#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9Y2T3 uniprotkb:Q92796 intact:EBI-7125239|ensembl:ENSP00000351170|ensembl:ENSP00000436619|intact:MINT-109340|intact:MINT-4888642|uniprotkb:Q5SZC7|uniprotkb:B4DTY5|uniprotkb:Q9ULG2|uniprotkb:Q9H335 intact:EBI-80440|ensembl:ENSP00000363480|uniprotkb:Q9ULI8|uniprotkb:Q5JUW7|uniprotkb:D3DVU5|uniprotkb:B4E0H1|uniprotkb:Q5JUW6 psi-mi:guad_human(display_long)|uniprotkb:GDA(gene name)|psi-mi:GDA(display_short)|uniprotkb:KIAA1258(gene name synonym)|uniprotkb:Guanine aminohydrolase(gene name synonym)|uniprotkb:p51-nedasin(gene name synonym) psi-mi:dlg3_human(display_long)|uniprotkb:DLG3(gene name)|psi-mi:DLG3(display_short)|uniprotkb:KIAA1232(gene name synonym)|uniprotkb:Synapse-associated protein 102(gene name synonym)|uniprotkb:Neuroendocrine-DLG(gene name synonym)|uniprotkb:XLMR(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Kuwahara et al. (1999) pubmed:10542258|mint:MINT-5211936 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7125234|mint:MINT-72690 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000119125(gene)|ensembl:ENST00000358399(transcript)|ensembl:ENST00000475764(transcript)|go:"GO:0000255"(allantoin metabolic process)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005829"(cytosol)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006147"(guanine catabolic process)|go:"GO:0006161"(deoxyguanosine catabolic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008892"(guanine deaminase activity)|go:"GO:0019239"(deaminase activity)|go:"GO:0046038"(GMP catabolic process)|go:"GO:0046055"(dGMP catabolic process)|go:"GO:0046098"(guanine metabolic process)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR014311(Guanine deaminase)|interpro:IPR032466|rcsb pdb:2UZ9|rcsb pdb:3E0L|rcsb pdb:4AQL|reactome:R-HSA-74259|refseq:NP_001229434.1|refseq:NP_001229435.1|refseq:NP_004284.1|refseq:NP_001229436.1|refseq:XP_005252374.1|refseq:XP_016870825.1|mint:MINT-376327(identity) ensembl:ENSG00000082458(gene)|ensembl:ENST00000374360(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019900"(kinase binding)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035763|interpro:IPR036028|interpro:IPR036034|rcsb pdb:1UM7|rcsb pdb:2FE5|rcsb pdb:2I1N|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|refseq:NP_001159750.1|refseq:NP_065781.1|refseq:NP_066943.2|refseq:XP_005262305.1|refseq:XP_016884815.1|mint:MINT-376322(identity) - comment:mint|function:Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F6C|comment:homomint|comment:mint taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain) - 2005/11/24 2014/10/16 rogid:ztSCAP6PF1P5jOFWSLNECi2JMGc9606 rogid:mnuw5iq2NexP1BL90IuQ1i21xo89606 intact-crc:1F082908DE3AFEBA|rigid:nWQy0HKtIOmuGhMUEjxfm57LUxc false - - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:Q9Y2T3 uniprotkb:Q92796 intact:EBI-7125239|ensembl:ENSP00000351170|ensembl:ENSP00000436619|intact:MINT-109340|intact:MINT-4888642|uniprotkb:Q5SZC7|uniprotkb:B4DTY5|uniprotkb:Q9ULG2|uniprotkb:Q9H335 intact:EBI-80440|ensembl:ENSP00000363480|uniprotkb:Q9ULI8|uniprotkb:Q5JUW7|uniprotkb:D3DVU5|uniprotkb:B4E0H1|uniprotkb:Q5JUW6 psi-mi:guad_human(display_long)|uniprotkb:GDA(gene name)|psi-mi:GDA(display_short)|uniprotkb:KIAA1258(gene name synonym)|uniprotkb:Guanine aminohydrolase(gene name synonym)|uniprotkb:p51-nedasin(gene name synonym) psi-mi:dlg3_human(display_long)|uniprotkb:DLG3(gene name)|psi-mi:DLG3(display_short)|uniprotkb:KIAA1232(gene name synonym)|uniprotkb:Synapse-associated protein 102(gene name synonym)|uniprotkb:Neuroendocrine-DLG(gene name synonym)|uniprotkb:XLMR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kuwahara et al. (1999) pubmed:10542258|mint:MINT-5211936 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7125369|mint:MINT-72686 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000119125(gene)|ensembl:ENST00000358399(transcript)|ensembl:ENST00000475764(transcript)|go:"GO:0000255"(allantoin metabolic process)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005829"(cytosol)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006147"(guanine catabolic process)|go:"GO:0006161"(deoxyguanosine catabolic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008892"(guanine deaminase activity)|go:"GO:0019239"(deaminase activity)|go:"GO:0046038"(GMP catabolic process)|go:"GO:0046055"(dGMP catabolic process)|go:"GO:0046098"(guanine metabolic process)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR014311(Guanine deaminase)|interpro:IPR032466|rcsb pdb:2UZ9|rcsb pdb:3E0L|rcsb pdb:4AQL|reactome:R-HSA-74259|refseq:NP_001229434.1|refseq:NP_001229435.1|refseq:NP_004284.1|refseq:NP_001229436.1|refseq:XP_005252374.1|refseq:XP_016870825.1|mint:MINT-1650234(identity) ensembl:ENSG00000082458(gene)|ensembl:ENST00000374360(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019900"(kinase binding)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035763|interpro:IPR036028|interpro:IPR036034|rcsb pdb:1UM7|rcsb pdb:2FE5|rcsb pdb:2I1N|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|refseq:NP_001159750.1|refseq:NP_065781.1|refseq:NP_066943.2|refseq:XP_005262305.1|refseq:XP_016884815.1|mint:MINT-1650227(identity) - comment:mint|function:Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F5|comment:homomint|comment:mint taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2005/11/24 2014/10/16 rogid:ztSCAP6PF1P5jOFWSLNECi2JMGc9606 rogid:mnuw5iq2NexP1BL90IuQ1i21xo89606 intact-crc:D9CFAB1C14D5452F|rigid:nWQy0HKtIOmuGhMUEjxfm57LUxc false myc tag:?-?(MINT-1650235) ha tag:?-?(MINT-1650228) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9Y2T3 uniprotkb:Q92796 intact:EBI-7125239|ensembl:ENSP00000351170|ensembl:ENSP00000436619|intact:MINT-109340|intact:MINT-4888642|uniprotkb:Q5SZC7|uniprotkb:B4DTY5|uniprotkb:Q9ULG2|uniprotkb:Q9H335 intact:EBI-80440|ensembl:ENSP00000363480|uniprotkb:Q9ULI8|uniprotkb:Q5JUW7|uniprotkb:D3DVU5|uniprotkb:B4E0H1|uniprotkb:Q5JUW6 psi-mi:guad_human(display_long)|uniprotkb:GDA(gene name)|psi-mi:GDA(display_short)|uniprotkb:KIAA1258(gene name synonym)|uniprotkb:Guanine aminohydrolase(gene name synonym)|uniprotkb:p51-nedasin(gene name synonym) psi-mi:dlg3_human(display_long)|uniprotkb:DLG3(gene name)|psi-mi:DLG3(display_short)|uniprotkb:KIAA1232(gene name synonym)|uniprotkb:Synapse-associated protein 102(gene name synonym)|uniprotkb:Neuroendocrine-DLG(gene name synonym)|uniprotkb:XLMR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kuwahara et al. (1999) pubmed:10542258|mint:MINT-5211936 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7125419|mint:MINT-72689 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000119125(gene)|ensembl:ENST00000358399(transcript)|ensembl:ENST00000475764(transcript)|go:"GO:0000255"(allantoin metabolic process)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005829"(cytosol)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006147"(guanine catabolic process)|go:"GO:0006161"(deoxyguanosine catabolic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008892"(guanine deaminase activity)|go:"GO:0019239"(deaminase activity)|go:"GO:0046038"(GMP catabolic process)|go:"GO:0046055"(dGMP catabolic process)|go:"GO:0046098"(guanine metabolic process)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR014311(Guanine deaminase)|interpro:IPR032466|rcsb pdb:2UZ9|rcsb pdb:3E0L|rcsb pdb:4AQL|reactome:R-HSA-74259|refseq:NP_001229434.1|refseq:NP_001229435.1|refseq:NP_004284.1|refseq:NP_001229436.1|refseq:XP_005252374.1|refseq:XP_016870825.1|mint:MINT-376344(identity) ensembl:ENSG00000082458(gene)|ensembl:ENST00000374360(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019900"(kinase binding)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035763|interpro:IPR036028|interpro:IPR036034|rcsb pdb:1UM7|rcsb pdb:2FE5|rcsb pdb:2I1N|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|refseq:NP_001159750.1|refseq:NP_065781.1|refseq:NP_066943.2|refseq:XP_005262305.1|refseq:XP_016884815.1|mint:MINT-376337(identity) - comment:mint|function:Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F5|comment:homomint|comment:mint taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2005/11/24 2014/10/16 rogid:ztSCAP6PF1P5jOFWSLNECi2JMGc9606 rogid:mnuw5iq2NexP1BL90IuQ1i21xo89606 intact-crc:0ED307BD3EA0D80C|rigid:nWQy0HKtIOmuGhMUEjxfm57LUxc false myc tag:?-?(MINT-376345) ha tag:?-?(MINT-376338) - - psi-mi:"MI:0072"(monoclonal antibody western blot) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:Q9Y2T3 uniprotkb:Q92796 intact:EBI-7125239|ensembl:ENSP00000351170|ensembl:ENSP00000436619|intact:MINT-109340|intact:MINT-4888642|uniprotkb:Q5SZC7|uniprotkb:B4DTY5|uniprotkb:Q9ULG2|uniprotkb:Q9H335 intact:EBI-80440|ensembl:ENSP00000363480|uniprotkb:Q9ULI8|uniprotkb:Q5JUW7|uniprotkb:D3DVU5|uniprotkb:B4E0H1|uniprotkb:Q5JUW6 psi-mi:guad_human(display_long)|uniprotkb:GDA(gene name)|psi-mi:GDA(display_short)|uniprotkb:KIAA1258(gene name synonym)|uniprotkb:Guanine aminohydrolase(gene name synonym)|uniprotkb:p51-nedasin(gene name synonym) psi-mi:dlg3_human(display_long)|uniprotkb:DLG3(gene name)|psi-mi:DLG3(display_short)|uniprotkb:KIAA1232(gene name synonym)|uniprotkb:Synapse-associated protein 102(gene name synonym)|uniprotkb:Neuroendocrine-DLG(gene name synonym)|uniprotkb:XLMR(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Kuwahara et al. (1999) pubmed:10542258|mint:MINT-5211936 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7125486|mint:MINT-72685 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000119125(gene)|ensembl:ENST00000358399(transcript)|ensembl:ENST00000475764(transcript)|go:"GO:0000255"(allantoin metabolic process)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005829"(cytosol)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006147"(guanine catabolic process)|go:"GO:0006161"(deoxyguanosine catabolic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008892"(guanine deaminase activity)|go:"GO:0019239"(deaminase activity)|go:"GO:0046038"(GMP catabolic process)|go:"GO:0046055"(dGMP catabolic process)|go:"GO:0046098"(guanine metabolic process)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR014311(Guanine deaminase)|interpro:IPR032466|rcsb pdb:2UZ9|rcsb pdb:3E0L|rcsb pdb:4AQL|reactome:R-HSA-74259|refseq:NP_001229434.1|refseq:NP_001229435.1|refseq:NP_004284.1|refseq:NP_001229436.1|refseq:XP_005252374.1|refseq:XP_016870825.1|mint:MINT-1568766(identity) ensembl:ENSG00000082458(gene)|ensembl:ENST00000374360(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019900"(kinase binding)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035763|interpro:IPR036028|interpro:IPR036034|rcsb pdb:1UM7|rcsb pdb:2FE5|rcsb pdb:2I1N|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|refseq:NP_001159750.1|refseq:NP_065781.1|refseq:NP_066943.2|refseq:XP_005262305.1|refseq:XP_016884815.1|mint:MINT-1568756(identity) - comment:mint|function:Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F4C|comment:homomint|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/11/24 2014/10/16 rogid:ztSCAP6PF1P5jOFWSLNECi2JMGc9606 rogid:mnuw5iq2NexP1BL90IuQ1i21xo89606 intact-crc:A5512109B752CEDC|rigid:nWQy0HKtIOmuGhMUEjxfm57LUxc false myc tag:?-?(MINT-1568767) binding-associated region:131-310(MINT-1568757)|glutathione s tranferase tag:?-?(MINT-1568760) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9Y2T3 uniprotkb:Q92796 intact:EBI-7125239|ensembl:ENSP00000351170|ensembl:ENSP00000436619|intact:MINT-109340|intact:MINT-4888642|uniprotkb:Q5SZC7|uniprotkb:B4DTY5|uniprotkb:Q9ULG2|uniprotkb:Q9H335 intact:EBI-80440|ensembl:ENSP00000363480|uniprotkb:Q9ULI8|uniprotkb:Q5JUW7|uniprotkb:D3DVU5|uniprotkb:B4E0H1|uniprotkb:Q5JUW6 psi-mi:guad_human(display_long)|uniprotkb:GDA(gene name)|psi-mi:GDA(display_short)|uniprotkb:KIAA1258(gene name synonym)|uniprotkb:Guanine aminohydrolase(gene name synonym)|uniprotkb:p51-nedasin(gene name synonym) psi-mi:dlg3_human(display_long)|uniprotkb:DLG3(gene name)|psi-mi:DLG3(display_short)|uniprotkb:KIAA1232(gene name synonym)|uniprotkb:Synapse-associated protein 102(gene name synonym)|uniprotkb:Neuroendocrine-DLG(gene name synonym)|uniprotkb:XLMR(gene name synonym) psi-mi:"MI:0096"(pull down) Kuwahara et al. (1999) pubmed:10542258|mint:MINT-5211936 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7125577|mint:MINT-72657 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000119125(gene)|ensembl:ENST00000358399(transcript)|ensembl:ENST00000475764(transcript)|go:"GO:0000255"(allantoin metabolic process)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005829"(cytosol)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006147"(guanine catabolic process)|go:"GO:0006161"(deoxyguanosine catabolic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008892"(guanine deaminase activity)|go:"GO:0019239"(deaminase activity)|go:"GO:0046038"(GMP catabolic process)|go:"GO:0046055"(dGMP catabolic process)|go:"GO:0046098"(guanine metabolic process)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR014311(Guanine deaminase)|interpro:IPR032466|rcsb pdb:2UZ9|rcsb pdb:3E0L|rcsb pdb:4AQL|reactome:R-HSA-74259|refseq:NP_001229434.1|refseq:NP_001229435.1|refseq:NP_004284.1|refseq:NP_001229436.1|refseq:XP_005252374.1|refseq:XP_016870825.1|mint:MINT-1593147(identity) ensembl:ENSG00000082458(gene)|ensembl:ENST00000374360(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019900"(kinase binding)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035763|interpro:IPR036028|interpro:IPR036034|rcsb pdb:1UM7|rcsb pdb:2FE5|rcsb pdb:2I1N|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|refseq:NP_001159750.1|refseq:NP_065781.1|refseq:NP_066943.2|refseq:XP_005262305.1|refseq:XP_016884815.1|mint:MINT-1593140(identity) - comment:mint|function:Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F4A|comment:homomint|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/11/24 2014/10/16 rogid:ztSCAP6PF1P5jOFWSLNECi2JMGc9606 rogid:mnuw5iq2NexP1BL90IuQ1i21xo89606 intact-crc:872E752491310EE6|rigid:nWQy0HKtIOmuGhMUEjxfm57LUxc false myc tag:?-?(MINT-1593148) glutathione s tranferase tag:?-?(MINT-1593141) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9Y2T3 uniprotkb:Q92796 intact:EBI-7125239|ensembl:ENSP00000351170|ensembl:ENSP00000436619|intact:MINT-109340|intact:MINT-4888642|uniprotkb:Q5SZC7|uniprotkb:B4DTY5|uniprotkb:Q9ULG2|uniprotkb:Q9H335 intact:EBI-80440|ensembl:ENSP00000363480|uniprotkb:Q9ULI8|uniprotkb:Q5JUW7|uniprotkb:D3DVU5|uniprotkb:B4E0H1|uniprotkb:Q5JUW6 psi-mi:guad_human(display_long)|uniprotkb:GDA(gene name)|psi-mi:GDA(display_short)|uniprotkb:KIAA1258(gene name synonym)|uniprotkb:Guanine aminohydrolase(gene name synonym)|uniprotkb:p51-nedasin(gene name synonym) psi-mi:dlg3_human(display_long)|uniprotkb:DLG3(gene name)|psi-mi:DLG3(display_short)|uniprotkb:KIAA1232(gene name synonym)|uniprotkb:Synapse-associated protein 102(gene name synonym)|uniprotkb:Neuroendocrine-DLG(gene name synonym)|uniprotkb:XLMR(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Kuwahara et al. (1999) pubmed:10542258|mint:MINT-5211936 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7125652|mint:MINT-72705 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000119125(gene)|ensembl:ENST00000358399(transcript)|ensembl:ENST00000475764(transcript)|go:"GO:0000255"(allantoin metabolic process)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005829"(cytosol)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006147"(guanine catabolic process)|go:"GO:0006161"(deoxyguanosine catabolic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008892"(guanine deaminase activity)|go:"GO:0019239"(deaminase activity)|go:"GO:0046038"(GMP catabolic process)|go:"GO:0046055"(dGMP catabolic process)|go:"GO:0046098"(guanine metabolic process)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR014311(Guanine deaminase)|interpro:IPR032466|rcsb pdb:2UZ9|rcsb pdb:3E0L|rcsb pdb:4AQL|reactome:R-HSA-74259|refseq:NP_001229434.1|refseq:NP_001229435.1|refseq:NP_004284.1|refseq:NP_001229436.1|refseq:XP_005252374.1|refseq:XP_016870825.1|mint:MINT-1770905(identity) ensembl:ENSG00000082458(gene)|ensembl:ENST00000374360(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019900"(kinase binding)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035763|interpro:IPR036028|interpro:IPR036034|rcsb pdb:1UM7|rcsb pdb:2FE5|rcsb pdb:2I1N|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|refseq:NP_001159750.1|refseq:NP_065781.1|refseq:NP_066943.2|refseq:XP_005262305.1|refseq:XP_016884815.1|mint:MINT-1770900(identity) - comment:mint|function:Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F7|comment:The two proteins co-localized closely in neuronal cell body.|comment:homomint|comment:mint taxid:9606("human-neuronal_precursor_cells(stem cells)")|taxid:9606(Human Neuronal Precursor Cells/neural stem progenitor cells) - 2005/11/24 2014/10/16 rogid:ztSCAP6PF1P5jOFWSLNECi2JMGc9606 rogid:mnuw5iq2NexP1BL90IuQ1i21xo89606 intact-crc:35EC4F21348B40BB|rigid:nWQy0HKtIOmuGhMUEjxfm57LUxc false - - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0072"(monoclonal antibody western blot)