#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O14727	uniprotkb:P55211	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-516799|uniprotkb:O95348|uniprotkb:Q92852|uniprotkb:Q9BQ62|uniprotkb:Q9UEQ3|uniprotkb:Q9UIJ8|uniprotkb:Q53Y70|uniprotkb:Q5JRU9|uniprotkb:Q5UGI1|uniprotkb:B4E1A3|ensembl:ENSP00000330237	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:casp9_human(display_long)|uniprotkb:ICE-like apoptotic protease 6(gene name synonym)|uniprotkb:Apoptotic protease Mch-6(gene name synonym)|uniprotkb:Apoptotic protease-activating factor 3(gene name synonym)|uniprotkb:CASP9(gene name)|psi-mi:CASP9(display_short)|uniprotkb:MCH6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zou et al. (1999)	pubmed:10206961	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-516795	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001264983.1|refseq:NP_001220.2|refseq:NP_127463.2|refseq:XP_005246071.1|dip:DIP-27625N|ensembl:ENSG00000132906(gene)|ensembl:ENST00000333868(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030220"(platelet formation)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033171|interpro:IPR042147|mint:P55211|rcsb pdb:1JXQ|rcsb pdb:1NW9|rcsb pdb:2AR9|rcsb pdb:3D9T|rcsb pdb:3V3K|rcsb pdb:3YGS|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|rcsb pdb:5WVE|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-168638|reactome:R-HSA-198323|reactome:R-HSA-418889|reactome:R-HSA-5674400|reactome:R-HSA-9627069	go:"GO:0043293"(apoptosome)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)	-	-	comment:dATP present in reaction|resulting-ptm:Procaspase-9 was rapidly auto-activated once bound to APAF-1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/03/09	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:IYW59Vh17AEnXa6/wLpkIPNE0Bo9606	intact-crc:66EE6A4993AEC866|rigid:mszthirEj3eOzEUWDRd2mq9G7wg	false	his tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14727	uniprotkb:P99999	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-446479|uniprotkb:A4D166|uniprotkb:P00001|uniprotkb:Q6NUR2|uniprotkb:Q6NX69|uniprotkb:Q96BV4|uniprotkb:B2R4I1|ensembl:ENSP00000307786|ensembl:ENSP00000386270|ensembl:ENSP00000387279	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:cyc_human(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zou et al. (1999)	pubmed:10206961	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-516795	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_061820.1|dip:DIP-29683N|ensembl:ENSG00000172115(gene)|ensembl:ENST00000305786(transcript)|ensembl:ENST00000409409(transcript)|ensembl:ENST00000409764(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045333"(cellular respiration)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|mint:P99999|rcsb pdb:1J3S|rcsb pdb:2N3Y|rcsb pdb:2N9I|rcsb pdb:2N9J|rcsb pdb:3NWV|rcsb pdb:3ZCF|rcsb pdb:3ZOO|rcsb pdb:5EXQ|rcsb pdb:5O10|rcsb pdb:5TY3|rcsb pdb:6DUJ|rcsb pdb:6ECJ|reactome:R-HSA-111457|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-2151201|reactome:R-HSA-3299685|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9627069|reactome:R-HSA-9707564	go:"GO:0043293"(apoptosome)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)	-	-	comment:dATP present in reaction|resulting-ptm:Procaspase-9 was rapidly auto-activated once bound to APAF-1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/03/09	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:vSMR7doWXd3VBP8jmhl6cUjccdY9606	intact-crc:66EE6A4993AEC866|rigid:mszthirEj3eOzEUWDRd2mq9G7wg	false	his tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14727	uniprotkb:P99999	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-446479|uniprotkb:A4D166|uniprotkb:P00001|uniprotkb:Q6NUR2|uniprotkb:Q6NX69|uniprotkb:Q96BV4|uniprotkb:B2R4I1|ensembl:ENSP00000307786|ensembl:ENSP00000386270|ensembl:ENSP00000387279	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:cyc_human(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zou et al. (1999)	pubmed:10206961	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-516863	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_061820.1|dip:DIP-29683N|ensembl:ENSG00000172115(gene)|ensembl:ENST00000305786(transcript)|ensembl:ENST00000409409(transcript)|ensembl:ENST00000409764(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045333"(cellular respiration)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|mint:P99999|rcsb pdb:1J3S|rcsb pdb:2N3Y|rcsb pdb:2N9I|rcsb pdb:2N9J|rcsb pdb:3NWV|rcsb pdb:3ZCF|rcsb pdb:3ZOO|rcsb pdb:5EXQ|rcsb pdb:5O10|rcsb pdb:5TY3|rcsb pdb:6DUJ|rcsb pdb:6ECJ|reactome:R-HSA-111457|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-2151201|reactome:R-HSA-3299685|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9627069|reactome:R-HSA-9707564	go:"GO:0043293"(apoptosome)	-	-	comment:dATP present in reaction|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/03/09	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:vSMR7doWXd3VBP8jmhl6cUjccdY9606	intact-crc:FC7700FBD37DB785|rigid:EgX6LmGCox9OGQOst8YF6PZFWSY	false	his tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14727	uniprotkb:P55211	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-516799|uniprotkb:O95348|uniprotkb:Q92852|uniprotkb:Q9BQ62|uniprotkb:Q9UEQ3|uniprotkb:Q9UIJ8|uniprotkb:Q53Y70|uniprotkb:Q5JRU9|uniprotkb:Q5UGI1|uniprotkb:B4E1A3|ensembl:ENSP00000330237	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:casp9_human(display_long)|uniprotkb:ICE-like apoptotic protease 6(gene name synonym)|uniprotkb:Apoptotic protease Mch-6(gene name synonym)|uniprotkb:Apoptotic protease-activating factor 3(gene name synonym)|uniprotkb:CASP9(gene name)|psi-mi:CASP9(display_short)|uniprotkb:MCH6(gene name synonym)	psi-mi:"MI:0027"(cosedimentation)	Zou et al. (1999)	pubmed:10206961	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-516878	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001264983.1|refseq:NP_001220.2|refseq:NP_127463.2|refseq:XP_005246071.1|dip:DIP-27625N|ensembl:ENSG00000132906(gene)|ensembl:ENST00000333868(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030220"(platelet formation)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033171|interpro:IPR042147|mint:P55211|rcsb pdb:1JXQ|rcsb pdb:1NW9|rcsb pdb:2AR9|rcsb pdb:3D9T|rcsb pdb:3V3K|rcsb pdb:3YGS|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|rcsb pdb:5WVE|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-168638|reactome:R-HSA-198323|reactome:R-HSA-418889|reactome:R-HSA-5674400|reactome:R-HSA-9627069	go:"GO:0043293"(apoptosome)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)	-	-	comment:dATP required for complex to form|resulting-ptm:Procaspase-9 was rapidly auto-activated once bound to APAF-1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/03/09	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:IYW59Vh17AEnXa6/wLpkIPNE0Bo9606	intact-crc:A6768DC74379A0CE|rigid:mszthirEj3eOzEUWDRd2mq9G7wg	false	his tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14727	uniprotkb:P99999	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-446479|uniprotkb:A4D166|uniprotkb:P00001|uniprotkb:Q6NUR2|uniprotkb:Q6NX69|uniprotkb:Q96BV4|uniprotkb:B2R4I1|ensembl:ENSP00000307786|ensembl:ENSP00000386270|ensembl:ENSP00000387279	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:cyc_human(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym)	psi-mi:"MI:0027"(cosedimentation)	Zou et al. (1999)	pubmed:10206961	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-516878	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_061820.1|dip:DIP-29683N|ensembl:ENSG00000172115(gene)|ensembl:ENST00000305786(transcript)|ensembl:ENST00000409409(transcript)|ensembl:ENST00000409764(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045333"(cellular respiration)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|mint:P99999|rcsb pdb:1J3S|rcsb pdb:2N3Y|rcsb pdb:2N9I|rcsb pdb:2N9J|rcsb pdb:3NWV|rcsb pdb:3ZCF|rcsb pdb:3ZOO|rcsb pdb:5EXQ|rcsb pdb:5O10|rcsb pdb:5TY3|rcsb pdb:6DUJ|rcsb pdb:6ECJ|reactome:R-HSA-111457|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-2151201|reactome:R-HSA-3299685|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9627069|reactome:R-HSA-9707564	go:"GO:0043293"(apoptosome)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)	-	-	comment:dATP required for complex to form|resulting-ptm:Procaspase-9 was rapidly auto-activated once bound to APAF-1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/03/09	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:vSMR7doWXd3VBP8jmhl6cUjccdY9606	intact-crc:A6768DC74379A0CE|rigid:mszthirEj3eOzEUWDRd2mq9G7wg	false	his tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14727	uniprotkb:P55211	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-516799|uniprotkb:O95348|uniprotkb:Q92852|uniprotkb:Q9BQ62|uniprotkb:Q9UEQ3|uniprotkb:Q9UIJ8|uniprotkb:Q53Y70|uniprotkb:Q5JRU9|uniprotkb:Q5UGI1|uniprotkb:B4E1A3|ensembl:ENSP00000330237	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:casp9_human(display_long)|uniprotkb:ICE-like apoptotic protease 6(gene name synonym)|uniprotkb:Apoptotic protease Mch-6(gene name synonym)|uniprotkb:Apoptotic protease-activating factor 3(gene name synonym)|uniprotkb:CASP9(gene name)|psi-mi:CASP9(display_short)|uniprotkb:MCH6(gene name synonym)	psi-mi:"MI:0027"(cosedimentation)	Zou et al. (1999)	pubmed:10206961	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-517006	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_001264983.1|refseq:NP_001220.2|refseq:NP_127463.2|refseq:XP_005246071.1|dip:DIP-27625N|ensembl:ENSG00000132906(gene)|ensembl:ENST00000333868(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030220"(platelet formation)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033171|interpro:IPR042147|mint:P55211|rcsb pdb:1JXQ|rcsb pdb:1NW9|rcsb pdb:2AR9|rcsb pdb:3D9T|rcsb pdb:3V3K|rcsb pdb:3YGS|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|rcsb pdb:5WVE|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-168638|reactome:R-HSA-198323|reactome:R-HSA-418889|reactome:R-HSA-5674400|reactome:R-HSA-9627069	go:"GO:0043293"(apoptosome)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)	-	-	comment:dATP required for complex to form|resulting-ptm:Procaspase-9 was rapidly auto-activated once bound to APAF-1.|comment:"Large complex (>1.3 million-dalton exclusion volume of the column) forms in vivo when cells undergo apoptosis"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2005/03/09	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:IYW59Vh17AEnXa6/wLpkIPNE0Bo9606	intact-crc:0D135B360D42FDD0|rigid:mszthirEj3eOzEUWDRd2mq9G7wg	false	his tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14727	uniprotkb:P99999	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-446479|uniprotkb:A4D166|uniprotkb:P00001|uniprotkb:Q6NUR2|uniprotkb:Q6NX69|uniprotkb:Q96BV4|uniprotkb:B2R4I1|ensembl:ENSP00000307786|ensembl:ENSP00000386270|ensembl:ENSP00000387279	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:cyc_human(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym)	psi-mi:"MI:0027"(cosedimentation)	Zou et al. (1999)	pubmed:10206961	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-517006	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)	refseq:NP_061820.1|dip:DIP-29683N|ensembl:ENSG00000172115(gene)|ensembl:ENST00000305786(transcript)|ensembl:ENST00000409409(transcript)|ensembl:ENST00000409764(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045333"(cellular respiration)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|mint:P99999|rcsb pdb:1J3S|rcsb pdb:2N3Y|rcsb pdb:2N9I|rcsb pdb:2N9J|rcsb pdb:3NWV|rcsb pdb:3ZCF|rcsb pdb:3ZOO|rcsb pdb:5EXQ|rcsb pdb:5O10|rcsb pdb:5TY3|rcsb pdb:6DUJ|rcsb pdb:6ECJ|reactome:R-HSA-111457|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-2151201|reactome:R-HSA-3299685|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9627069|reactome:R-HSA-9707564	go:"GO:0043293"(apoptosome)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)	-	-	comment:dATP required for complex to form|resulting-ptm:Procaspase-9 was rapidly auto-activated once bound to APAF-1.|comment:"Large complex (>1.3 million-dalton exclusion volume of the column) forms in vivo when cells undergo apoptosis"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2005/03/09	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:vSMR7doWXd3VBP8jmhl6cUjccdY9606	intact-crc:0D135B360D42FDD0|rigid:mszthirEj3eOzEUWDRd2mq9G7wg	false	his tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)