#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P09208	uniprotkb:P09208	intact:EBI-92063|uniprotkb:Q24023|uniprotkb:Q24089|uniprotkb:Q9VD94|uniprotkb:B7Z0N6|ensemblmetazoa:FBpp0083519|ensemblmetazoa:FBpp0288669|ensemblmetazoa:FBpp0288670|ensemblmetazoa:FBpp0288671	intact:EBI-92063|uniprotkb:Q24023|uniprotkb:Q24089|uniprotkb:Q9VD94|uniprotkb:B7Z0N6|ensemblmetazoa:FBpp0083519|ensemblmetazoa:FBpp0288669|ensemblmetazoa:FBpp0288670|ensemblmetazoa:FBpp0288671	psi-mi:insr_drome(display_long)|uniprotkb:InR(gene name)|psi-mi:InR(display_short)|uniprotkb:dinr(gene name synonym)|uniprotkb:Dir-a(gene name synonym)|uniprotkb:Inr-a(gene name synonym)|uniprotkb:dIRH(gene name synonym)|uniprotkb:CG18402(orf name)	psi-mi:insr_drome(display_long)|uniprotkb:InR(gene name)|psi-mi:InR(display_short)|uniprotkb:dinr(gene name synonym)|uniprotkb:Dir-a(gene name synonym)|uniprotkb:Inr-a(gene name synonym)|uniprotkb:dIRH(gene name synonym)|uniprotkb:CG18402(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Marin-Hincapie et al. (1999)	pubmed:10455177	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-524327	-	-	psi-mi:"MI:0503"(self)	psi-mi:"MI:0503"(self)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138093.1|refseq:NP_001138094.1|refseq:NP_001138095.1|refseq:NP_524436.2|flybase:FBgn0283499|go:"GO:0007411"(axon guidance)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007446"(imaginal disc growth)|go:"GO:0007568"(aging)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008585"(female gonad development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0033500"(carbohydrate homeostasis)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034059"(response to anoxia)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042321"(negative regulation of circadian sleep/wake cycle, sleep)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048132"(female germ-line stem cell asymmetric division)|go:"GO:0048133"(male germ-line stem cell asymmetric division)|go:"GO:0048542"(lymph gland development)|go:"GO:0048589"(developmental growth)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060180"(female mating behavior)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0061964"(negative regulation of entry into reproductive diapause)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070346"(positive regulation of fat cell proliferation)|go:"GO:0090278"(negative regulation of peptide hormone secretion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1904801"(positive regulation of neuron remodeling)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|reactome:R-DME-110478|reactome:R-DME-77387|reactome:R-DME-9009391|ensemblmetazoa:FBgn0283499(gene)|ensemblmetazoa:FBtr0084121(transcript)|ensemblmetazoa:FBtr0290230(transcript)|ensemblmetazoa:FBtr0290231(transcript)|ensemblmetazoa:FBtr0290232(transcript)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007285"(primary spermatocyte growth)|go:"GO:0007390"(germ-band shortening)|go:"GO:0007399"(nervous system development)	refseq:NP_001138093.1|refseq:NP_001138094.1|refseq:NP_001138095.1|refseq:NP_524436.2|flybase:FBgn0283499|go:"GO:0007411"(axon guidance)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007446"(imaginal disc growth)|go:"GO:0007568"(aging)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008585"(female gonad development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0033500"(carbohydrate homeostasis)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034059"(response to anoxia)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042321"(negative regulation of circadian sleep/wake cycle, sleep)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048132"(female germ-line stem cell asymmetric division)|go:"GO:0048133"(male germ-line stem cell asymmetric division)|go:"GO:0048542"(lymph gland development)|go:"GO:0048589"(developmental growth)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060180"(female mating behavior)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0061964"(negative regulation of entry into reproductive diapause)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070346"(positive regulation of fat cell proliferation)|go:"GO:0090278"(negative regulation of peptide hormone secretion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1904801"(positive regulation of neuron remodeling)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|reactome:R-DME-110478|reactome:R-DME-77387|reactome:R-DME-9009391|ensemblmetazoa:FBgn0283499(gene)|ensemblmetazoa:FBtr0084121(transcript)|ensemblmetazoa:FBtr0290230(transcript)|ensemblmetazoa:FBtr0290231(transcript)|ensemblmetazoa:FBtr0290232(transcript)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007285"(primary spermatocyte growth)|go:"GO:0007390"(germ-band shortening)|go:"GO:0007399"(nervous system development)	go:"GO:0016310"(phosphorylation)	-	-	stimulant:Increased reaction observed upon insulin stimulation.|resulting-ptm:phosphorylation of INR observed.	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/03/30	2014/10/16	rogid:IS/+aD6emSortrv0wVSEn2MIlLw7227	rogid:IS/+aD6emSortrv0wVSEn2MIlLw7227	intact-crc:F86DA535A8BE73C7|rigid:bwzhE2fyfLyTABtjJ12fAVPqgtY	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09208	uniprotkb:P09208	intact:EBI-92063|uniprotkb:Q24023|uniprotkb:Q24089|uniprotkb:Q9VD94|uniprotkb:B7Z0N6|ensemblmetazoa:FBpp0083519|ensemblmetazoa:FBpp0288669|ensemblmetazoa:FBpp0288670|ensemblmetazoa:FBpp0288671	intact:EBI-92063|uniprotkb:Q24023|uniprotkb:Q24089|uniprotkb:Q9VD94|uniprotkb:B7Z0N6|ensemblmetazoa:FBpp0083519|ensemblmetazoa:FBpp0288669|ensemblmetazoa:FBpp0288670|ensemblmetazoa:FBpp0288671	psi-mi:insr_drome(display_long)|uniprotkb:InR(gene name)|psi-mi:InR(display_short)|uniprotkb:dinr(gene name synonym)|uniprotkb:Dir-a(gene name synonym)|uniprotkb:Inr-a(gene name synonym)|uniprotkb:dIRH(gene name synonym)|uniprotkb:CG18402(orf name)	psi-mi:insr_drome(display_long)|uniprotkb:InR(gene name)|psi-mi:InR(display_short)|uniprotkb:dinr(gene name synonym)|uniprotkb:Dir-a(gene name synonym)|uniprotkb:Inr-a(gene name synonym)|uniprotkb:dIRH(gene name synonym)|uniprotkb:CG18402(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Marin-Hincapie et al. (1999)	pubmed:10455177	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-524335	-	-	psi-mi:"MI:0503"(self)	psi-mi:"MI:0503"(self)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138093.1|refseq:NP_001138094.1|refseq:NP_001138095.1|refseq:NP_524436.2|flybase:FBgn0283499|go:"GO:0007411"(axon guidance)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007446"(imaginal disc growth)|go:"GO:0007568"(aging)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008585"(female gonad development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0033500"(carbohydrate homeostasis)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034059"(response to anoxia)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042321"(negative regulation of circadian sleep/wake cycle, sleep)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048132"(female germ-line stem cell asymmetric division)|go:"GO:0048133"(male germ-line stem cell asymmetric division)|go:"GO:0048542"(lymph gland development)|go:"GO:0048589"(developmental growth)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060180"(female mating behavior)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0061964"(negative regulation of entry into reproductive diapause)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070346"(positive regulation of fat cell proliferation)|go:"GO:0090278"(negative regulation of peptide hormone secretion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1904801"(positive regulation of neuron remodeling)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|reactome:R-DME-110478|reactome:R-DME-77387|reactome:R-DME-9009391|ensemblmetazoa:FBgn0283499(gene)|ensemblmetazoa:FBtr0084121(transcript)|ensemblmetazoa:FBtr0290230(transcript)|ensemblmetazoa:FBtr0290231(transcript)|ensemblmetazoa:FBtr0290232(transcript)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007285"(primary spermatocyte growth)|go:"GO:0007390"(germ-band shortening)|go:"GO:0007399"(nervous system development)	refseq:NP_001138093.1|refseq:NP_001138094.1|refseq:NP_001138095.1|refseq:NP_524436.2|flybase:FBgn0283499|go:"GO:0007411"(axon guidance)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007446"(imaginal disc growth)|go:"GO:0007568"(aging)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008585"(female gonad development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0033500"(carbohydrate homeostasis)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034059"(response to anoxia)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042321"(negative regulation of circadian sleep/wake cycle, sleep)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048132"(female germ-line stem cell asymmetric division)|go:"GO:0048133"(male germ-line stem cell asymmetric division)|go:"GO:0048542"(lymph gland development)|go:"GO:0048589"(developmental growth)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060180"(female mating behavior)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0061964"(negative regulation of entry into reproductive diapause)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070346"(positive regulation of fat cell proliferation)|go:"GO:0090278"(negative regulation of peptide hormone secretion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1904801"(positive regulation of neuron remodeling)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|reactome:R-DME-110478|reactome:R-DME-77387|reactome:R-DME-9009391|ensemblmetazoa:FBgn0283499(gene)|ensemblmetazoa:FBtr0084121(transcript)|ensemblmetazoa:FBtr0290230(transcript)|ensemblmetazoa:FBtr0290231(transcript)|ensemblmetazoa:FBtr0290232(transcript)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007285"(primary spermatocyte growth)|go:"GO:0007390"(germ-band shortening)|go:"GO:0007399"(nervous system development)	go:"GO:0016310"(phosphorylation)	-	-	comment:"competition of phosphorylation was observed with cold INR peptide (AA 1702-1720)"|comment:transient transfection of constructs|resulting-ptm:phosphorylation of INR observed.	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/03/30	2014/10/16	rogid:IS/+aD6emSortrv0wVSEn2MIlLw7227	rogid:IS/+aD6emSortrv0wVSEn2MIlLw7227	intact-crc:DE0668BC4A622353|rigid:bwzhE2fyfLyTABtjJ12fAVPqgtY	false	myc tag:?-?	myc tag:?-?	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09208	uniprotkb:Q9XTN2	intact:EBI-92063|uniprotkb:Q24023|uniprotkb:Q24089|uniprotkb:Q9VD94|uniprotkb:B7Z0N6|ensemblmetazoa:FBpp0083519|ensemblmetazoa:FBpp0288669|ensemblmetazoa:FBpp0288670|ensemblmetazoa:FBpp0288671	intact:EBI-176370|uniprotkb:Q5U0V5|uniprotkb:Q9U4G2|uniprotkb:D0UY43|uniprotkb:D0UY45|uniprotkb:D0UY46|uniprotkb:D0UY47|uniprotkb:D0UY49|uniprotkb:D0UY50|uniprotkb:D0UY51|uniprotkb:D0UY52|uniprotkb:D0UY54|uniprotkb:D0UY55|uniprotkb:D0UY61|uniprotkb:D0UY62|uniprotkb:D0UY64|uniprotkb:D0UY65|uniprotkb:D0UY66|uniprotkb:D0UY67|uniprotkb:D0UY68|ensemblmetazoa:FBpp0079677|ensemblmetazoa:FBpp0292907|ensemblmetazoa:FBpp0305604	psi-mi:insr_drome(display_long)|uniprotkb:InR(gene name)|psi-mi:InR(display_short)|uniprotkb:dinr(gene name synonym)|uniprotkb:Dir-a(gene name synonym)|uniprotkb:Inr-a(gene name synonym)|uniprotkb:dIRH(gene name synonym)|uniprotkb:CG18402(orf name)	psi-mi:irs1_drome(display_long)|uniprotkb:chico(gene name)|psi-mi:chico(display_short)|uniprotkb:IRS(gene name synonym)|uniprotkb:CG5686(orf name)|uniprotkb:Protein chico(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Marin-Hincapie et al. (1999)	pubmed:10455177	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-524350	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138093.1|refseq:NP_001138094.1|refseq:NP_001138095.1|refseq:NP_524436.2|flybase:FBgn0283499|go:"GO:0007411"(axon guidance)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007446"(imaginal disc growth)|go:"GO:0007568"(aging)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008585"(female gonad development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0033500"(carbohydrate homeostasis)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034059"(response to anoxia)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042321"(negative regulation of circadian sleep/wake cycle, sleep)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048132"(female germ-line stem cell asymmetric division)|go:"GO:0048133"(male germ-line stem cell asymmetric division)|go:"GO:0048542"(lymph gland development)|go:"GO:0048589"(developmental growth)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060180"(female mating behavior)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0061964"(negative regulation of entry into reproductive diapause)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070346"(positive regulation of fat cell proliferation)|go:"GO:0090278"(negative regulation of peptide hormone secretion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1904801"(positive regulation of neuron remodeling)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|reactome:R-DME-110478|reactome:R-DME-77387|reactome:R-DME-9009391|ensemblmetazoa:FBgn0283499(gene)|ensemblmetazoa:FBtr0084121(transcript)|ensemblmetazoa:FBtr0290230(transcript)|ensemblmetazoa:FBtr0290231(transcript)|ensemblmetazoa:FBtr0290232(transcript)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007285"(primary spermatocyte growth)|go:"GO:0007390"(germ-band shortening)|go:"GO:0007399"(nervous system development)	refseq:NP_001188772.1|refseq:NP_723540.1|flybase:FBgn0024248|refseq:NP_001260316.1|dip:DIP-23631N|ensemblmetazoa:FBgn0024248(gene)|ensemblmetazoa:FBtr0080088(transcript)|ensemblmetazoa:FBtr0303904(transcript)|ensemblmetazoa:FBtr0333412(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007285"(primary spermatocyte growth)|go:"GO:0007295"(growth of a germarium-derived egg chamber)|go:"GO:0007296"(vitellogenesis)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008355"(olfactory learning)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0034059"(response to anoxia)|go:"GO:0035159"(regulation of tube length, open tracheal system)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048133"(male germ-line stem cell asymmetric division)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061964"(negative regulation of entry into reproductive diapause)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-DME-109704|reactome:R-DME-110478|reactome:R-DME-112399|reactome:R-DME-112412|reactome:R-DME-1257604|reactome:R-DME-198203|reactome:R-DME-5673001|reactome:R-DME-6811558|reactome:R-DME-74749|reactome:R-DME-9027276|reactome:R-DME-9027284	-	-	-	-	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2005/03/30	2014/10/16	rogid:IS/+aD6emSortrv0wVSEn2MIlLw7227	rogid:ewOZtT+2P14/RsctVcnrQEmQEjY7227	intact-crc:FF3DA0D0716076CD|rigid:JR2wgtBhea8uJ+UQzq+LPj21Ryo	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)