#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P29452	uniprotkb:Q56134	intact:EBI-489700|ensembl:ENSMUSP00000027015	intact:EBI-489689|uniprotkb:Q7AME0|uniprotkb:Q7C7N1|ensemblbacteria:AAO70348	psi-mi:casp1_mouse(display_long)|uniprotkb:Interleukin-1 beta convertase(gene name synonym)|uniprotkb:Interleukin-1 beta-converting enzyme(gene name synonym)|uniprotkb:p45(gene name synonym)|uniprotkb:Casp1(gene name)|psi-mi:Casp1(display_short)|uniprotkb:Il1bc(gene name synonym)	psi-mi:sipb_salti(display_long)|uniprotkb:Effector protein SipB(gene name synonym)|uniprotkb:STY3008(locus name)|uniprotkb:t2787(locus name)|uniprotkb:sipB(gene name)|psi-mi:sipB(display_short)	psi-mi:"MI:0096"(pull down)	Hersh et al. (1999)	pubmed:10051653	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:90370(salti)|taxid:90370(Salmonella typhi)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-489717	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033937.2|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046010"(positive regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0070269"(pyroptosis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097179"(protease inhibitor complex)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0140447"(cytokine precursor processing)|go:"GO:0140448"(signaling receptor ligand precursor processing)|go:"GO:1901998"(toxin transport)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|reactome:R-MMU-168638|reactome:R-MMU-448706|reactome:R-MMU-5620971|ensembl:ENSMUSG00000025888(gene)|ensembl:ENSMUST00000027015(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007613"(memory)|go:"GO:0008233"(peptidase activity)|go:"GO:0009617"(response to bacterium)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016485"(protein processing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019900"(kinase binding)|go:"GO:0032496"(response to lipopolysaccharide)|dip:DIP-34659N	interpro:IPR006972("Secretion system effector C (SseC) like protein")|interpro:IPR003895(Salmonella/Shigella invasin protein B)|refseq:NP_457279.1|interpro:IPR032391|refseq:WP_000245782.1|go:"GO:0020002"(host cell plasma membrane)|ensemblbacteria:AAO70348(transcript)|ensemblbacteria:t2787(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2005/02/01	2014/10/16	rogid:XhG0cS+c25k1ktN7Kbn4d0BS14810090	rogid:PvUmHQ2MfzkNR3KnMm4SEb0zuXo90370	intact-crc:33AA3B67725AA9C9|rigid:t9SjLwjMGifq5nrSOmhDE9so68U	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q56134	uniprotkb:P29452	intact:EBI-489689|uniprotkb:Q7AME0|uniprotkb:Q7C7N1|ensemblbacteria:AAO70348	intact:EBI-489700|ensembl:ENSMUSP00000027015	psi-mi:sipb_salti(display_long)|uniprotkb:Effector protein SipB(gene name synonym)|uniprotkb:STY3008(locus name)|uniprotkb:t2787(locus name)|uniprotkb:sipB(gene name)|psi-mi:sipB(display_short)	psi-mi:casp1_mouse(display_long)|uniprotkb:Interleukin-1 beta convertase(gene name synonym)|uniprotkb:Interleukin-1 beta-converting enzyme(gene name synonym)|uniprotkb:p45(gene name synonym)|uniprotkb:Casp1(gene name)|psi-mi:Casp1(display_short)|uniprotkb:Il1bc(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Hersh et al. (1999)	pubmed:10051653	taxid:90370(salti)|taxid:90370(Salmonella typhi)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-489736	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR006972("Secretion system effector C (SseC) like protein")|interpro:IPR003895(Salmonella/Shigella invasin protein B)|refseq:NP_457279.1|interpro:IPR032391|refseq:WP_000245782.1|go:"GO:0020002"(host cell plasma membrane)|ensemblbacteria:AAO70348(transcript)|ensemblbacteria:t2787(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)	refseq:NP_033937.2|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046010"(positive regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0070269"(pyroptosis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097179"(protease inhibitor complex)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0140447"(cytokine precursor processing)|go:"GO:0140448"(signaling receptor ligand precursor processing)|go:"GO:1901998"(toxin transport)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|reactome:R-MMU-168638|reactome:R-MMU-448706|reactome:R-MMU-5620971|ensembl:ENSMUSG00000025888(gene)|ensembl:ENSMUST00000027015(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007613"(memory)|go:"GO:0008233"(peptidase activity)|go:"GO:0009617"(response to bacterium)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016485"(protein processing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019900"(kinase binding)|go:"GO:0032496"(response to lipopolysaccharide)|dip:DIP-34659N	-	-	-	comment:"The co-ip is carried out after infection of mouse macrophage j77a4.1 by the shigella strain (defective of sipb homologue IpaB) expressing salmonella sipb."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:10090(mouse-j774a-1)|taxid:10090(Mus musculus macrophage)	-	2005/02/01	2014/10/16	rogid:PvUmHQ2MfzkNR3KnMm4SEb0zuXo90370	rogid:XhG0cS+c25k1ktN7Kbn4d0BS14810090	intact-crc:FE634CDBD40DC595|rigid:t9SjLwjMGifq5nrSOmhDE9so68U	false	flag tag:n-n	-	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)