#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q95241	uniprotkb:P00760	intact:EBI-8619383|intact:MINT-1513021	intact:EBI-986385|ensembl:ENSBTAP00000004737|ensembl:ENSBTAP00000033392|uniprotkb:A6H6Y3	psi-mi:a4_saisc(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:try1_bovin(display_long)|uniprotkb:Beta-trypsin(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Scheidig et al. (1997)	mint:MINT-5221641|pubmed:9300481	taxid:9521(saisc)|taxid:9521("Saimiri sciureus (Common squirrel monkey)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8619436|mint:MINT-25103	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003677"(DNA binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008201"(heparin binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016358"(dendrite development)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0043204"(perikaryon)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0048669"(collateral sprouting in absence of injury)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0005634"(nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0007155"(cell adhesion)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007617"(mating behavior)|go:"GO:0007626"(locomotory behavior)|interpro:IPR011178(Amyloidogenic glycoprotein, copper-binding)|interpro:IPR015849(Amyloidogenic glycoprotein, heparin-binding)|interpro:IPR019744|interpro:IPR020901|interpro:IPR019543|interpro:IPR019745|interpro:IPR013803(Amyloidogenic glycoprotein, amyloid-beta peptide)|interpro:IPR024329|interpro:IPR028866|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036176|interpro:IPR036454|interpro:IPR036669|interpro:IPR036880|interpro:IPR037071|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR008154(Amyloidogenic glycoprotein, extracellular)|interpro:IPR008155(Amyloidogenic glycoprotein, core)|mint:MINT-1527461(identity)	ensembl:ENSBTAG00000052726(gene)|ensembl:ENSBTAT00000004737(transcript)|ensembl:ENSBTAT00000033479(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0007586"(digestion)|go:"GO:0046872"(metal ion binding)|go:"GO:0097180"(serine protease inhibitor complex)|go:"GO:0097655"(serpin family protein binding)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|mint:P00760|rcsb pdb:1AQ7|ensembl:ENSBTAG00000050323(gene)|rcsb pdb:1AUJ|rcsb pdb:1AZ8|rcsb pdb:1BJU|rcsb pdb:1BJV|rcsb pdb:1BTP|rcsb pdb:1BTW|rcsb pdb:1BTX|rcsb pdb:1BTY|rcsb pdb:1BTZ|rcsb pdb:1C1N|rcsb pdb:1C1O|rcsb pdb:1C1P|rcsb pdb:1C1Q|rcsb pdb:1C1R|rcsb pdb:1C1S|rcsb pdb:1C1T|rcsb pdb:1C2D|rcsb pdb:1C2E|rcsb pdb:1C2F|rcsb pdb:1C2G|rcsb pdb:1C2H|rcsb pdb:1C2I|rcsb pdb:1C2J|rcsb pdb:1C2K|rcsb pdb:1C2L|rcsb pdb:1C2M|rcsb pdb:1C5P|rcsb pdb:1C5Q|rcsb pdb:1C5R|rcsb pdb:1C5S|rcsb pdb:1C5T|rcsb pdb:1C5U|rcsb pdb:1C5V|rcsb pdb:1C9T|rcsb pdb:1CE5|rcsb pdb:1CU7|rcsb pdb:1CU8|rcsb pdb:1CU9|rcsb pdb:1D6R|rcsb pdb:1EB2|rcsb pdb:1EJM|rcsb pdb:1EZX|rcsb pdb:1F0T|rcsb pdb:1F0U|rcsb pdb:1F2S|rcsb pdb:1G36|rcsb pdb:1G3B|rcsb pdb:1G3C|rcsb pdb:1G3D|rcsb pdb:1G3E|rcsb pdb:1G9I|rcsb pdb:1GBT|rcsb pdb:1GHZ|rcsb pdb:1GI0|rcsb pdb:1GI1|rcsb pdb:1GI2|rcsb pdb:1GI3|rcsb pdb:1GI4|rcsb pdb:1GI5|rcsb pdb:1GI6|rcsb pdb:1GJ6|rcsb pdb:1HJ9|rcsb pdb:1J8A|rcsb pdb:1JIR|rcsb pdb:1JRS|rcsb pdb:1JRT|rcsb pdb:1K1I|rcsb pdb:1K1J|rcsb pdb:1K1L|rcsb pdb:1K1M|rcsb pdb:1K1N|rcsb pdb:1K1O|rcsb pdb:1K1P|rcsb pdb:1LQE|rcsb pdb:1MAY|rcsb pdb:1MTS|rcsb pdb:1MTU|rcsb pdb:1MTV|rcsb pdb:1MTW|rcsb pdb:1N6X|rcsb pdb:1N6Y|rcsb pdb:1NC6|rcsb pdb:1NTP|rcsb pdb:1O2H|rcsb pdb:1O2I|rcsb pdb:1O2J|rcsb pdb:1O2K|rcsb pdb:1O2L|rcsb pdb:1O2M|rcsb pdb:1O2N|rcsb pdb:1O2O|rcsb pdb:1MAX|rcsb pdb:1O2P|rcsb pdb:1O2Q|rcsb pdb:1O2R|rcsb pdb:1O2S|rcsb pdb:3A8C|rcsb pdb:3A8D|rcsb pdb:3AAS|rcsb pdb:3AAU|rcsb pdb:3AAV|rcsb pdb:3ATI|rcsb pdb:3ATK|rcsb pdb:3ATL|rcsb pdb:3ATM|rcsb pdb:3BTD|rcsb pdb:3BTE|rcsb pdb:3BTF|rcsb pdb:3BTG|rcsb pdb:3BTH|rcsb pdb:3BTK|rcsb pdb:3BTM|rcsb pdb:3BTQ|rcsb pdb:3BTT|rcsb pdb:3BTW|rcsb pdb:3D65|rcsb pdb:3E8L|rcsb pdb:3GY2|rcsb pdb:3GY3|rcsb pdb:3GY4|rcsb pdb:3GY5|rcsb pdb:3GY6|rcsb pdb:3GY7|rcsb pdb:3GY8|rcsb pdb:3I29|rcsb pdb:3ITI|rcsb pdb:3LJJ|rcsb pdb:3LJO|rcsb pdb:3M35|rcsb pdb:3M7Q|rcsb pdb:3MFJ|rcsb pdb:3MI4|rcsb pdb:3NK8|rcsb pdb:3NKK|rcsb pdb:3OTJ|rcsb pdb:3PLB|rcsb pdb:3PLK|rcsb pdb:3PLP|rcsb pdb:3PM3|rcsb pdb:3PMJ|rcsb pdb:3PTB|rcsb pdb:3PTN|rcsb pdb:3PWB|rcsb pdb:3PWC|rcsb pdb:3PYH|rcsb pdb:3Q00|rcsb pdb:3QK1|rcsb pdb:3RDZ|rcsb pdb:3RU4|rcsb pdb:3RXA|rcsb pdb:3RXB|rcsb pdb:3RXC|rcsb pdb:3RXD|rcsb pdb:3RXE|rcsb pdb:3RXJ|rcsb pdb:3RXK|rcsb pdb:3RXL|rcsb pdb:3RXM|rcsb pdb:3RXO|rcsb pdb:3RXF|rcsb pdb:3RXG|rcsb pdb:3RXH|rcsb pdb:3RXI|rcsb pdb:3RXP|rcsb pdb:3RXQ|rcsb pdb:3RXR|rcsb pdb:3RXS|rcsb pdb:3RXT|rcsb pdb:3RXU|rcsb pdb:3RXV|rcsb pdb:3T25|rcsb pdb:3T26|rcsb pdb:3T27|rcsb pdb:3T28|rcsb pdb:3T29|rcsb pdb:3TPI|rcsb pdb:3UNQ|rcsb pdb:3UNR|rcsb pdb:3UNS|rcsb pdb:3UOP|rcsb pdb:3UPE|rcsb pdb:3UQO|rcsb pdb:3UQV|rcsb pdb:3UUZ|rcsb pdb:3UWI|rcsb pdb:3UY9|rcsb pdb:3V0X|rcsb pdb:3V12|rcsb pdb:3V13|rcsb pdb:3VEQ|rcsb pdb:3VPK|rcsb pdb:4AB8|rcsb pdb:4AB9|rcsb pdb:4ABA|rcsb pdb:4ABB|rcsb pdb:4ABD|rcsb pdb:4ABE|rcsb pdb:4ABF|rcsb pdb:4ABG|rcsb pdb:4ABH|rcsb pdb:4ABI|rcsb pdb:4ABJ|rcsb pdb:4AOQ|rcsb pdb:4AOR|rcsb pdb:4B1T|rcsb pdb:4B2A|rcsb pdb:4B2B|rcsb pdb:4B2C|rcsb pdb:4GUX|rcsb pdb:4HGC|rcsb pdb:4I8G|rcsb pdb:4I8H|rcsb pdb:4I8J|rcsb pdb:4I8K|rcsb pdb:4I8L|rcsb pdb:4J2Y|rcsb pdb:4KTS|rcsb pdb:4KTU|rcsb pdb:4MTB|rcsb pdb:4NCY|rcsb pdb:4NIV|rcsb pdb:4NIW|rcsb pdb:4NIX|rcsb pdb:4NIY|rcsb pdb:4TPI|rcsb pdb:4TPY|rcsb pdb:4U2W|rcsb pdb:4XOJ|rcsb pdb:4Y0Y|rcsb pdb:4Y0Z|rcsb pdb:4Y10|rcsb pdb:4Y11|rcsb pdb:4YTA|rcsb pdb:5EG4|rcsb pdb:5F6M|rcsb pdb:5FXL|rcsb pdb:5GIB|rcsb pdb:5GXP|rcsb pdb:5JYI|rcsb pdb:5K7R|rcsb pdb:5LGO|rcsb pdb:5LH4|rcsb pdb:5LH8|rcsb pdb:5MN1|rcsb pdb:5MNA|rcsb pdb:5MNB|rcsb pdb:5MNC|rcsb pdb:5MNE|rcsb pdb:5MNF|rcsb pdb:5MNG|rcsb pdb:5MNH|rcsb pdb:5MNK|rcsb pdb:5MNL|rcsb pdb:5MNM|rcsb pdb:5MNN|rcsb pdb:5MNO|rcsb pdb:5MNP|rcsb pdb:5MNQ|rcsb pdb:5MNX|rcsb pdb:5MNY|rcsb pdb:5MNZ|rcsb pdb:5MO0|rcsb pdb:5MO1|rcsb pdb:5MO2|rcsb pdb:5MON|rcsb pdb:5MOO|rcsb pdb:5MOP|rcsb pdb:5MOQ|rcsb pdb:5MOR|rcsb pdb:5MOS|rcsb pdb:5PTP|rcsb pdb:5T3H|rcsb pdb:6AVL|rcsb pdb:6B6N|rcsb pdb:6B6O|rcsb pdb:6B6P|rcsb pdb:6B6Q|rcsb pdb:6B6R|rcsb pdb:6B6S|rcsb pdb:6B6T|rcsb pdb:6BFP|rcsb pdb:6BVH|rcsb pdb:6DWF|rcsb pdb:6DWH|rcsb pdb:6DWR|rcsb pdb:6DWU|rcsb pdb:6DZF|rcsb pdb:6E5M|rcsb pdb:6EAT|rcsb pdb:6EAU|rcsb pdb:6EAV|rcsb pdb:6EAW|rcsb pdb:6EAX|rcsb pdb:6FID|rcsb pdb:6MRQ|rcsb pdb:6QIH|rcsb pdb:6QL0|rcsb pdb:6SUX|rcsb pdb:6SV0|rcsb pdb:6SV6|rcsb pdb:6SV8|rcsb pdb:6SV9|rcsb pdb:1Y3Y|rcsb pdb:1Y59|rcsb pdb:1Y5A|rcsb pdb:1Y5B|rcsb pdb:1Y5U|rcsb pdb:1YP9|rcsb pdb:1YYY|rcsb pdb:1ZR0|rcsb pdb:1ZZZ|rcsb pdb:2A7H|rcsb pdb:2AGE|rcsb pdb:2AGG|rcsb pdb:2AGI|rcsb pdb:2AH4|rcsb pdb:2AYW|rcsb pdb:2BLV|rcsb pdb:2BLW|rcsb pdb:2BTC|rcsb pdb:2BY5|rcsb pdb:2BY6|rcsb pdb:2BY7|rcsb pdb:2BY8|rcsb pdb:6SVB|rcsb pdb:6SVD|rcsb pdb:6SVG|rcsb pdb:6SVI|rcsb pdb:6SVJ|rcsb pdb:6SVN|rcsb pdb:6SVR|rcsb pdb:6SVU|rcsb pdb:6SVV|rcsb pdb:6SVW|rcsb pdb:6SVX|rcsb pdb:6SVZ|rcsb pdb:6SW0|rcsb pdb:6SWV|rcsb pdb:6SY3|rcsb pdb:6T0M|rcsb pdb:6T0P|rcsb pdb:6T5W|rcsb pdb:6T9U|rcsb pdb:6T9V|rcsb pdb:6U22|rcsb pdb:6VXY|rcsb pdb:6XYG|rcsb pdb:6XYK|rcsb pdb:6YDY|rcsb pdb:6YIS|rcsb pdb:6YIT|rcsb pdb:6YIU|rcsb pdb:6YIV|rcsb pdb:6YIW|rcsb pdb:6YIX|rcsb pdb:6YIY|rcsb pdb:6YZA|rcsb pdb:6YZC|rcsb pdb:6ZFJ|rcsb pdb:6ZFK|rcsb pdb:7AYS|rcsb pdb:2BYA|rcsb pdb:2BZA|rcsb pdb:2CMY|rcsb pdb:2D8W|rcsb pdb:2F3C|rcsb pdb:2FI3|rcsb pdb:2FI4|rcsb pdb:2FI5|rcsb pdb:2FTL|rcsb pdb:2FTM|rcsb pdb:2FX4|rcsb pdb:2FX6|rcsb pdb:2G55|rcsb pdb:2G5N|rcsb pdb:2G5V|rcsb pdb:2G81|rcsb pdb:2G8T|rcsb pdb:2ILN|rcsb pdb:2J9N|rcsb pdb:2O9Q|rcsb pdb:2OTV|rcsb pdb:2OXS|rcsb pdb:2PLX|rcsb pdb:2PTC|rcsb pdb:2PTN|rcsb pdb:2QN5|rcsb pdb:2QYI|rcsb pdb:2TGA|rcsb pdb:2BY9|rcsb pdb:1O2T|rcsb pdb:1O2U|rcsb pdb:1O2V|rcsb pdb:1O2W|rcsb pdb:1O2X|rcsb pdb:1O2Y|rcsb pdb:1O2Z|rcsb pdb:1O30|rcsb pdb:1O31|rcsb pdb:1O32|rcsb pdb:1O33|rcsb pdb:1O34|rcsb pdb:1O35|rcsb pdb:1O36|rcsb pdb:1O37|rcsb pdb:1O38|rcsb pdb:1O39|rcsb pdb:1O3A|rcsb pdb:1O3B|rcsb pdb:1O3C|rcsb pdb:1O3D|rcsb pdb:1O3E|rcsb pdb:1O3F|rcsb pdb:1O3G|rcsb pdb:1O3H|rcsb pdb:1O3I|rcsb pdb:1O3J|rcsb pdb:1O3K|rcsb pdb:1O3L|rcsb pdb:1O3M|rcsb pdb:1O3N|rcsb pdb:1O3O|rcsb pdb:1OPH|rcsb pdb:1OX1|rcsb pdb:1OYQ|rcsb pdb:1P2I|rcsb pdb:1P2J|rcsb pdb:1P2K|rcsb pdb:1PPC|rcsb pdb:1PPE|rcsb pdb:1PPH|rcsb pdb:1QA0|rcsb pdb:1QB1|rcsb pdb:1QB6|rcsb pdb:1QB9|rcsb pdb:2TGD|rcsb pdb:1QBN|rcsb pdb:1QBO|rcsb pdb:1QCP|rcsb pdb:1QL7|rcsb pdb:1QL8|rcsb pdb:1RXP|rcsb pdb:1S0Q|rcsb pdb:1S0R|rcsb pdb:1SBW|rcsb pdb:1SFI|rcsb pdb:1SMF|rcsb pdb:1TAB|rcsb pdb:1TAW|rcsb pdb:1TGB|rcsb pdb:1TGC|rcsb pdb:1TGN|rcsb pdb:1TGS|rcsb pdb:1TGT|rcsb pdb:1TIO|rcsb pdb:1TLD|rcsb pdb:1TNG|rcsb pdb:1TNH|rcsb pdb:1TNI|rcsb pdb:1TNJ|rcsb pdb:1TNK|rcsb pdb:1TNL|rcsb pdb:1TPA|rcsb pdb:1TPO|rcsb pdb:1TPP|rcsb pdb:1TPS|rcsb pdb:2TGP|rcsb pdb:7BRV|rcsb pdb:7BRW|rcsb pdb:7BRX|rcsb pdb:7BRY|rcsb pdb:7BRZ|rcsb pdb:7BS0|rcsb pdb:7BS1|rcsb pdb:7BS2|rcsb pdb:7BS3|rcsb pdb:7BS4|rcsb pdb:7BS5|rcsb pdb:7BS6|rcsb pdb:7BS7|rcsb pdb:7BS8|rcsb pdb:7BS9|rcsb pdb:7BSA|rcsb pdb:1TX7|rcsb pdb:1TX8|rcsb pdb:1TYN|rcsb pdb:1UTN|rcsb pdb:1UTO|rcsb pdb:1UTP|rcsb pdb:1UTQ|rcsb pdb:1V2J|rcsb pdb:1V2K|rcsb pdb:1V2L|rcsb pdb:1V2M|rcsb pdb:1V2N|rcsb pdb:1V2O|rcsb pdb:1V2P|rcsb pdb:1V2Q|rcsb pdb:1V2R|rcsb pdb:1V2S|rcsb pdb:1V2T|rcsb pdb:1V2U|rcsb pdb:1V2V|rcsb pdb:1V2W|rcsb pdb:1XUF|rcsb pdb:1XUG|rcsb pdb:1XUH|rcsb pdb:1XUI|rcsb pdb:1XUJ|rcsb pdb:1XUK|rcsb pdb:1Y3U|rcsb pdb:1Y3V|rcsb pdb:1Y3W|rcsb pdb:1Y3X|rcsb pdb:2TGT|rcsb pdb:2TLD|rcsb pdb:2TPI|rcsb pdb:2UUY|rcsb pdb:2XTT|rcsb pdb:2ZDK|rcsb pdb:2ZDL|rcsb pdb:2ZDM|rcsb pdb:2TIO|rcsb pdb:2ZDN|rcsb pdb:2ZFS|rcsb pdb:2ZFT|rcsb pdb:2ZHD|rcsb pdb:2ZQ1|rcsb pdb:2ZQ2|rcsb pdb:3A7T|rcsb pdb:3A7V|rcsb pdb:3A7W|rcsb pdb:3A7X|rcsb pdb:3A7Y|rcsb pdb:3A7Z|rcsb pdb:3A80|rcsb pdb:3A81|rcsb pdb:3A82|rcsb pdb:3A83|rcsb pdb:3A84|rcsb pdb:3A85|rcsb pdb:3A86|rcsb pdb:3A87|rcsb pdb:3A88|rcsb pdb:3A89|rcsb pdb:3A8A|rcsb pdb:3A8B|refseq:NP_001107199.1|refseq:XP_002687054.3|refseq:XP_871686.4|mint:MINT-1527454(identity)	-	comment:mint|function:The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis|function:"Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1/Tip60 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP (By similarity). Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). May be involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation (By similarity). Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV (By similarity). The splice isoforms that contain the BPTI domain possess protease inhibitor activity"|function:Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:In the xray complex 1taw, P00760 is chain A and Q95241 is chain B Resolution 1.800|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/02/12	2014/10/16	rogid:QEcP5QCqC2OMPp7bJd0SIrIYD5Y9521	rogid:kRsMDeTkB4zEz28dX3UQHCwz8uI9913	intact-crc:A2A3B659C2C471ED|rigid:CjJIGQiMqEyBA3KX1L+WMA62kEI	false	tag:?-?(MINT-1527462)	tag:?-?(MINT-1527455)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)