#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P03122	uniprotkb:Q16637-1	intact:EBI-7028618|uniprotkb:Q9WMH0|intact:MINT-95676	intact:EBI-395436|ensembl:ENSP00000305857|ensembl:ENSP00000370083|ensembl:ENSP00000479920|ensembl:ENSP00000370119|ensembl:ENSP00000370117|ensembl:ENSP00000482966|ensembl:ENSP00000483515|ensembl:ENSP00000483819|ensembl:ENSP00000487206|ensembl:ENSP00000487421|intact:EBI-7028827|intact:MINT-95584|intact:EBI-7028912|intact:EBI-7028796|intact:EBI-7028596|intact:EBI-7028873|intact:EBI-7028963|intact:EBI-7028717|intact:EBI-7028683	psi-mi:ve2_bpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:q16637-1(display_long)|uniprotkb:Full-SMN(isoform synonym)|uniprotkb:SMN1(gene name)|psi-mi:SMN1(display_short)|uniprotkb:SMN2(gene name)|psi-mi:SMN2(display_short)|uniprotkb:SMN(gene name synonym)|uniprotkb:SMNT(gene name synonym)|uniprotkb:SMNC(gene name synonym)|uniprotkb:Component of gems 1(gene name synonym)|uniprotkb:Gemin-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Strasswimmer et al. (1999)	pubmed:10369867|mint:MINT-5211564	taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7028612|mint:MINT-73368	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056740.1|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042504|rcsb pdb:1DBD|rcsb pdb:1JJH|rcsb pdb:2BOP|rcsb pdb:2JEU|rcsb pdb:2JEX|rcsb pdb:6BUS|interpro:IPR042503|dip:DIP-40866N|mint:MINT-369045(identity)	intact:EBI-395421(smn_human)|ensembl:ENSG00000172062(gene)|ensembl:ENSG00000205571(gene)|ensembl:ENSG00000273772(gene)|ensembl:ENSG00000275349(gene)|ensembl:ENSG00000277773(gene)|ensembl:ENST00000351205(transcript)|ensembl:ENST00000380707(transcript)|ensembl:ENST00000380741(transcript)|ensembl:ENST00000380743(transcript)|ensembl:ENST00000614610(transcript)|ensembl:ENST00000618251(transcript)|ensembl:ENST00000618661(transcript)|ensembl:ENST00000622739(transcript)|ensembl:ENST00000627341(transcript)|ensembl:ENST00000629122(transcript)|uniprotkb:Q16637-1(isoform-parent)|mint:MINT-369052(identity)	-	comment:mint|function:"E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:homomint|comment:"Stoichiometry: 1.0"	isoform-comment:Primarily derived from SMN1 gene.|comment:"Stoichiometry: 1.0"	figure legend:F1A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/22	2014/10/16	rogid:q+tFpuRXU8hhZnmVO8ZNtF5YS5o337052	rogid:QGivm7E8suciCWXO4l0zCUzCl2g9606	intact-crc:05DBE2ACF51A3197|rigid:Mg3zV0dley6F0rGhQLUc9LjDbRo	false	glutathione s tranferase tag:?-?(MINT-369046)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P03122	uniprotkb:Q16637-1	intact:EBI-7028618|uniprotkb:Q9WMH0|intact:MINT-95676	intact:EBI-395436|ensembl:ENSP00000305857|ensembl:ENSP00000370083|ensembl:ENSP00000479920|ensembl:ENSP00000370119|ensembl:ENSP00000370117|ensembl:ENSP00000482966|ensembl:ENSP00000483515|ensembl:ENSP00000483819|ensembl:ENSP00000487206|ensembl:ENSP00000487421|intact:EBI-7028827|intact:MINT-95584|intact:EBI-7028912|intact:EBI-7028796|intact:EBI-7028596|intact:EBI-7028873|intact:EBI-7028963|intact:EBI-7028717|intact:EBI-7028683	psi-mi:ve2_bpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:q16637-1(display_long)|uniprotkb:Full-SMN(isoform synonym)|uniprotkb:SMN1(gene name)|psi-mi:SMN1(display_short)|uniprotkb:SMN2(gene name)|psi-mi:SMN2(display_short)|uniprotkb:SMN(gene name synonym)|uniprotkb:SMNT(gene name synonym)|uniprotkb:SMNC(gene name synonym)|uniprotkb:Component of gems 1(gene name synonym)|uniprotkb:Gemin-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Strasswimmer et al. (1999)	pubmed:10369867|mint:MINT-5211564	taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7028699|mint:MINT-73369	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056740.1|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042504|rcsb pdb:1DBD|rcsb pdb:1JJH|rcsb pdb:2BOP|rcsb pdb:2JEU|rcsb pdb:2JEX|rcsb pdb:6BUS|interpro:IPR042503|dip:DIP-40866N|mint:MINT-369120(identity)	intact:EBI-395421(smn_human)|ensembl:ENSG00000172062(gene)|ensembl:ENSG00000205571(gene)|ensembl:ENSG00000273772(gene)|ensembl:ENSG00000275349(gene)|ensembl:ENSG00000277773(gene)|ensembl:ENST00000351205(transcript)|ensembl:ENST00000380707(transcript)|ensembl:ENST00000380741(transcript)|ensembl:ENST00000380743(transcript)|ensembl:ENST00000614610(transcript)|ensembl:ENST00000618251(transcript)|ensembl:ENST00000618661(transcript)|ensembl:ENST00000622739(transcript)|ensembl:ENST00000627341(transcript)|ensembl:ENST00000629122(transcript)|uniprotkb:Q16637-1(isoform-parent)|mint:MINT-369127(identity)	-	comment:mint|function:"E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:homomint|comment:"Stoichiometry: 1.0"	isoform-comment:Primarily derived from SMN1 gene.|comment:"Stoichiometry: 1.0"	figure legend:F1B F1C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/22	2014/10/16	rogid:q+tFpuRXU8hhZnmVO8ZNtF5YS5o337052	rogid:QGivm7E8suciCWXO4l0zCUzCl2g9606	intact-crc:547CD913815C8034|rigid:Mg3zV0dley6F0rGhQLUc9LjDbRo	false	his tag:?-?(MINT-369121)	glutathione s tranferase tag:?-?(MINT-369128)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P03120	uniprotkb:Q16637-1	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-395436|ensembl:ENSP00000305857|ensembl:ENSP00000370083|ensembl:ENSP00000479920|ensembl:ENSP00000370119|ensembl:ENSP00000370117|ensembl:ENSP00000482966|ensembl:ENSP00000483515|ensembl:ENSP00000483819|ensembl:ENSP00000487206|ensembl:ENSP00000487421|intact:EBI-7028827|intact:MINT-95584|intact:EBI-7028912|intact:EBI-7028796|intact:EBI-7028596|intact:EBI-7028873|intact:EBI-7028963|intact:EBI-7028717|intact:EBI-7028683	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:q16637-1(display_long)|uniprotkb:Full-SMN(isoform synonym)|uniprotkb:SMN1(gene name)|psi-mi:SMN1(display_short)|uniprotkb:SMN2(gene name)|psi-mi:SMN2(display_short)|uniprotkb:SMN(gene name synonym)|uniprotkb:SMNT(gene name synonym)|uniprotkb:SMNC(gene name synonym)|uniprotkb:Component of gems 1(gene name synonym)|uniprotkb:Gemin-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Strasswimmer et al. (1999)	pubmed:10369867|mint:MINT-5211564	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7028812|mint:MINT-73371	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7|mint:MINT-369090(identity)	intact:EBI-395421(smn_human)|ensembl:ENSG00000172062(gene)|ensembl:ENSG00000205571(gene)|ensembl:ENSG00000273772(gene)|ensembl:ENSG00000275349(gene)|ensembl:ENSG00000277773(gene)|ensembl:ENST00000351205(transcript)|ensembl:ENST00000380707(transcript)|ensembl:ENST00000380741(transcript)|ensembl:ENST00000380743(transcript)|ensembl:ENST00000614610(transcript)|ensembl:ENST00000618251(transcript)|ensembl:ENST00000618661(transcript)|ensembl:ENST00000622739(transcript)|ensembl:ENST00000627341(transcript)|ensembl:ENST00000629122(transcript)|uniprotkb:Q16637-1(isoform-parent)|mint:MINT-369095(identity)	-	comment:"Stoichiometry: 1.0"	isoform-comment:Primarily derived from SMN1 gene.|comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/22	2014/10/16	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:QGivm7E8suciCWXO4l0zCUzCl2g9606	intact-crc:BFDC1B2DEA04E8CC|rigid:ecd0spphxqec29OSK+rKV5qVjVY	false	-	glutathione s tranferase tag:?-?(MINT-369096)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P04015	uniprotkb:Q16637-1	intact:EBI-7010556|intact:MINT-95651	intact:EBI-395436|ensembl:ENSP00000305857|ensembl:ENSP00000370083|ensembl:ENSP00000479920|ensembl:ENSP00000370119|ensembl:ENSP00000370117|ensembl:ENSP00000482966|ensembl:ENSP00000483515|ensembl:ENSP00000483819|ensembl:ENSP00000487206|ensembl:ENSP00000487421|intact:EBI-7028827|intact:MINT-95584|intact:EBI-7028912|intact:EBI-7028796|intact:EBI-7028596|intact:EBI-7028873|intact:EBI-7028963|intact:EBI-7028717|intact:EBI-7028683	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:q16637-1(display_long)|uniprotkb:Full-SMN(isoform synonym)|uniprotkb:SMN1(gene name)|psi-mi:SMN1(display_short)|uniprotkb:SMN2(gene name)|psi-mi:SMN2(display_short)|uniprotkb:SMN(gene name synonym)|uniprotkb:SMNT(gene name synonym)|uniprotkb:SMNC(gene name synonym)|uniprotkb:Component of gems 1(gene name synonym)|uniprotkb:Gemin-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Strasswimmer et al. (1999)	pubmed:10369867|mint:MINT-5211564	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7028733|mint:MINT-73370	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|mint:MINT-369105(identity)	intact:EBI-395421(smn_human)|ensembl:ENSG00000172062(gene)|ensembl:ENSG00000205571(gene)|ensembl:ENSG00000273772(gene)|ensembl:ENSG00000275349(gene)|ensembl:ENSG00000277773(gene)|ensembl:ENST00000351205(transcript)|ensembl:ENST00000380707(transcript)|ensembl:ENST00000380741(transcript)|ensembl:ENST00000380743(transcript)|ensembl:ENST00000614610(transcript)|ensembl:ENST00000618251(transcript)|ensembl:ENST00000618661(transcript)|ensembl:ENST00000622739(transcript)|ensembl:ENST00000627341(transcript)|ensembl:ENST00000629122(transcript)|uniprotkb:Q16637-1(isoform-parent)|mint:MINT-369110(identity)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:"Stoichiometry: 1.0"	isoform-comment:Primarily derived from SMN1 gene.|comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/22	2014/10/16	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:QGivm7E8suciCWXO4l0zCUzCl2g9606	intact-crc:C048DD8D80EBCF38|rigid:YxMvHQRal2yFagasUjHuCcEmySI	false	-	glutathione s tranferase tag:?-?(MINT-369111)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P06790	uniprotkb:Q16637-1	intact:EBI-7010629|intact:MINT-95532	intact:EBI-395436|ensembl:ENSP00000305857|ensembl:ENSP00000370083|ensembl:ENSP00000479920|ensembl:ENSP00000370119|ensembl:ENSP00000370117|ensembl:ENSP00000482966|ensembl:ENSP00000483515|ensembl:ENSP00000483819|ensembl:ENSP00000487206|ensembl:ENSP00000487421|intact:EBI-7028827|intact:MINT-95584|intact:EBI-7028912|intact:EBI-7028796|intact:EBI-7028596|intact:EBI-7028873|intact:EBI-7028963|intact:EBI-7028717|intact:EBI-7028683	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:q16637-1(display_long)|uniprotkb:Full-SMN(isoform synonym)|uniprotkb:SMN1(gene name)|psi-mi:SMN1(display_short)|uniprotkb:SMN2(gene name)|psi-mi:SMN2(display_short)|uniprotkb:SMN(gene name synonym)|uniprotkb:SMNT(gene name synonym)|uniprotkb:SMNC(gene name synonym)|uniprotkb:Component of gems 1(gene name synonym)|uniprotkb:Gemin-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Strasswimmer et al. (1999)	pubmed:10369867|mint:MINT-5211564	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7028843|mint:MINT-73372	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|mint:MINT-369075(identity)	intact:EBI-395421(smn_human)|ensembl:ENSG00000172062(gene)|ensembl:ENSG00000205571(gene)|ensembl:ENSG00000273772(gene)|ensembl:ENSG00000275349(gene)|ensembl:ENSG00000277773(gene)|ensembl:ENST00000351205(transcript)|ensembl:ENST00000380707(transcript)|ensembl:ENST00000380741(transcript)|ensembl:ENST00000380743(transcript)|ensembl:ENST00000614610(transcript)|ensembl:ENST00000618251(transcript)|ensembl:ENST00000618661(transcript)|ensembl:ENST00000622739(transcript)|ensembl:ENST00000627341(transcript)|ensembl:ENST00000629122(transcript)|uniprotkb:Q16637-1(isoform-parent)|mint:MINT-369080(identity)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint|comment:"Stoichiometry: 1.0"	isoform-comment:Primarily derived from SMN1 gene.|comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/22	2014/10/16	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:QGivm7E8suciCWXO4l0zCUzCl2g9606	intact-crc:B28C6455140433A7|rigid:U+92yeT16JkdY3l6ndamYH2pkw4	false	-	glutathione s tranferase tag:?-?(MINT-369081)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P03122	uniprotkb:Q16637-1	intact:EBI-7028618|uniprotkb:Q9WMH0|intact:MINT-95676	intact:EBI-395436|ensembl:ENSP00000305857|ensembl:ENSP00000370083|ensembl:ENSP00000479920|ensembl:ENSP00000370119|ensembl:ENSP00000370117|ensembl:ENSP00000482966|ensembl:ENSP00000483515|ensembl:ENSP00000483819|ensembl:ENSP00000487206|ensembl:ENSP00000487421|intact:EBI-7028827|intact:MINT-95584|intact:EBI-7028912|intact:EBI-7028796|intact:EBI-7028596|intact:EBI-7028873|intact:EBI-7028963|intact:EBI-7028717|intact:EBI-7028683	psi-mi:ve2_bpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:q16637-1(display_long)|uniprotkb:Full-SMN(isoform synonym)|uniprotkb:SMN1(gene name)|psi-mi:SMN1(display_short)|uniprotkb:SMN2(gene name)|psi-mi:SMN2(display_short)|uniprotkb:SMN(gene name synonym)|uniprotkb:SMNT(gene name synonym)|uniprotkb:SMNC(gene name synonym)|uniprotkb:Component of gems 1(gene name synonym)|uniprotkb:Gemin-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Strasswimmer et al. (1999)	pubmed:10369867|mint:MINT-5211564	taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7028889|mint:MINT-73374	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056740.1|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042504|rcsb pdb:1DBD|rcsb pdb:1JJH|rcsb pdb:2BOP|rcsb pdb:2JEU|rcsb pdb:2JEX|rcsb pdb:6BUS|interpro:IPR042503|dip:DIP-40866N|mint:MINT-369060(identity)	intact:EBI-395421(smn_human)|ensembl:ENSG00000172062(gene)|ensembl:ENSG00000205571(gene)|ensembl:ENSG00000273772(gene)|ensembl:ENSG00000275349(gene)|ensembl:ENSG00000277773(gene)|ensembl:ENST00000351205(transcript)|ensembl:ENST00000380707(transcript)|ensembl:ENST00000380741(transcript)|ensembl:ENST00000380743(transcript)|ensembl:ENST00000614610(transcript)|ensembl:ENST00000618251(transcript)|ensembl:ENST00000618661(transcript)|ensembl:ENST00000622739(transcript)|ensembl:ENST00000627341(transcript)|ensembl:ENST00000629122(transcript)|uniprotkb:Q16637-1(isoform-parent)|mint:MINT-369065(identity)	-	comment:mint|function:"E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:homomint|comment:"Stoichiometry: 1.0"	isoform-comment:Primarily derived from SMN1 gene.|comment:"Stoichiometry: 1.0"	figure legend:F2C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/12/22	2014/10/16	rogid:q+tFpuRXU8hhZnmVO8ZNtF5YS5o337052	rogid:QGivm7E8suciCWXO4l0zCUzCl2g9606	intact-crc:0F6930EE856739EB|rigid:Mg3zV0dley6F0rGhQLUc9LjDbRo	false	-	glutathione s tranferase tag:?-?(MINT-369066)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P03122	uniprotkb:Q16637-1	intact:EBI-7028618|uniprotkb:Q9WMH0|intact:MINT-95676	intact:EBI-395436|ensembl:ENSP00000305857|ensembl:ENSP00000370083|ensembl:ENSP00000479920|ensembl:ENSP00000370119|ensembl:ENSP00000370117|ensembl:ENSP00000482966|ensembl:ENSP00000483515|ensembl:ENSP00000483819|ensembl:ENSP00000487206|ensembl:ENSP00000487421|intact:EBI-7028827|intact:MINT-95584|intact:EBI-7028912|intact:EBI-7028796|intact:EBI-7028596|intact:EBI-7028873|intact:EBI-7028963|intact:EBI-7028717|intact:EBI-7028683	psi-mi:ve2_bpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:q16637-1(display_long)|uniprotkb:Full-SMN(isoform synonym)|uniprotkb:SMN1(gene name)|psi-mi:SMN1(display_short)|uniprotkb:SMN2(gene name)|psi-mi:SMN2(display_short)|uniprotkb:SMN(gene name synonym)|uniprotkb:SMNT(gene name synonym)|uniprotkb:SMNC(gene name synonym)|uniprotkb:Component of gems 1(gene name synonym)|uniprotkb:Gemin-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Strasswimmer et al. (1999)	pubmed:10369867|mint:MINT-5211564	taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7028928|mint:MINT-73373	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056740.1|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042504|rcsb pdb:1DBD|rcsb pdb:1JJH|rcsb pdb:2BOP|rcsb pdb:2JEU|rcsb pdb:2JEX|rcsb pdb:6BUS|interpro:IPR042503|dip:DIP-40866N|mint:MINT-369139(identity)	intact:EBI-395421(smn_human)|ensembl:ENSG00000172062(gene)|ensembl:ENSG00000205571(gene)|ensembl:ENSG00000273772(gene)|ensembl:ENSG00000275349(gene)|ensembl:ENSG00000277773(gene)|ensembl:ENST00000351205(transcript)|ensembl:ENST00000380707(transcript)|ensembl:ENST00000380741(transcript)|ensembl:ENST00000380743(transcript)|ensembl:ENST00000614610(transcript)|ensembl:ENST00000618251(transcript)|ensembl:ENST00000618661(transcript)|ensembl:ENST00000622739(transcript)|ensembl:ENST00000627341(transcript)|ensembl:ENST00000629122(transcript)|uniprotkb:Q16637-1(isoform-parent)|mint:MINT-369144(identity)	-	comment:mint|function:"E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:homomint|comment:"Stoichiometry: 1.0"	isoform-comment:Primarily derived from SMN1 gene.|comment:"Stoichiometry: 1.0"	figure legend:F2B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2005/12/22	2014/10/16	rogid:q+tFpuRXU8hhZnmVO8ZNtF5YS5o337052	rogid:QGivm7E8suciCWXO4l0zCUzCl2g9606	intact-crc:27F955C116039CDB|rigid:Mg3zV0dley6F0rGhQLUc9LjDbRo	false	-	-	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P03122	uniprotkb:Q16637-1	intact:EBI-7028618|uniprotkb:Q9WMH0|intact:MINT-95676	intact:EBI-395436|ensembl:ENSP00000305857|ensembl:ENSP00000370083|ensembl:ENSP00000479920|ensembl:ENSP00000370119|ensembl:ENSP00000370117|ensembl:ENSP00000482966|ensembl:ENSP00000483515|ensembl:ENSP00000483819|ensembl:ENSP00000487206|ensembl:ENSP00000487421|intact:EBI-7028827|intact:MINT-95584|intact:EBI-7028912|intact:EBI-7028796|intact:EBI-7028596|intact:EBI-7028873|intact:EBI-7028963|intact:EBI-7028717|intact:EBI-7028683	psi-mi:ve2_bpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:q16637-1(display_long)|uniprotkb:Full-SMN(isoform synonym)|uniprotkb:SMN1(gene name)|psi-mi:SMN1(display_short)|uniprotkb:SMN2(gene name)|psi-mi:SMN2(display_short)|uniprotkb:SMN(gene name synonym)|uniprotkb:SMNT(gene name synonym)|uniprotkb:SMNC(gene name synonym)|uniprotkb:Component of gems 1(gene name synonym)|uniprotkb:Gemin-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Strasswimmer et al. (1999)	pubmed:10369867|mint:MINT-5211564	taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7028979|mint:MINT-73367	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056740.1|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042504|rcsb pdb:1DBD|rcsb pdb:1JJH|rcsb pdb:2BOP|rcsb pdb:2JEU|rcsb pdb:2JEX|rcsb pdb:6BUS|interpro:IPR042503|dip:DIP-40866N|mint:MINT-369154(identity)	intact:EBI-395421(smn_human)|ensembl:ENSG00000172062(gene)|ensembl:ENSG00000205571(gene)|ensembl:ENSG00000273772(gene)|ensembl:ENSG00000275349(gene)|ensembl:ENSG00000277773(gene)|ensembl:ENST00000351205(transcript)|ensembl:ENST00000380707(transcript)|ensembl:ENST00000380741(transcript)|ensembl:ENST00000380743(transcript)|ensembl:ENST00000614610(transcript)|ensembl:ENST00000618251(transcript)|ensembl:ENST00000618661(transcript)|ensembl:ENST00000622739(transcript)|ensembl:ENST00000627341(transcript)|ensembl:ENST00000629122(transcript)|uniprotkb:Q16637-1(isoform-parent)|mint:MINT-369163(identity)	-	comment:mint|function:"E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:homomint|comment:"Stoichiometry: 1.0"	isoform-comment:Primarily derived from SMN1 gene.|comment:"Stoichiometry: 1.0"	figure legend:T2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2005/12/22	2014/10/16	rogid:q+tFpuRXU8hhZnmVO8ZNtF5YS5o337052	rogid:QGivm7E8suciCWXO4l0zCUzCl2g9606	intact-crc:BCA61362A75E7404|rigid:Mg3zV0dley6F0rGhQLUc9LjDbRo	false	tag:?-?(MINT-369157)|binding-associated region:115-215(MINT-369155)	tag:?-?(MINT-369164)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)