#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O43516 uniprotkb:P42768 intact:EBI-346356|uniprotkb:Q15220|uniprotkb:Q6MZU9|uniprotkb:Q9BU37|uniprotkb:Q9UNP1|uniprotkb:Q53TA9|uniprotkb:B8ZZM1|uniprotkb:D3DPE4|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENSP00000503603 intact:EBI-346375|uniprotkb:Q9BU11|uniprotkb:Q9UNJ9|ensembl:ENSP00000365891 psi-mi:wipf1_human(display_long)|uniprotkb:WIPF1(gene name)|psi-mi:WIPF1(display_short)|uniprotkb:WIP(gene name synonym)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Protein PRPL-2(gene name synonym)|uniprotkb:WASPIP(gene name synonym) psi-mi:wasp_human(display_long)|uniprotkb:WAS(gene name)|psi-mi:WAS(display_short)|uniprotkb:IMD2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Stewart et al. (1999) pubmed:10202051 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-603205 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001070737.1|refseq:NP_003378.3|refseq:XP_011510082.1|ensembl:ENST00000272746|ensembl:ENSP00000272746|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENST00000409891|ensembl:ENSP00000386431|ensembl:ENSP00000503603|dip:DIP-17015N|ensembl:ENSG00000115935(gene)|ensembl:ENST00000359761(transcript)|ensembl:ENST00000392546(transcript)|ensembl:ENST00000392547(transcript)|ensembl:ENST00000679041(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:O43516|rcsb pdb:2A41|reactome:R-HSA-2029482|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9664422 refseq:NP_000368.1|dip:DIP-431N|ensembl:ENSG00000015285(gene)|ensembl:ENST00000376701(transcript)|go:"GO:0002625"(regulation of T cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007596"(blood coagulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008544"(epidermis development)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0012506"(vesicle membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|interpro:IPR036936|mint:P42768|rcsb pdb:1CEE|rcsb pdb:1EJ5|rcsb pdb:1T84|rcsb pdb:2A3Z|rcsb pdb:2K42|rcsb pdb:2OT0|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013409|reactome:R-HSA-9664422 - - - dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2005/06/20 2014/10/16 rogid:8qaxT2n0EXIVTi08xHsryCSSt9k9606 rogid:VHtlRNZQYpIU2btQV28coDiNsO09606 intact-crc:71DC9B14125EE415|rigid:bXBCynyKqn/DBI3pHqn8h6rAq2M false - mutation decreasing interaction:134-134|binding-associated region:2-152|mutation decreasing interaction:107-107|mutation decreasing interaction:86-86 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O43516 uniprotkb:P42768 intact:EBI-346356|uniprotkb:Q15220|uniprotkb:Q6MZU9|uniprotkb:Q9BU37|uniprotkb:Q9UNP1|uniprotkb:Q53TA9|uniprotkb:B8ZZM1|uniprotkb:D3DPE4|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENSP00000503603 intact:EBI-346375|uniprotkb:Q9BU11|uniprotkb:Q9UNJ9|ensembl:ENSP00000365891 psi-mi:wipf1_human(display_long)|uniprotkb:WIPF1(gene name)|psi-mi:WIPF1(display_short)|uniprotkb:WIP(gene name synonym)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Protein PRPL-2(gene name synonym)|uniprotkb:WASPIP(gene name synonym) psi-mi:wasp_human(display_long)|uniprotkb:WAS(gene name)|psi-mi:WAS(display_short)|uniprotkb:IMD2(gene name synonym) psi-mi:"MI:0096"(pull down) Stewart et al. (1999) pubmed:10202051 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-603228 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001070737.1|refseq:NP_003378.3|refseq:XP_011510082.1|ensembl:ENST00000272746|ensembl:ENSP00000272746|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENST00000409891|ensembl:ENSP00000386431|ensembl:ENSP00000503603|dip:DIP-17015N|ensembl:ENSG00000115935(gene)|ensembl:ENST00000359761(transcript)|ensembl:ENST00000392546(transcript)|ensembl:ENST00000392547(transcript)|ensembl:ENST00000679041(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:O43516|rcsb pdb:2A41|reactome:R-HSA-2029482|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9664422 refseq:NP_000368.1|dip:DIP-431N|ensembl:ENSG00000015285(gene)|ensembl:ENST00000376701(transcript)|go:"GO:0002625"(regulation of T cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007596"(blood coagulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008544"(epidermis development)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0012506"(vesicle membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|interpro:IPR036936|mint:P42768|rcsb pdb:1CEE|rcsb pdb:1EJ5|rcsb pdb:1T84|rcsb pdb:2A3Z|rcsb pdb:2K42|rcsb pdb:2OT0|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013409|reactome:R-HSA-9664422 - - - dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/20 2014/10/16 rogid:8qaxT2n0EXIVTi08xHsryCSSt9k9606 rogid:VHtlRNZQYpIU2btQV28coDiNsO09606 intact-crc:D78A4D4979458D42|rigid:bXBCynyKqn/DBI3pHqn8h6rAq2M false binding-associated region:?-?|glutathione s tranferase tag:?-?|radiolabel:?-? mutation decreasing interaction:86-86|mutation decreasing interaction:107-107|mutation decreasing interaction:134-134|tag:?-?|glutathione s tranferase tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)