|ensembl:ENSRNOG00000001709(gene)|ensembl:ENSRNOT00000088821(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008289"(lipid binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097494"(regulation of vesicle size)|rgd:620135|refseq:NP_446289.1|dip:DIP-29761N|mint:MINT-412571(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5|comment:GST pull-down is from rat brain cytosol.|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/05/04	2014/10/16	rogid:wpLSa4t2I+sHqUBOftWeW3eCayU9913	rogid:AyJEJTqzHtIRWEnMGBzLQP3H5lA10116	intact-crc:91BE40AECAB7E312|rigid:er8vKWYkVg96xM087dFDFS2tykc	false	tag:?-?(MINT-412566)|binding-associated region:1-579(MINT-412564)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:O08838	uniprotkb:P49951	intact:EBI-80080	intact:EBI-448355|ensembl:ENSBTAP00000060092	psi-mi:amph_rat(display_long)|uniprotkb:Amph(gene name)|psi-mi:Amph(display_short)|uniprotkb:Amph1(gene name synonym)	psi-mi:clh1_bovin(display_long)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)	psi-mi:"MI:0096"(pull down)	Drake et al. (2000)	pubmed:10692452|mint:MINT-5212271	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7202807|mint:MINT-58296	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098833"(presynaptic endocytic zone)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003017(Amphiphysin, isoform 1)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035470|interpro:IPR036028|rcsb pdb:2VJ0|rcsb pdb:5M5T|reactome:R-RNO-8856828|rgd:620274|refseq:NP_071553.1|mint:O08838|dip:DIP-30977N|mint:MINT-412713(identity)	refseq:NP_776448.1|dip:DIP-31603N|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:P49951|rcsb pdb:1B89|rcsb pdb:1UTC|rcsb pdb:1XI4|rcsb pdb:1XI5|rcsb pdb:3GC3|rcsb pdb:3GD1|rcsb pdb:3IYV|rcsb pdb:3LVH|rcsb pdb:3QIL|rcsb pdb:5M5R|rcsb pdb:5M5S|rcsb pdb:5M5T|rcsb pdb:5M5U|rcsb pdb:5M5V|rcsb pdb:5M61|rcsb pdb:6WCJ|rcsb pdb:3LVG|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0033572"(transferrin transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|ensembl:ENSBTAG00000016708(gene)|ensembl:ENSBTAT00000077192(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|mint:MINT-412705(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5|comment:GST pull-down in from rat brain cytosol.|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/05/04	2014/10/16	rogid:wTANhsy4BxCZYbSIhwlrr+m9Tt810116	rogid:wpLSa4t2I+sHqUBOftWeW3eCayU9913	intact-crc:F8F2F0FE413D2B68|rigid:idu13/gfe9trhis6Llj6Z/s4ukY	false	-	binding-associated region:1-579(MINT-412706)|tag:?-?(MINT-412708)	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49951	uniprotkb:Q05140	intact:EBI-448355|ensembl:ENSBTAP00000060092	intact:EBI-1374805	psi-mi:clh1_bovin(display_long)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)	psi-mi:ap180_rat(display_long)|uniprotkb:Snap91(gene name)|psi-mi:Snap91(display_short)|uniprotkb:Clathrin coat-associated protein AP180(gene name synonym)|uniprotkb:91 kDa synaptosomal-associated protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Drake et al. (2000)	pubmed:10692452|mint:MINT-5212271	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7202789|mint:MINT-58295	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776448.1|dip:DIP-31603N|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:P49951|rcsb pdb:1B89|rcsb pdb:1UTC|rcsb pdb:1XI4|rcsb pdb:1XI5|rcsb pdb:3GC3|rcsb pdb:3GD1|rcsb pdb:3IYV|rcsb pdb:3LVH|rcsb pdb:3QIL|rcsb pdb:5M5R|rcsb pdb:5M5S|rcsb pdb:5M5T|rcsb pdb:5M5U|rcsb pdb:5M5V|rcsb pdb:5M61|rcsb pdb:6WCJ|rcsb pdb:3LVG|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0033572"(transferrin transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|ensembl:ENSBTAG00000016708(gene)|ensembl:ENSBTAT00000077192(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|mint:MINT-412547(identity)	rgd:69276|refseq:NP_113916.1|interpro:IPR011417(ANTH)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|mint:Q05140|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098830"(presynaptic endosome)|go:"GO:0098833"(presynaptic endocytic zone)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1900275"(negative regulation of phospholipase C activity)|go:"GO:1904006"(negative regulation of phospholipase D activity)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0000149"(SNARE binding)|go:"GO:0000822"(inositol hexakisphosphate binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043679"(axon terminus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0051899"(membrane depolarization)|interpro:IPR030428|mint:MINT-412555(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5|comment:GST pull-down is from rat brain cytosol.|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/05/04	2014/10/16	rogid:wpLSa4t2I+sHqUBOftWeW3eCayU9913	rogid:LXxIlR8jL+mLJ94McATz+sj4xF410116	intact-crc:0E9A914E4A6ECF97|rigid:g/5Z27r61AzmLxqVvB/lKxtrUxY	false	binding-associated region:1-579(MINT-412548)|tag:?-?(MINT-412550)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:P49951	uniprotkb:P11442	intact:EBI-448355|ensembl:ENSBTAP00000060092	intact:EBI-397997	psi-mi:clh1_bovin(display_long)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)	psi-mi:clh1_rat(display_long)|uniprotkb:Cltc(gene name)|psi-mi:Cltc(display_short)	psi-mi:"MI:0096"(pull down)	Drake et al. (2000)	pubmed:10692452|mint:MINT-5212271	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7202843|mint:MINT-58299	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776448.1|dip:DIP-31603N|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:P49951|rcsb pdb:1B89|rcsb pdb:1UTC|rcsb pdb:1XI4|rcsb pdb:1XI5|rcsb pdb:3GC3|rcsb pdb:3GD1|rcsb pdb:3IYV|rcsb pdb:3LVH|rcsb pdb:3QIL|rcsb pdb:5M5R|rcsb pdb:5M5S|rcsb pdb:5M5T|rcsb pdb:5M5U|rcsb pdb:5M5V|rcsb pdb:5M61|rcsb pdb:6WCJ|rcsb pdb:3LVG|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0033572"(transferrin transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|ensembl:ENSBTAG00000016708(gene)|ensembl:ENSBTAT00000077192(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|mint:MINT-412497(identity)	rgd:2364|refseq:NP_062172.1|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030118"(clathrin coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042277"(peptide binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043195"(terminal bouton)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|rcsb pdb:1BPO|rcsb pdb:1C9I|rcsb pdb:1C9L|reactome:R-RNO-177504|reactome:R-RNO-190873|reactome:R-RNO-196025|reactome:R-RNO-2132295|reactome:R-RNO-432720|reactome:R-RNO-432722|reactome:R-RNO-437239|reactome:R-RNO-5099900|reactome:R-RNO-5140745|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8866427|reactome:R-RNO-8964038|reactome:R-RNO-9013420|reactome:R-RNO-9013424|mint:P11442|dip:DIP-36966N|mint:MINT-412505(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F7|comment:GST pull-down is from rat brain cytosol.|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/05/04	2014/10/16	rogid:wpLSa4t2I+sHqUBOftWeW3eCayU9913	rogid:IRKdzbAIpw7D7qHqyxStNyfI38g10116	intact-crc:F00C34E7D9EC61DF|rigid:C3YbdoRzRxg4urTLGvGgVW7r2kI	false	binding-associated region:229-319(MINT-412498)|tag:?-?(MINT-412500)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:P49951	uniprotkb:O08839	intact:EBI-448355|ensembl:ENSBTAP00000060092	intact:EBI-80095	psi-mi:clh1_bovin(display_long)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)	psi-mi:bin1_rat(display_long)|uniprotkb:Bin1(gene name)|psi-mi:Bin1(display_short)|uniprotkb:Amph2(gene name synonym)|uniprotkb:Amphl(gene name synonym)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym)	psi-mi:"MI:0096"(pull down)	Drake et al. (2000)	pubmed:10692452|mint:MINT-5212271	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7202825|mint:MINT-58297	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776448.1|dip:DIP-31603N|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:P49951|rcsb pdb:1B89|rcsb pdb:1UTC|rcsb pdb:1XI4|rcsb pdb:1XI5|rcsb pdb:3GC3|rcsb pdb:3GD1|rcsb pdb:3IYV|rcsb pdb:3LVH|rcsb pdb:3QIL|rcsb pdb:5M5R|rcsb pdb:5M5S|rcsb pdb:5M5T|rcsb pdb:5M5U|rcsb pdb:5M5V|rcsb pdb:5M61|rcsb pdb:6WCJ|rcsb pdb:3LVG|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0033572"(transferrin transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|ensembl:ENSBTAG00000016708(gene)|ensembl:ENSBTAT00000077192(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|mint:MINT-412632(identity)	go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005768"(endosome)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0043196"(varicosity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048156"(tau protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060987"(lipid tube)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|rcsb pdb:1BB9|reactome:R-RNO-8856828|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|rgd:621786|refseq:NP_446411.1|mint:O08839|dip:DIP-30979N|mint:MINT-412640(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5|comment:GST pull-down is from rat brain cytosol.|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/05/04	2014/10/16	rogid:wpLSa4t2I+sHqUBOftWeW3eCayU9913	rogid:xqcXQWo+FXHjCGGI0Q9agaz9LMk10116	intact-crc:E5FE07333C023E32|rigid:AAwS2y54OftnhCXXxfRQ4w+veIs	false	binding-associated region:1-579(MINT-412633)|tag:?-?(MINT-412635)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:P18484	uniprotkb:P49951	intact:EBI-539360	intact:EBI-448355|ensembl:ENSBTAP00000060092	psi-mi:ap2a2_rat(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-2(gene name synonym)|uniprotkb:Alpha2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit(gene name synonym)|uniprotkb:Alpha-adaptin C(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-C large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein C(gene name synonym)|uniprotkb:Ap2a2(gene name)|psi-mi:Ap2a2(display_short)|uniprotkb:Adtab(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-2(gene name synonym)	psi-mi:clh1_bovin(display_long)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)	psi-mi:"MI:0096"(pull down)	Drake et al. (2000)	pubmed:10692452|mint:MINT-5212271	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7202879|mint:MINT-58301	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:71015|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|rcsb pdb:2VGL|rcsb pdb:2XA7|go:"GO:0008021"(synaptic vesicle)|rcsb pdb:4NEE|rcsb pdb:4UQI|rcsb pdb:6OWT|rcsb pdb:6QH5|rcsb pdb:6QH6|rcsb pdb:6QH7|go:"GO:0019900"(kinase binding)|rcsb pdb:6URI|rcsb pdb:6YAE|rcsb pdb:6YAF|rcsb pdb:6YAH|reactome:R-RNO-177504|reactome:R-RNO-2132295|reactome:R-RNO-416993|reactome:R-RNO-437239|reactome:R-RNO-5099900|reactome:R-RNO-5140745|reactome:R-RNO-6798695|reactome:R-RNO-8856825|go:"GO:0019901"(protein kinase binding)|reactome:R-RNO-8856828|go:"GO:0019904"(protein domain specific binding)|reactome:R-RNO-8866427|reactome:R-RNO-8964038|go:"GO:0030117"(membrane coat)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140312"(cargo adaptor activity)|mint:P18484|dip:DIP-29765N|mint:MINT-412603(identity)	refseq:NP_776448.1|dip:DIP-31603N|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:P49951|rcsb pdb:1B89|rcsb pdb:1UTC|rcsb pdb:1XI4|rcsb pdb:1XI5|rcsb pdb:3GC3|rcsb pdb:3GD1|rcsb pdb:3IYV|rcsb pdb:3LVH|rcsb pdb:3QIL|rcsb pdb:5M5R|rcsb pdb:5M5S|rcsb pdb:5M5T|rcsb pdb:5M5U|rcsb pdb:5M5V|rcsb pdb:5M61|rcsb pdb:6WCJ|rcsb pdb:3LVG|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0033572"(transferrin transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|ensembl:ENSBTAG00000016708(gene)|ensembl:ENSBTAT00000077192(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|mint:MINT-412595(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F7|comment:GST pull-down is from rat brain cytosol.|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/05/04	2014/10/16	rogid:/3UaX0n3j6Lo0w7GMn0uWzL5GI010116	rogid:wpLSa4t2I+sHqUBOftWeW3eCayU9913	intact-crc:1F0509B2717E82D5|rigid:wKm66pt+z0G7LY6hvgI2pLnzyxs	false	-	tag:?-?(MINT-412598)|binding-associated region:294-319(MINT-412596)	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P62944	uniprotkb:P49951	intact:EBI-7048246|ensembl:ENSRNOP00000072290|uniprotkb:P21851|intact:MINT-122517	intact:EBI-448355|ensembl:ENSBTAP00000060092	psi-mi:ap2b1_rat(display_long)|uniprotkb:Ap2b1(gene name)|psi-mi:Ap2b1(display_short)|uniprotkb:Clapb1(gene name synonym)|uniprotkb:Beta-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 beta large chain(gene name synonym)|uniprotkb:AP105B(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit beta(gene name synonym)|uniprotkb:Beta-2-adaptin(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit beta(gene name synonym)	psi-mi:clh1_bovin(display_long)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)	psi-mi:"MI:0096"(pull down)	Drake et al. (2000)	pubmed:10692452|mint:MINT-5212271	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7202897|mint:MINT-58302	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008766157.1|refseq:XP_008766158.1|refseq:XP_008766159.1|refseq:XP_008766160.1|refseq:XP_008766161.1|ensembl:ENSRNOG00000061543(gene)|ensembl:ENSRNOT00000085799(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007507"(heart development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030118"(clathrin coat)|go:"GO:0030119"(AP-type membrane coat adaptor complex)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0035904"(aorta development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR000225(Armadillo)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|mint:P62944|rcsb pdb:3H1Z|rcsb pdb:3HS9|rcsb pdb:6OWT|reactome:R-RNO-177504|reactome:R-RNO-2132295|reactome:R-RNO-416993|reactome:R-RNO-437239|reactome:R-RNO-5099900|reactome:R-RNO-5140745|go:"GO:0072583"(clathrin-dependent endocytosis)|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8866427|reactome:R-RNO-8964038|refseq:XP_017452462.1|refseq:NP_542150.1|rgd:71048|dip:DIP-40944N|mint:MINT-412587(identity)	refseq:NP_776448.1|dip:DIP-31603N|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:P49951|rcsb pdb:1B89|rcsb pdb:1UTC|rcsb pdb:1XI4|rcsb pdb:1XI5|rcsb pdb:3GC3|rcsb pdb:3GD1|rcsb pdb:3IYV|rcsb pdb:3LVH|rcsb pdb:3QIL|rcsb pdb:5M5R|rcsb pdb:5M5S|rcsb pdb:5M5T|rcsb pdb:5M5U|rcsb pdb:5M5V|rcsb pdb:5M61|rcsb pdb:6WCJ|rcsb pdb:3LVG|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0033572"(transferrin transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|ensembl:ENSBTAG00000016708(gene)|ensembl:ENSBTAT00000077192(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|mint:MINT-412579(identity)	-	function:Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP2B1 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositides|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F7|comment:GST pull-down is from rat brain cytosol.|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/05/04	2014/10/16	rogid:Q5oFhdE1hcmqu7xLG3MteCu0Zcg10116	rogid:wpLSa4t2I+sHqUBOftWeW3eCayU9913	intact-crc:7F0DDF028DE70B42|rigid:BK5RhGwaSOqNRP3NS4WqCnLYdcA	false	-	tag:?-?(MINT-412582)|binding-associated region:294-319(MINT-412580)	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P08081	uniprotkb:P49951	intact:EBI-916140|ensembl:ENSRNOP00000019737	intact:EBI-448355|ensembl:ENSBTAP00000060092	psi-mi:clca_rat(display_long)|uniprotkb:Clta(gene name)|psi-mi:Clta(display_short)	psi-mi:clh1_bovin(display_long)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)	psi-mi:"MI:0096"(pull down)	Drake et al. (2000)	pubmed:10692452|mint:MINT-5212271	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7202861|mint:MINT-58300	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000014635(gene)|ensembl:ENSRNOT00000019737(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007049"(cell cycle)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0042277"(peptide binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098843"(postsynaptic endocytic zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|mint:P08081|reactome:R-RNO-177504|reactome:R-RNO-190873|reactome:R-RNO-196025|reactome:R-RNO-2132295|reactome:R-RNO-432720|reactome:R-RNO-432722|reactome:R-RNO-437239|reactome:R-RNO-5099900|reactome:R-RNO-5140745|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8866427|reactome:R-RNO-8964038|rgd:70919|refseq:NP_114180.1|refseq:XP_006238166.1|refseq:XP_006238168.1|dip:DIP-36947N|mint:MINT-412489(identity)	refseq:NP_776448.1|dip:DIP-31603N|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:P49951|rcsb pdb:1B89|rcsb pdb:1UTC|rcsb pdb:1XI4|rcsb pdb:1XI5|rcsb pdb:3GC3|rcsb pdb:3GD1|rcsb pdb:3IYV|rcsb pdb:3LVH|rcsb pdb:3QIL|rcsb pdb:5M5R|rcsb pdb:5M5S|rcsb pdb:5M5T|rcsb pdb:5M5U|rcsb pdb:5M5V|rcsb pdb:5M61|rcsb pdb:6WCJ|rcsb pdb:3LVG|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0033572"(transferrin transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|ensembl:ENSBTAG00000016708(gene)|ensembl:ENSBTAT00000077192(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|mint:MINT-412481(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F7|comment:GST pull-down is from rat brain cytosol.|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/05/04	2014/10/16	rogid:josnOtPnIhM+WCMg+3/jsbSvdec10116	rogid:wpLSa4t2I+sHqUBOftWeW3eCayU9913	intact-crc:730A81C2FF0464C0|rigid:of9BER5rWfGA+mbZGDpcDpQrUfM	false	-	binding-associated region:229-319(MINT-412482)|tag:?-?(MINT-412484)	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88339	uniprotkb:P18484	intact:EBI-7066728|intact:MINT-101104	intact:EBI-539360	psi-mi:epn1_rat(display_long)|uniprotkb:Epn1(gene name)|psi-mi:Epn1(display_short)|uniprotkb:EPS-15-interacting protein 1(gene name synonym)	psi-mi:ap2a2_rat(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-2(gene name synonym)|uniprotkb:Alpha2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit(gene name synonym)|uniprotkb:Alpha-adaptin C(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-C large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein C(gene name synonym)|uniprotkb:Ap2a2(gene name)|psi-mi:Ap2a2(display_short)|uniprotkb:Adtab(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Drake et al. (2000)	pubmed:10692452|mint:MINT-5212271	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7202943|mint:MINT-58280	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:O88339|go:"GO:1905445"(positive regulation of clathrin coat assembly)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|rcsb pdb:1EDU|rcsb pdb:1EYH|rcsb pdb:1H0A|rcsb pdb:1KY6|reactome:R-RNO-182971|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0090148"(membrane fission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|rgd:619772|refseq:NP_476477.1|dip:DIP-40738N|mint:MINT-412515(identity)	rgd:71015|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|rcsb pdb:2VGL|rcsb pdb:2XA7|go:"GO:0008021"(synaptic vesicle)|rcsb pdb:4NEE|rcsb pdb:4UQI|rcsb pdb:6OWT|rcsb pdb:6QH5|rcsb pdb:6QH6|rcsb pdb:6QH7|go:"GO:0019900"(kinase binding)|rcsb pdb:6URI|rcsb pdb:6YAE|rcsb pdb:6YAF|rcsb pdb:6YAH|reactome:R-RNO-177504|reactome:R-RNO-2132295|reactome:R-RNO-416993|reactome:R-RNO-437239|reactome:R-RNO-5099900|reactome:R-RNO-5140745|reactome:R-RNO-6798695|reactome:R-RNO-8856825|go:"GO:0019901"(protein kinase binding)|reactome:R-RNO-8856828|go:"GO:0019904"(protein domain specific binding)|reactome:R-RNO-8866427|reactome:R-RNO-8964038|go:"GO:0030117"(membrane coat)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140312"(cargo adaptor activity)|mint:P18484|dip:DIP-29765N|mint:MINT-412523(identity)	-	comment:mint|function:"Binds to membranes enriched in phosphatidylinositol-4,5-biphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. Regulates receptor-mediated endocytosis"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1 F4|comment:GST pull-down from rat brain cytosol|comment:homomint|comment:mint	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2005/05/04	2014/10/16	rogid:HSxImXvS6/UJyI9kGWz36B0oxiM10116	rogid:/3UaX0n3j6Lo0w7GMn0uWzL5GI010116	intact-crc:15665C8B65120F54|rigid:EeQtUffp/rfYecIrxI0m150hwkk	false	binding-associated region:229-407(MINT-412516)|tag:?-?(MINT-412518)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:O88339	uniprotkb:Q8R525	intact:EBI-7066728|intact:MINT-101104	intact:EBI-7048152|intact:MINT-122799	psi-mi:epn1_rat(display_long)|uniprotkb:Epn1(gene name)|psi-mi:Epn1(display_short)|uniprotkb:EPS-15-interacting protein 1(gene name synonym)	psi-mi:q8r525_rat(display_long)	psi-mi:"MI:0096"(pull down)	Drake et al. (2000)	pubmed:10692452|mint:MINT-5212271	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7203004|mint:MINT-58282	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:O88339|go:"GO:1905445"(positive regulation of clathrin coat assembly)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|rcsb pdb:1EDU|rcsb pdb:1EYH|rcsb pdb:1H0A|rcsb pdb:1KY6|reactome:R-RNO-182971|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0090148"(membrane fission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|rgd:619772|refseq:NP_476477.1|dip:DIP-40738N|mint:MINT-412666(identity)	mint:Q8R525|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0098793"(presynapse)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR011989(Armadillo-like helical)|mint:MINT-412675(identity)	-	comment:mint|function:"Binds to membranes enriched in phosphatidylinositol-4,5-biphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. Regulates receptor-mediated endocytosis"|comment:"Stoichiometry: 1.0"	comment:"fragmentation type: fragment"|comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F1|comment:GST pull-down is from rat brain cytosol.|comment:mint	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2005/05/04	2014/10/16	rogid:HSxImXvS6/UJyI9kGWz36B0oxiM10116	rogid:Wf7CrhWRGmhGIVds6LBR3KkFC8A10116	intact-crc:5197A7DB6E88F9C0|rigid:VEJcR+ucczjhOMpwUtsmw6TAzvc	false	tag:?-?(MINT-412670)|binding-associated region:229-407(MINT-412667)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:O88339	uniprotkb:P08081	intact:EBI-7066728|intact:MINT-101104	intact:EBI-916140|ensembl:ENSRNOP00000019737	psi-mi:epn1_rat(display_long)|uniprotkb:Epn1(gene name)|psi-mi:Epn1(display_short)|uniprotkb:EPS-15-interacting protein 1(gene name synonym)	psi-mi:clca_rat(display_long)|uniprotkb:Clta(gene name)|psi-mi:Clta(display_short)	psi-mi:"MI:0096"(pull down)	Drake et al. (2000)	pubmed:10692452|mint:MINT-5212271	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7202962|mint:MINT-58281	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:O88339|go:"GO:1905445"(positive regulation of clathrin coat assembly)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|rcsb pdb:1EDU|rcsb pdb:1EYH|rcsb pdb:1H0A|rcsb pdb:1KY6|reactome:R-RNO-182971|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0090148"(membrane fission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|rgd:619772|refseq:NP_476477.1|dip:DIP-40738N|mint:MINT-412684(identity)	ensembl:ENSRNOG00000014635(gene)|ensembl:ENSRNOT00000019737(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007049"(cell cycle)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0042277"(peptide binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098843"(postsynaptic endocytic zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|mint:P08081|reactome:R-RNO-177504|reactome:R-RNO-190873|reactome:R-RNO-196025|reactome:R-RNO-2132295|reactome:R-RNO-432720|reactome:R-RNO-432722|reactome:R-RNO-437239|reactome:R-RNO-5099900|reactome:R-RNO-5140745|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8866427|reactome:R-RNO-8964038|rgd:70919|refseq:NP_114180.1|refseq:XP_006238166.1|refseq:XP_006238168.1|dip:DIP-36947N|mint:MINT-412696(identity)	-	comment:mint|function:"Binds to membranes enriched in phosphatidylinositol-4,5-biphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. Regulates receptor-mediated endocytosis"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:GST pull-down is from rat brain cytosol.|figure legend:F1 F4|comment:homomint|comment:mint	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2005/05/04	2014/10/16	rogid:HSxImXvS6/UJyI9kGWz36B0oxiM10116	rogid:josnOtPnIhM+WCMg+3/jsbSvdec10116	intact-crc:645AFC8153D51683|rigid:AWHg3/HeZ2YCJIm/KPW6EGSXq9I	false	mutation decreasing interaction:260-263,257-259(MINT-412688)|tag:?-?(MINT-412691)|binding-associated region:229-407(MINT-412685)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:O88339	uniprotkb:P84092	intact:EBI-7066728|intact:MINT-101104	intact:EBI-297693|uniprotkb:P53679|uniprotkb:P20172|ensembl:ENSRNOP00000070202	psi-mi:epn1_rat(display_long)|uniprotkb:Epn1(gene name)|psi-mi:Epn1(display_short)|uniprotkb:EPS-15-interacting protein 1(gene name synonym)	psi-mi:ap2m1_rat(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit mu(gene name synonym)|uniprotkb:AP-2 mu chain(gene name synonym)|uniprotkb:Ap2m1(gene name)|psi-mi:Ap2m1(display_short)|uniprotkb:Mu2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor AP-2 50 kDa protein(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP50(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP50(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 mu medium chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit mu(gene name synonym)	psi-mi:"MI:0096"(pull down)	Drake et al. (2000)	pubmed:10692452|mint:MINT-5212271	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7203045|mint:MINT-58284	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:O88339|go:"GO:1905445"(positive regulation of clathrin coat assembly)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|rcsb pdb:1EDU|rcsb pdb:1EYH|rcsb pdb:1H0A|rcsb pdb:1KY6|reactome:R-RNO-182971|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0090148"(membrane fission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|rgd:619772|refseq:NP_476477.1|dip:DIP-40738N|mint:MINT-412737(identity)	go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR022775|interpro:IPR028565|interpro:IPR036168|interpro:IPR043512|interpro:IPR043532|mint:P84092|rcsb pdb:1BW8|rcsb pdb:1BXX|rcsb pdb:1HES|rcsb pdb:1I31|rcsb pdb:2BP5|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2PR9|rcsb pdb:2VGL|rcsb pdb:2XA7|rcsb pdb:3H85|rcsb pdb:3ML6|rcsb pdb:4UQI|rcsb pdb:5C7Z|rcsb pdb:5FPI|rcsb pdb:5WRK|go:"GO:0097718"(disordered domain specific binding)|rcsb pdb:5WRL|rcsb pdb:5WRM|rcsb pdb:6QH5|rcsb pdb:6QH6|rcsb pdb:6RH6|rcsb pdb:6YAE|rcsb pdb:6YAF|rcsb pdb:6YAH|reactome:R-RNO-177504|reactome:R-RNO-190873|reactome:R-RNO-196025|reactome:R-RNO-2132295|reactome:R-RNO-416993|reactome:R-RNO-437239|reactome:R-RNO-5099900|reactome:R-RNO-5140745|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8866427|reactome:R-RNO-8964038|ensembl:ENSRNOG00000001709(gene)|ensembl:ENSRNOT00000088821(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008289"(lipid binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097494"(regulation of vesicle size)|rgd:620135|refseq:NP_446289.1|dip:DIP-29761N|mint:MINT-412746(identity)	-	comment:mint|function:"Binds to membranes enriched in phosphatidylinositol-4,5-biphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. Regulates receptor-mediated endocytosis"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1|comment:GST pull-down is from rat brain cytosol.|comment:homomint|comment:mint	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2005/05/04	2014/10/16	rogid:HSxImXvS6/UJyI9kGWz36B0oxiM10116	rogid:AyJEJTqzHtIRWEnMGBzLQP3H5lA10116	intact-crc:E3F3414A21DC3A45|rigid:AArCAMgDrly0lHWqlEUZmI7nuHU	false	binding-associated region:229-407(MINT-412738)|tag:?-?(MINT-412741)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:O88339	uniprotkb:P08081	intact:EBI-7066728|intact:MINT-101104	intact:EBI-916140|ensembl:ENSRNOP00000019737	psi-mi:epn1_rat(display_long)|uniprotkb:Epn1(gene name)|psi-mi:Epn1(display_short)|uniprotkb:EPS-15-interacting protein 1(gene name synonym)	psi-mi:clca_rat(display_long)|uniprotkb:Clta(gene name)|psi-mi:Clta(display_short)	psi-mi:"MI:0096"(pull down)	Drake et al. (2000)	pubmed:10692452|mint:MINT-5212271	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7203066|mint:MINT-58288	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:O88339|go:"GO:1905445"(positive regulation of clathrin coat assembly)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|rcsb pdb:1EDU|rcsb pdb:1EYH|rcsb pdb:1H0A|rcsb pdb:1KY6|reactome:R-RNO-182971|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0090148"(membrane fission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|rgd:619772|refseq:NP_476477.1|dip:DIP-40738N|mint:MINT-412611(identity)	ensembl:ENSRNOG00000014635(gene)|ensembl:ENSRNOT00000019737(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007049"(cell cycle)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0042277"(peptide binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098843"(postsynaptic endocytic zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|mint:P08081|reactome:R-RNO-177504|reactome:R-RNO-190873|reactome:R-RNO-196025|reactome:R-RNO-2132295|reactome:R-RNO-432720|reactome:R-RNO-432722|reactome:R-RNO-437239|reactome:R-RNO-5099900|reactome:R-RNO-5140745|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8866427|reactome:R-RNO-8964038|rgd:70919|refseq:NP_114180.1|refseq:XP_006238166.1|refseq:XP_006238168.1|dip:DIP-36947N|mint:MINT-412623(identity)	-	comment:mint|function:"Binds to membranes enriched in phosphatidylinositol-4,5-biphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. Regulates receptor-mediated endocytosis"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5|comment:GST pull-down is from rat brain cytosol.|comment:homomint|comment:mint	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2005/05/04	2014/10/16	rogid:HSxImXvS6/UJyI9kGWz36B0oxiM10116	rogid:josnOtPnIhM+WCMg+3/jsbSvdec10116	intact-crc:B7DDAC539618EE63|rigid:AWHg3/HeZ2YCJIm/KPW6EGSXq9I	false	binding-associated region:229-407(MINT-412612)|mutation decreasing interaction:257-259,260-263(MINT-412615)|tag:?-?(MINT-412618)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:O88339	uniprotkb:P62944	intact:EBI-7066728|intact:MINT-101104	intact:EBI-7048246|ensembl:ENSRNOP00000072290|uniprotkb:P21851|intact:MINT-122517	psi-mi:epn1_rat(display_long)|uniprotkb:Epn1(gene name)|psi-mi:Epn1(display_short)|uniprotkb:EPS-15-interacting protein 1(gene name synonym)	psi-mi:ap2b1_rat(display_long)|uniprotkb:Ap2b1(gene name)|psi-mi:Ap2b1(display_short)|uniprotkb:Clapb1(gene name synonym)|uniprotkb:Beta-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 beta large chain(gene name synonym)|uniprotkb:AP105B(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit beta(gene name synonym)|uniprotkb:Beta-2-adaptin(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Drake et al. (2000)	pubmed:10692452|mint:MINT-5212271	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7203024|mint:MINT-58283	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:O88339|go:"GO:1905445"(positive regulation of clathrin coat assembly)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|rcsb pdb:1EDU|rcsb pdb:1EYH|rcsb pdb:1H0A|rcsb pdb:1KY6|reactome:R-RNO-182971|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0090148"(membrane fission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|rgd:619772|refseq:NP_476477.1|dip:DIP-40738N|mint:MINT-412648(identity)	refseq:XP_008766157.1|refseq:XP_008766158.1|refseq:XP_008766159.1|refseq:XP_008766160.1|refseq:XP_008766161.1|ensembl:ENSRNOG00000061543(gene)|ensembl:ENSRNOT00000085799(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007507"(heart development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030118"(clathrin coat)|go:"GO:0030119"(AP-type membrane coat adaptor complex)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0035904"(aorta development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR000225(Armadillo)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|mint:P62944|rcsb pdb:3H1Z|rcsb pdb:3HS9|rcsb pdb:6OWT|reactome:R-RNO-177504|reactome:R-RNO-2132295|reactome:R-RNO-416993|reactome:R-RNO-437239|reactome:R-RNO-5099900|reactome:R-RNO-5140745|go:"GO:0072583"(clathrin-dependent endocytosis)|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8866427|reactome:R-RNO-8964038|refseq:XP_017452462.1|refseq:NP_542150.1|rgd:71048|dip:DIP-40944N|mint:MINT-412657(identity)	-	comment:mint|function:"Binds to membranes enriched in phosphatidylinositol-4,5-biphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. Regulates receptor-mediated endocytosis"|comment:"Stoichiometry: 1.0"	function:Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP2B1 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositides|comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F1|comment:GST pull-down is from rat brain cytosol.|comment:homomint|comment:mint	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2005/05/04	2014/10/16	rogid:HSxImXvS6/UJyI9kGWz36B0oxiM10116	rogid:Q5oFhdE1hcmqu7xLG3MteCu0Zcg10116	intact-crc:C85BE2B3AA90D1D4|rigid:cA3sKMj6FcIcQJ9/3g8AQAk9EPQ	false	binding-associated region:229-407(MINT-412649)|tag:?-?(MINT-412652)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:O88339	uniprotkb:P11442	intact:EBI-7066728|intact:MINT-101104	intact:EBI-397997	psi-mi:epn1_rat(display_long)|uniprotkb:Epn1(gene name)|psi-mi:Epn1(display_short)|uniprotkb:EPS-15-interacting protein 1(gene name synonym)	psi-mi:clh1_rat(display_long)|uniprotkb:Cltc(gene name)|psi-mi:Cltc(display_short)	psi-mi:"MI:0096"(pull down)	Drake et al. (2000)	pubmed:10692452|mint:MINT-5212271	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7203093|mint:MINT-58289	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:O88339|go:"GO:1905445"(positive regulation of clathrin coat assembly)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|rcsb pdb:1EDU|rcsb pdb:1EYH|rcsb pdb:1H0A|rcsb pdb:1KY6|reactome:R-RNO-182971|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0090148"(membrane fission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|rgd:619772|refseq:NP_476477.1|dip:DIP-40738N|mint:MINT-412755(identity)	rgd:2364|refseq:NP_062172.1|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030118"(clathrin coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042277"(peptide binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043195"(terminal bouton)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|rcsb pdb:1BPO|rcsb pdb:1C9I|rcsb pdb:1C9L|reactome:R-RNO-177504|reactome:R-RNO-190873|reactome:R-RNO-196025|reactome:R-RNO-2132295|reactome:R-RNO-432720|reactome:R-RNO-432722|reactome:R-RNO-437239|reactome:R-RNO-5099900|reactome:R-RNO-5140745|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8866427|reactome:R-RNO-8964038|reactome:R-RNO-9013420|reactome:R-RNO-9013424|mint:P11442|dip:DIP-36966N|mint:MINT-412767(identity)	-	comment:mint|function:"Binds to membranes enriched in phosphatidylinositol-4,5-biphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. Regulates receptor-mediated endocytosis"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:GST pull-down is from rat brain cytosol.|figure legend:F1 F4|comment:homomint|comment:mint	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2005/05/04	2014/10/16	rogid:HSxImXvS6/UJyI9kGWz36B0oxiM10116	rogid:IRKdzbAIpw7D7qHqyxStNyfI38g10116	intact-crc:DE5B671EEC328D4B|rigid:nqGRMjOPQVgISecmFIi2nlgepeg	false	mutation decreasing interaction:257-259,260-263(MINT-412759)|tag:?-?(MINT-412762)|binding-associated region:229-407(MINT-412756)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)