#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9GJP9 uniprotkb:P31751 intact:EBI-6961732|ensembl:ENSOCUP00000023874|intact:MINT-87758|uniprotkb:G1U3B4 intact:EBI-296058|uniprotkb:Q05BV0|ensembl:ENSP00000375892|uniprotkb:Q0VAN1|uniprotkb:Q68GC0|uniprotkb:B2RBD8|uniprotkb:Q0VAN0 psi-mi:q9gjp9_rabit(display_long)|uniprotkb:MYH13(gene name)|psi-mi:MYH13(display_short) psi-mi:akt2_human(display_long)|uniprotkb:AKT2(gene name)|psi-mi:AKT2(display_short)|uniprotkb:RAC-PK-beta(gene name synonym)|uniprotkb:Protein kinase Akt-2(gene name synonym)|uniprotkb:Protein kinase B beta(gene name synonym) psi-mi:"MI:0096"(pull down) Tanaka et al. (1999) pubmed:10082674|mint:MINT-5211247 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6961726|mint:MINT-58643 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSOCUG00000010207(gene)|ensembl:ENSOCUT00000022677(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016459"(myosin complex)|go:"GO:0030016"(myofibril)|go:"GO:0051015"(actin filament binding)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|interpro:IPR027417|interpro:IPR036961|interpro:IPR042702|rcsb pdb:5H53|go:"GO:0005524"(ATP binding)|refseq:NP_001156538.1|mint:MINT-364756(identity) ensembl:ENSG00000105221(gene)|ensembl:ENST00000392038(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006417"(regulation of translation)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0065002"(intracellular protein transmembrane transport)|go:"GO:0071486"(cellular response to high light intensity)|go:"GO:0072659"(protein localization to plasma membrane)|rcsb pdb:1MRV|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097473"(retinal rod cell apoptotic process)|rcsb pdb:1MRY|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034677|interpro:IPR039026|mint:P31751|rcsb pdb:1GZK|rcsb pdb:1GZN|rcsb pdb:1GZO|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3D0E|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|reactome:R-HSA-111447|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-1445148|reactome:R-HSA-165158|reactome:R-HSA-165160|reactome:R-HSA-165181|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|reactome:R-HSA-211163|reactome:R-HSA-3769402|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-5218920|rcsb pdb:1P6S|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-6804759|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|reactome:R-HSA-6804758|refseq:NP_001617.1|refseq:XP_011524916.1|refseq:XP_011524917.1|refseq:XP_011524918.1|refseq:XP_011524920.1|refseq:XP_011524921.1|refseq:XP_011524922.1|refseq:XP_016881959.1|refseq:NP_001317440.1|dip:DIP-32583N|mint:MINT-364747(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1B|comment:"The whole PH domain of PKB beta is required for the interaction to occur, as indicated by negative results when using short regions of the domain in the same pull down experiments (F3)"|kd:0.11 picomolar|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/15 2014/10/16 rogid:0gH7Rl2iNA7dNOt1mqzkrm4ntFs9986 rogid:hr5vfkjrLrU6uIISuFxlsHnf4MA9606 intact-crc:22DDFCF92F7C47F6|rigid:zN+3byvCvv+0FR55Md5xZBbz5QY false - binding-associated region:1-113(MINT-364748)|tag:?-?(MINT-364751) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9GJP9 uniprotkb:Q16760 intact:EBI-6961732|ensembl:ENSOCUP00000023874|intact:MINT-87758|uniprotkb:G1U3B4 intact:EBI-719333|uniprotkb:Q14158|uniprotkb:Q6PK55|uniprotkb:Q8NG53|ensembl:ENSP00000264057|ensembl:ENSP00000487220 psi-mi:q9gjp9_rabit(display_long)|uniprotkb:MYH13(gene name)|psi-mi:MYH13(display_short) psi-mi:dgkd_human(display_long)|uniprotkb:Diglyceride kinase delta(gene name synonym)|uniprotkb:130 kDa diacylglycerol kinase(gene name synonym)|uniprotkb:DGKD(gene name)|psi-mi:DGKD(display_short)|uniprotkb:KIAA0145(gene name synonym) psi-mi:"MI:0096"(pull down) Tanaka et al. (1999) pubmed:10082674|mint:MINT-5211247 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6961764|mint:MINT-58644 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSOCUG00000010207(gene)|ensembl:ENSOCUT00000022677(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016459"(myosin complex)|go:"GO:0030016"(myofibril)|go:"GO:0051015"(actin filament binding)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|interpro:IPR027417|interpro:IPR036961|interpro:IPR042702|rcsb pdb:5H53|go:"GO:0005524"(ATP binding)|refseq:NP_001156538.1|mint:MINT-364740(identity) refseq:NP_003639.2|refseq:NP_690618.2|ensembl:ENSG00000077044(gene)|ensembl:ENSG00000280873(gene)|ensembl:ENST00000264057(transcript)|ensembl:ENST00000628356(transcript)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0004143"(diacylglycerol kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0010033"(response to organic substance)|go:"GO:0015031"(protein transport)|go:"GO:0019900"(kinase binding)|go:"GO:0019932"(second-messenger-mediated signaling)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030168"(platelet activation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046339"(diacylglycerol metabolic process)|go:"GO:0046834"(lipid phosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0090038"(negative regulation of protein kinase C signaling)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000756(Diacylglycerol kinase accessory region)|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|interpro:IPR037606|interpro:IPR037607|mint:Q16760|rcsb pdb:1R79|rcsb pdb:3BQ7|reactome:R-HSA-114508|dip:DIP-29646N|mint:MINT-364731(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1C|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2005/06/15 2014/10/16 rogid:0gH7Rl2iNA7dNOt1mqzkrm4ntFs9986 rogid:rMLPKsHWpeF6qbY0eBQcCeFyMo09606 intact-crc:F5B7F743EF7B00A9|rigid:Pn46U4LYvIazRv5MN6l2Vje6x90 false - binding-associated region:53-146(MINT-364732)|tag:?-?(MINT-364735) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)