#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01647	uniprotkb:P05803	intact:EBI-8629496|intact:MINT-1511096	intact:EBI-8629512|intact:MINT-1511103	psi-mi:kv5ae_mouse(display_long)	psi-mi:nram_i84a1(display_long)|uniprotkb:NA(gene name)|psi-mi:NA(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Malby et al. (1994)	pubmed:7994573|mint:MINT-5220686	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:11484(i84a1)|taxid:11484("Influenza A virus (strain A/Whale/Maine/1/1984 H13N9)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8629491|mint:MINT-24780	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4PD4|go:"GO:0002250"(adaptive immune response)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0019814"(immunoglobulin complex)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2VWE|rcsb pdb:1EZV|rcsb pdb:2V7H|rcsb pdb:3U0W|interpro:IPR036179|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|mint:MINT-1511110(identity)	interpro:IPR033654|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0052794"("exo-alpha-(2->3)-sialidase activity")|go:"GO:0052795"("exo-alpha-(2->6)-sialidase activity")|go:"GO:0052796"("exo-alpha-(2->8)-sialidase activity")|go:"GO:0055036"(virion membrane)|rcsb pdb:1NMB|rcsb pdb:1NCD|rcsb pdb:2B8H|rcsb pdb:1NMA|interpro:IPR036278|interpro:IPR001860(Glycoside hydrolase, family 34)|mint:MINT-1511117(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|function:Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication|comment:"Stoichiometry: 1.0"	comment:In the xray complex 1nmb, P01647 is chain L and P05803 is chain N Resolution 2.500|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/02/12	2014/10/16	rogid:cTUHhqEQVSv3WGhstV6KaQd/71Q10090	rogid:NDCgJjEkHk2Vznfo0AF3ONCp0XI11484	intact-crc:7D1ACC59194FDCAB|rigid:aA31gshJKd1lf8MgEZGlbKs7Syo	false	tag:?-?(MINT-1511111)	tag:?-?(MINT-1511118)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)